{"id":"https://openalex.org/W1970772422","doi":"https://doi.org/10.1186/1752-0509-2-80","title":"The use of Gene Ontology terms for predicting highly-connected 'hub' nodes in protein-protein interaction networks","display_name":"The use of Gene Ontology terms for predicting highly-connected 'hub' nodes in protein-protein interaction networks","publication_year":2008,"publication_date":"2008-09-16","ids":{"openalex":"https://openalex.org/W1970772422","doi":"https://doi.org/10.1186/1752-0509-2-80","mag":"1970772422","pmid":"https://pubmed.ncbi.nlm.nih.gov/18796161"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-80","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-80.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-80.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016605046","display_name":"Michael Hsing","orcid":"https://orcid.org/0000-0003-3437-7669"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michael Hsing","raw_affiliation_strings":["Faculty of Graduate Studies, Bioinformatics Graduate Program, University of British Columbia, Vancouver, BC, Canada. mhsing@interchange.ubc.ca","Bioinformatics Graduate Program, Faculty of Graduate Studies, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Graduate Studies, Bioinformatics Graduate Program, University of British Columbia, Vancouver, BC, Canada. mhsing@interchange.ubc.ca","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Bioinformatics Graduate Program, Faculty of Graduate Studies, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031150614","display_name":"Kendall Byler","orcid":"https://orcid.org/0000-0003-3621-2438"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kendall Grant Byler","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, D 452 HP, VGH. 2733 Heather Streee, Vancouver, BC, V5Z 3J5, Canada","Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, D 452 HP, VGH. 2733 Heather Streee, Vancouver, BC, V5Z 3J5, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070580886","display_name":"Artem Cherkasov","orcid":"https://orcid.org/0000-0002-1599-1439"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Artem Cherkasov","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, D 452 HP, VGH. 2733 Heather Streee, Vancouver, BC, V5Z 3J5, Canada","Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, D 452 HP, VGH. 2733 Heather Streee, Vancouver, BC, V5Z 3J5, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016605046"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":null,"apc_paid":null,"fwci":2.2464,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.87237552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"80","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6625427603721619},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.6466306447982788},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.624847412109375},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.6081257462501526},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5753412842750549},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.492045134305954},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.48531001806259155},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4709889590740204},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4680597186088562},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4397546350955963},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4350605607032776},{"id":"https://openalex.org/keywords/protein-interaction-networks","display_name":"Protein Interaction Networks","score":0.4322658181190491},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.4300973415374756},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3477713465690613},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3475821018218994},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26265233755111694},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22065439820289612},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08021646738052368}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6625427603721619},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.6466306447982788},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.624847412109375},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6081257462501526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5753412842750549},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.492045134305954},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.48531001806259155},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4709889590740204},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4680597186088562},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4397546350955963},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4350605607032776},{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.4322658181190491},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.4300973415374756},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3477713465690613},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3475821018218994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26265233755111694},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22065439820289612},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08021646738052368}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-2-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-80","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-80.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18796161","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18796161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:circle.library.ubc.ca:2429/55038","is_oa":true,"landing_page_url":"http://hdl.handle.net/2429/55038","pdf_url":null,"source":{"id":"https://openalex.org/S4377196297","display_name":"cIRcle (University of British Columbia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I141945490","host_organization_name":"University of British Columbia","host_organization_lineage":["https://openalex.org/I141945490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:7faa60d519344cddb6c010c507c7c61d","is_oa":false,"landing_page_url":"https://doaj.org/article/7faa60d519344cddb6c010c507c7c61d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 2, Iss 1, p 80 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2553323","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553323","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-80","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-80.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310787","display_name":"Genome Canada","ror":"https://ror.org/029s29983"},{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320319973","display_name":"Genome British Columbia","ror":"https://ror.org/03gne5057"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1970772422.pdf","grobid_xml":"https://content.openalex.org/works/W1970772422.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W20514746","https://openalex.org/W1554944419","https://openalex.org/W1588911128","https://openalex.org/W1974139890","https://openalex.org/W1983913286","https://openalex.org/W1989921625","https://openalex.org/W1994803330","https://openalex.org/W1995117714","https://openalex.org/W2006683252","https://openalex.org/W2007756405","https://openalex.org/W2010577059","https://openalex.org/W2037036397","https://openalex.org/W2045729458","https://openalex.org/W2050721857","https://openalex.org/W2057885377","https://openalex.org/W2061439657","https://openalex.org/W2065304353","https://openalex.org/W2065769502","https://openalex.org/W2083978969","https://openalex.org/W2096143705","https://openalex.org/W2101181377","https://openalex.org/W2101330776","https://openalex.org/W2102701612","https://openalex.org/W2103017472","https://openalex.org/W2104315543","https://openalex.org/W2107424557","https://openalex.org/W2107811186","https://openalex.org/W2107903949","https://openalex.org/W2108491719","https://openalex.org/W2109715166","https://openalex.org/W2113019448","https://openalex.org/W2116117181","https://openalex.org/W2123060905","https://openalex.org/W2124463526","https://openalex.org/W2126469373","https://openalex.org/W2130687290","https://openalex.org/W2130790725","https://openalex.org/W2133138357","https://openalex.org/W2136280642","https://openalex.org/W2146312020","https://openalex.org/W2151326548","https://openalex.org/W2152653671","https://openalex.org/W2155723007","https://openalex.org/W2160223331","https://openalex.org/W2160238006","https://openalex.org/W2163480486","https://openalex.org/W2167188257","https://openalex.org/W2167869241","https://openalex.org/W2171033594","https://openalex.org/W3103071483","https://openalex.org/W4245265000","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W1987705964","https://openalex.org/W2099913238","https://openalex.org/W1841073402","https://openalex.org/W4377086792","https://openalex.org/W2414873431","https://openalex.org/W2949751838","https://openalex.org/W2145100112","https://openalex.org/W2137238644"],"abstract_inverted_index":{"BACKGROUND:":[0],"Protein-protein":[1],"interactions":[2,46],"mediate":[3],"a":[4,153,170,207,280],"wide":[5],"range":[6],"of":[7,26,31,44,56,77,101,145,160,169,184,210,214,247,287,292,299],"cellular":[8,57,293],"functions":[9],"and":[10,12,22,47,54,118,133,195,296],"responses":[11],"have":[13],"been":[14,66,110,220],"studied":[15],"rigorously":[16],"through":[17],"recent":[18],"large-scale":[19,229,311],"proteomics":[20],"experiments":[21,231],"bioinformatics":[23,102,155,217,275],"analyses.":[24],"One":[25],"the":[27,35,52,114,126,141,158,167,177,215,223,273,284,290,297],"most":[28],"important":[29,75],"findings":[30],"those":[32,306],"endeavours":[33],"was":[34],"observation":[36],"that":[37,68,162,199,232,253,272,308],"'hub'":[38],"proteins":[39,71,90,124,161,205,255],"participate":[40],"in":[41,51,125,172,189,264,305],"significant":[42],"numbers":[43],"protein":[45,58,107,173,186,225,312],"play":[48,166],"critical":[49],"roles":[50],"organization":[53],"function":[55],"interaction":[59,116,174,187,238,313],"networks":[60,239],"(PINs)":[61],"12.":[62],"It":[63,269],"has":[64,109,219],"also":[65,98],"demonstrated":[67,198,252],"such":[69],"hub":[70,89,106,171,179,204,250,276],"may":[72],"constitute":[73],"an":[74,248],"pool":[76],"attractive":[78],"drug":[79,301],"targets.Thus,":[80],"it":[81],"is":[82,270],"crucial":[83],"to":[84,87,151,165,234,257],"be":[85],"able":[86,150],"identify":[88],"based":[91,112],"not":[92],"only":[93],"on":[94,113,181],"experimental":[95,185],"data":[96,117,188],"but":[97],"by":[99,139,222],"means":[100],"predictions.":[103],"RESULTS:":[104],"A":[105],"classifier":[108,180,251,277],"developed":[111,178,216,274],"available":[115],"Gene":[119,266],"Ontology":[120,267],"(GO)":[121],"annotations":[122],"for":[123,157,228,240,283],"Escherichia":[127],"coli,":[128],"Saccharomyces":[129],"cerevisiae,":[130],"Drosophila":[131],"melanogaster":[132],"Homo":[134],"sapiens":[135],"genomes.":[136],"In":[137],"particular,":[138],"utilizing":[140],"machine":[142],"learning":[143],"method":[144,218],"boosting":[146],"trees":[147],"we":[148],"were":[149],"create":[152],"predictive":[154],"tool":[156,282],"identification":[159,298],"are":[163],"likely":[164],"role":[168],"networks.":[175],"Testing":[176],"external":[182],"sets":[183],"Methicillin-resistant":[190],"Staphylococcus":[191],"aureus":[192],"(MRSA)":[193],"252":[194],"Caenorhabditis":[196],"elegans":[197],"our":[200],"approach":[201],"can":[202],"predict":[203],"with":[206],"high":[208],"degree":[209],"accuracy.A":[211],"practical":[212],"application":[213],"illustrated":[221],"effective":[224],"bait":[226],"selection":[227],"pull-down":[230],"aim":[233],"map":[235],"complete":[236],"protein-protein":[237],"several":[241],"species.":[242],"CONCLUSION:":[243],"The":[244],"successful":[245],"development":[246],"accurate":[249],"highly-connected":[254],"tend":[256],"share":[258],"certain":[259],"relevant":[260],"functional":[261],"properties":[262],"reflected":[263],"their":[265],"annotations.":[268],"anticipated":[271],"will":[278],"represent":[279],"useful":[281],"theoretical":[285],"prediction":[286],"highly-interacting":[288],"proteins,":[289],"study":[291],"network":[294],"organizations,":[295],"prospective":[300],"targets":[302],"-":[303],"even":[304],"organisms":[307],"currently":[309],"lack":[310],"data.":[314]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}
