{"id":"https://openalex.org/W2162471251","doi":"https://doi.org/10.1186/1752-0509-2-71","title":"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism","display_name":"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism","publication_year":2008,"publication_date":"2008-08-07","ids":{"openalex":"https://openalex.org/W2162471251","doi":"https://doi.org/10.1186/1752-0509-2-71","mag":"2162471251","pmid":"https://pubmed.ncbi.nlm.nih.gov/18687109"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-71","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-71","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-71","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-71","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008739880","display_name":"Intawat Nookaew","orcid":"https://orcid.org/0000-0001-8901-1088"},"institutions":[{"id":"https://openalex.org/I60837268","display_name":"King Mongkut's University of Technology Thonburi","ror":"https://ror.org/0057ax056","country_code":"TH","type":"education","lineage":["https://openalex.org/I60837268"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Intawat Nookaew","raw_affiliation_strings":["Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand. intawat.in@gmail.com","Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand. intawat.in@gmail.com","institution_ids":["https://openalex.org/I60837268"]},{"raw_affiliation_string":"Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand","institution_ids":["https://openalex.org/I60837268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059800162","display_name":"Michael C. Jewett","orcid":"https://orcid.org/0000-0003-2948-6211"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Michael C Jewett","raw_affiliation_strings":["Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark,","Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and","Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, Lyngby, DK-2800 Kgs, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark,","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, Lyngby, DK-2800 Kgs, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059388448","display_name":"Asawin Meechai","orcid":null},"institutions":[{"id":"https://openalex.org/I60837268","display_name":"King Mongkut's University of Technology Thonburi","ror":"https://ror.org/0057ax056","country_code":"TH","type":"education","lineage":["https://openalex.org/I60837268"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Asawin Meechai","raw_affiliation_strings":["Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand,","Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand,","institution_ids":["https://openalex.org/I60837268"]},{"raw_affiliation_string":"Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand","institution_ids":["https://openalex.org/I60837268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074852262","display_name":"Chinae Thammarongtham","orcid":"https://orcid.org/0000-0001-5834-4795"},"institutions":[{"id":"https://openalex.org/I60837268","display_name":"King Mongkut's University of Technology Thonburi","ror":"https://ror.org/0057ax056","country_code":"TH","type":"education","lineage":["https://openalex.org/I60837268"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chinae Thammarongtham","raw_affiliation_strings":["Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand,","Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, 10150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand,","institution_ids":["https://openalex.org/I60837268"]},{"raw_affiliation_string":"Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, 10150, Thailand","institution_ids":["https://openalex.org/I60837268","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000807929","display_name":"Kobkul Laoteng","orcid":"https://orcid.org/0000-0002-7263-4892"},"institutions":[{"id":"https://openalex.org/I60837268","display_name":"King Mongkut's University of Technology Thonburi","ror":"https://ror.org/0057ax056","country_code":"TH","type":"education","lineage":["https://openalex.org/I60837268"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kobkul Laoteng","raw_affiliation_strings":["Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand,","Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, 10150, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand,","institution_ids":["https://openalex.org/I60837268"]},{"raw_affiliation_string":"Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok, 10150, Thailand","institution_ids":["https://openalex.org/I60837268","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075797029","display_name":"Supapon Cheevadhanarak","orcid":null},"institutions":[{"id":"https://openalex.org/I60837268","display_name":"King Mongkut's University of Technology Thonburi","ror":"https://ror.org/0057ax056","country_code":"TH","type":"education","lineage":["https://openalex.org/I60837268"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Supapon Cheevadhanarak","raw_affiliation_strings":["School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand,","School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand,","institution_ids":["https://openalex.org/I60837268"]},{"raw_affiliation_string":"School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, 10140, Thailand","institution_ids":["https://openalex.org/I60837268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083238115","display_name":"Jens Nielsen","orcid":"https://orcid.org/0000-0002-9955-6003"},"institutions":[{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Jens Nielsen","raw_affiliation_strings":["Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark,","Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, Lyngby, DK-2800 Kgs, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark,","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, Lyngby, DK-2800 Kgs, Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014410545","display_name":"Sakarindr Bhumiratana","orcid":null},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I4210129478","display_name":"Ministry of Science and Technology Thailand","ror":"https://ror.org/02nfy5246","country_code":"TH","type":"government","lineage":["https://openalex.org/I2801080794","https://openalex.org/I4210129478"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Sakarindr Bhumiratana","raw_affiliation_strings":["National Science and Technology Development Agency, Ministry of Science and Technology, Thailand Science Park, Klong Luang, Pathumthani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Science and Technology Development Agency, Ministry of Science and Technology, Thailand Science Park, Klong Luang, Pathumthani, 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4210129478"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5014410545"],"corresponding_institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I4210129478"],"apc_list":null,"apc_paid":null,"fwci":7.1926,"has_fulltext":true,"cited_by_count":201,"citation_normalized_percentile":{"value":0.97856582,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"71","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7183854579925537},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.715764582157135},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6430865526199341},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4983408451080322},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"Lipid metabolism","score":0.4648849666118622},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.46378031373023987},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.44365808367729187},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39279916882514954},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3621700406074524},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21537154912948608},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21428680419921875},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.17739355564117432},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12548363208770752},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1026710569858551}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7183854579925537},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.715764582157135},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6430865526199341},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4983408451080322},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4648849666118622},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.46378031373023987},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.44365808367729187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39279916882514954},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3621700406074524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21537154912948608},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21428680419921875},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.17739355564117432},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12548363208770752},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1026710569858551},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-2-71","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-71","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-71","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18687109","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18687109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2542360","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2542360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/c49f3413-3a84-4d2e-8ee5-144646199e99","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/c49f3413-3a84-4d2e-8ee5-144646199e99","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nookaew , I , Jewett , M C , Meechai , A , Thammarongtham , C , Laoteng , K , Cheevadhanarak , S , Nielsen , J & Bhumiratana , S 2008 , ' The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism ' , BMC Systems Biology , vol. 2 , pp. 71 . https://doi.org/10.1186/1752-0509-2-71","raw_type":"article"},{"id":"pmh:oai:research.chalmers.se:92214","is_oa":false,"landing_page_url":"https://research.chalmers.se/en/publication/92214","pdf_url":null,"source":{"id":"https://openalex.org/S4306402469","display_name":"Chalmers Research (Chalmers University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66862912","host_organization_name":"Chalmers University of Technology","host_organization_lineage":["https://openalex.org/I66862912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-71","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-71","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-71","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320326787","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67"},{"id":"https://openalex.org/F4320335223","display_name":"Thailand Graduate Institute of Science and Technology","ror":"https://ror.org/02edr8z79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162471251.pdf","grobid_xml":"https://content.openalex.org/works/W2162471251.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1513501940","https://openalex.org/W1524141331","https://openalex.org/W1579394698","https://openalex.org/W1589178615","https://openalex.org/W1597762351","https://openalex.org/W1604052462","https://openalex.org/W1606232948","https://openalex.org/W1807210160","https://openalex.org/W1971266246","https://openalex.org/W1979255038","https://openalex.org/W1979328799","https://openalex.org/W1990547365","https://openalex.org/W2001202526","https://openalex.org/W2002880495","https://openalex.org/W2005071799","https://openalex.org/W2011477134","https://openalex.org/W2024725497","https://openalex.org/W2028232771","https://openalex.org/W2028561804","https://openalex.org/W2035305851","https://openalex.org/W2036799174","https://openalex.org/W2048020511","https://openalex.org/W2048214825","https://openalex.org/W2048317717","https://openalex.org/W2054719673","https://openalex.org/W2063050867","https://openalex.org/W2063862573","https://openalex.org/W2066341288","https://openalex.org/W2077854212","https://openalex.org/W2080498142","https://openalex.org/W2085465508","https://openalex.org/W2086473717","https://openalex.org/W2086922902","https://openalex.org/W2096245011","https://openalex.org/W2099735525","https://openalex.org/W2101501829","https://openalex.org/W2103328552","https://openalex.org/W2113736266","https://openalex.org/W2120886934","https://openalex.org/W2127957413","https://openalex.org/W2128572161","https://openalex.org/W2132992030","https://openalex.org/W2137450588","https://openalex.org/W2140948740","https://openalex.org/W2141018553","https://openalex.org/W2143891630","https://openalex.org/W2153283265","https://openalex.org/W2153373497","https://openalex.org/W2159675211","https://openalex.org/W2160668169","https://openalex.org/W2161682449","https://openalex.org/W2163485494","https://openalex.org/W2163823651","https://openalex.org/W2170427655","https://openalex.org/W4243634040"],"related_works":["https://openalex.org/W4315558101","https://openalex.org/W3200271510","https://openalex.org/W63366483","https://openalex.org/W1516770101","https://openalex.org/W1897466773","https://openalex.org/W2357011584","https://openalex.org/W4380882399","https://openalex.org/W2623087137","https://openalex.org/W1509801266","https://openalex.org/W3085090520"],"abstract_inverted_index":{"BACKGROUND:":[0],"Up":[1],"to":[2,35,168,202],"now,":[3],"there":[4],"have":[5,181],"been":[6,182],"three":[7,21],"published":[8],"versions":[9],"of":[10,28,65,80,113,119,155,173,211],"a":[11,25,62,74,166,197,204],"yeast":[12],"genome-scale":[13,69],"metabolic":[14,86,213],"model:":[15],"iFF708,":[16],"iND750":[17],"and":[18,31,77,91,123,147,177],"iLL672.":[19],"All":[20],"models,":[22],"however,":[23],"lack":[24],"detailed":[26,78],"description":[27,79],"lipid":[29,45,81,100,174,221,233],"metabolism":[30,46,175,222],"thus":[32],"are":[33],"unable":[34],"be":[36,163,203,225],"used":[37,164,226],"as":[38,165,196],"integrated":[39,192],"scaffolds":[40],"for":[41,207,216,227,231],"gaining":[42],"insights":[43],"into":[44],"from":[47,187],"multilevel":[48],"omic":[49],"measurement":[50],"technologies":[51],"(e.g.":[52],"genome-wide":[53],"mRNA":[54],"levels).":[55],"To":[56,151],"overcome":[57],"this":[58],"limitation,":[59],"we":[60,102,157],"reconstructed":[61,85],"new":[63,96,105,144],"version":[64],"the":[66,110,143,153,160,170,209],"Saccharomyces":[67],"cerevisiae":[68],"model,":[70],"iIN800":[71,132,195],"that":[72,108,159,179,223],"includes":[73],"more":[75],"rigorous":[76],"metabolism.":[82],"RESULTS:":[83],"The":[84],"model":[87,161],"comprises":[88],"1446":[89],"reactions":[90,97],"1013":[92],"metabolites.":[93],"Beyond":[94],"incorporating":[95],"involved":[98],"in":[99,126,184,220],"metabolism,":[101],"also":[103],"present":[104],"biomass":[106,145],"equations":[107,146],"improve":[109],"predictive":[111],"power":[112],"flux":[114],"balance":[115],"analysis":[116],"simulations.":[117],"Predictions":[118],"both":[120],"growth":[121],"capability":[122],"large":[124],"scale":[125],"silico":[127],"single":[128],"gene":[129],"deletions":[130],"by":[131],"were":[133],"consistent":[134],"with":[135],"experimental":[136],"data.":[137],"In":[138],"addition,":[139],"13C-labeling":[140],"experiments":[141],"validated":[142],"calculated":[148],"intracellular":[149],"fluxes.":[150],"demonstrate":[152],"applicability":[154],"iIN800,":[156],"show":[158],"can":[162,224],"scaffold":[167,199],"reveal":[169],"regulatory":[171,218],"importance":[172],"precursors":[176],"intermediates":[178],"would":[180],"missed":[183],"previous":[185],"models":[186],"transcriptome":[188],"datasets.":[189],"CONCLUSION:":[190],"Performing":[191],"analyses":[193],"using":[194],"network":[198],"is":[200],"shown":[201],"valuable":[205],"tool":[206],"elucidating":[208],"behavior":[210],"complex":[212],"networks,":[214],"particularly":[215],"identifying":[217],"targets":[219],"industrial":[228],"applications":[229],"or":[230],"understanding":[232],"disease":[234],"states.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":20}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}