{"id":"https://openalex.org/W2100526049","doi":"https://doi.org/10.1186/1752-0509-2-95","title":"Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome","display_name":"Integrated Weighted Gene Co-expression Network Analysis with an Application to Chronic Fatigue Syndrome","publication_year":2008,"publication_date":"2008-11-06","ids":{"openalex":"https://openalex.org/W2100526049","doi":"https://doi.org/10.1186/1752-0509-2-95","mag":"2100526049","pmid":"https://pubmed.ncbi.nlm.nih.gov/18986552"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-95","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-95","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-95","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-95","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061198124","display_name":"Angela P. Presson","orcid":"https://orcid.org/0000-0001-7400-3923"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela P Presson","raw_affiliation_strings":["Biostatistics, University of California, Los Angeles, CA, USA. apresson@ucla.edu","Biostatistics, University of California, Los Angeles, USA","Pediatrics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, University of California, Los Angeles, CA, USA. apresson@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Biostatistics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Pediatrics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061772385","display_name":"Eric M. Sobel","orcid":"https://orcid.org/0000-0002-1718-0031"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M Sobel","raw_affiliation_strings":["Human Genetics, University of California, Los Angeles, CA, USA","Human Genetics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067468133","display_name":"Jeanette C. Papp","orcid":"https://orcid.org/0000-0001-9561-7860"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanette C Papp","raw_affiliation_strings":["Human Genetics, University of California, Los Angeles, CA, USA","Human Genetics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064429958","display_name":"Charlyn Suarez","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlyn J Suarez","raw_affiliation_strings":["Human Genetics, University of California, Los Angeles, CA, USA","Human Genetics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061740477","display_name":"Toni Whistler","orcid":"https://orcid.org/0000-0002-7250-908X"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210121439","display_name":"National Center for Emerging and Zoonotic Infectious Diseases","ror":"https://ror.org/02ggwpx62","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toni Whistler","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111993184","display_name":"Mangalathu S. Rajeevan","orcid":null},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210121439","display_name":"National Center for Emerging and Zoonotic Infectious Diseases","ror":"https://ror.org/02ggwpx62","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mangalathu S Rajeevan","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024901363","display_name":"Suzanne D. Vernon","orcid":"https://orcid.org/0000-0002-5241-8914"},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210121439","display_name":"National Center for Emerging and Zoonotic Infectious Diseases","ror":"https://ror.org/02ggwpx62","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439"]},{"id":"https://openalex.org/I4210141991","display_name":"Solve ME/CFS Initiative","ror":"https://ror.org/04mhkhc08","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210141991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne D Vernon","raw_affiliation_strings":["Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), PO Box 220398, Charlotte, NC, USA","Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), Charlotte, USA","Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), PO Box 220398, Charlotte, NC, USA","institution_ids":["https://openalex.org/I4210141991"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, CA, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]},{"raw_affiliation_string":"Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), Charlotte, USA","institution_ids":["https://openalex.org/I4210141991"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000192581","display_name":"Steve Horvath","orcid":"https://orcid.org/0000-0002-4110-3589"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steve Horvath","raw_affiliation_strings":["Biostatistics, University of California, Los Angeles, CA, USA","Human Genetics, University of California, Los Angeles, CA, USA","Biostatistics, University of California, Los Angeles, USA","Human Genetics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Biostatistics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Human Genetics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000192581"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":5.3559,"has_fulltext":true,"cited_by_count":214,"citation_normalized_percentile":{"value":0.96152111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9466999769210815,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.9466999769210815,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6134118437767029},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.5278403759002686},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.50179123878479},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5009775161743164},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4686203598976135},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.43193280696868896},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4058927297592163},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32702702283859253},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32473647594451904},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23822951316833496}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6134118437767029},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5278403759002686},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.50179123878479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5009775161743164},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4686203598976135},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.43193280696868896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4058927297592163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32702702283859253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32473647594451904},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23822951316833496},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1752-0509-2-95","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-95","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-95","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18986552","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18986552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8d50r14w","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8d50r14w","pdf_url":"https://escholarship.org/content/qt8d50r14w/qt8d50r14w.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol 2, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2625353","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2625353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:ark:/13030/qt8d50r14w","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:3640959c481f41d490be9565775198b5","is_oa":false,"landing_page_url":"https://doaj.org/article/3640959c481f41d490be9565775198b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 2, Iss 1, p 95 (2008)","raw_type":"article"},{"id":"pmh:qt8d50r14w","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/8d50r14w","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Presson, AP; Sobel, EM; Papp, JC; Suarez, CJ; Whistler, T; Rajeevan, MS; \u00c2\u00a0et al.(2008). Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome. BMC Systems Biology, 2. doi: 10.1186/1752-0509-2-95. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8d50r14w","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-95","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-95","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-95","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1391103144","display_name":null,"funder_award_id":"P30 CA016042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1543282891","display_name":null,"funder_award_id":"CA-16 042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1728546362","display_name":null,"funder_award_id":"HL28481","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2044847461","display_name":null,"funder_award_id":"P50CA09213","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2355553396","display_name":null,"funder_award_id":"T32\u2010HG002536","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G476016981","display_name":null,"funder_award_id":"U19AI063603","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G491034554","display_name":null,"funder_award_id":"P01HL028481","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G864096937","display_name":null,"funder_award_id":"P50-CA092131","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2100526049.pdf","grobid_xml":"https://content.openalex.org/works/W2100526049.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W3969464","https://openalex.org/W141674964","https://openalex.org/W1497043879","https://openalex.org/W1502421007","https://openalex.org/W1517511965","https://openalex.org/W1964895626","https://openalex.org/W1965553156","https://openalex.org/W1966610596","https://openalex.org/W1968747399","https://openalex.org/W1971937094","https://openalex.org/W1973051306","https://openalex.org/W1973085272","https://openalex.org/W1973651601","https://openalex.org/W1976114760","https://openalex.org/W1976568856","https://openalex.org/W1983259675","https://openalex.org/W1989119979","https://openalex.org/W1995987937","https://openalex.org/W1998522750","https://openalex.org/W1999182152","https://openalex.org/W2001340083","https://openalex.org/W2002063846","https://openalex.org/W2007219090","https://openalex.org/W2015548335","https://openalex.org/W2018045523","https://openalex.org/W2025940841","https://openalex.org/W2029639609","https://openalex.org/W2030833218","https://openalex.org/W2036363967","https://openalex.org/W2036744872","https://openalex.org/W2041274449","https://openalex.org/W2055674608","https://openalex.org/W2056687480","https://openalex.org/W2056853166","https://openalex.org/W2057498577","https://openalex.org/W2060293501","https://openalex.org/W2060705109","https://openalex.org/W2068229930","https://openalex.org/W2069733150","https://openalex.org/W2073667935","https://openalex.org/W2080355313","https://openalex.org/W2086119541","https://openalex.org/W2090808827","https://openalex.org/W2091901410","https://openalex.org/W2095099152","https://openalex.org/W2098287790","https://openalex.org/W2105296479","https://openalex.org/W2106036991","https://openalex.org/W2106406245","https://openalex.org/W2117007075","https://openalex.org/W2125934144","https://openalex.org/W2128463395","https://openalex.org/W2128678581","https://openalex.org/W2130362331","https://openalex.org/W2130410032","https://openalex.org/W2130971919","https://openalex.org/W2136451976","https://openalex.org/W2138445399","https://openalex.org/W2145759110","https://openalex.org/W2149640531","https://openalex.org/W2150756306","https://openalex.org/W2151820055","https://openalex.org/W2162142896","https://openalex.org/W2163921837","https://openalex.org/W2166031611","https://openalex.org/W2166994421","https://openalex.org/W2171701188","https://openalex.org/W2262033203","https://openalex.org/W2337579309","https://openalex.org/W2430719897","https://openalex.org/W2556406237","https://openalex.org/W2582743722","https://openalex.org/W4290344561"],"related_works":["https://openalex.org/W5284979","https://openalex.org/W2156421048","https://openalex.org/W2135896045","https://openalex.org/W2032799661","https://openalex.org/W4245853730","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W2171763327","https://openalex.org/W2154615478","https://openalex.org/W2031892952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systems":[1],"biologic":[2],"approaches":[3],"such":[4],"as":[5,43,78],"Weighted":[6],"Gene":[7],"Co-expression":[8],"Network":[9],"Analysis":[10,214],"(WGCNA)":[11],"can":[12,228,251],"effectively":[13],"integrate":[14],"gene":[15,118,170,221],"expression":[16],"and":[17,23,68,125,149,193,210,239],"trait":[18,151],"data":[19,36,53,62,143,205,234],"to":[20,39,63,77,108,121,131,140,207,216,235,255],"identify":[21,64,96,122,154,236],"pathways":[22,238],"candidate":[24,123,176,220],"biomarkers.":[25],"Here":[26],"we":[27,75,84,153],"show":[28,179,225],"that":[29,162,180,187],"the":[30,86,100,112,190,219,240],"additional":[31],"inclusion":[32],"of":[33,146,157],"genetic":[34,60,106,232,258],"marker":[35,61,107,233],"allows":[37],"one":[38],"characterize":[40],"network":[41],"relationships":[42],"causal":[44,70,195,241],"or":[45,81],"reactive":[46],"in":[47,174,189,260],"a":[48,65,92,104,141,155,203],"chronic":[49],"fatigue":[50],"syndrome":[51],"(CFS)":[52],"set.":[54],"RESULTS:":[55],"We":[56,178,201,224],"combine":[57],"WGCNA":[58,227],"with":[59,165,231],"disease-related":[66,237],"pathway":[67,192],"its":[69],"drivers,":[71],"an":[72,116],"analysis":[73],"which":[74],"refer":[76],"\"Integrated":[79],"WGCNA\"":[80],"IWGCNA.":[82],"Specifically,":[83],"present":[85],"following":[87],"IWGCNA":[88],"approach:":[89],"1)":[90],"construct":[91],"co-expression":[93],"network,":[94,101],"2)":[95],"trait-related":[97,105],"modules":[98],"within":[99,111,243],"3)":[102],"use":[103,202,211],"prioritize":[109,134],"genes":[110,124,161,186],"module,":[113],"4)":[114],"apply":[115],"integrated":[117,169],"screening":[119,171],"strategy":[120,139,172],"5)":[126],"carry":[127],"out":[128],"causality":[129],"testing":[130],"verify":[132],"and/or":[133],"results.":[135],"By":[136],"applying":[137],"this":[138],"CFS":[142,166],"set":[144,206],"consisting":[145],"microarray,":[147],"SNP":[148],"clinical":[150],"data,":[152],"module":[156],"299":[158],"highly":[159],"correlated":[160],"is":[163],"associated":[164],"severity.":[167],"Our":[168],"results":[173],"20":[175],"genes.":[177],"our":[181],"approach":[182,248],"yields":[183],"biologically":[184],"interesting":[185],"function":[188],"same":[191],"are":[194],"drivers":[196,242],"for":[197],"their":[198],"parent":[199],"module.":[200],"separate":[204],"replicate":[208],"findings":[209],"Ingenuity":[212],"Pathways":[213],"software":[215],"functionally":[217],"annotate":[218],"pathways.":[222],"CONCLUSION:":[223],"how":[226],"be":[229,253],"combined":[230],"them.":[244],"The":[245],"systems":[246],"genetics":[247],"described":[249],"here":[250],"easily":[252],"used":[254],"generate":[256],"testable":[257],"hypotheses":[259],"other":[261],"complex":[262],"disease":[263],"studies.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":49},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":11}],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2025-10-10T00:00:00"}
