{"id":"https://openalex.org/W2024662249","doi":"https://doi.org/10.1186/1752-0509-1-s1-s9","title":"Engineering a synthetic molecular oscillator based on the Lotka-Volterra dynamic","display_name":"Engineering a synthetic molecular oscillator based on the Lotka-Volterra dynamic","publication_year":2007,"publication_date":"2007-05-08","ids":{"openalex":"https://openalex.org/W2024662249","doi":"https://doi.org/10.1186/1752-0509-1-s1-s9","mag":"2024662249"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-s1-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-s1-s9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-1-S1-S9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-1-S1-S9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014362679","display_name":"Christin Y.M. Sander","orcid":"https://orcid.org/0000-0001-6003-8615","observed_orcids":["https://orcid.org/0000-0001-6003-8615"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christin Sander","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084416436","display_name":"Farah Vohra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Farah Vohra","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001251375","display_name":"John Chattaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Chattaway","raw_affiliation_strings":["Department of Biology, Imperial College, London, SW7 2AZ, UK","Department of Biology, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biology, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042583044","display_name":"Tom Hinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tom Hinson","raw_affiliation_strings":["Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","Department of Biochemistry, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108437709","display_name":"John Sy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Sy","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010675811","display_name":"Jiongjun Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jiongjun Bai","raw_affiliation_strings":["Department of Electrical Engineering, Imperial College, London, SW7 2AZ, UK","Department of Electrical Engineering, Imperial College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Electrical Engineering, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111683909","display_name":"Jonathan Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Wells","raw_affiliation_strings":["Department of Biology, Imperial College, London, SW7 2AZ, UK","Department of Biology, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biology, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081747667","display_name":"Deepti Aswani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Deepti Aswani","raw_affiliation_strings":["Department of Biology, Imperial College, London, SW7 2AZ, UK","Department of Biology, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biology, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045650204","display_name":"Vincent Rouilly","orcid":"https://orcid.org/0000-0003-3704-9310","observed_orcids":["https://orcid.org/0000-0003-3704-9310"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vincent Rouilly","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049366102","display_name":"C.-L. Poh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chueh-Loo Poh","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051218799","display_name":"Matthieu Bultelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthieu Bultelle","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102993321","display_name":"Kirsten Jensen","orcid":"https://orcid.org/0000-0002-3722-2235","observed_orcids":["https://orcid.org/0000-0002-3722-2235"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kirsten Jensen","raw_affiliation_strings":["Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","Department of Biochemistry, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104304541","display_name":"David J. Mann","orcid":"https://orcid.org/0000-0003-3023-1734","observed_orcids":["https://orcid.org/0000-0003-3023-1734"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Mann","raw_affiliation_strings":["Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","Department of Biochemistry, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083556767","display_name":"Paul S. Freemont","orcid":"https://orcid.org/0000-0002-5658-8486","observed_orcids":["https://orcid.org/0000-0002-5658-8486"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Freemont","raw_affiliation_strings":["Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","Department of Biochemistry, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Biochemistry, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082526083","display_name":"Richard Ian Kitney","orcid":"https://orcid.org/0000-0002-6499-5209","observed_orcids":["https://orcid.org/0000-0002-6499-5209"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard Kitney","raw_affiliation_strings":["Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","Department of Bioengineering, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College, London, SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Bioengineering, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082526083"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.2415,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.53765731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-oscillators","display_name":"biological oscillators","score":0.7419999837875366},{"id":"https://openalex.org/keywords/lotka-volterra-dynamics","display_name":"Lotka-Volterra dynamics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/predator-prey-dynamics","display_name":"predator-prey dynamics","score":0.8450000286102295},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.8970000147819519},{"id":"https://openalex.org/keywords/n-acyl-homoserine-lactones","display_name":"N-acyl homoserine lactones","score":0.9089999794960022},{"id":"https://openalex.org/keywords/quenching","display_name":"quenching","score":0.7099999785423279},{"id":"https://openalex.org/keywords/biobricks","display_name":"BioBricks","score":0.7689999938011169},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.921999990940094},{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5925307273864746},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5189547538757324},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48142167925834656},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4180459678173065},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4135928153991699},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28874850273132324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2886617183685303},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2788565158843994}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/1752-0509-1-s1-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-s1-s9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-1-S1-S9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3449776f871646a49fa509be70cad7c4","is_oa":false,"landing_page_url":"https://doaj.org/article/3449776f871646a49fa509be70cad7c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss Suppl 1, p S9 (2007)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-s1-s9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-s1-s9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-1-S1-S9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024662249.pdf","grobid_xml":"https://content.openalex.org/works/W2024662249.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2057769265","https://openalex.org/W2338895903","https://openalex.org/W2024161258","https://openalex.org/W1911418903","https://openalex.org/W3044523069","https://openalex.org/W2136248167","https://openalex.org/W2126646394","https://openalex.org/W2211443823","https://openalex.org/W1987445442","https://openalex.org/W4211049090"],"abstract_inverted_index":{"Oscillators":[0,20],"are":[1,21,35],"a":[2,58,65,172,184,199,210,228,261,293,395,420,529],"fundamental":[3,497],"building":[4],"block":[5],"in":[6,23,213,292,362,400,448,538],"many":[7,24],"engineering":[8,157,169,181],"fields,":[9],"as":[10,28,257,466],"they":[11],"provide":[12],"the":[13,44,81,98,105,110,114,132,150,160,179,218,242,245,271,274,283,288,297,300,311,323,330,337,341,344,352,363,365,374,377,383,388,398,410,414,428,438,442,456,469,480,486,491,495,500,511,539],"basis":[14,45],"for":[15,47,244],"counting,":[16],"timing":[17],"and":[18,51,142,153,191,333,346,385,413,419,430,483,504,523],"synchronisation.":[19],"found":[22],"everyday":[25],"devices":[26,320],"such":[27,256],"clocks,":[29],"computers":[30],"or":[31,119],"radios.":[32],"Similarly,":[33],"oscillations":[34,115,301,465,487],"an":[36,88,126,147],"essential":[37],"part":[38,79],"of":[39,80,186,236,260,273,299,343,397,405,422,441,455,468,475,485,499,513],"biological":[40,61,195,201,211],"systems":[41],"\u2013":[42,183,193],"providing":[43],"for,":[46],"example,":[48],"rhythmic":[49],"patterns":[50],"regulatory":[52],"networks.":[53],"The":[54,138,203,434,453,473,517],"ability":[55],"to":[56,84,86,104,159,197,208,226,240,253,269,281,305,321,328,510,527,535],"build":[57,87,209],"stable,":[59],"controllable":[60],"oscillator":[62,91,128,148,212,416,443,534],"would":[63],"be":[64,303,392,536],"major":[66],"step":[67],"towards":[68],"reliable":[69],"synthetic":[70,200,229,531],"biology":[71,532],"based":[72,93,216,533],"circuits.":[73],"Elowitz":[74],"et":[75],"al":[76],".":[77,550],"were":[78,116,251,279,355,360,380,417,425,444,502],"first":[82],"ones":[83],"try":[85],"oscillator.":[89,202,324],"Their":[90],"was":[92,207,224,367,488,520],"on":[94,217,336,387,479],"genetic":[95,168],"network":[96],"at":[97,109,135,149],"single":[99],"cell":[100],"level.":[101],"However,":[102],"due":[103],"stochastic":[106],"behaviour":[107],"inherent":[108],"gene":[111],"expression":[112],"level,":[113],"not":[117],"stable":[118,464,530],"persistent.":[120],"In":[121,238,267,494],"this":[122],"paper,":[123],"we":[124,524],"present":[125],"original":[127],"design":[129,227,289],"produced":[130],"during":[131],"iGEM-2006":[133],"competition":[134],"Imperial":[136],"College.":[137],"project":[139,166],"addressed":[140],"stability":[141,484],"reliability":[143],"issues":[144],"by":[145,154],"defining":[146],"population":[151,220,295,314],"level":[152],"applying":[155],"strict":[156],"rules":[158],"system":[161,285,312,390,477,501],"development":[162,175],"process.":[163],"This":[164,222],"iGEM":[165,547],"combined":[167],"methods":[170],"with":[171,194,351,370,490],"clearly":[173],"defined":[174],"cycle,":[176],"copied":[177],"from":[178,427,446],"traditional":[180],"approach":[182,223],"cycle":[185],"specification,":[187],"design,":[188,364],"modelling,":[189],"testing":[190,375,431,447],"implementation":[192,366],"processes":[196],"produce":[198],"overall":[204,275,338],"specification":[205],"aim":[206],"E.":[214,449],"Coli":[215,450],"Lotka-Volterra":[219,348,492],"dynamics.":[221],"used":[225,361],"quorum":[230],"sensing":[231],"&":[232],"quenching":[233],"mechanism,":[234],"made":[235],"BioBricks.":[237],"order":[239,268],"satisfy":[241],"requirements":[243],"Lotka":[246],"Volterra":[247],"predator-prey":[248],"dynamics":[249],"BioBricks":[250,291,359,408],"constructed":[252],"show":[254],"properties":[255,332,384],"exponential":[258],"growth":[259],"prey":[262],"molecule":[263],"(Acyl":[264],"Homoserine":[265],"Lactone).":[266],"reduce":[270],"complexity":[272],"assembly,":[276],"test":[277,353,378,411,435,457],"constructs":[278,379,412],"built":[280],"characterise":[282],"different":[284,439],"components.":[286],"Because":[287,358],"comprises":[290],"two":[294],"system,":[296],"parameters":[298,478],"can":[302],"controlled":[304],"achieve":[306],"synchronised":[307],"oscillations.":[308],"Furthermore,":[309],"since":[310],"uses":[313],"wide":[315],"oscillations,":[316],"it":[317],"enables":[318],"other":[319],"synchronise":[322],"It":[325],"is":[326],"important":[327,423],"determine":[329],"component":[331],"their":[334],"impact":[335],"system.":[339,471],"Hence,":[340],"modelling":[342,429,518],"pure":[345],"modified":[347],"dynamics,":[349],"along":[350],"constructs,":[354,458],"carried":[356,368],"out.":[357],"out":[369],"standard":[371],"assembly.":[372],"At":[373],"stage,":[376],"characterised.":[381,505],"Consequently,":[382],"constraints":[386],"full":[389,470,543],"could":[391],"extracted.":[393],"(See":[394],"summary":[396],"method":[399],"Figure":[401],"1":[402],")":[403],"Summary":[404],"our":[406,546],"methodology.":[407],"composing":[409],"final":[415],"engineered":[418],"number":[421],"results":[424],"extracted":[426],"stages:":[432],"i)":[433],"constructs/BioBricks":[436],"representing":[437],"parts":[440],"characterised":[445],"(DH5\u03b1).":[451],"ii)":[452],"model":[454],"which":[459],"included":[460],"experimental":[461],"data,":[462],"predicted":[463],"output":[467],"iii)":[472],"influence":[474],"specific":[476],"frequency,":[481],"amplitude":[482],"investigated":[489],"model.":[493],"project,":[496],"units":[498],"fabricated":[503],"These":[506],"have":[507],"been":[508],"added":[509],"Registry":[512],"Standard":[514],"Biological":[515],"Parts.":[516],"exercise":[519],"highly":[521],"successful":[522],"fully":[525],"expect":[526],"complete":[528],"completed":[537],"near":[540],"future.":[541],"For":[542],"details":[544],"visit":[545],"website":[548],"http://openwetware.org/wiki/IGEM:IMPERIAL/2006":[549]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}