{"id":"https://openalex.org/W2096691821","doi":"https://doi.org/10.1186/1752-0509-1-34","title":"A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network","display_name":"A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network","publication_year":2007,"publication_date":"2007-07-31","ids":{"openalex":"https://openalex.org/W2096691821","doi":"https://doi.org/10.1186/1752-0509-1-34","mag":"2096691821","pmid":"https://pubmed.ncbi.nlm.nih.gov/17672894"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-34","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Gregory D Amoutzias","orcid":null},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gregory D Amoutzias","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK. grigoris.amoutzias@psb.ugent.be","Faculty of Life Sciences, University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK. grigoris.amoutzias@psb.ugent.be","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029393168","display_name":"Elgar E Pichler","orcid":null},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Elgar E Pichler","raw_affiliation_strings":["Discovery Information, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA, 02451, USA","Discovery Information, AstraZeneca R&D Boston, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Information, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA, 02451, USA","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Discovery Information, AstraZeneca R&D Boston, Waltham, USA","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091483259","display_name":"Nina Mian","orcid":null},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nina Mian","raw_affiliation_strings":["AstraZeneca R&D, Alderley Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D, Alderley Park, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105937161","display_name":"David de Graaf","orcid":null},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"David De Graaf","raw_affiliation_strings":["Discovery Information, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA, 02451, USA","Pfizer RTC Cambridge, Cambridge, MA, USA","Discovery Information, AstraZeneca R&D Boston, Waltham, USA","Pfizer RTC Cambridge, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Information, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA, 02451, USA","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Pfizer RTC Cambridge, Cambridge, MA, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Discovery Information, AstraZeneca R&D Boston, Waltham, USA","institution_ids":["https://openalex.org/I105036370"]},{"raw_affiliation_string":"Pfizer RTC Cambridge, Cambridge, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037556975","display_name":"Anastasia Imsiridou","orcid":null},"institutions":[{"id":"https://openalex.org/I77990126","display_name":"Alexander Technological Educational Institute of Thessaloniki","ror":"https://ror.org/04h36ea57","country_code":"GR","type":"education","lineage":["https://openalex.org/I77990126"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Imsiridou","raw_affiliation_strings":["Higher Technological Educational Institute of Thessaloniki, 63200 Nea Moudania, Halkidiki, Greece","Higher Technological Educational Institute of Thessaloniki, Halkidiki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higher Technological Educational Institute of Thessaloniki, 63200 Nea Moudania, Halkidiki, Greece","institution_ids":["https://openalex.org/I77990126"]},{"raw_affiliation_string":"Higher Technological Educational Institute of Thessaloniki, Halkidiki, Greece","institution_ids":["https://openalex.org/I77990126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054250703","display_name":"Marc Robinson\u2010Rechavi","orcid":"https://orcid.org/0000-0002-3437-3329"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marc Robinson-Rechavi","raw_affiliation_strings":["Department of Ecology and Evolution, University of Lausanne & Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland","Department of Ecology and Evolution, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Lausanne & Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Department of Ecology and Evolution, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072841736","display_name":"Erich Bornberg\u2010Bauer","orcid":"https://orcid.org/0000-0002-1826-3576"},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210096541","display_name":"Institute for Biodiversity","ror":"https://ror.org/01n8ggb71","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210096541"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Erich Bornberg-Bauer","raw_affiliation_strings":["Bioinformatics Division, Institute for Evolution and Biodiversity, School of Biological Sciences, University of Muenster, Schlossplatz 4, D48149, Muenster, Germany","Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","Faculty of Life Sciences, University of Manchester, Manchester, UK","Bioinformatics Division, Institute for Evolution and Biodiversity, School of Biological Sciences, University of Muenster, Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Division, Institute for Evolution and Biodiversity, School of Biological Sciences, University of Muenster, Schlossplatz 4, D48149, Muenster, Germany","institution_ids":["https://openalex.org/I4210096541"]},{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Bioinformatics Division, Institute for Evolution and Biodiversity, School of Biological Sciences, University of Muenster, Muenster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082064376","display_name":"David L. Robertson","orcid":"https://orcid.org/0000-0001-6338-0221"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David L Robertson","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","[Faculty of Life Sciences, University of Manchester, Manchester, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"[Faculty of Life Sciences, University of Manchester, Manchester, UK]","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075883279","display_name":"Stephen G. Oliver","orcid":"https://orcid.org/0000-0003-3410-6439"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen G Oliver","raw_affiliation_strings":["Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","[Faculty of Life Sciences, University of Manchester, Manchester, UK]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"[Faculty of Life Sciences, University of Manchester, Manchester, UK]","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":1.7489,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.84012913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"1","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4641999900341034,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.4641999900341034,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6717429757118225},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5896139144897461},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5516173839569092},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.5386012196540833},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.510714054107666},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4949416518211365},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48487338423728943},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.4825286567211151},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4766836166381836},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.41491276025772095},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.41034919023513794},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3523186445236206},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2800803482532501},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.25404930114746094},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.19487199187278748}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6717429757118225},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5896139144897461},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5516173839569092},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.5386012196540833},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.510714054107666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4949416518211365},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48487338423728943},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4825286567211151},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4766836166381836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41491276025772095},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41034919023513794},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3523186445236206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2800803482532501},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25404930114746094},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.19487199187278748},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1752-0509-1-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17672894","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17672894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ccce1b9f-be64-470a-8379-dfca3d411ca2","is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ccce1b9f-be64-470a-8379-dfca3d411ca2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amoutzias, G D, Pichler, E E, Mian, N, De Graaf, D, Imsiridou, A, Robinson-Rechavi, M, Bornberg-Bauer, E, Robertson, D L & Oliver, S G 2007, 'A protein interaction atlas for the nuclear receptors: Properties and quality of a hub-based dimerisation network', BMC Systems Biology, vol. 1, 34. https://doi.org/10.1186/1752-0509-1-34","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:eprints.gla.ac.uk:152166","is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/view/author/39082.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:iris.unil.ch:iris/188829","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/188829","pdf_url":"https://iris.unil.ch/bitstreams/30cad1f4-317b-4173-aae5-df6acf55cdb2/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:archive.ugent.be:744049","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-744049","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1752-0509","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:1971058","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1971058","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:serval.unil.ch:BIB_8C6B61D79078","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_8C6B61D79078","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, vol. 1, pp. 34","raw_type":"info:eu-repo/semantics/submittedVersion"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-34","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-34","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-34","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.5099999904632568},{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.5099999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096691821.pdf","grobid_xml":"https://content.openalex.org/works/W2096691821.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W64392749","https://openalex.org/W71393100","https://openalex.org/W180493639","https://openalex.org/W582702544","https://openalex.org/W1505090413","https://openalex.org/W1523820703","https://openalex.org/W1758188602","https://openalex.org/W1919133853","https://openalex.org/W1927826942","https://openalex.org/W1969839676","https://openalex.org/W1972375217","https://openalex.org/W1972589661","https://openalex.org/W1980182582","https://openalex.org/W1983057459","https://openalex.org/W1983202741","https://openalex.org/W1988904501","https://openalex.org/W1994803330","https://openalex.org/W1995754186","https://openalex.org/W2020952430","https://openalex.org/W2029725115","https://openalex.org/W2038012561","https://openalex.org/W2047405437","https://openalex.org/W2050175422","https://openalex.org/W2060460012","https://openalex.org/W2062244421","https://openalex.org/W2065304353","https://openalex.org/W2065769502","https://openalex.org/W2066718232","https://openalex.org/W2070428103","https://openalex.org/W2070672503","https://openalex.org/W2070974284","https://openalex.org/W2076180893","https://openalex.org/W2081536949","https://openalex.org/W2084080562","https://openalex.org/W2097418721","https://openalex.org/W2101181377","https://openalex.org/W2104315543","https://openalex.org/W2106607972","https://openalex.org/W2110699703","https://openalex.org/W2112090702","https://openalex.org/W2114934263","https://openalex.org/W2115188607","https://openalex.org/W2128701949","https://openalex.org/W2128937741","https://openalex.org/W2130494035","https://openalex.org/W2130790725","https://openalex.org/W2131059659","https://openalex.org/W2132741387","https://openalex.org/W2132933799","https://openalex.org/W2134923278","https://openalex.org/W2138365237","https://openalex.org/W2139823369","https://openalex.org/W2142343504","https://openalex.org/W2143399071","https://openalex.org/W2144983282","https://openalex.org/W2150910849","https://openalex.org/W2153392210","https://openalex.org/W2156070536","https://openalex.org/W2156281856","https://openalex.org/W2156454518","https://openalex.org/W2156809636","https://openalex.org/W2158188555","https://openalex.org/W2159719851","https://openalex.org/W2163480486","https://openalex.org/W2167075350","https://openalex.org/W2167869241","https://openalex.org/W2171623083","https://openalex.org/W2172184136","https://openalex.org/W2743254891","https://openalex.org/W3103071483","https://openalex.org/W4240661460","https://openalex.org/W4240915622","https://openalex.org/W4247420482","https://openalex.org/W4252312048"],"related_works":["https://openalex.org/W2086397253","https://openalex.org/W2133122801","https://openalex.org/W600422426","https://openalex.org/W2007156430","https://openalex.org/W2170882281","https://openalex.org/W3081478936","https://openalex.org/W2785612136","https://openalex.org/W1539291615","https://openalex.org/W1988224651","https://openalex.org/W1967925377"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,118],"nuclear":[2,70,98,172],"receptors":[3],"are":[4],"a":[5,58,85,133,143,159,206],"large":[6],"family":[7],"of":[8,26,63,68,97,106,121,130,146,170,180,200,220],"eukaryotic":[9],"transcription":[10,183],"factors":[11,184],"that":[12,89,103,204],"constitute":[13],"major":[14,160],"pharmacological":[15],"targets.":[16],"They":[17],"exert":[18],"their":[19],"combinatorial":[20],"control":[21],"through":[22],"homotypic":[23],"heterodimerisation.":[24],"Elucidation":[25],"this":[27,107],"dimerisation":[28,178],"network":[29,73,108,123,174,179],"is":[30,109,150],"vital":[31],"in":[32,74,185,195],"order":[33,186],"to":[34,56,187],"understand":[35],"the":[36,64,69,94,104,122,125,138,153,165,171,176,181],"complex":[37],"dynamics":[38],"and":[39,49,60,66,80,83,111,124,168,192,218],"potential":[40,91],"cross-talk":[41,92],"involved.":[42],"RESULTS:":[43],"Phylogeny,":[44],"protein-protein":[45],"interactions,":[46],"protein-DNA":[47],"interactions":[48],"gene":[50,196],"expression":[51,128],"data":[52,221],"have":[53],"been":[54],"integrated":[55],"provide":[57,84],"comprehensive":[59,86,207],"up-to-date":[61],"description":[62],"topology":[65,105,120,167],"properties":[67,169,194],"receptor":[71,173],"interaction":[72,87],"humans.":[75],"We":[76,101,162],"discriminate":[77],"between":[78,93],"DNA-binding":[79],"non-DNA-binding":[81],"dimers,":[82],"map,":[88],"identifies":[90],"various":[95,223],"pathways":[96],"receptors.":[99],"CONCLUSION:":[100],"infer":[102],"hub-based,":[110],"much":[112],"more":[113],"connected":[114],"than":[115],"previously":[116],"thought.":[117],"hub-based":[119,177],"wide":[126],"tissue":[127],"pattern":[129],"NRs":[131],"create":[132],"highly":[134],"competitive":[135],"environment":[136],"for":[137],"common":[139],"heterodimerising":[140],"partners.":[141],"Furthermore,":[142],"significant":[144],"number":[145],"negative":[147],"feedback":[148],"loops":[149],"present,":[151],"with":[152,175],"hub":[154],"protein":[155],"SHP":[156],"[NR0B2]":[157],"playing":[158],"role.":[161],"also":[163],"compare":[164],"evolution,":[166],"bHLH":[182],"identify":[188],"both":[189],"unique":[190],"themes":[191],"ubiquitous":[193],"regulation.":[197],"In":[198],"terms":[199],"methodology,":[201],"we":[202],"conclude":[203],"such":[205],"picture":[208],"can":[209],"only":[210],"be":[211],"assembled":[212],"by":[213],"semi-automated":[214],"text-mining,":[215],"manual":[216],"curation":[217],"integration":[219],"from":[222],"sources.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}