{"id":"https://openalex.org/W2132160618","doi":"https://doi.org/10.1186/1752-0509-3-28","title":"Protein-protein interaction as a predictor of subcellular location","display_name":"Protein-protein interaction as a predictor of subcellular location","publication_year":2009,"publication_date":"2009-02-25","ids":{"openalex":"https://openalex.org/W2132160618","doi":"https://doi.org/10.1186/1752-0509-3-28","mag":"2132160618","pmid":"https://pubmed.ncbi.nlm.nih.gov/19243629"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-28","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-28","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109163964","display_name":"Chang Jin Shin","orcid":null},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Chang Jin Shin","raw_affiliation_strings":["The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD, Australia. c.shin@imb.uq.edu.au","The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD, Australia. c.shin@imb.uq.edu.au","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027570038","display_name":"Simon Wong","orcid":"https://orcid.org/0000-0002-5503-4510"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Wong","raw_affiliation_strings":["The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018252802","display_name":"Melissa J. Davis","orcid":"https://orcid.org/0000-0003-4864-7033"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Melissa J Davis","raw_affiliation_strings":["The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023552489","display_name":"Mark A. Ragan","orcid":"https://orcid.org/0000-0003-1672-7020"},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark A Ragan","raw_affiliation_strings":["The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"The University of Queensland, Institute for Molecular Bioscience, and ARC Centre of Excellence in Bioinformatics, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109163964"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":null,"apc_paid":null,"fwci":3.6933,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.9380502,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.848800003528595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.848800003528595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.11010000109672546,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.6793075203895569},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.665591835975647},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5290409922599792},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5252922177314758},{"id":"https://openalex.org/keywords/complement","display_name":"Complement (music)","score":0.4468122124671936},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.4442600607872009},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4329306483268738},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.42036256194114685},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.4192708134651184},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.4146638810634613},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.31277042627334595},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19291698932647705},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.14466944336891174}],"concepts":[{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.6793075203895569},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.665591835975647},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5290409922599792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5252922177314758},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.4468122124671936},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4442600607872009},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4329306483268738},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.42036256194114685},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.4192708134651184},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4146638810634613},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31277042627334595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19291698932647705},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.14466944336891174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-3-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-28","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-28","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19243629","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19243629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/262732","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/262732","pdf_url":"http://hdl.handle.net/11343/262732","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2f67021bc0ff48cca44126b1daa1f4e3","is_oa":false,"landing_page_url":"https://doaj.org/article/2f67021bc0ff48cca44126b1daa1f4e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 28 (2009)","raw_type":"article"},{"id":"pmh:oai:espace.library.uq.edu.au:UQ:181273","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402388","display_name":"Queensland's institutional digital repository (The University of Queensland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165143802","host_organization_name":"The University of Queensland","host_organization_lineage":["https://openalex.org/I165143802"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1415533","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2663780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-28","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-28","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3903182093","display_name":"ARC Centre in Bioinformatics","funder_award_id":"CE0348221","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132160618.pdf","grobid_xml":"https://content.openalex.org/works/W2132160618.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W147903483","https://openalex.org/W597056798","https://openalex.org/W1486817521","https://openalex.org/W1508416409","https://openalex.org/W1579879095","https://openalex.org/W1647729745","https://openalex.org/W1918391659","https://openalex.org/W1969944745","https://openalex.org/W1973253766","https://openalex.org/W1977186059","https://openalex.org/W1982428412","https://openalex.org/W1994803330","https://openalex.org/W2001969264","https://openalex.org/W2006933206","https://openalex.org/W2030903159","https://openalex.org/W2040411864","https://openalex.org/W2040630248","https://openalex.org/W2044071061","https://openalex.org/W2047757567","https://openalex.org/W2053906518","https://openalex.org/W2060460012","https://openalex.org/W2065304353","https://openalex.org/W2079818352","https://openalex.org/W2080182143","https://openalex.org/W2083309296","https://openalex.org/W2084619201","https://openalex.org/W2094027833","https://openalex.org/W2095627884","https://openalex.org/W2101181377","https://openalex.org/W2101330776","https://openalex.org/W2103017472","https://openalex.org/W2104315543","https://openalex.org/W2108238425","https://openalex.org/W2108898978","https://openalex.org/W2113654464","https://openalex.org/W2115998090","https://openalex.org/W2117805756","https://openalex.org/W2121343862","https://openalex.org/W2121507105","https://openalex.org/W2124463526","https://openalex.org/W2126544665","https://openalex.org/W2128036243","https://openalex.org/W2130479394","https://openalex.org/W2130687290","https://openalex.org/W2131924932","https://openalex.org/W2133548874","https://openalex.org/W2134711219","https://openalex.org/W2135526239","https://openalex.org/W2137335580","https://openalex.org/W2137464714","https://openalex.org/W2139042094","https://openalex.org/W2144244209","https://openalex.org/W2145753039","https://openalex.org/W2149676146","https://openalex.org/W2150408357","https://openalex.org/W2151790371","https://openalex.org/W2155723007","https://openalex.org/W2158173168","https://openalex.org/W2161189461","https://openalex.org/W2162533342","https://openalex.org/W2164813401","https://openalex.org/W2166043581","https://openalex.org/W2166558964","https://openalex.org/W2167609307","https://openalex.org/W2167869241","https://openalex.org/W2170652857","https://openalex.org/W2172049947","https://openalex.org/W2406531951","https://openalex.org/W2412123125","https://openalex.org/W2600206387","https://openalex.org/W2916288174"],"related_works":["https://openalex.org/W171823940","https://openalex.org/W2010825547","https://openalex.org/W2559424312","https://openalex.org/W2045131140","https://openalex.org/W2095910716","https://openalex.org/W1504224152","https://openalex.org/W1970034234","https://openalex.org/W1973695911","https://openalex.org/W1993087844","https://openalex.org/W1987582651"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"biological":[2,223,226,234,313],"processes":[3],"are":[4,32,42,74,153],"mediated":[5],"by":[6,192],"dynamic":[7],"interactions":[8,26],"between":[9],"and":[10,22,28,39,44,102,104,107,212,217,230,256,295],"among":[11],"proteins.":[12,264,276,297],"In":[13],"order":[14],"to":[15,52,67,85,105,113,161,287],"interact,":[16],"two":[17],"proteins":[18,58,70,97,127,152],"must":[19,128],"co-occur":[20],"spatially":[21],"temporally.":[23],"As":[24],"protein-protein":[25],"(PPIs)":[27],"subcellular":[29,134],"location":[30],"(SCL)":[31],"discovered":[33],"via":[34],"separate":[35],"empirical":[36],"approaches,":[37],"PPI":[38,65,91,142,280],"SCL":[40,95,164,171,252,273,290],"annotations":[41,66],"independent":[43],"might":[45],"complement":[46],"each":[47],"other":[48],"in":[49,59,72,76,93,98,154,179,249,303],"helping":[50],"us":[51],"understand":[53],"the":[54,77,87,109,123,132,163,170,180,251,272,312],"role":[55],"of":[56,89,96,150,165,172,185,194,197,204,210,214,222,253,271,274,306,311,315],"individual":[57],"cellular":[60,79,267,307],"networks.":[61],"We":[62,157,277],"expect":[63],"reliable":[64,289],"show":[68,278],"that":[69,111,125,146],"interacting":[71,126,151,275],"vivo":[73],"co-located":[75,130],"same":[78,133],"compartment.":[80,135],"Our":[81,240],"goal":[82],"here":[83],"is":[84],"evaluate":[86,122],"potential":[88],"using":[90],"annotation":[92],"determining":[94],"human,":[99],"mouse,":[100],"fly":[101],"yeast,":[103],"identify":[106],"quantify":[108],"factors":[110],"contribute":[112],"this":[114],"complementarity.":[115],"RESULTS:":[116],"Using":[117],"publicly":[118],"available":[119],"data,":[120],"we":[121,144],"hypothesis":[124],"be":[129,190,283],"within":[131],"Based":[136],"on":[137,169,202,220],"a":[138,147,166],"large,":[139],"manually":[140],"curated":[141],"dataset,":[143],"demonstrate":[145],"substantial":[148],"proportion":[149],"fact":[155],"co-located.":[156],"develop":[158],"an":[159],"approach":[160,241],"predict":[162],"protein":[167],"based":[168,201,219],"its":[173],"interaction":[174,181],"partners,":[175],"given":[176],"sufficient":[177],"confidence":[178],"itself.":[182],"The":[183],"frequency":[184],"false":[186],"positive":[187],"PPIs":[188],"can":[189,282],"reduced":[191],"use":[193],"six":[195],"lines":[196],"supporting":[198],"evidence,":[199],"three":[200,218],"type":[203,221],"recorded":[205,238],"evidence":[206,224,235],"(empirical":[207],"approach,":[208],"multiplicity":[209,213],"databases,":[211],"literature":[215],"citations)":[216],"(inferred":[225],"process,":[227],"domain-domain":[228],"interactions,":[229],"orthology":[231],"relationships),":[232],"with":[233],"more-effective":[236],"than":[237,244],"evidence.":[239],"performs":[242],"better":[243,261],"four":[245],"existing":[246],"prediction":[247],"methods":[248],"identifying":[250],"membrane":[254,296],"proteins,":[255],"as":[257,259],"well":[258],"or":[260],"for":[262,292,300],"soluble":[263,294],"CONCLUSION:":[265],"Understanding":[266],"systems":[268],"requires":[269],"knowledge":[270],"how":[279],"data":[281],"used":[284],"more":[285],"effectively":[286],"yield":[288],"predictions":[291],"both":[293],"Scope":[298],"exists":[299],"further":[301],"improvement":[302],"our":[304],"understanding":[305],"function":[308],"through":[309],"consideration":[310],"context":[314],"molecular":[316],"interactions.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}