{"id":"https://openalex.org/W2138672920","doi":"https://doi.org/10.1186/1752-0509-1-42","title":"Analysis of global control of Escherichia coli carbohydrate uptake","display_name":"Analysis of global control of Escherichia coli carbohydrate uptake","publication_year":2007,"publication_date":"2007-09-13","ids":{"openalex":"https://openalex.org/W2138672920","doi":"https://doi.org/10.1186/1752-0509-1-42","mag":"2138672920","pmid":"https://pubmed.ncbi.nlm.nih.gov/17854493"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-42","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040121825","display_name":"Andreas Kremling","orcid":"https://orcid.org/0000-0001-9533-6786"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Kremling","raw_affiliation_strings":["Max-Planck-Institut Magdeburg, Systems Biology, Sandtorstr, 1, 39106 Magdeburg, Germany. kremling@mpi-magdeburg.mpg.de","Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institut Magdeburg, Systems Biology, Sandtorstr, 1, 39106 Magdeburg, Germany. kremling@mpi-magdeburg.mpg.de","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064532054","display_name":"Katja Bettenbrock","orcid":"https://orcid.org/0000-0002-2444-7777"},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Bettenbrock","raw_affiliation_strings":["Systems Biology, Max-Planck-Institut Magdeburg, Sandtorstr. 1, 39106, Magdeburg, Germany","Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology, Max-Planck-Institut Magdeburg, Sandtorstr. 1, 39106, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112798796","display_name":"Ernst Dieter Gilles","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127568","display_name":"Max Planck Institute for Dynamics of Complex Technical Systems","ror":"https://ror.org/030h7k016","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127568"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ernst Dieter Gilles","raw_affiliation_strings":["Systems Biology, Max-Planck-Institut Magdeburg, Sandtorstr. 1, 39106, Magdeburg, Germany","Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology, Max-Planck-Institut Magdeburg, Sandtorstr. 1, 39106, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210127568"]},{"raw_affiliation_string":"Systems Biology, Max-Planck-Institut Magdeburg, Magdeburg, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040121825"],"corresponding_institution_ids":["https://openalex.org/I4210127568"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1250,"currency":"EUR","value_usd":1348},"fwci":2.4215,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.90008529,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"42","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8113999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8113999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pep-group-translocation","display_name":"PEP group translocation","score":0.8907451629638672},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6482567191123962},{"id":"https://openalex.org/keywords/response-regulator","display_name":"Response regulator","score":0.6428678631782532},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.6239438056945801},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5872846841812134},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.552937924861908},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5328035354614258},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5150918364524841},{"id":"https://openalex.org/keywords/carbohydrate","display_name":"Carbohydrate","score":0.5074824690818787},{"id":"https://openalex.org/keywords/growth-rate","display_name":"Growth rate","score":0.4883217513561249},{"id":"https://openalex.org/keywords/glucose-transporter","display_name":"Glucose transporter","score":0.4860706627368927},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.46978631615638733},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4443097710609436},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4272683560848236},{"id":"https://openalex.org/keywords/phosphotransferase","display_name":"Phosphotransferase","score":0.41705769300460815},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3917385935783386},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37299686670303345},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3230828642845154},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.2782619595527649},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.21625375747680664},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20339363813400269},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19691607356071472},{"id":"https://openalex.org/keywords/bacterial-protein","display_name":"Bacterial protein","score":0.17026492953300476}],"concepts":[{"id":"https://openalex.org/C45656491","wikidata":"https://www.wikidata.org/wiki/Q1538418","display_name":"PEP group translocation","level":4,"score":0.8907451629638672},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6482567191123962},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.6428678631782532},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.6239438056945801},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5872846841812134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.552937924861908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5328035354614258},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5150918364524841},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.5074824690818787},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.4883217513561249},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.4860706627368927},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.46978631615638733},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4443097710609436},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4272683560848236},{"id":"https://openalex.org/C2777504003","wikidata":"https://www.wikidata.org/wiki/Q3381520","display_name":"Phosphotransferase","level":3,"score":0.41705769300460815},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3917385935783386},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37299686670303345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3230828642845154},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2782619595527649},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.21625375747680664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20339363813400269},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19691607356071472},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.17026492953300476},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007785","descriptor_name":"Lactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007785","descriptor_name":"Lactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007785","descriptor_name":"Lactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019289","descriptor_name":"Pyruvic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019298","descriptor_name":"Glucose-6-Phosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-1-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17854493","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17854493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pure.mpg.de:item_1757094","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-991D-2","pdf_url":"http://hdl.handle.net/11858/00-001M-0000-0013-991D-2","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:1171275","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2148058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:cc482f74f0fc4ce28c52ed8b887aa02b","is_oa":false,"landing_page_url":"https://doaj.org/article/cc482f74f0fc4ce28c52ed8b887aa02b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 42 (2007)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:329739","is_oa":false,"landing_page_url":"http://edoc.mpg.de/329739","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, v.1 (2007)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-42","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-42","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-42","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.75,"display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2138672920.pdf","grobid_xml":"https://content.openalex.org/works/W2138672920.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W139884376","https://openalex.org/W1578261346","https://openalex.org/W1852134768","https://openalex.org/W1964843324","https://openalex.org/W1966638085","https://openalex.org/W1966992945","https://openalex.org/W2014119909","https://openalex.org/W2018073151","https://openalex.org/W2020011621","https://openalex.org/W2030305001","https://openalex.org/W2040545589","https://openalex.org/W2064483836","https://openalex.org/W2068079504","https://openalex.org/W2090628795","https://openalex.org/W2105627149","https://openalex.org/W2127366503","https://openalex.org/W2130394726","https://openalex.org/W2140013686","https://openalex.org/W2147303597","https://openalex.org/W2159209020","https://openalex.org/W2168920221","https://openalex.org/W4232767240","https://openalex.org/W4239300697"],"related_works":["https://openalex.org/W2216617737","https://openalex.org/W2913500940","https://openalex.org/W2123159138","https://openalex.org/W1652028037","https://openalex.org/W2006276480","https://openalex.org/W2145658523","https://openalex.org/W1585151690","https://openalex.org/W2033434138","https://openalex.org/W2022604348","https://openalex.org/W2146695490"],"abstract_inverted_index":{"BACKGROUND:":[0],"Global":[1],"control":[2,19,40],"influences":[3],"the":[4,18,25,36,39,48,69,75,78,86,96,99,103,137,161,165,168,187,191],"regulation":[5],"of":[6,20,35,38,41,50,77,85,105,107,113,134,146,167,190],"many":[7],"individual":[8,42],"subsystems":[9],"by":[10,24,115,178],"superimposed":[11],"regulator":[12],"proteins.":[13],"A":[14,32],"prominent":[15],"example":[16],"is":[17,61,139,176,181],"carbohydrate":[21],"uptake":[22],"systems":[23],"transcription":[26],"factor":[27],"Crp":[28],"in":[29,53],"Escherichia":[30],"coli.":[31],"detailed":[33],"understanding":[34],"coordination":[37],"transporters":[43],"offers":[44],"possibilities":[45],"to":[46,74,141,185],"explore":[47],"potential":[49],"microorganisms":[51],"e.g.":[52],"biotechnology.":[54],"RESULTS:":[55],"An":[56],"o.d.e.":[57],"based":[58],"mathematical":[59],"model":[60,94,138],"presented":[62,156],"that":[63,120,175],"maps":[64],"a":[65,83,111,116,131,143,158,182],"physiological":[66],"parameter":[67],"-":[68,73],"specific":[70],"growth":[71,100,162],"rate":[72,101,163],"sensor":[76,169,180],"signal":[79],"transduction":[80],"unit,":[81],"here":[82],"component":[84],"bacterial":[87],"phosphotransferase":[88],"system":[89,170],"(PTS),":[90],"namely":[91],"EIIACrr.":[92],"The":[93,153,172],"describes":[95],"relation":[97],"between":[98,122,160],"and":[102,126,149,164],"degree":[104],"phosphorylation":[106],"EIIA":[108],"crr":[109],"for":[110],"number":[112,133],"carbohydrates":[114,125],"distinctive":[117],"response":[118],"curve,":[119],"differentiates":[121],"PTS":[123],"transported":[124],"non-PTS":[127],"carbohydrates.":[128],"With":[129],"only":[130],"small":[132],"kinetic":[135],"parameters,":[136],"able":[140],"describe":[142],"broad":[144],"range":[145],"experimental":[147],"steady-state":[148,154],"dynamical":[150],"conditions.":[151],"CONCLUSION:":[152],"characteristic":[155],"shows":[157],"relationship":[159],"output":[166],"PTS.":[171],"glycolytic":[173],"flux":[174],"measured":[177],"this":[179],"good":[183],"indicator":[184],"represent":[186],"nutritional":[188],"status":[189],"cell.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":10}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}