{"id":"https://openalex.org/W2160413577","doi":"https://doi.org/10.1186/1752-0509-3-116","title":"Human synthetic lethal inference as potential anti-cancer target gene detection","display_name":"Human synthetic lethal inference as potential anti-cancer target gene detection","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2160413577","doi":"https://doi.org/10.1186/1752-0509-3-116","mag":"2160413577","pmid":"https://pubmed.ncbi.nlm.nih.gov/20015360"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-3-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-116","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-116","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029775011","display_name":"N\u00faria Conde\u2013Pueyo","orcid":"https://orcid.org/0000-0001-5766-309X"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Nuria Conde-Pueyo","raw_affiliation_strings":["ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003 Barcelona, Spain. nuria.conde@upf.edu","ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003 Barcelona, Spain. nuria.conde@upf.edu","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I2801864671"]},{"raw_affiliation_string":"ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220","https://openalex.org/I2801864671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083847559","display_name":"Andreea Munteanu","orcid":null},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andreea Munteanu","raw_affiliation_strings":["ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220","https://openalex.org/I2801864671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046878011","display_name":"Ricard V. Sol\u00e9","orcid":"https://orcid.org/0000-0001-6974-1008"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ricard V Sol\u00e9","raw_affiliation_strings":["ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain","Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM, 87501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220","https://openalex.org/I2801864671"]},{"raw_affiliation_string":"Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM, 87501, USA","institution_ids":["https://openalex.org/I1308548392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031550518","display_name":"Carlos Rodr\u00edguez\u2010Caso","orcid":"https://orcid.org/0000-0002-0423-6681"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I2801864671","display_name":"Barcelona Biomedical Research Park","ror":"https://ror.org/05sajct49","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801864671"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Rodr\u00edguez-Caso","raw_affiliation_strings":["ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220","https://openalex.org/I2801864671"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029775011"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I170486558","https://openalex.org/I2801864671"],"apc_list":null,"apc_paid":null,"fwci":0.9575,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.75286675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"116","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5891000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5891000032424927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.09489999711513519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.9048504829406738},{"id":"https://openalex.org/keywords/ensembl","display_name":"Ensembl","score":0.6745399236679077},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6118658781051636},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6037271618843079},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.573712944984436},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5210461020469666},{"id":"https://openalex.org/keywords/lethal-allele","display_name":"Lethal allele","score":0.5127900242805481},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4860709011554718},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.41347670555114746},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32615137100219727},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.23457184433937073},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.1920483112335205},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.14157822728157043},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.08016461133956909}],"concepts":[{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.9048504829406738},{"id":"https://openalex.org/C141674004","wikidata":"https://www.wikidata.org/wiki/Q1344256","display_name":"Ensembl","level":5,"score":0.6745399236679077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6118658781051636},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6037271618843079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.573712944984436},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5210461020469666},{"id":"https://openalex.org/C43934763","wikidata":"https://www.wikidata.org/wiki/Q927843","display_name":"Lethal allele","level":3,"score":0.5127900242805481},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4860709011554718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41347670555114746},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32615137100219727},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.23457184433937073},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.1920483112335205},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14157822728157043},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08016461133956909},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-3-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-116","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-116","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:20015360","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20015360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:recercat.cat:2072/213068","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/16451","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.604.9553","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.604.9553","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"http://www.santafe.edu/media/workingpapers/09-03-006.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:408943907377445e8f7c2361338cc641","is_oa":false,"landing_page_url":"https://doaj.org/article/408943907377445e8f7c2361338cc641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 3, Iss 1, p 116 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2804737","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2804737","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-3-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-3-116","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-3-116","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5797461206","display_name":null,"funder_award_id":"CA 113004","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160413577.pdf","grobid_xml":"https://content.openalex.org/works/W2160413577.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1530814332","https://openalex.org/W1544009106","https://openalex.org/W1877472591","https://openalex.org/W1963558939","https://openalex.org/W1970534502","https://openalex.org/W1970651561","https://openalex.org/W1974966731","https://openalex.org/W1977057342","https://openalex.org/W1981557521","https://openalex.org/W1982418865","https://openalex.org/W1986947222","https://openalex.org/W1988369885","https://openalex.org/W1990085600","https://openalex.org/W1995562684","https://openalex.org/W1998187004","https://openalex.org/W2000832682","https://openalex.org/W2003438913","https://openalex.org/W2009313526","https://openalex.org/W2010562878","https://openalex.org/W2011242261","https://openalex.org/W2012983621","https://openalex.org/W2013952758","https://openalex.org/W2013970469","https://openalex.org/W2017289276","https://openalex.org/W2018824728","https://openalex.org/W2023350337","https://openalex.org/W2024908724","https://openalex.org/W2027145418","https://openalex.org/W2029939216","https://openalex.org/W2029971236","https://openalex.org/W2037849836","https://openalex.org/W2038796778","https://openalex.org/W2039378089","https://openalex.org/W2048182261","https://openalex.org/W2051000382","https://openalex.org/W2052815101","https://openalex.org/W2058368225","https://openalex.org/W2058879820","https://openalex.org/W2060834498","https://openalex.org/W2062941476","https://openalex.org/W2063000913","https://openalex.org/W2083045667","https://openalex.org/W2083255534","https://openalex.org/W2083646206","https://openalex.org/W2086276659","https://openalex.org/W2087668378","https://openalex.org/W2091686779","https://openalex.org/W2096814387","https://openalex.org/W2103017472","https://openalex.org/W2103382198","https://openalex.org/W2119240864","https://openalex.org/W2123558100","https://openalex.org/W2123820544","https://openalex.org/W2124140932","https://openalex.org/W2124156743","https://openalex.org/W2126367887","https://openalex.org/W2127073167","https://openalex.org/W2137507165","https://openalex.org/W2137640596","https://openalex.org/W2138301753","https://openalex.org/W2138882303","https://openalex.org/W2142378195","https://openalex.org/W2145958344","https://openalex.org/W2146081769","https://openalex.org/W2147681274","https://openalex.org/W2150749732","https://openalex.org/W2155606054","https://openalex.org/W2159460045","https://openalex.org/W2159675211","https://openalex.org/W2161560609","https://openalex.org/W2163485494","https://openalex.org/W2163571202","https://openalex.org/W2167398354","https://openalex.org/W2170583315","https://openalex.org/W2171030481","https://openalex.org/W2325613032","https://openalex.org/W2530014580","https://openalex.org/W2599294066","https://openalex.org/W4237095724"],"related_works":["https://openalex.org/W2365158734","https://openalex.org/W2009313526","https://openalex.org/W2465211533","https://openalex.org/W2157969515","https://openalex.org/W2137827821","https://openalex.org/W2156564520","https://openalex.org/W129624489","https://openalex.org/W2767891136","https://openalex.org/W4388615774","https://openalex.org/W2160413577"],"abstract_inverted_index":{"BACKGROUND:":[0],"Two":[1],"genes":[2,137],"are":[3],"called":[4],"synthetic":[5],"lethal":[6],"(SL)":[7],"if":[8],"mutation":[9,17],"of":[10,18,32,50,54,156,187,197],"either":[11],"alone":[12],"is":[13,77,89],"not":[14],"lethal,":[15],"but":[16],"both":[19],"leads":[20],"to":[21,69,80,91,121,166,193],"death":[22],"or":[23],"a":[24,37,47,163],"significant":[25],"decrease":[26],"in":[27,119,177],"organism's":[28],"fitness.":[29],"The":[30],"detection":[31],"SL":[33,58,75,87,125,181],"gene":[34,126,174],"pairs":[35],"constitutes":[36],"promising":[38],"alternative":[39,165],"for":[40,107,112,116,128,170],"anti-cancer":[41,63,178],"therapy.":[42],"As":[43],"cancer":[44,135],"cells":[45],"exhibit":[46],"large":[48],"number":[49],"mutations,":[51],"the":[52,70,83,96,123,167,185,195],"identification":[53,176],"these":[55],"mutated":[56,136],"genes'":[57],"partners":[59],"may":[60],"provide":[61],"specific":[62],"drug":[64,171],"candidates,":[65],"with":[66],"minor":[67],"perturbations":[68],"healthy":[71],"cells.":[72],"Since":[73],"existent":[74,148],"data":[76,133],"mainly":[78],"restricted":[79],"yeast":[81],"screenings,":[82],"road":[84],"towards":[85],"human":[86],"candidates":[88],"limited":[90],"inference":[92],"methods.":[93],"RESULTS:":[94],"In":[95,130],"present":[97],"work,":[98],"we":[99],"use":[100,186],"phylogenetic":[101],"analysis":[102,183],"and":[103,110,139,173,184],"database":[104],"manipulation":[105],"(BioGRID":[106],"interactions,":[108],"Ensembl":[109],"NCBI":[111],"homology,":[113],"Gene":[114,141],"Ontology":[115],"GO":[117],"attributes)":[118],"order":[120],"reconstruct":[122],"phylogenetically-inferred":[124],"network":[127],"human.":[129],"addition,":[131],"available":[132],"on":[134,147],"(COSMIC":[138],"Cancer":[140],"Census":[142],"databases)":[143],"as":[144,146],"well":[145],"approved":[149],"drugs":[150],"(DrugBank":[151],"database)":[152],"supports":[153],"our":[154],"selection":[155],"cancer-therapy":[157],"candidates.":[158],"CONCLUSIONS:":[159],"Our":[160],"work":[161],"provides":[162],"complementary":[164],"current":[168],"methods":[169],"discovering":[172],"target":[175],"research.":[179],"Novel":[180],"screening":[182],"highly":[188],"curated":[189],"databases":[190],"would":[191],"contribute":[192],"improve":[194],"results":[196],"this":[198],"methodology.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}