{"id":"https://openalex.org/W2046242662","doi":"https://doi.org/10.1186/1752-0509-1-57","title":"Threshold-dominated regulation hides genetic variation in gene expression networks","display_name":"Threshold-dominated regulation hides genetic variation in gene expression networks","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2046242662","doi":"https://doi.org/10.1186/1752-0509-1-57","mag":"2046242662","pmid":"https://pubmed.ncbi.nlm.nih.gov/18062810"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-57","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-57","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-57","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-57","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065521519","display_name":"Arne B. Gjuvsland","orcid":"https://orcid.org/0000-0002-4391-3411"},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Arne B Gjuvsland","raw_affiliation_strings":["Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432 As, Norway. arne.gjuvsland@cigene.no","Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432, \u00c5s, Norway"],"affiliations":[{"raw_affiliation_string":"Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432 As, Norway. arne.gjuvsland@cigene.no","institution_ids":["https://openalex.org/I54108979"]},{"raw_affiliation_string":"Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077278896","display_name":"Erik Plahte","orcid":null},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Erik Plahte","raw_affiliation_strings":["Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, 1432, \u00c5s, Norway","Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432, \u00c5s, Norway"],"affiliations":[{"raw_affiliation_string":"Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, 1432, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]},{"raw_affiliation_string":"Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065487078","display_name":"Stig W. Omholt","orcid":"https://orcid.org/0000-0002-8320-4337"},"institutions":[{"id":"https://openalex.org/I54108979","display_name":"Norwegian University of Life Sciences","ror":"https://ror.org/04a1mvv97","country_code":"NO","type":"education","lineage":["https://openalex.org/I54108979"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Stig W Omholt","raw_affiliation_strings":["Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, 1432, \u00c5s, Norway","Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432, \u00c5s, Norway"],"affiliations":[{"raw_affiliation_string":"Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, 1432, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]},{"raw_affiliation_string":"Department of Animal Science and Aquaculture, Norwegian University of Life Sciences, 1432, \u00c5s, Norway","institution_ids":["https://openalex.org/I54108979"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065521519"],"corresponding_institution_ids":["https://openalex.org/I54108979"],"apc_list":null,"apc_paid":null,"fwci":1.6135,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.82335712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"57","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7109278440475464},{"id":"https://openalex.org/keywords/sigmoid-function","display_name":"Sigmoid function","score":0.6690344214439392},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5058166980743408},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.49680355191230774},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.49024444818496704},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4883112907409668},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4638289213180542},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4556984007358551},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4492729902267456},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4432925581932068},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4340208172798157},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3686775863170624},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.32954341173171997},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3200473189353943},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3085929751396179},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30722081661224365},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30101943016052246}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7109278440475464},{"id":"https://openalex.org/C81388566","wikidata":"https://www.wikidata.org/wiki/Q526668","display_name":"Sigmoid function","level":3,"score":0.6690344214439392},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5058166980743408},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.49680355191230774},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49024444818496704},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4883112907409668},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4638289213180542},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4556984007358551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4492729902267456},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4432925581932068},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4340208172798157},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3686775863170624},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.32954341173171997},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3200473189353943},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3085929751396179},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30722081661224365},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30101943016052246},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-1-57","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-57","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-57","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18062810","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18062810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:7455d36240bb4e0b85ec9e35b6700bae","is_oa":true,"landing_page_url":"https://doaj.org/article/7455d36240bb4e0b85ec9e35b6700bae","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 57 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:776199","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2238762","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-57","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-57","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-57","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3748656914","display_name":null,"funder_award_id":"Norway","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2046242662.pdf","grobid_xml":"https://content.openalex.org/works/W2046242662.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W8014543","https://openalex.org/W234963275","https://openalex.org/W1557270760","https://openalex.org/W1590222219","https://openalex.org/W1599969036","https://openalex.org/W1623155147","https://openalex.org/W1644749979","https://openalex.org/W1979230873","https://openalex.org/W1979833590","https://openalex.org/W1986040959","https://openalex.org/W2003845577","https://openalex.org/W2003858005","https://openalex.org/W2007415331","https://openalex.org/W2022891974","https://openalex.org/W2025399691","https://openalex.org/W2027789855","https://openalex.org/W2028118090","https://openalex.org/W2031369606","https://openalex.org/W2041603328","https://openalex.org/W2046538693","https://openalex.org/W2046871615","https://openalex.org/W2058221907","https://openalex.org/W2060915805","https://openalex.org/W2061188858","https://openalex.org/W2065769502","https://openalex.org/W2078470194","https://openalex.org/W2079319076","https://openalex.org/W2092313542","https://openalex.org/W2100790213","https://openalex.org/W2102216585","https://openalex.org/W2104123948","https://openalex.org/W2105057212","https://openalex.org/W2110071847","https://openalex.org/W2123511816","https://openalex.org/W2130278727","https://openalex.org/W2134759932","https://openalex.org/W2134800568","https://openalex.org/W2140347764","https://openalex.org/W2141170384","https://openalex.org/W2142072523","https://openalex.org/W2144347639","https://openalex.org/W2151794037","https://openalex.org/W2153800196","https://openalex.org/W2155408323","https://openalex.org/W2164078761","https://openalex.org/W2164143390","https://openalex.org/W2166884834","https://openalex.org/W2167193572","https://openalex.org/W2528271650","https://openalex.org/W3103071483","https://openalex.org/W4211017114","https://openalex.org/W4233339098","https://openalex.org/W4299328967"],"related_works":["https://openalex.org/W4385957115","https://openalex.org/W2061372042","https://openalex.org/W3047779762","https://openalex.org/W2156421048","https://openalex.org/W2135896045","https://openalex.org/W2884256268","https://openalex.org/W2171763327","https://openalex.org/W3108451992","https://openalex.org/W2511617859","https://openalex.org/W2031892952"],"abstract_inverted_index":{"Threshold":[0,76],"robustness":[1,77],"of":[2,93],"a":[3,20,58],"variable":[4,41],"can":[5,87],"be":[6,88],"seen":[7],"as":[8],"its":[9,17,49],"ability":[10],"to":[11,48],"maintain":[12],"an":[13],"active":[14],"regulation":[15,56],"around":[16],"threshold":[18,55],"in":[19,34,61,78],"homeostatic":[21],"state":[22],"despite":[23],"external":[24],"perturbations.":[25],"The":[26],"feedback":[27],"loop":[28],"that":[29,38,54,83],"the":[30,39,94],"system":[31],"necessarily":[32],"possesses":[33],"this":[35],"state,":[36],"ensures":[37],"robust":[40],"is":[42,57,72],"itself":[43],"regulated":[44],"and":[45],"kept":[46],"close":[47],"threshold.":[50],"Our":[51],"results":[52],"suggest":[53],"generic":[59],"phenomenon":[60],"feedback-regulated":[62],"networks":[63,81],"with":[64],"sigmoidal":[65],"response":[66],"functions,":[67],"at":[68],"least":[69],"when":[70],"there":[71],"no":[73],"positive":[74],"feedback.":[75],"gene":[79],"regulatory":[80],"illustrates":[82],"hidden":[84],"genetic":[85],"variation":[86],"explained":[89],"by":[90],"systemic":[91],"properties":[92],"genotype-phenotype":[95],"map.":[96]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}