{"id":"https://openalex.org/W2163642716","doi":"https://doi.org/10.1186/1752-0509-1-40","title":"Epstein-Barr virus latency switch in human B-cells: a physico-chemical model","display_name":"Epstein-Barr virus latency switch in human B-cells: a physico-chemical model","publication_year":2007,"publication_date":"2007-08-31","ids":{"openalex":"https://openalex.org/W2163642716","doi":"https://doi.org/10.1186/1752-0509-1-40","mag":"2163642716","pmid":"https://pubmed.ncbi.nlm.nih.gov/17764547"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-40","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061076198","display_name":"Maria Fernanda de Paula Werner","orcid":"https://orcid.org/0000-0001-5979-8676"},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Maria Werner","raw_affiliation_strings":["Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91 Stockholm, Sweden. mariawer@kth.se","Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91 Stockholm, Sweden. mariawer@kth.se","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016","https://openalex.org/I4210135511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032129206","display_name":"Ingemar Ernberg","orcid":"https://orcid.org/0000-0001-6518-1648"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingemar Ernberg","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110305371","display_name":"Jie\u2010Zhi Zou","orcid":null},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"JieZhi Zou","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077279030","display_name":"Jenny Almqvist","orcid":null},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jenny Almqvist","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE-171 77, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047019776","display_name":"Erik Aurell","orcid":"https://orcid.org/0000-0003-4906-3603"},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Erik Aurell","raw_affiliation_strings":["Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biological Physics, School of Computer Science and Communication, Royal Institute of Technology, AlbaNova University Center, SE-106 91, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016","https://openalex.org/I4210135511"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5061076198"],"corresponding_institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"],"apc_list":null,"apc_paid":null,"fwci":0.904,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75274228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"40","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/latency","display_name":"Latency (audio)","score":0.7341444492340088},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6789937019348145},{"id":"https://openalex.org/keywords/virus-latency","display_name":"Virus latency","score":0.6234270334243774},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5376722812652588},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.5318811535835266},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4571703374385834},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"Transcriptional activity","score":0.45015284419059753},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4386943280696869},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.43708518147468567},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.43571770191192627},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.38157325983047485},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.37055009603500366},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.35947132110595703},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.28043484687805176},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.2785114049911499},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22255375981330872}],"concepts":[{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.7341444492340088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6789937019348145},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.6234270334243774},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5376722812652588},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5318811535835266},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4571703374385834},{"id":"https://openalex.org/C2992339755","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transcriptional activity","level":4,"score":0.45015284419059753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4386943280696869},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.43708518147468567},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43571770191192627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38157325983047485},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37055009603500366},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.35947132110595703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28043484687805176},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2785114049911499},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22255375981330872},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050813","descriptor_name":"Octamer Transcription Factor-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-1-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17764547","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17764547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:b7d3ce666d51446e8d23992297ad8585","is_oa":false,"landing_page_url":"https://doaj.org/article/b7d3ce666d51446e8d23992297ad8585","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 40 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2164963","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2164963","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-40","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-40","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-40","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313607","display_name":"Swedish Cancer Foundation","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2163642716.pdf","grobid_xml":"https://content.openalex.org/works/W2163642716.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W117387909","https://openalex.org/W194945112","https://openalex.org/W1487461106","https://openalex.org/W1547334779","https://openalex.org/W1558813989","https://openalex.org/W1573217573","https://openalex.org/W1578954095","https://openalex.org/W1582214457","https://openalex.org/W1593308984","https://openalex.org/W1594478849","https://openalex.org/W1597905259","https://openalex.org/W1758582089","https://openalex.org/W1763440968","https://openalex.org/W1816090311","https://openalex.org/W1850316869","https://openalex.org/W1874041651","https://openalex.org/W1930835920","https://openalex.org/W1957748504","https://openalex.org/W1964632614","https://openalex.org/W1979342595","https://openalex.org/W2002495914","https://openalex.org/W2004553600","https://openalex.org/W2007717461","https://openalex.org/W2011212343","https://openalex.org/W2014667800","https://openalex.org/W2022891974","https://openalex.org/W2026723036","https://openalex.org/W2042583382","https://openalex.org/W2044672159","https://openalex.org/W2048737737","https://openalex.org/W2051385715","https://openalex.org/W2054807376","https://openalex.org/W2063388904","https://openalex.org/W2070531819","https://openalex.org/W2072327741","https://openalex.org/W2075084453","https://openalex.org/W2079816176","https://openalex.org/W2096403595","https://openalex.org/W2096483869","https://openalex.org/W2096591944","https://openalex.org/W2108116883","https://openalex.org/W2111386157","https://openalex.org/W2112962319","https://openalex.org/W2127536294","https://openalex.org/W2143118331","https://openalex.org/W2143346689","https://openalex.org/W2146935052","https://openalex.org/W2151473316","https://openalex.org/W2156682639","https://openalex.org/W2159040707","https://openalex.org/W4237960799","https://openalex.org/W4251411553"],"related_works":["https://openalex.org/W1889931991","https://openalex.org/W2766251888","https://openalex.org/W2768853365","https://openalex.org/W2888184647","https://openalex.org/W2558343753","https://openalex.org/W1968241666","https://openalex.org/W1997376202","https://openalex.org/W3098663942","https://openalex.org/W2028748599","https://openalex.org/W2152129968"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,75,157,166],"Epstein-Barr":[2,239],"virus":[3,27,240],"is":[4,11,81,86,169,267],"widespread":[5],"in":[6,78,131,161,192,226,242,290],"all":[7],"human":[8,15,51,90,330],"populations":[9],"and":[10,55,72,91,96,113,133,138,154,163,197,253,260,265,283,286,297],"strongly":[12],"associated":[13],"with":[14,173,204,228,245],"disease,":[16],"ranging":[17],"from":[18,179],"infectious":[19],"mononucleosis":[20],"to":[21,103,151,188,269,310],"cancer.":[22],"In":[23],"infected":[24],"cells":[25],"the":[26,35,106,110,120,142,185,193,215,238,276,312,322,325],"can":[28,210,250,305],"adopt":[29],"several":[30],"different":[31,68,195],"latency":[32,48,62,122,148],"programs,":[33,49,149,196],"affecting":[34,214],"cells'":[36],"behaviour.":[37],"Experimental":[38],"results":[39,127,319],"indicate":[40],"that":[41,82,234,258],"a":[42,67,100,152,174,287],"specific":[43],"genetic":[44,84,278],"switch":[45,85],"between":[46,53,119,136,208],"viral":[47,69,92,181],"reprograms":[50],"B-cells":[52],"proliferative":[54],"resting":[56,137,153],"states.":[57],"Each":[58],"of":[59,66,109,218,237,263,314,324,329],"these":[60,301],"two":[61,121,146,158,194],"programs":[63,159,209],"makes":[64],"use":[65],"promoter,":[70],"Cp":[71,264],"Qp,":[73],"respectively.":[74],"hypothesis":[76],"tested":[77],"this":[79,83,315],"study":[80],"controlled":[87],"by":[88,213],"both":[89,281],"transcription":[93,220,331],"factors;":[94],"Oct-2":[95,134,261],"EBNA-1.":[97],"We":[98,183,232,256],"build":[99],"physico-chemical":[101],"model":[102,143],"investigate":[104],"quantitatively":[105],"dynamical":[107],"properties":[108,236],"promoter":[111,186,200,298],"regulation":[112,262,328],"experimentally":[114],"examine":[115],"protein":[116,216],"level":[117],"variations":[118],"programs.":[123,140],"RESULTS:":[124],"Our":[125,318],"experimental":[126,205,229],"display":[128],"significant":[129],"differences":[130],"EBNA-1":[132,259],"levels":[135,217],"proliferating":[139,155,167],"With":[141],"we":[144,303],"identify":[145],"stable":[147],"corresponding":[150],"cell.":[156],"differ":[160],"robustness":[162],"transcriptional":[164,177],"activity.":[165],"state":[168],"markedly":[170],"more":[171],"stable,":[172],"very":[175],"high":[176],"activity":[178],"its":[180],"promoter.":[182],"predict":[184,280],"activities":[187,201],"be":[189,211,251,306],"mutually":[190,271],"exclusive":[191,272],"our":[198,219],"relative":[199],"correlate":[202],"well":[203],"data.":[206],"Transitions":[207],"induced,":[212],"factors.":[221],"Simulated":[222],"time":[223],"scales":[224],"are":[225],"line":[227],"results.":[230],"CONCLUSION:":[231],"show":[233],"fundamental":[235],"involvement":[241],"latent":[243],"infection,":[244],"implications":[246],"for":[247],"tumor":[248],"biology,":[249],"modelled":[252,277],"understood":[254],"mathematically.":[255],"conclude":[257],"Qp":[266],"sufficient":[268],"establish":[270],"expression":[273],"patterns.":[274],"Moreover,":[275],"control":[279],"mono-":[282],"bistable":[284],"behavior":[285],"considerable":[288],"difference":[289],"transition":[291],"dynamics,":[292],"based":[293],"on":[294],"program":[295],"stability":[296],"activities.":[299],"Both":[300],"phenomena":[302],"hope":[304],"further":[307],"investigated":[308],"experimentally,":[309],"increase":[311],"understanding":[313],"important":[316],"switch.":[317],"also":[320],"stress":[321],"importance":[323],"little":[326],"known":[327],"factor":[332],"Oct-2.":[333]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}