{"id":"https://openalex.org/W1975788468","doi":"https://doi.org/10.1186/1752-0509-3-2","title":"Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network","display_name":"Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network","publication_year":2009,"publication_date":"2009-01-06","ids":{"openalex":"https://openalex.org/W1975788468","doi":"https://doi.org/10.1186/1752-0509-3-2","mag":"1975788468","pmid":"https://pubmed.ncbi.nlm.nih.gov/19126203"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070466334","display_name":"Robert Modre\u2010Osprian","orcid":"https://orcid.org/0000-0003-3456-8780"},"institutions":[{"id":"https://openalex.org/I132118926","display_name":"Austrian Institute of Technology","ror":"https://ror.org/04knbh022","country_code":"AT","type":"facility","lineage":["https://openalex.org/I132118926"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Robert Modre-Osprian","raw_affiliation_strings":["eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH - ARC, Eduard Wallnoefer Zentrum 1, 6060 Hall in Tirol, Austria. robert.modre@arcsmed.at","eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Hall in Tirol, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH - ARC, Eduard Wallnoefer Zentrum 1, 6060 Hall in Tirol, Austria. robert.modre@arcsmed.at","institution_ids":["https://openalex.org/I132118926"]},{"raw_affiliation_string":"eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Hall in Tirol, Austria","institution_ids":["https://openalex.org/I132118926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046973191","display_name":"Ingrid Osprian","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146003","display_name":"Biocrates Life Sciences (Austria)","ror":"https://ror.org/05168x816","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210146003"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ingrid Osprian","raw_affiliation_strings":["BIOCRATES life sciences AG, Innrain 66/2, Innsbruck, 6020, Austria","BIOCRATES life sciences AG, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOCRATES life sciences AG, Innrain 66/2, Innsbruck, 6020, Austria","institution_ids":["https://openalex.org/I4210146003"]},{"raw_affiliation_string":"BIOCRATES life sciences AG, Innsbruck, Austria","institution_ids":["https://openalex.org/I4210146003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109086901","display_name":"B. Tilg","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114246","display_name":"UMIT - Private Universit\u00e4t f\u00fcr Gesundheitswissenschaften, Medizinische Informatik und Technik","ror":"https://ror.org/02d0kps43","country_code":"AT","type":"education","lineage":["https://openalex.org/I4210114246"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bernhard Tilg","raw_affiliation_strings":["Institute for Biomedical Engineering, UMIT, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","Institute for Biomedical Engineering, UMIT, Hall in Tirol, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, UMIT, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","institution_ids":["https://openalex.org/I4210114246"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, UMIT, Hall in Tirol, Austria","institution_ids":["https://openalex.org/I4210114246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007533806","display_name":"G. Schreier","orcid":"https://orcid.org/0000-0003-3724-4255"},"institutions":[{"id":"https://openalex.org/I132118926","display_name":"Austrian Institute of Technology","ror":"https://ror.org/04knbh022","country_code":"AT","type":"facility","lineage":["https://openalex.org/I132118926"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Schreier","raw_affiliation_strings":["eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Hall in Tirol, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","institution_ids":["https://openalex.org/I132118926"]},{"raw_affiliation_string":"eHealth systems, Biomedical Engineering, Austrian Research Centers GmbH \u2013 ARC, Hall in Tirol, Austria","institution_ids":["https://openalex.org/I132118926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078595079","display_name":"Klaus M. Weinberger","orcid":"https://orcid.org/0000-0002-8947-5306"},"institutions":[{"id":"https://openalex.org/I4210146003","display_name":"Biocrates Life Sciences (Austria)","ror":"https://ror.org/05168x816","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210146003"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Klaus M Weinberger","raw_affiliation_strings":["BIOCRATES life sciences AG, Innrain 66/2, Innsbruck, 6020, Austria","BIOCRATES life sciences AG, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOCRATES life sciences AG, Innrain 66/2, Innsbruck, 6020, Austria","institution_ids":["https://openalex.org/I4210146003"]},{"raw_affiliation_string":"BIOCRATES life sciences AG, Innsbruck, Austria","institution_ids":["https://openalex.org/I4210146003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111907321","display_name":"Armin Graber","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114246","display_name":"UMIT - Private Universit\u00e4t f\u00fcr Gesundheitswissenschaften, Medizinische Informatik und Technik","ror":"https://ror.org/02d0kps43","country_code":"AT","type":"education","lineage":["https://openalex.org/I4210114246"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Armin Graber","raw_affiliation_strings":["Institute for Bioinformatics, UMIT, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","Institute for Bioinformatics, UMIT, Hall in Tirol, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioinformatics, UMIT, Eduard Wallnoefer Zentrum 1, Hall in Tirol, 6060, Austria","institution_ids":["https://openalex.org/I4210114246"]},{"raw_affiliation_string":"Institute for Bioinformatics, UMIT, Hall in Tirol, Austria","institution_ids":["https://openalex.org/I4210114246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5070466334"],"corresponding_institution_ids":["https://openalex.org/I132118926"],"apc_list":null,"apc_paid":null,"fwci":2.876,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89034616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-oxidation","display_name":"Beta oxidation","score":0.8023897409439087},{"id":"https://openalex.org/keywords/catabolism","display_name":"Catabolism","score":0.6815140247344971},{"id":"https://openalex.org/keywords/fatty-acid","display_name":"Fatty acid","score":0.5999006628990173},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.5344903469085693},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.49378499388694763},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"Fatty acid metabolism","score":0.4606592059135437},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.4569239616394043},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4155113399028778},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3748432397842407},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.36154812574386597},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3584028482437134},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24878844618797302}],"concepts":[{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.8023897409439087},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6815140247344971},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5999006628990173},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5344903469085693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49378499388694763},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.4606592059135437},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4569239616394043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4155113399028778},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3748432397842407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36154812574386597},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3584028482437134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24878844618797302}],"mesh":[{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044944","descriptor_name":"Acyl-CoA Dehydrogenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-3-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19126203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19126203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2633313","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2633313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.44999998807907104,"display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975788468.pdf","grobid_xml":"https://content.openalex.org/works/W1975788468.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W150396229","https://openalex.org/W1481171004","https://openalex.org/W1483242733","https://openalex.org/W1499024850","https://openalex.org/W1510158417","https://openalex.org/W1511971459","https://openalex.org/W1523365786","https://openalex.org/W1560517732","https://openalex.org/W1578006044","https://openalex.org/W1592751125","https://openalex.org/W1728928179","https://openalex.org/W1919138803","https://openalex.org/W1934325817","https://openalex.org/W1968137491","https://openalex.org/W1982179617","https://openalex.org/W2000009197","https://openalex.org/W2004235323","https://openalex.org/W2014637024","https://openalex.org/W2017414485","https://openalex.org/W2017424454","https://openalex.org/W2020743769","https://openalex.org/W2037887958","https://openalex.org/W2045672866","https://openalex.org/W2053345988","https://openalex.org/W2071605024","https://openalex.org/W2082975401","https://openalex.org/W2095372497","https://openalex.org/W2100783210","https://openalex.org/W2102653059","https://openalex.org/W2111420033","https://openalex.org/W2118351550","https://openalex.org/W2123037718","https://openalex.org/W2142554782","https://openalex.org/W2147457396","https://openalex.org/W2160080742","https://openalex.org/W2163781123","https://openalex.org/W2163841023","https://openalex.org/W2167259990","https://openalex.org/W2169559860","https://openalex.org/W2399641583","https://openalex.org/W2599434612","https://openalex.org/W3005410459","https://openalex.org/W4301627359"],"related_works":["https://openalex.org/W2062289338","https://openalex.org/W4288453896","https://openalex.org/W2035110639","https://openalex.org/W1765877479","https://openalex.org/W2565639355","https://openalex.org/W2016418884","https://openalex.org/W97978755","https://openalex.org/W4206330155","https://openalex.org/W2023240488","https://openalex.org/W74866672"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,174],"oxidation":[2,57,99,120],"of":[3,18,41,49,79,130,145,152,162,165,177,197,201,210,225,243,250,261,277,293,310,317,341],"fatty":[4,55,97,106,118,147,203,244,300],"acids":[5,107,245],"in":[6,12,34,168,187,194,314],"mitochondria":[7],"plays":[8],"an":[9],"important":[10],"role":[11],"energy":[13,215],"metabolism":[14,30,295],"and":[15,37,85,136,157,171,192,256,305,333],"genetic":[16],"disorders":[17,51],"this":[19,286],"pathway":[20],"may":[21],"cause":[22],"metabolic":[23,312],"diseases.":[24],"Enzyme":[25],"deficiencies":[26,151,185],"can":[27,345],"block":[28],"the":[29,35,50,115,182,198,202,208,222,229,240,257,271,307,315,325],"at":[31],"defined":[32],"reactions":[33,132],"mitochondrion":[36],"lead":[38],"to":[39,141,181,228,232,269,303,331],"accumulation":[40,176,242],"specific":[42,178,297],"substrates":[43,252],"causing":[44],"severe":[45,80],"clinical":[46],"manifestations.":[47],"Ten":[48],"directly":[52],"affecting":[53],"mitochondrial":[54,146,294],"acid":[56,98,119,148,204,301],"have":[58,87,280],"been":[59,88,281],"well-defined,":[60],"implicating":[61],"episodic":[62],"hypoketotic":[63],"hypoglycemia":[64],"provoked":[65],"by":[66,96],"catabolic":[67,254],"stress,":[68],"multiple":[69],"organ":[70],"failure,":[71],"muscle":[72],"weakness,":[73],"or":[74,112],"hypertrophic":[75],"cardiomyopathy.":[76],"Additionally,":[77],"syndromes":[78],"maternal":[81],"illness":[82],"(HELLP":[83],"syndrome":[84],"AFLP)":[86],"associated":[89],"with":[90,133,159,189,247,296],"pregnancies":[91],"carrying":[92],"a":[93,289],"fetus":[94],"affected":[95],"deficiencies.":[100],"However,":[101],"little":[102],"is":[103,121,218],"known":[104],"about":[105],"kinetics,":[108],"especially":[109],"during":[110,253],"fasting":[111,226],"exercise":[113],"when":[114],"demand":[116],"for":[117,214],"increased":[122],"(catabolic":[123],"stress).":[124],"RESULTS:":[125],"A":[126],"computational":[127],"kinetic":[128,291],"network":[129,313],"64":[131],"91":[134],"compounds":[135],"301":[137],"parameters":[138],"was":[139],"constructed":[140],"study":[142],"dynamic":[143,199,308],"properties":[144,200],"beta-oxidation.":[149],"Various":[150],"acyl-CoA":[153],"dehydrogenase":[154],"were":[155],"simulated":[156,175],"verified":[158],"measured":[160],"concentrations":[161],"indicative":[163],"metabolites":[164],"screened":[166],"newborns":[167],"Middle":[169],"Europe":[170],"South":[172],"Australia.":[173],"acyl-CoAs":[179],"according":[180],"investigated":[183],"enzyme":[184],"are":[186],"agreement":[188],"experimental":[190,350],"data":[191,351],"findings":[193,264,321],"literature.":[195],"Investigation":[196],"beta-oxidation":[205,302],"reveals":[206],"that":[207,273,311],"formation":[209],"acetyl-CoA":[211],"-":[212,217],"substrate":[213],"production":[216,259],"highly":[219],"impaired":[220],"within":[221,234],"first":[223],"hours":[224],"corresponding":[227],"rapid":[230,329],"progress":[231,330],"coma":[233],"1-2":[235],"hours.":[236],"LCAD":[237,278,342],"deficiency":[238,279],"exhibits":[239],"highest":[241],"along":[246],"marked":[248],"increase":[249],"these":[251],"stress":[255],"lowest":[258],"rate":[260],"acetyl-CoA.":[262],"These":[263],"might":[265,334],"confirm":[266,335],"gestational":[267],"loss":[268],"be":[270,347],"explanation":[272],"no":[274],"human":[275,318,339],"cases":[276,340],"described.":[282],"CONCLUSION:":[283],"In":[284],"summary,":[285],"work":[287],"provides":[288],"detailed":[290],"model":[292],"focus":[298],"on":[299],"simulate":[304],"predict":[306],"response":[309],"context":[316],"disease.":[319],"Our":[320],"offer":[322],"insight":[323],"into":[324],"disease":[326],"process":[327],"(e.g.":[328],"coma)":[332],"new":[336],"explanations":[337],"(no":[338],"deficiency),":[343],"which":[344],"hardly":[346],"obtained":[348],"from":[349],"alone.":[352]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}