{"id":"https://openalex.org/W1964305071","doi":"https://doi.org/10.1186/1752-0509-1-54","title":"Eigengene networks for studying the relationships between co-expression modules","display_name":"Eigengene networks for studying the relationships between co-expression modules","publication_year":2007,"publication_date":"2007-11-21","ids":{"openalex":"https://openalex.org/W1964305071","doi":"https://doi.org/10.1186/1752-0509-1-54","mag":"1964305071","pmid":"https://pubmed.ncbi.nlm.nih.gov/18031580"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-54","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-54","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-54","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-54","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008135470","display_name":"Peter Langfelder","orcid":"https://orcid.org/0000-0003-3418-4146"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter Langfelder","raw_affiliation_strings":["Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, CA 90095, USA. peter.langfelder@gmail.com","Department of Human Genetics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, CA 90095, USA. peter.langfelder@gmail.com","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Human Genetics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000192581","display_name":"Steve Horvath","orcid":"https://orcid.org/0000-0002-4110-3589"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Horvath","raw_affiliation_strings":["Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, CA, 90095, USA","Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, CA, 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Human Genetics and Department of Biostatistics, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008135470"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":3.3638,"has_fulltext":true,"cited_by_count":946,"citation_normalized_percentile":{"value":0.92651211,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9376000165939331,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9376000165939331,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.6213562488555908},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5595760941505432},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5404790639877319},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.537154495716095},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5316736102104187},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5175894498825073},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"Gene co-expression network","score":0.4933749735355377},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46828481554985046},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.43833810091018677},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42659080028533936},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.375108540058136},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1697472631931305},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.10734686255455017},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.07743895053863525}],"concepts":[{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.6213562488555908},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5595760941505432},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5404790639877319},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.537154495716095},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5316736102104187},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5175894498825073},{"id":"https://openalex.org/C2778022302","wikidata":"https://www.wikidata.org/wiki/Q18207329","display_name":"Gene co-expression network","level":5,"score":0.4933749735355377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46828481554985046},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.43833810091018677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42659080028533936},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.375108540058136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1697472631931305},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.10734686255455017},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07743895053863525}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-1-54","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-54","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-54","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:18031580","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18031580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:b2fe041805d54ddf989bbcebd0dcbb97","is_oa":false,"landing_page_url":"https://doaj.org/article/b2fe041805d54ddf989bbcebd0dcbb97","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 54 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2267703","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2267703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-54","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-54","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-54","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964305071.pdf","grobid_xml":"https://content.openalex.org/works/W1964305071.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W404240460","https://openalex.org/W1502421007","https://openalex.org/W1644749979","https://openalex.org/W1932560099","https://openalex.org/W1973651601","https://openalex.org/W1989921625","https://openalex.org/W2018045523","https://openalex.org/W2053126761","https://openalex.org/W2057498577","https://openalex.org/W2060705109","https://openalex.org/W2068229930","https://openalex.org/W2069733150","https://openalex.org/W2102955435","https://openalex.org/W2118340207","https://openalex.org/W2122683221","https://openalex.org/W2140176439","https://openalex.org/W2142720308","https://openalex.org/W2147881874","https://openalex.org/W2148541040","https://openalex.org/W2151820055","https://openalex.org/W2154475586","https://openalex.org/W2156247618","https://openalex.org/W2160875291","https://openalex.org/W2161732139","https://openalex.org/W2162142896","https://openalex.org/W2163296727","https://openalex.org/W2163480486","https://openalex.org/W2163921837","https://openalex.org/W2166994421","https://openalex.org/W2167190345","https://openalex.org/W2905060314","https://openalex.org/W4232999705","https://openalex.org/W4249273120"],"related_works":["https://openalex.org/W2796517744","https://openalex.org/W2008014943","https://openalex.org/W15348386","https://openalex.org/W2807926763","https://openalex.org/W2158714033","https://openalex.org/W2951915565","https://openalex.org/W2090574217","https://openalex.org/W2129949791","https://openalex.org/W2509687359","https://openalex.org/W2362023034"],"abstract_inverted_index":{"BACKGROUND:":[0],"There":[1],"is":[2,48],"evidence":[3],"that":[4,53,65,92,151,213],"genes":[5],"and":[6,19,79,181,193,197,205,235,267],"their":[7],"protein":[8],"products":[9],"are":[10,93,130],"organized":[11,218],"into":[12,219],"functional":[13],"modules":[14,43,78,91,178,188,204,244],"according":[15],"to":[16,27,39,56,72,101,154,226],"cellular":[17],"processes":[18],"pathways.":[20],"Gene":[21],"co-expression":[22,77,140,248],"networks":[23,45,99,171,231],"have":[24],"been":[25],"used":[26,71],"describe":[28,73,86],"the":[29,58,74,81,107,128,136,139,156,167,174,184,198,241,260,265,274],"relationships":[30,59,75,175,185,199,242],"between":[31,60,76,176,186,200,243],"gene":[32,108,247],"transcripts.":[33],"Ample":[34],"literature":[35],"exists":[36],"on":[37,135],"how":[38],"detect":[40],"biologically":[41,236],"meaningful":[42,237],"in":[44,172,179,189],"but":[46,132],"there":[47],"a":[49,120,246,255],"need":[50],"for":[51,89,122,146,239],"methods":[52,67,88,145,252],"allow":[54,152],"one":[55,153],"study":[57],"modules.":[61],"RESULTS:":[62],"We":[63,105,165],"show":[64],"network":[66,149,159],"can":[68,216,232,270],"also":[69],"be":[70,217,233,271],"present":[80],"following":[82,275],"methodology.":[83],"First,":[84],"we":[85,118,143,211,224],"several":[87],"detecting":[90],"shared":[94],"by":[95,114],"two":[96],"or":[97],"more":[98],"(referred":[100],"as":[102,227],"consensus":[103,177,187,203],"modules).":[104],"represent":[106],"expression":[109],"profiles":[110],"of":[111,138,158,169,245,259],"each":[112],"module":[113,214],"an":[115,124],"eigengene.":[116],"Second,":[117],"propose":[119,144],"method":[121],"constructing":[123],"eigengene":[125,148,170],"network,":[126],"where":[127],"edges":[129],"undirected":[131],"maintain":[133],"information":[134],"sign":[137],"information.":[141],"Third,":[142],"differential":[147],"analysis":[150],"assess":[155],"preservation":[157],"properties":[160],"across":[161],"different":[162],"data":[163],"sets.":[164],"illustrate":[166],"value":[168],"studying":[173,240],"human":[180],"chimpanzee":[182],"brains;":[183],"brain,":[190],"muscle,":[191],"liver,":[192],"adipose":[194],"mouse":[195,202],"tissues;":[196],"male-female":[201],"clinical":[206],"traits.":[207],"In":[208],"some":[209],"applications,":[210],"find":[212],"eigengenes":[215],"higher":[220,256],"level":[221],"clusters":[222],"which":[223],"refer":[225],"meta-modules.":[228],"CONCLUSION:":[229],"Eigengene":[230],"effective":[234],"tools":[238],"network.":[249],"The":[250],"proposed":[251],"may":[253],"reveal":[254],"order":[257],"organization":[258],"transcriptome.":[261],"R":[262],"software":[263],"tutorials,":[264],"data,":[266],"supplementary":[268],"material":[269],"found":[272],"at":[273],"webpage:":[276],"http://www.genetics.ucla.edu/labs/horvath/CoexpressionNetwork/EigengeneNetwork.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":43},{"year":2024,"cited_by_count":84},{"year":2023,"cited_by_count":73},{"year":2022,"cited_by_count":98},{"year":2021,"cited_by_count":127},{"year":2020,"cited_by_count":82},{"year":2019,"cited_by_count":76},{"year":2018,"cited_by_count":64},{"year":2017,"cited_by_count":72},{"year":2016,"cited_by_count":59},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":23}],"updated_date":"2026-05-13T08:25:38.343686","created_date":"2025-10-10T00:00:00"}