{"id":"https://openalex.org/W1788683850","doi":"https://doi.org/10.1186/1752-0509-1-4","title":"Qualitative networks: a symbolic approach to analyze biological signaling networks","display_name":"Qualitative networks: a symbolic approach to analyze biological signaling networks","publication_year":2007,"publication_date":"2007-01-08","ids":{"openalex":"https://openalex.org/W1788683850","doi":"https://doi.org/10.1186/1752-0509-1-4","mag":"1788683850","pmid":"https://pubmed.ncbi.nlm.nih.gov/17408511"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078601813","display_name":"Marc A. Schaub","orcid":null},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Marc A Schaub","raw_affiliation_strings":["School of Computer and Communication Sciences EPFL, 1015 Lausanne, Switzerland. marc.schaub@a3.epfl.ch","School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, 1015 Lausanne, Switzerland. marc.schaub@a3.epfl.ch","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080555605","display_name":"Thomas A. Henzinger","orcid":"https://orcid.org/0000-0002-2985-7724"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas A Henzinger","raw_affiliation_strings":["School of Computer and Communication Sciences EPFL, 1015, Lausanne, Switzerland","School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, 1015, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066189305","display_name":"Jasmin Fisher","orcid":"https://orcid.org/0000-0003-4477-9047"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jasmin Fisher","raw_affiliation_strings":["School of Computer and Communication Sciences EPFL, 1015, Lausanne, Switzerland","School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, 1015, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"School of Computer and Communication Sciences EPFL, Lausanne, Switzerland#TAB#","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078601813"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":2.9597,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.91115192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.12520000338554382,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6944307684898376},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6918795108795166},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.6020990610122681},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.5980031490325928},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5641899108886719},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5512607097625732},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.5056955814361572},{"id":"https://openalex.org/keywords/model-checking","display_name":"Model checking","score":0.5027151107788086},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.479207843542099},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.42967474460601807},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.41771215200424194},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.31617194414138794},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30077266693115234},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.28956490755081177},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.20299673080444336},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16443142294883728},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15498849749565125},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.12427258491516113}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6944307684898376},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6918795108795166},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.6020990610122681},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.5980031490325928},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5641899108886719},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5512607097625732},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.5056955814361572},{"id":"https://openalex.org/C110251889","wikidata":"https://www.wikidata.org/wiki/Q1569697","display_name":"Model checking","level":2,"score":0.5027151107788086},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.479207843542099},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.42967474460601807},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41771215200424194},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.31617194414138794},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30077266693115234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28956490755081177},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.20299673080444336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16443142294883728},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15498849749565125},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.12427258491516113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/1752-0509-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17408511","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17408511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.622.2683","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.622.2683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://pub.ist.ac.at/~tah/Publications/qualitative_networks.pdf","raw_type":"text"},{"id":"pmh:oai:europepmc.org:1191420","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1839894","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4474538940","display_name":"Formal Modeling of Cell Fate Decisions","funder_award_id":"111840","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1788683850.pdf","grobid_xml":"https://content.openalex.org/works/W1788683850.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1488659932","https://openalex.org/W1518865745","https://openalex.org/W1532361198","https://openalex.org/W1535220465","https://openalex.org/W1791710463","https://openalex.org/W1902852561","https://openalex.org/W1971224531","https://openalex.org/W1978486653","https://openalex.org/W1990139847","https://openalex.org/W1995004385","https://openalex.org/W2002526701","https://openalex.org/W2005486846","https://openalex.org/W2026824634","https://openalex.org/W2046538693","https://openalex.org/W2053961182","https://openalex.org/W2061438988","https://openalex.org/W2080267935","https://openalex.org/W2085021251","https://openalex.org/W2085682228","https://openalex.org/W2095701698","https://openalex.org/W2097920274","https://openalex.org/W2098739408","https://openalex.org/W2104855667","https://openalex.org/W2105161851","https://openalex.org/W2108723074","https://openalex.org/W2109110326","https://openalex.org/W2109380828","https://openalex.org/W2110012716","https://openalex.org/W2110119905","https://openalex.org/W2113251992","https://openalex.org/W2114518254","https://openalex.org/W2116509046","https://openalex.org/W2118039525","https://openalex.org/W2118109822","https://openalex.org/W2121149194","https://openalex.org/W2123976282","https://openalex.org/W2125281005","https://openalex.org/W2127574686","https://openalex.org/W2131463591","https://openalex.org/W2133693398","https://openalex.org/W2140347764","https://openalex.org/W2153624566","https://openalex.org/W2155507705","https://openalex.org/W2158395308","https://openalex.org/W2160314966","https://openalex.org/W2160533336","https://openalex.org/W2162884852","https://openalex.org/W2165061154","https://openalex.org/W2294236252","https://openalex.org/W2340735175","https://openalex.org/W2912904668","https://openalex.org/W4240640923"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W1975586684","https://openalex.org/W2063941210","https://openalex.org/W2127864418","https://openalex.org/W4206945140","https://openalex.org/W2606847111","https://openalex.org/W2598362101","https://openalex.org/W2947028852","https://openalex.org/W2212032968"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"central":[2],"goal":[3],"of":[4,31,110,122,134,140,148,154,181,188,199,209,221],"Systems":[5],"Biology":[6],"is":[7,47,57,213],"to":[8,20,42,65,105,127,130,206,234,243],"model":[9,46,61,72,106,153],"and":[10,73,99,137,160,168,191,212],"analyze":[11],"biological":[12,182,223],"signaling":[13,163],"pathways":[14,164],"that":[15,103,184],"interact":[16],"with":[17,49],"one":[18],"another":[19],"form":[21],"complex":[22,210,222],"networks.":[23,33],"Here":[24],"we":[25,37,68],"introduce":[26,174],"Qualitative":[27],"networks,":[28,124],"an":[29,175],"extension":[30],"Boolean":[32,97,189],"With":[34],"this":[35,149,238],"framework,":[36],"use":[38],"formal":[39,193],"verification":[40,194],"methods":[41,195],"check":[43],"whether":[44],"a":[45,70,89,107,114,131,152,215],"consistent":[48],"the":[50,60,66,74,119,146,155,158,161,186,197,200,219,241],"laboratory":[51],"experimental":[52,246],"observations":[53],"on":[54],"which":[55,85],"it":[56],"based.":[58],"If":[59],"does":[62],"not":[63],"conform":[64],"data,":[67],"suggest":[69,231],"revised":[71],"new":[75,232],"hypotheses":[76,226],"are":[77],"tested":[78],"in-silico.":[79],"RESULTS:":[80],"We":[81,112,144,173],"consider":[82],"networks":[83,190],"in":[84,165,248],"elements":[86,136],"range":[87],"over":[88],"small":[90],"finite":[91],"domain":[92],"allowing":[93,125],"more":[94],"flexibility":[95],"than":[96],"values,":[98],"add":[100],"target":[101],"functions":[102],"allow":[104],"rich":[108],"set":[109],"behaviors.":[111],"propose":[113],"symbolic":[115],"algorithm":[116],"for":[117,177,196,218],"analyzing":[118],"steady":[120],"state":[121,138],"these":[123],"us":[126],"scale":[128,205],"up":[129],"system":[132],"consisting":[133],"144":[135],"spaces":[139],"approximately":[141],"10(86)":[142],"states.":[143],"illustrate":[145],"usefulness":[147],"approach":[150,176,203,239],"through":[151],"interaction":[156],"between":[157],"Notch":[159],"Wnt":[162],"mammalian":[166],"skin,":[167],"its":[169],"extensive":[170],"analysis.":[171],"CONCLUSION:":[172],"constructing":[178],"computational":[179],"models":[180,208],"systems":[183],"extends":[185],"framework":[187],"uses":[192],"analysis":[198,220],"model.":[201],"This":[202],"can":[204],"multicellular":[207],"pathways,":[211],"therefore":[214],"useful":[216],"tool":[217],"systems.":[224],"The":[225],"formulated":[227],"during":[228],"in-silico":[229],"testing":[230],"avenues":[233],"explore":[235],"experimentally.":[236],"Hence,":[237],"has":[240],"potential":[242],"efficiently":[244],"complement":[245],"studies":[247],"biology.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}