{"id":"https://openalex.org/W1992960705","doi":"https://doi.org/10.1186/1752-0509-1-48","title":"Receptor downregulation and desensitization enhance the information processing ability of signalling receptors","display_name":"Receptor downregulation and desensitization enhance the information processing ability of signalling receptors","publication_year":2007,"publication_date":"2007-11-09","ids":{"openalex":"https://openalex.org/W1992960705","doi":"https://doi.org/10.1186/1752-0509-1-48","mag":"1992960705","pmid":"https://pubmed.ncbi.nlm.nih.gov/17996096"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-48","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013793470","display_name":"Harish Shankaran","orcid":null},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harish Shankaran","raw_affiliation_strings":["Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland WA 99352, USA. harish.shankaran@pnl.gov","Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory,Richland,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland WA 99352, USA. harish.shankaran@pnl.gov","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory,Richland,USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032610249","display_name":"H Wiley","orcid":"https://orcid.org/0000-0003-0232-6867"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Steven Wiley","raw_affiliation_strings":["Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061290912","display_name":"Haluk Resat","orcid":"https://orcid.org/0000-0001-6174-4431"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haluk Resat","raw_affiliation_strings":["Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory,Richland,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99352, USA","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory,Richland,USA","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013793470"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":null,"apc_paid":null,"fwci":1.7493,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.83344048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7408000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7408000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.8541553020477295},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6454634666442871},{"id":"https://openalex.org/keywords/desensitization","display_name":"Desensitization (medicine)","score":0.6317502856254578},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.5337677001953125},{"id":"https://openalex.org/keywords/homologous-desensitization","display_name":"Homologous desensitization","score":0.4883391559123993},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4517410099506378},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4516788721084595},{"id":"https://openalex.org/keywords/internalization","display_name":"Internalization","score":0.4125971794128418},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35334235429763794},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09696990251541138}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8541553020477295},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6454634666442871},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.6317502856254578},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5337677001953125},{"id":"https://openalex.org/C92759361","wikidata":"https://www.wikidata.org/wiki/Q5891436","display_name":"Homologous desensitization","level":4,"score":0.4883391559123993},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4517410099506378},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4516788721084595},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4125971794128418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35334235429763794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09696990251541138},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-1-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17996096","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17996096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:79e6851cca1144b598146569761c0227","is_oa":false,"landing_page_url":"https://doaj.org/article/79e6851cca1144b598146569761c0227","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 48 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2228318","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228318","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-48","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-48","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-48","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1724155629","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G2506945562","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4121556046","display_name":null,"funder_award_id":"5R01GM072821","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4499092682","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G5321382714","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G7247582730","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G7288853145","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1992960705.pdf","grobid_xml":"https://content.openalex.org/works/W1992960705.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1589488717","https://openalex.org/W1592646667","https://openalex.org/W1623155147","https://openalex.org/W1637936532","https://openalex.org/W1644749979","https://openalex.org/W1797197920","https://openalex.org/W1820918747","https://openalex.org/W1866851443","https://openalex.org/W1945832201","https://openalex.org/W1972814063","https://openalex.org/W1978486653","https://openalex.org/W1986482900","https://openalex.org/W1986700361","https://openalex.org/W2016883388","https://openalex.org/W2027729471","https://openalex.org/W2041042514","https://openalex.org/W2042313347","https://openalex.org/W2043911313","https://openalex.org/W2049707782","https://openalex.org/W2058241031","https://openalex.org/W2060605538","https://openalex.org/W2061475648","https://openalex.org/W2061671663","https://openalex.org/W2062844139","https://openalex.org/W2068602646","https://openalex.org/W2085229836","https://openalex.org/W2093868559","https://openalex.org/W2103331163","https://openalex.org/W2106362845","https://openalex.org/W2125589729","https://openalex.org/W2131763008","https://openalex.org/W2133254839","https://openalex.org/W2135970284","https://openalex.org/W2136147374","https://openalex.org/W2138321569","https://openalex.org/W2142072523","https://openalex.org/W2142925367","https://openalex.org/W2143784594","https://openalex.org/W2143891754","https://openalex.org/W2158033922","https://openalex.org/W2163352150","https://openalex.org/W2302508446","https://openalex.org/W4244120980"],"related_works":["https://openalex.org/W4386700781","https://openalex.org/W4243031069","https://openalex.org/W2008054558","https://openalex.org/W2561950586","https://openalex.org/W2414340276","https://openalex.org/W1586219219","https://openalex.org/W2405844234","https://openalex.org/W48708315","https://openalex.org/W2111847843","https://openalex.org/W2429511732"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"addition":[2,247],"to":[3,76,96,111,130,165,186,204,213,229,248,278],"initiating":[4],"signaling":[5,26,109],"events,":[6],"the":[7,19,50,55,63,72,77,82,99,106,151,161,178,183,199,223,234,237,272,283],"activation":[8],"of":[9,21,25,34,52,65,101,108,140,150,236,286],"cell":[10,73],"surface":[11],"receptors":[12,35,91,110],"also":[13],"triggers":[14],"regulatory":[15],"processes":[16],"that":[17,123,147,198,221,245],"restrict":[18],"duration":[20],"signaling.":[22],"Acute":[23],"attenuation":[24],"can":[27,128,258],"be":[28,279],"accomplished":[29],"either":[30],"via":[31,39],"ligand-induced":[32,40],"internalization":[33],"(endocytic":[36],"downregulation)":[37],"or":[38],"receptor":[41,56,86,184,200,254],"desensitization.":[42],"These":[43],"phenomena":[44,220],"have":[45],"traditionally":[46],"been":[47],"viewed":[48],"in":[49,62,189,227,246,263,281],"context":[51],"adaptation":[53],"wherein":[54],"system":[57,162,238],"enters":[58],"a":[59,118,170,190,260],"refractory":[60],"state":[61],"presence":[64],"sustained":[66],"ligand":[67,114,141,230],"stimuli":[68],"and":[69,88,103,125,132,153,175,217,256],"thereby":[70,136,181,232],"prevents":[71],"from":[74],"over-responding":[75],"ligand.":[78],"Here":[79],"we":[80,121],"use":[81],"epidermal":[83],"growth":[84],"factor":[85],"(EGFR)":[87],"G-protein":[89],"coupled":[90],"(GPCR)":[92],"as":[93,219,250,271],"model":[94],"systems":[95,185,201,224],"respectively":[97],"examine":[98],"effects":[100],"downregulation":[102,124,174,216,255],"desensitization":[104,126,176,218,257],"on":[105],"ability":[107],"decode":[112,187],"time-varying":[113],"stimuli.":[115],"RESULTS:":[116],"Using":[117],"mathematical":[119],"model,":[120],"show":[122],"mechanisms":[127,251],"lead":[129],"tight":[131],"efficient":[133],"input-output":[134],"coupling":[135],"ensuring":[137],"synchronous":[138],"processing":[139],"inputs.":[142],"Frequency":[143],"response":[144],"analysis":[145,196],"indicates":[146],"upstream":[148],"elements":[149],"EGFR":[152],"GPCR":[154],"networks":[155],"behave":[156],"like":[157],"low-pass":[158],"filters":[159],"with":[160],"being":[163],"able":[164],"faithfully":[166],"transduce":[167],"inputs":[168,188],"below":[169],"critical":[171,261],"frequency.":[172],"Receptor":[173],"increase":[177],"filter":[179],"bandwidth":[180],"enabling":[182],"wider":[191],"frequency":[192],"range.":[193],"Further,":[194],"system-theoretic":[195],"reveals":[197],"are":[202],"analogous":[203],"classical":[205],"mechanical":[206],"over-damped":[207],"systems.":[208,288],"This":[209],"analogy":[210],"enables":[211],"us":[212],"metaphorically":[214],"describe":[215],"make":[222],"more":[225],"resilient":[226],"responding":[228],"perturbations":[231],"improving":[233],"stability":[235],"resting":[239],"state.":[240],"CONCLUSION:":[241],"Our":[242],"findings":[243],"suggest":[244],"serving":[249],"for":[252],"adaptation,":[253],"play":[259],"role":[262],"temporal":[264],"information":[265],"processing.":[266],"Furthermore,":[267],"engineering":[268],"metaphors":[269],"such":[270],"ones":[273],"described":[274],"here":[275],"could":[276],"prove":[277],"invaluable":[280],"understanding":[282],"design":[284],"principles":[285],"biological":[287]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}