{"id":"https://openalex.org/W2163219351","doi":"https://doi.org/10.1186/1752-0509-3-117","title":"Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network","display_name":"Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2163219351","doi":"https://doi.org/10.1186/1752-0509-3-117","mag":"2163219351","pmid":"https://pubmed.ncbi.nlm.nih.gov/20021680"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109908878","display_name":"Bevan Kai Sheng Chung","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Bevan Kai Sheng Chung","raw_affiliation_strings":["NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore. g0801781@nus.edu.sg","NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore. g0801781@nus.edu.sg","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011206845","display_name":"Dong\u2010Yup Lee","orcid":"https://orcid.org/0000-0003-0901-708X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210137615","display_name":"Bioprocessing Technology Institute","ror":"https://ror.org/049fnxe71","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210137615"]},{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dong-Yup Lee","raw_affiliation_strings":["Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, 138668, Singapore","Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576, Singapore","NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, 138668, Singapore","institution_ids":["https://openalex.org/I4210137615","https://openalex.org/I115228651"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, 117456, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109908878"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":null,"apc_paid":null,"fwci":1.7799,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.84737337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12643","display_name":"Sustainability and Ecological Systems Analysis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.8849713802337646},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.744883120059967},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.7042864561080933},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.6882791519165039},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.5980843305587769},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.5453991889953613},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5270267724990845},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5191792249679565},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5081725120544434},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45258626341819763},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4465397298336029},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4261627793312073},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3379126191139221},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32938098907470703},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26086121797561646},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.24698090553283691},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.24640494585037231},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21117347478866577},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07711425423622131}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8849713802337646},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.744883120059967},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.7042864561080933},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6882791519165039},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.5980843305587769},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5453991889953613},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5270267724990845},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5191792249679565},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5081725120544434},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45258626341819763},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4465397298336029},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4261627793312073},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3379126191139221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32938098907470703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26086121797561646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24698090553283691},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.24640494585037231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21117347478866577},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07711425423622131},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-3-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20021680","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20021680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/63936","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/63936","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4ce68eea163a4a0bbddbbfe27a8f3bc4","is_oa":false,"landing_page_url":"https://doaj.org/article/4ce68eea163a4a0bbddbbfe27a8f3bc4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 117 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2805632","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2805632","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-117","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-117","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G259319590","display_name":null,"funder_award_id":"R-279-000-258-112","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"}],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163219351.pdf","grobid_xml":"https://content.openalex.org/works/W2163219351.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1484198052","https://openalex.org/W1543833632","https://openalex.org/W1561767438","https://openalex.org/W1580425878","https://openalex.org/W1969983517","https://openalex.org/W1975113414","https://openalex.org/W1996529795","https://openalex.org/W2003835605","https://openalex.org/W2004340874","https://openalex.org/W2022012525","https://openalex.org/W2029030701","https://openalex.org/W2037614307","https://openalex.org/W2073837631","https://openalex.org/W2076262841","https://openalex.org/W2078775934","https://openalex.org/W2097588479","https://openalex.org/W2099551325","https://openalex.org/W2102164505","https://openalex.org/W2107460841","https://openalex.org/W2110384600","https://openalex.org/W2130364940","https://openalex.org/W2134981469","https://openalex.org/W2143861551","https://openalex.org/W2145996960","https://openalex.org/W2146538795","https://openalex.org/W2152428375","https://openalex.org/W2162666840","https://openalex.org/W2170427655","https://openalex.org/W2171793445","https://openalex.org/W2410295001","https://openalex.org/W2605543710","https://openalex.org/W3106353906"],"related_works":["https://openalex.org/W1999460937","https://openalex.org/W2113329733","https://openalex.org/W1984242440","https://openalex.org/W1983989854","https://openalex.org/W2070388085","https://openalex.org/W2341681417","https://openalex.org/W2133150343","https://openalex.org/W2047334633","https://openalex.org/W2350881169","https://openalex.org/W2613838074"],"abstract_inverted_index":{"BACKGROUND:":[0],"Constraint-based":[1],"flux":[2,11],"analysis":[3,70,164,178],"of":[4,17,40,71,81,91,109,147,168,196],"metabolic":[5,27,84,145],"network":[6,28,85],"model":[7,53,67,102,146],"quantifies":[8],"the":[9,15,26,30,38,44,49,62,66,69,72,83,88,101,107,127,137,141,157,166,171,180,194],"reaction":[10],"distribution":[12],"to":[13,48,60,121],"characterize":[14],"state":[16],"cellular":[18,45],"metabolism.":[19],"However,":[20],"metabolites":[21,169],"are":[22],"key":[23,97,181],"players":[24],"in":[25,52,143,170,193],"and":[29,198],"current":[31],"reaction-centric":[32,159],"approach":[33,80],"may":[34],"not":[35],"account":[36],"for":[37,68],"effect":[39,108],"metabolite":[41,63,111,133,176,190],"perturbation":[42,177],"on":[43,113,136],"physiology":[46],"due":[47],"inherent":[50],"limitation":[51],"formulation.":[54,103],"Thus,":[55],"it":[56],"would":[57],"be":[58,117],"practical":[59,184],"incorporate":[61],"states":[64],"into":[65],"network.":[73,172],"RESULTS:":[74],"Presented":[75],"herein":[76],"is":[77,187],"a":[78],"metabolite-centric":[79],"analyzing":[82],"by":[86,119],"including":[87],"turnover":[89],"rate":[90],"metabolite,":[92],"known":[93],"as":[94,96],"flux-sum,":[95],"descriptive":[98],"variable":[99],"within":[100],"By":[104],"doing":[105],"so,":[106],"varying":[110],"flux-sum":[112,138,163,191],"physiological":[114],"change":[115],"can":[116],"simulated":[118],"resorting":[120],"mixed":[122],"integer":[123],"linear":[124],"programming.":[125],"From":[126],"results,":[128],"we":[129,150],"could":[130],"classify":[131],"various":[132],"types":[134],"based":[135],"profile.":[139],"Using":[140],"iAF1260":[142],"silico":[144],"Escherichia":[148],"coli,":[149],"demonstrated":[151],"that":[152],"this":[153,175],"novel":[154],"concept":[155],"complements":[156],"conventional":[158],"analysis.":[160],"CONCLUSIONS:":[161],"Metabolite":[162],"elucidates":[165],"roles":[167],"In":[173],"addition,":[174],"identifies":[179],"metabolites,":[182],"implicating":[183],"application":[185],"which":[186],"achievable":[188],"through":[189],"manipulation":[192],"areas":[195],"biotechnology":[197],"biomedical":[199],"research.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}