{"id":"https://openalex.org/W2041844855","doi":"https://doi.org/10.1186/1752-0509-2-102","title":"From pathway to population \u2013 a multiscale model of juxtacrine EGFR-MAPK signalling","display_name":"From pathway to population \u2013 a multiscale model of juxtacrine EGFR-MAPK signalling","publication_year":2008,"publication_date":"2008-11-26","ids":{"openalex":"https://openalex.org/W2041844855","doi":"https://doi.org/10.1186/1752-0509-2-102","mag":"2041844855","pmid":"https://pubmed.ncbi.nlm.nih.gov/19036127"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-102","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-102","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-102","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100858118","display_name":"DC Walker","orcid":null},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"DC Walker","raw_affiliation_strings":["Department of Computer Science, University of Sheffield, Kroto Research Institute, North Campus, Broad Lane, Sheffield, S3 7HQ, UK. d.c.walker@sheffield.ac.uk","Department of Computer Science, University of Sheffield, Kroto Research Institute, North Campus, Broad Lane, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Kroto Research Institute, North Campus, Broad Lane, Sheffield, S3 7HQ, UK. d.c.walker@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Computer Science, University of Sheffield, Kroto Research Institute, North Campus, Broad Lane, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027449310","display_name":"Nikolaos T. Georgopoulos","orcid":"https://orcid.org/0000-0002-6330-4947"},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"NT Georgopoulos","raw_affiliation_strings":["Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, YO10 5YW, UK","Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, YO10 5YW, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, UK","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025375470","display_name":"Jennifer Southgate","orcid":"https://orcid.org/0000-0002-0135-480X"},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Southgate","raw_affiliation_strings":["Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, YO10 5YW, UK","Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, YO10 5YW, UK","institution_ids":["https://openalex.org/I52099693"]},{"raw_affiliation_string":"Department of Biology, Jack Birch Unit of Molecular Carcinogenesis, University of York, York, UK","institution_ids":["https://openalex.org/I52099693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100858118"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.8424,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.72470211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"102","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7473000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.7473000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juxtacrine-signalling","display_name":"Juxtacrine signalling","score":0.8501524925231934},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.7411812543869019},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.7030410170555115},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5852351784706116},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49535122513771057},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.44530221819877625},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.32126784324645996},{"id":"https://openalex.org/keywords/paracrine-signalling","display_name":"Paracrine signalling","score":0.2491980791091919},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.16667091846466064},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1543479859828949},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06265631318092346}],"concepts":[{"id":"https://openalex.org/C64863464","wikidata":"https://www.wikidata.org/wiki/Q3190616","display_name":"Juxtacrine signalling","level":4,"score":0.8501524925231934},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.7411812543869019},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7030410170555115},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5852351784706116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49535122513771057},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44530221819877625},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32126784324645996},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.2491980791091919},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16667091846466064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1543479859828949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06265631318092346},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-2-102","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-102","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-102","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:19036127","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19036127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:eprints.hud.ac.uk:6448","is_oa":true,"landing_page_url":null,"pdf_url":"http://eprints.hud.ac.uk/id/eprint/6448/1/1752-0509-2-102.pdf","source":{"id":"https://openalex.org/S4306401852","display_name":"University of Huddersfield Repository (University of Huddersfield)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I133837150","host_organization_name":"University of Huddersfield","host_organization_lineage":["https://openalex.org/I133837150"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:9757","is_oa":true,"landing_page_url":"http://www.biomedcentral.com/1752-0509/2/102","pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2651861","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2651861","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-102","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-102","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-2-102","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320240","display_name":"Research Councils UK","ror":"https://ror.org/00dq2kk65"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041844855.pdf","grobid_xml":"https://content.openalex.org/works/W2041844855.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1584652055","https://openalex.org/W1866851443","https://openalex.org/W1966260349","https://openalex.org/W1978932874","https://openalex.org/W1986402843","https://openalex.org/W1990736894","https://openalex.org/W1996449803","https://openalex.org/W2001620484","https://openalex.org/W2006006356","https://openalex.org/W2007393641","https://openalex.org/W2025399691","https://openalex.org/W2038398800","https://openalex.org/W2046314718","https://openalex.org/W2057112584","https://openalex.org/W2062657417","https://openalex.org/W2070147440","https://openalex.org/W2075161553","https://openalex.org/W2078415101","https://openalex.org/W2083693850","https://openalex.org/W2084817237","https://openalex.org/W2091758912","https://openalex.org/W2095959177","https://openalex.org/W2117852044","https://openalex.org/W2118272259","https://openalex.org/W2120889810","https://openalex.org/W2130119800","https://openalex.org/W2130929414","https://openalex.org/W2132218454","https://openalex.org/W2132629429","https://openalex.org/W2136147374","https://openalex.org/W2156842451","https://openalex.org/W2168012657","https://openalex.org/W2172291394","https://openalex.org/W2181692905","https://openalex.org/W4251084954"],"related_works":["https://openalex.org/W1782372789","https://openalex.org/W2171142519","https://openalex.org/W2055325161","https://openalex.org/W2009037891","https://openalex.org/W1521411817","https://openalex.org/W2360066506","https://openalex.org/W1982459028","https://openalex.org/W2367042309","https://openalex.org/W772272767","https://openalex.org/W2085490657"],"abstract_inverted_index":{"BACKGROUND:":[0],"Most":[1],"mathematical":[2],"models":[3],"of":[4,30,43,45,47,87,104,108,121,148,155,171,175,192,199,208,220,227,231,272,283,313,342],"biochemical":[5],"pathways":[6],"consider":[7],"either":[8],"signalling":[9,65,89],"events":[10],"that":[11,54,78,236,290],"take":[12],"place":[13],"within":[14,56,93],"a":[15,31,57,74,94,146,158,172,215,224,343],"single":[16,159,173],"cell":[17,23,32,64,128,160,245,256,275,298],"in":[18,68,124,145,203,214,260,278,328],"isolation,":[19],"or":[20,161],"an":[21,101,118,125,273,301,324],"'average'":[22],"which":[24,280],"is":[25,300],"considered":[26],"to":[27,99,114,117,138,151,223,229,253,308,320,338],"be":[28,306,333],"representative":[29],"population.":[33,95,130],"Likewise,":[34],"experimental":[35,292],"measurements":[36],"are":[37],"often":[38],"averaged":[39],"over":[40,335],"populations":[41,299],"consisting":[42,170,226],"hundreds":[44,228],"thousands":[46,230],"cells.":[48,315],"This":[49,131,266,316],"approach":[50,97,134,319],"ignores":[51],"the":[52,85,109,153,187,196,237,243,264,310,340],"fact":[53],"even":[55],"genetically-homogeneous":[58],"population,":[59],"local":[60],"conditions":[61],"may":[62,251,332],"influence":[63],"and":[66,113,150,190,210,250,303],"result":[67],"phenotypic":[69],"heterogeneity.":[70],"We":[71],"have":[72],"developed":[73],"multi-scale":[75],"computational":[76],"model":[77,103,169,222],"accounts":[79],"for":[80],"emergent":[81],"heterogeneity":[82,259,282],"arising":[83],"from":[84,295],"influences":[86],"intercellular":[88,193],"on":[90,186],"individual":[91,122,255,314],"cells":[92,123,149,234],"Our":[96],"was":[98,247,268],"develop":[100],"ODE":[102],"juxtacrine":[105],"EGFR-ligand":[106],"activation":[107,144,182,207],"MAPK":[110],"intracellular":[111],"pathway":[112],"couple":[115],"this":[116,221],"agent-based":[119],"representation":[120],"expanding":[126],"epithelial":[127,274],"culture":[129],"multi-scale,":[132,317],"multi-paradigm":[133,318],"has":[135],"enabled":[136],"us":[137],"simulate":[139],"Extracellular":[140],"signal-regulated":[141],"kinase":[142],"(Erk)":[143],"population":[147,225,246,261,276],"examine":[152],"consequences":[154],"interpretation":[156],"at":[157],"population-based":[162],"level":[163],"using":[164],"virtual":[165,233],"assays.":[166],"RESULTS:":[167],"A":[168],"pair":[174],"interacting":[176,232],"agents":[177],"predicted":[178],"very":[179,248],"different":[180,249],"Erk":[181,217,239,284],"(phosphorylation)":[183],"profiles,":[184],"depending":[185],"formation":[188,198],"rate":[189],"stability":[191],"contacts,":[194],"with":[195],"slow":[197],"stable":[200],"contacts":[201,212],"resulting":[202,213],"low":[204],"but":[205],"sustained":[206],"Erk,":[209],"transient":[211,216],"signal.":[218],"Extension":[219],"revealed":[235],"activated":[238],"profile":[240],"measured":[241],"across":[242,263],"entire":[244,297],"appear":[252],"contradict":[254],"findings,":[257],"reflecting":[258],"density":[262],"culture.":[265],"prediction":[267],"supported":[269],"by":[270],"immunolabelling":[271],"grown":[277],"vitro,":[279],"confirmed":[281],"activation.":[285],"CONCLUSION:":[286],"These":[287],"results":[288],"illustrate":[289],"mean":[291],"data":[293],"obtained":[294],"analysing":[296],"oversimplification,":[302],"should":[304],"not":[305],"extrapolated":[307],"deduce":[309],"signal:response":[311],"paradigm":[312],"biological":[321,344],"simulation":[322],"provides":[323],"important":[325],"conceptual":[326],"tool":[327],"addressing":[329],"how":[330],"information":[331],"integrated":[334],"multiple":[336],"scales":[337],"predict":[339],"behaviour":[341],"system.":[345]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
