{"id":"https://openalex.org/W2147985467","doi":"https://doi.org/10.1186/1752-0509-2-78","title":"Exact model reduction of combinatorial reaction networks","display_name":"Exact model reduction of combinatorial reaction networks","publication_year":2008,"publication_date":"2008-08-28","ids":{"openalex":"https://openalex.org/W2147985467","doi":"https://doi.org/10.1186/1752-0509-2-78","mag":"2147985467","pmid":"https://pubmed.ncbi.nlm.nih.gov/18755034"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-78","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-78","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-78","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052161376","display_name":"H. Conzelmann","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger Conzelmann","raw_affiliation_strings":["Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr, 1, 39106, Magdeburg, Germany. Conzelmann@isr.uni-stuttgart.de","Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, Magdeburg, 39106, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr, 1, 39106, Magdeburg, Germany. Conzelmann@isr.uni-stuttgart.de","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, Magdeburg, 39106, Germany","institution_ids":["https://openalex.org/I4210127568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077163269","display_name":"Dirk Fey","orcid":"https://orcid.org/0000-0002-5558-0167"},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dirk Fey","raw_affiliation_strings":["Department of Electronic & Electrical Engineering, Industrial Control Centre, University of Strathclyde, Glasgow, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic & Electrical Engineering, Industrial Control Centre, University of Strathclyde, Glasgow, Scotland, UK","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105425269","display_name":"Ernst D Gilles","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ernst D Gilles","raw_affiliation_strings":["Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, Magdeburg, 39106, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, Magdeburg, 39106, Germany","institution_ids":["https://openalex.org/I4210127568"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052161376"],"corresponding_institution_ids":["https://openalex.org/I4210127568"],"apc_list":null,"apc_paid":{"value":1219,"currency":"EUR","value_usd":1314},"fwci":2.6676,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.90254544,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.804099977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.804099977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.6127252578735352},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5912017226219177},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5548299551010132},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5259597301483154},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.4997854232788086},{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.4951590597629547},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.4873534142971039},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3422123193740845},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33605140447616577},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.32773637771606445},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.23240864276885986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22274786233901978},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21517497301101685},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13287431001663208},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.10949087142944336}],"concepts":[{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.6127252578735352},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5912017226219177},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5548299551010132},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5259597301483154},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.4997854232788086},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.4951590597629547},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4873534142971039},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3422123193740845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33605140447616577},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.32773637771606445},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.23240864276885986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22274786233901978},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21517497301101685},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13287431001663208},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.10949087142944336},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/1752-0509-2-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-78","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-78","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18755034","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18755034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:strathprints.strath.ac.uk:19459","is_oa":false,"landing_page_url":"https://strathprints.strath.ac.uk/view/author/623808.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pure.mpg.de:item_1756751","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-9696-8","pdf_url":"http://hdl.handle.net/11858/00-001M-0000-0013-9696-8","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e2a23f2c57784d87a3d0b73b71b944f9","is_oa":false,"landing_page_url":"https://doaj.org/article/e2a23f2c57784d87a3d0b73b71b944f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 2, Iss 1, p 78 (2008)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:380014","is_oa":false,"landing_page_url":"http://edoc.mpg.de/380014","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, v.2 (2008)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:1218212","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2570670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:opus4.hsfu:9042","is_oa":true,"landing_page_url":"https://opus.hs-furtwangen.de/frontdoor/index/index/docId/9042","pdf_url":null,"source":{"id":"https://openalex.org/S4377196512","display_name":"Repository of Futwangen University of Applied Sciences (Furtwangen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I882953328","host_organization_name":"Furtwangen University","host_organization_lineage":["https://openalex.org/I882953328"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/12771","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/12771","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2, 78 (2008)","raw_type":"peer reviewed"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-78","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-78","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-78","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147985467.pdf","grobid_xml":"https://content.openalex.org/works/W2147985467.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W607148426","https://openalex.org/W1224821644","https://openalex.org/W1484198052","https://openalex.org/W1495323209","https://openalex.org/W1585751449","https://openalex.org/W1599936794","https://openalex.org/W1607824205","https://openalex.org/W1660272337","https://openalex.org/W1782369362","https://openalex.org/W1807981783","https://openalex.org/W1887006513","https://openalex.org/W1966129049","https://openalex.org/W1966658428","https://openalex.org/W1969369091","https://openalex.org/W1972337004","https://openalex.org/W1977290213","https://openalex.org/W1984886691","https://openalex.org/W1995242599","https://openalex.org/W1997344583","https://openalex.org/W1998219095","https://openalex.org/W2001620484","https://openalex.org/W2002908987","https://openalex.org/W2007393641","https://openalex.org/W2028415754","https://openalex.org/W2030060324","https://openalex.org/W2033488181","https://openalex.org/W2034456930","https://openalex.org/W2034492556","https://openalex.org/W2034626992","https://openalex.org/W2038398800","https://openalex.org/W2039168276","https://openalex.org/W2043502953","https://openalex.org/W2054571512","https://openalex.org/W2058083313","https://openalex.org/W2071523020","https://openalex.org/W2072515105","https://openalex.org/W2073035303","https://openalex.org/W2075161553","https://openalex.org/W2075260598","https://openalex.org/W2081441817","https://openalex.org/W2094358340","https://openalex.org/W2111058026","https://openalex.org/W2111184079","https://openalex.org/W2121811364","https://openalex.org/W2125947965","https://openalex.org/W2139941949","https://openalex.org/W2140355533","https://openalex.org/W2145080853","https://openalex.org/W2152585118","https://openalex.org/W2163321605","https://openalex.org/W2163493106","https://openalex.org/W2165700291","https://openalex.org/W2167101540","https://openalex.org/W3160954918","https://openalex.org/W4211075026","https://openalex.org/W4253418569"],"related_works":["https://openalex.org/W3082668976","https://openalex.org/W2517973022","https://openalex.org/W1543121148","https://openalex.org/W1580703421","https://openalex.org/W2996841952","https://openalex.org/W2618518959","https://openalex.org/W2231364979","https://openalex.org/W4295745414","https://openalex.org/W4288093367","https://openalex.org/W4382202915"],"abstract_inverted_index":{"BACKGROUND:":[0],"Receptors":[1],"and":[2,39,54,63,75,86,137],"scaffold":[3],"proteins":[4],"usually":[5],"possess":[6],"a":[7,49,112,133,148],"high":[8],"number":[9,27,35,51],"of":[10,17,28,36,52,77,101,121,135,169],"distinct":[11],"binding":[12,37,55],"domains":[13,38,56],"inducing":[14],"the":[15,26,34,57,72,88,99,118,162],"formation":[16,100],"large":[18,62],"multiprotein":[19],"signaling":[20],"complexes.":[21],"Due":[22],"to":[23,97,131,147,165],"combinatorial":[24,170],"reasons":[25],"distinguishable":[29],"species":[30],"grows":[31],"exponentially":[32],"with":[33,150],"can":[40],"easily":[41],"reach":[42],"several":[43],"millions.":[44],"Even":[45],"by":[46],"including":[47],"only":[48],"limited":[50],"components":[53],"resulting":[58],"models":[59,168],"are":[60,129],"very":[61],"hardly":[64],"manageable.":[65],"A":[66],"novel":[67],"model":[68,124,134,149],"reduction":[69,74],"technique":[70],"allows":[71,117],"significant":[73],"modularization":[76],"these":[78],"models.":[79],"RESULTS:":[80],"We":[81],"introduce":[82],"methods":[83,128,164],"that":[84,116],"extend":[85],"complete":[87],"already":[89],"introduced":[90],"approach.":[91],"For":[92],"instance,":[93],"we":[94,110],"provide":[95],"techniques":[96],"handle":[98],"multi-scaffold":[102],"complexes":[103],"as":[104,106],"well":[105],"receptor":[107,139],"dimerization.":[108],"Furthermore,":[109],"discuss":[111],"new":[113],"modeling":[114],"approach":[115],"direct":[119],"generation":[120],"exactly":[122,166],"reduced":[123],"structures.":[125],"The":[126,154],"developed":[127],"used":[130],"reduce":[132,167],"EGF":[136],"insulin":[138],"crosstalk":[140],"comprising":[141],"5,182":[142],"ordinary":[143],"differential":[144],"equations":[145],"(ODEs)":[146],"87":[151],"ODEs.":[152],"CONCLUSION:":[153],"methods,":[155],"presented":[156],"in":[157],"this":[158],"contribution,":[159],"significantly":[160],"enhance":[161],"available":[163],"reaction":[171],"networks.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}