{"id":"https://openalex.org/W2169576771","doi":"https://doi.org/10.1186/1752-0509-2-10","title":"Identification of gene interactions associated with disease from gene expression data using synergy networks","display_name":"Identification of gene interactions associated with disease from gene expression data using synergy networks","publication_year":2008,"publication_date":"2008-01-30","ids":{"openalex":"https://openalex.org/W2169576771","doi":"https://doi.org/10.1186/1752-0509-2-10","mag":"2169576771","pmid":"https://pubmed.ncbi.nlm.nih.gov/18234101"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-2-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-10","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-10.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-10.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110713844","display_name":"John Watkinson","orcid":null},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Watkinson","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027, USA. jw2322@columbia.edu","Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027, USA. jw2322@columbia.edu","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382664","display_name":"Xiaodong Wang","orcid":"https://orcid.org/0000-0002-4304-5482"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Wang","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044625906","display_name":"Tian Zheng","orcid":"https://orcid.org/0000-0003-4889-0391"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Zheng","raw_affiliation_strings":["Department of Statistics, Columbia University, 1255 Amsterdam Avenue, New York, NY, 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Columbia University, 1255 Amsterdam Avenue, New York, NY, 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053783737","display_name":"Dimitris Anastassiou","orcid":"https://orcid.org/0000-0003-2459-909X"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dimitris Anastassiou","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY, 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053783737"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":2.9172,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.91370813,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9440000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9440000057220459,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6901105642318726},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.6134082078933716},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5981159806251526},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5903692245483398},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5830510258674622},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5754551887512207},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5600641965866089},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.553825318813324},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.5166792869567871},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.48812994360923767},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.483294278383255},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4501478672027588},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4399043023586273},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4295908510684967},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4152836799621582},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3788982331752777},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33495962619781494},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2718442380428314},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1416078507900238},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09186553955078125}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6901105642318726},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.6134082078933716},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5981159806251526},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5903692245483398},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5830510258674622},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5754551887512207},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5600641965866089},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.553825318813324},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.5166792869567871},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.48812994360923767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.483294278383255},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4501478672027588},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4399043023586273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4295908510684967},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4152836799621582},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3788982331752777},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33495962619781494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2718442380428314},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1416078507900238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09186553955078125},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1752-0509-2-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-10","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-10.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18234101","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18234101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:academiccommons.columbia.edu:10.7916/D81835DP","is_oa":false,"landing_page_url":"https://doi.org/10.7916/D81835DP","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:europepmc.org:776361","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2258206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.7916/d81835dp","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d81835dp","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-2-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-2-10","pdf_url":"https://link.springer.com/content/pdf/10.1186/1752-0509-2-10.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2169576771.pdf","grobid_xml":"https://content.openalex.org/works/W2169576771.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1571917377","https://openalex.org/W1576096421","https://openalex.org/W1605638342","https://openalex.org/W1964743637","https://openalex.org/W1965800022","https://openalex.org/W1967556326","https://openalex.org/W1989076816","https://openalex.org/W1991097065","https://openalex.org/W2023303342","https://openalex.org/W2024983955","https://openalex.org/W2032279931","https://openalex.org/W2035936829","https://openalex.org/W2043904301","https://openalex.org/W2047446484","https://openalex.org/W2053484352","https://openalex.org/W2058596530","https://openalex.org/W2058829665","https://openalex.org/W2058846847","https://openalex.org/W2065825082","https://openalex.org/W2069839014","https://openalex.org/W2078149659","https://openalex.org/W2081764750","https://openalex.org/W2093797884","https://openalex.org/W2099111195","https://openalex.org/W2100850281","https://openalex.org/W2110065044","https://openalex.org/W2112364930","https://openalex.org/W2115108153","https://openalex.org/W2117994680","https://openalex.org/W2123106337","https://openalex.org/W2125631472","https://openalex.org/W2127053639","https://openalex.org/W2130410032","https://openalex.org/W2143571146","https://openalex.org/W2159080219","https://openalex.org/W2159400887","https://openalex.org/W2161409973","https://openalex.org/W2161715331","https://openalex.org/W2164805147","https://openalex.org/W2167769381","https://openalex.org/W2168245581","https://openalex.org/W2170989872","https://openalex.org/W2323327238","https://openalex.org/W2413446283","https://openalex.org/W2478708596","https://openalex.org/W2559577701","https://openalex.org/W2798084948","https://openalex.org/W4248389956","https://openalex.org/W4248415074"],"related_works":["https://openalex.org/W2155492529","https://openalex.org/W4252504573","https://openalex.org/W2158714033","https://openalex.org/W4385510321","https://openalex.org/W2101315668","https://openalex.org/W15348386","https://openalex.org/W78967844","https://openalex.org/W2131550814","https://openalex.org/W2063978705","https://openalex.org/W2128085946"],"abstract_inverted_index":{"BACKGROUND:":[0],"Analysis":[1],"of":[2,11,21,50,62,80,89,93,101,115,125,136],"microarray":[3,51],"data":[4,142],"has":[5],"been":[6],"used":[7],"for":[8,28,162,178,196,201],"the":[9,16,19,26,55,60,83,102,123],"inference":[10],"gene-gene":[12,117],"interactions.":[13],"If,":[14],"however,":[15],"aim":[17],"is":[18,72],"discovery":[20],"disease-related":[22],"biological":[23,160,183,189,198],"mechanisms,":[24],"then":[25],"criterion":[27],"defining":[29],"such":[30],"interactions":[31,118],"must":[32],"be":[33,152,194],"specifically":[34],"linked":[35],"to":[36,74,111,154],"disease.":[37,202],"RESULTS:":[38],"Here":[39],"we":[40],"present":[41],"a":[42,63,106,112,126,134,159,174],"computational":[43,175],"methodology":[44,176],"that":[45,149],"jointly":[46],"analyzes":[47],"two":[48,103],"sets":[49],"data,":[52],"one":[53,58],"in":[54,59,95,105,122],"presence":[56],"and":[57,109,143,157],"absence":[61],"disease,":[64,121],"identifying":[65],"gene":[66,96,163],"pairs":[67,97,164],"whose":[68],"correlation":[69],"with":[70,120,165,187],"disease":[71],"due":[73,153],"cooperative,":[75],"rather":[76],"than":[77],"independent,":[78],"contributions":[79],"genes,":[81],"using":[82],"recently":[84],"developed":[85],"information":[86],"theoretic":[87],"measure":[88],"synergy.":[90,168],"High":[91],"levels":[92],"synergy":[94,171],"indicates":[98],"possible":[99],"membership":[100],"genes":[104],"shared":[107],"pathway":[108],"leads":[110],"graphical":[113],"representation":[114],"inferred":[116],"associated":[119],"form":[124],"\"synergy":[127],"network.\"":[128],"We":[129],"apply":[130],"this":[131],"technique":[132],"on":[133],"set":[135],"publicly":[137],"available":[138],"prostate":[139],"cancer":[140],"expression":[141],"successfully":[144],"validate":[145],"our":[146],"results,":[147],"confirming":[148],"they":[150,191],"cannot":[151],"pure":[155],"chance":[156],"providing":[158],"explanation":[161],"exceptionally":[166],"high":[167],"CONCLUSION:":[169],"Thus,":[170],"networks":[172],"provide":[173],"helpful":[177,195],"deriving":[179],"\"disease":[180],"interactomes\"":[181],"from":[182],"data.":[184],"When":[185],"coupled":[186],"additional":[188],"knowledge,":[190],"can":[192],"also":[193],"deciphering":[197],"mechanisms":[199],"responsible":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}
