{"id":"https://openalex.org/W2053266278","doi":"https://doi.org/10.1186/1752-0509-3-19","title":"A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation","display_name":"A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation","publication_year":2009,"publication_date":"2009-02-12","ids":{"openalex":"https://openalex.org/W2053266278","doi":"https://doi.org/10.1186/1752-0509-3-19","mag":"2053266278","pmid":"https://pubmed.ncbi.nlm.nih.gov/19216740"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-19","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089147261","display_name":"Reza Mobini","orcid":"https://orcid.org/0000-0002-3690-5739"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Reza Mobini","raw_affiliation_strings":["Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden. reza.mobini@pediat.gu.se","Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden. reza.mobini@pediat.gu.se","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004233255","display_name":"Bengt \u00c5ndersson","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bengt A Andersson","raw_affiliation_strings":["Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053631623","display_name":"Jonas S. Erjef\u00e4lt","orcid":"https://orcid.org/0000-0002-6716-3010"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Erjef\u00e4lt","raw_affiliation_strings":["Department of Experimental Medicine, Lund University, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000096322","display_name":"Mirjana Hahn\u2010Zoric","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirjana Hahn-Zoric","raw_affiliation_strings":["Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011863644","display_name":"Michael A. Langston","orcid":"https://orcid.org/0000-0001-5945-5796"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Langston","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA","Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005914571","display_name":"Andy Perkins","orcid":"https://orcid.org/0000-0002-3583-1010"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy D Perkins","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA","Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035165090","display_name":"Lars\u2010Olaf Cardell","orcid":"https://orcid.org/0000-0003-0538-9580"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Olaf Cardell","raw_affiliation_strings":["Department of Oto-rhino-largyngeology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-rhino-largyngeology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049770857","display_name":"Mikael Benson","orcid":"https://orcid.org/0000-0002-7753-9181"},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mikael Benson","raw_affiliation_strings":["Department of Pediatrics, Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Unit for Clinical Systems Biology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5089147261"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":2.4324,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.88772227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.16920000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6752626895904541},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5979103446006775},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5963528156280518},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5837619304656982},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5789792537689209},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4949769377708435},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4778282642364502},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2853706479072571},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1825774908065796}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6752626895904541},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5979103446006775},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5963528156280518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5837619304656982},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5789792537689209},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4949769377708435},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4778282642364502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2853706479072571},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1825774908065796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020395","descriptor_name":"Receptors, Interleukin-7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020395","descriptor_name":"Receptors, Interleukin-7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020395","descriptor_name":"Receptors, Interleukin-7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050990","descriptor_name":"GATA3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-3-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19216740","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19216740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:DiVA.org:liu-98573","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-98573","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article in journal"},{"id":"pmh:oai:lup.lub.lu.se:a23dda3d-2977-4b72-bec0-c204f22ffab3","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1401920","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1752-0509","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2653464","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2653464","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-19","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-19","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-19","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[{"id":"https://openalex.org/G8315095418","display_name":"Mapping Polygranular Parallel Processing to Shared, Heterogeneous, High-Performance Reconfigurable Computers","funder_award_id":"0311500","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053266278.pdf","grobid_xml":"https://content.openalex.org/works/W2053266278.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1530803355","https://openalex.org/W1567696770","https://openalex.org/W1967209901","https://openalex.org/W1969074282","https://openalex.org/W1979141644","https://openalex.org/W1982434943","https://openalex.org/W2002998653","https://openalex.org/W2005227391","https://openalex.org/W2005691583","https://openalex.org/W2006353878","https://openalex.org/W2020681752","https://openalex.org/W2031863208","https://openalex.org/W2044475056","https://openalex.org/W2047062588","https://openalex.org/W2055289764","https://openalex.org/W2057626690","https://openalex.org/W2068324124","https://openalex.org/W2083045667","https://openalex.org/W2083358433","https://openalex.org/W2083804971","https://openalex.org/W2120051475","https://openalex.org/W2126692031","https://openalex.org/W2129431737","https://openalex.org/W2152913934","https://openalex.org/W2155335955","https://openalex.org/W2166607989","https://openalex.org/W4237308814"],"related_works":["https://openalex.org/W1983994322","https://openalex.org/W2998765584","https://openalex.org/W2415025170","https://openalex.org/W2362238002","https://openalex.org/W2900947575","https://openalex.org/W2053053668","https://openalex.org/W2006024165","https://openalex.org/W1879733234","https://openalex.org/W2383598698","https://openalex.org/W2373357709"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,44,148,175],"identification":[2,103],"of":[3,9,18,46,83,87,95,104,117,155,163,178],"novel":[4,73,152,216],"genes":[5,24,217],"by":[6,14,130,200],"high-throughput":[7],"studies":[8],"complex":[10,219],"diseases":[11],"is":[12,30,211],"complicated":[13],"the":[15,102,132,140,157,160],"large":[16,85],"number":[17,86,162],"potential":[19],"genes.":[20,75,121],"However,":[21],"since":[22],"disease-associated":[23,74,153],"tend":[25],"to":[26,31,66,101,113,214],"interact,":[27],"one":[28,70,158],"solution":[29],"arrange":[32],"them":[33],"in":[34,60,126,135,180,218],"modules":[35],"based":[36],"on":[37],"co-expression":[38],"data":[39],"and":[40,58,63,68,119],"known":[41,166],"gene":[42,88,109],"interactions.":[43],"hypothesis":[45],"this":[47],"study":[48],"was":[49,97,111,124,170,198],"that":[50,110,206],"such":[51],"a":[52,84,115,207],"module":[53,116,123,149],"could":[54],"be":[55],"a)":[56],"found":[57],"validated":[59,107,125],"allergic":[61],"disease":[62,167],"b)":[64],"used":[65,112],"find":[67,215],"validate":[69],"ore":[71],"more":[72],"RESULTS:":[76],"To":[77],"test":[78],"these":[79],"hypotheses":[80],"integrated":[81],"analysis":[82],"expression":[89,133,176],"microarray":[90],"experiments":[91],"from":[92],"different":[93],"forms":[94],"allergy":[96],"performed.":[98],"This":[99,122,192],"led":[100],"an":[105,127,194],"experimentally":[106],"reference":[108],"construct":[114],"co-expressed":[118],"interacting":[120],"independent":[128],"material,":[129],"replicating":[131],"changes":[134,141],"allergen-challenged":[136],"CD4+":[137,183],"cells.":[138],"Moreover,":[139],"were":[142],"reversed":[143],"following":[144,186],"treatment":[145],"with":[146,159,165],"corticosteroids.":[147],"contained":[150],"several":[151],"genes,":[154,168],"which":[156,197],"highest":[161],"interactions":[164],"IL7R,":[169],"selected":[171],"for":[172],"further":[173],"validation.":[174],"levels":[177],"IL7R":[179],"allergen":[181],"challenged":[182],"cells":[184],"decreased":[185],"challenge":[187],"but":[188],"increased":[189],"after":[190],"treatment.":[191],"suggested":[193],"inhibitory":[195],"role,":[196],"confirmed":[199],"functional":[201],"studies.":[202],"CONCLUSION:":[203],"We":[204],"propose":[205],"module-based":[208],"analytical":[209],"strategy":[210],"generally":[212],"applicable":[213],"diseases.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}