{"id":"https://openalex.org/W2154345166","doi":"https://doi.org/10.1186/1752-0509-2-42","title":"A Dominated Coupling From The Past algorithm for the stochastic simulation of networks of biochemical reactions","display_name":"A Dominated Coupling From The Past algorithm for the stochastic simulation of networks of biochemical reactions","publication_year":2008,"publication_date":"2008-05-08","ids":{"openalex":"https://openalex.org/W2154345166","doi":"https://doi.org/10.1186/1752-0509-2-42","mag":"2154345166","pmid":"https://pubmed.ncbi.nlm.nih.gov/18466612"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-42","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022843288","display_name":"Martin Hemberg","orcid":"https://orcid.org/0000-0001-8895-5239"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Hemberg","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. martin.hemberg03@imperial.ac.uk","Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. martin.hemberg03@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058010593","display_name":"Mauricio Barahona","orcid":"https://orcid.org/0000-0002-1089-5675"},"institutions":[{"id":"https://openalex.org/I4210123447","display_name":"London Institute for Mathematical Sciences","ror":"https://ror.org/0390mzx53","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210123447"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mauricio Barahona","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK and","Institute for Mathematical Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK and","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Institute for Mathematical Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I4210123447","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1404,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56781712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"42","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/master-equation","display_name":"Master equation","score":0.6136434078216553},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5690417289733887},{"id":"https://openalex.org/keywords/stochastic-simulation","display_name":"Stochastic simulation","score":0.5575618147850037},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.525922417640686},{"id":"https://openalex.org/keywords/monotone-polygon","display_name":"Monotone polygon","score":0.5192065834999084},{"id":"https://openalex.org/keywords/convergence","display_name":"Convergence (economics)","score":0.5086594223976135},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.46703454852104187},{"id":"https://openalex.org/keywords/stationary-distribution","display_name":"Stationary distribution","score":0.4519389569759369},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3812558054924011},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3399536609649658},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.3292394280433655},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3253210484981537},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2799851596355438},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1676023006439209},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11020827293395996},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10952556133270264},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.08972877264022827},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.08510318398475647},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08450064063072205}],"concepts":[{"id":"https://openalex.org/C128805008","wikidata":"https://www.wikidata.org/wiki/Q722878","display_name":"Master equation","level":3,"score":0.6136434078216553},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5690417289733887},{"id":"https://openalex.org/C25915931","wikidata":"https://www.wikidata.org/wiki/Q4180825","display_name":"Stochastic simulation","level":2,"score":0.5575618147850037},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.525922417640686},{"id":"https://openalex.org/C2834757","wikidata":"https://www.wikidata.org/wiki/Q4925424","display_name":"Monotone polygon","level":2,"score":0.5192065834999084},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.5086594223976135},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.46703454852104187},{"id":"https://openalex.org/C98951983","wikidata":"https://www.wikidata.org/wiki/Q7604341","display_name":"Stationary distribution","level":3,"score":0.4519389569759369},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3812558054924011},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3399536609649658},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3292394280433655},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3253210484981537},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2799851596355438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1676023006439209},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11020827293395996},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10952556133270264},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.08972877264022827},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.08510318398475647},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08450064063072205},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-2-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18466612","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18466612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2529164","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2529164","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/12809","is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/12809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154345166.pdf","grobid_xml":"https://content.openalex.org/works/W2154345166.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W73235108","https://openalex.org/W1535793628","https://openalex.org/W1595409123","https://openalex.org/W1641480268","https://openalex.org/W1645305843","https://openalex.org/W1973890190","https://openalex.org/W1978319180","https://openalex.org/W1985213899","https://openalex.org/W1993862407","https://openalex.org/W2033229837","https://openalex.org/W2033900415","https://openalex.org/W2039571025","https://openalex.org/W2042321087","https://openalex.org/W2059053384","https://openalex.org/W2083117595","https://openalex.org/W2085061065","https://openalex.org/W2090639770","https://openalex.org/W2099970615","https://openalex.org/W2102787760","https://openalex.org/W2128014106","https://openalex.org/W2134759932","https://openalex.org/W2141688036","https://openalex.org/W2166792981","https://openalex.org/W2168173277","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2899702797","https://openalex.org/W3008437073","https://openalex.org/W4250181240","https://openalex.org/W4253069708"],"related_works":["https://openalex.org/W2332288878","https://openalex.org/W1997869057","https://openalex.org/W3012129038","https://openalex.org/W2141137682","https://openalex.org/W1485307137","https://openalex.org/W2754234032","https://openalex.org/W1844369525","https://openalex.org/W2963008666","https://openalex.org/W55544075","https://openalex.org/W2154345166"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"recent":[2],"years,":[3],"stochastic":[4,167,201],"descriptions":[5],"of":[6,42,53,65,100,108,110,148,166,170,193,200],"biochemical":[7,111,202],"reactions":[8,112,149],"based":[9],"on":[10],"the":[11,33,39,51,54,61,67,77,86,106,123,138,190,194],"Master":[12],"Equation":[13],"(ME)":[14],"have":[15],"become":[16],"widespread.":[17],"These":[18],"are":[19],"especially":[20],"relevant":[21],"for":[22,38,56,105,196],"models":[23],"involving":[24],"gene":[25,115],"regulation.":[26],"Gillespie's":[27,184],"Stochastic":[28],"Simulation":[29],"Algorithm":[30],"(SSA)":[31],"is":[32,64,144],"most":[34],"widely":[35],"used":[36],"method":[37],"numerical":[40,98],"evaluation":[41],"these":[43],"models.":[44],"The":[45,129,141,178],"SSA":[46,68,124,185],"produces":[47],"exact":[48],"samples":[49],"from":[50,85,137,189],"distribution":[52,63,88],"ME":[55,107,195],"finite":[57],"times.":[58],"However,":[59],"if":[60],"stationary":[62,87,139,191],"interest,":[66],"provides":[69,180],"no":[70],"information":[71],"about":[72],"convergence":[73],"or":[74],"how":[75],"long":[76],"algorithm":[78,104,121],"needs":[79],"to":[80,83,133,146,183],"be":[81],"run":[82],"sample":[84],"with":[89,125,150,186],"given":[90],"accuracy.":[91],"RESULTS:":[92],"We":[93,159],"present":[94],"a":[95,101,197],"proof":[96],"and":[97,117,153,174],"characterization":[99],"Perfect":[102],"Sampling":[103],"networks":[109,147,169],"prevalent":[113],"in":[114,172],"regulation":[116],"enzymatic":[118],"catalysis.":[119],"Our":[120],"combines":[122],"Dominated":[126],"Coupling":[127],"From":[128],"Past":[130],"(DCFTP)":[131],"techniques":[132],"provide":[134],"guaranteed":[135,187],"sampling":[136,188],"distribution.":[140],"resulting":[142],"DCFTP-SSA":[143,179],"applicable":[145],"uni-molecular":[151],"stoichiometries":[152],"sub-linear,":[154],"(anti-)":[155],"monotone":[156],"propensity":[157],"functions.":[158],"showcase":[160],"its":[161],"applicability":[162],"studying":[163],"steady-state":[164],"properties":[165],"regulatory":[168],"relevance":[171],"synthetic":[173],"systems":[175],"biology.":[176],"CONCLUSION:":[177],"an":[181],"extension":[182],"solution":[192],"broad":[198],"class":[199],"networks.":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}