{"id":"https://openalex.org/W2055638870","doi":"https://doi.org/10.1186/1752-0509-3-3","title":"Efficiency of complex production in changing environment","display_name":"Efficiency of complex production in changing environment","publication_year":2009,"publication_date":"2009-01-07","ids":{"openalex":"https://openalex.org/W2055638870","doi":"https://doi.org/10.1186/1752-0509-3-3","mag":"2055638870","pmid":"https://pubmed.ncbi.nlm.nih.gov/19128449"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049650069","display_name":"Shai Carmi","orcid":"https://orcid.org/0000-0002-0188-2610"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Shai Carmi","raw_affiliation_strings":["Minerva Center & Department of Physics, Bar-Ilan University, Ramat Gan, Israel. scarmi@shoshi.ph.biu.ac.il","Department of Physics, Minerva Center &, Bar-Ilan University, Ramat Gan, Israel","Center for Polymer Studies, Boston University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minerva Center & Department of Physics, Bar-Ilan University, Ramat Gan, Israel. scarmi@shoshi.ph.biu.ac.il","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Department of Physics, Minerva Center &, Bar-Ilan University, Ramat Gan, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Center for Polymer Studies, Boston University, Boston, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076478183","display_name":"Erez Y. Levanon","orcid":"https://orcid.org/0000-0002-3641-4198"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erez Y Levanon","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA, USA","Department of Genetics, Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084507913","display_name":"Eli Eisenberg","orcid":"https://orcid.org/0000-0001-8681-3202"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eli Eisenberg","raw_affiliation_strings":["Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel","[Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"[Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel]","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049650069"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I13955877"],"apc_list":null,"apc_paid":null,"fwci":0.6839,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69587644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"3","issue":"1","first_page":"3","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.7754999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.7754999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5977789163589478},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.507628321647644},{"id":"https://openalex.org/keywords/production","display_name":"Production (economics)","score":0.49996256828308105},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4868866503238678},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4458921551704407},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3419145941734314},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14388525485992432}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5977789163589478},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.507628321647644},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.49996256828308105},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4868866503238678},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4458921551704407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3419145941734314},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14388525485992432},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-3-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19128449","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19128449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.215.2143","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.215.2143","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1752-0509-3-3.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5d90619e7d3944a6b09ea7f72d79ad9e","is_oa":false,"landing_page_url":"https://doaj.org/article/5d90619e7d3944a6b09ea7f72d79ad9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 3 (2009)","raw_type":"article"},{"id":"pmh:oai:open.bu.edu:2144/3342","is_oa":true,"landing_page_url":"https://hdl.handle.net/2144/3342","pdf_url":null,"source":{"id":"https://openalex.org/S4306402183","display_name":"OpenBU/Boston University Institutional Repository (Boston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I111088046","host_organization_name":"Boston University","host_organization_lineage":["https://openalex.org/I111088046"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2647903","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647903","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322248","display_name":"Israel Academy of Sciences and Humanities","ror":"https://ror.org/03c6c9520"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2055638870.pdf","grobid_xml":"https://content.openalex.org/works/W2055638870.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1540866880","https://openalex.org/W1588911128","https://openalex.org/W1644749979","https://openalex.org/W1970970926","https://openalex.org/W1988496202","https://openalex.org/W1993009001","https://openalex.org/W1993616323","https://openalex.org/W2008003969","https://openalex.org/W2008083733","https://openalex.org/W2013947447","https://openalex.org/W2017057004","https://openalex.org/W2037036397","https://openalex.org/W2050721857","https://openalex.org/W2054755820","https://openalex.org/W2061439657","https://openalex.org/W2065304353","https://openalex.org/W2076710572","https://openalex.org/W2084619201","https://openalex.org/W2092047856","https://openalex.org/W2097520363","https://openalex.org/W2109281577","https://openalex.org/W2110762658","https://openalex.org/W2116117181","https://openalex.org/W2124354935","https://openalex.org/W2137786672","https://openalex.org/W2142437744","https://openalex.org/W2146264532","https://openalex.org/W2151326548","https://openalex.org/W2159710443","https://openalex.org/W2160689765","https://openalex.org/W2163480486","https://openalex.org/W2166558964","https://openalex.org/W2167869241","https://openalex.org/W2168258419","https://openalex.org/W2169805130","https://openalex.org/W4236956086"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cell":[1],"function":[2],"necessitates":[3],"the":[4,19,26,54,61,71,88,124,141,163,174,199],"assemblage":[5],"of":[6,18,30,56,63,87,145,153,165,170,173,195,201],"proteins":[7,83,108],"into":[8],"complexes,":[9,138],"a":[10,31,100,150],"process":[11],"which":[12,84,96],"requires":[13],"further":[14],"regulation":[15,191],"on":[16,53],"top":[17],"fairly":[20],"understood":[21],"mechanisms":[22],"used":[23],"to":[24,45,68,76,92,132,156,180],"control":[25],"transcription":[27],"and":[28,60,105,129,139,177],"translation":[29],"single":[32],"protein.":[33],"However,":[34],"not":[35],"much":[36],"is":[37],"known":[38],"about":[39],"how":[40,70,158],"protein":[41,58,65,74,127,196],"levels":[42,75,95,128,194],"are":[43,85],"controlled":[44],"realize":[46],"that":[47,82,106],"regulation.":[48],"RESULTS:":[49],"We":[50,80,121,148],"integrated":[51],"data":[52],"composition":[55],"yeast":[57],"complexes":[59],"dynamics":[62],"their":[64,113],"building-blocks":[66],"concentrations":[67],"show":[69],"cell":[72],"regulates":[73],"optimize":[77],"complex":[78,90,154,166,203],"formation.":[79,204],"find":[81,130],"subunits":[86],"same":[89],"tend":[91],"have":[93],"similar":[94],"change":[97,101],"similarly":[98],"following":[99],"in":[102,112,118,126,136,140,168],"growth":[103],"conditions,":[104],"abundant":[107,143],"undergo":[109],"larger":[110],"decrease":[111],"copy":[114],"number":[115],"when":[116],"grown":[117],"minimal":[119],"media.":[120],"also":[122],"study":[123],"fluctuations":[125],"them":[131],"be":[133],"significantly":[134],"smaller":[135],"large":[137],"least":[142],"subunit":[144],"each":[146],"complex.":[147],"use":[149],"mathematical":[151],"model":[152],"synthesis":[155],"explain":[157],"all":[159,193],"these":[160,186],"observations":[161],"increase":[162],"efficiency":[164],"synthesis,":[167],"terms":[169],"better":[171,178],"utilization":[172],"available":[175],"molecules":[176],"resilience":[179],"stochastic":[181],"variations.":[182],"CONCLUSION:":[183],"In":[184],"conclusion,":[185],"results":[187],"indicate":[188],"an":[189],"intricate":[190],"at":[192],"production":[197],"for":[198],"purpose":[200],"optimizing":[202]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}