{"id":"https://openalex.org/W2059546521","doi":"https://doi.org/10.1186/1752-0509-1-26","title":"Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets","display_name":"Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ 661 and proposing alternative drug targets","publication_year":2007,"publication_date":"2007-06-08","ids":{"openalex":"https://openalex.org/W2059546521","doi":"https://doi.org/10.1186/1752-0509-1-26","mag":"2059546521","pmid":"https://pubmed.ncbi.nlm.nih.gov/17555602"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-26","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-26","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031218218","display_name":"Neema Jamshidi","orcid":"https://orcid.org/0000-0003-3857-9735"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neema Jamshidi","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA. neema@ucsd.edu","Department of Bioengineering, University of California, San Diego La Jolla, CA 92093-0412, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412, USA. neema@ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego La Jolla, CA 92093-0412, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051097609","display_name":"Bernhard \u00d8. Palsson","orcid":"https://orcid.org/0000-0003-2357-6785"},"institutions":[{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernhard \u00d8 Palsson","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA","Department of Bioengineering, University of California, San Diego La Jolla, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093-0412, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego La Jolla, USA","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031218218"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":12.1946,"has_fulltext":true,"cited_by_count":270,"citation_normalized_percentile":{"value":0.9927747,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"26","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7365999817848206,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.7365999817848206,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.12479999661445618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8669870495796204},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.6917896270751953},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.614305853843689},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5207265019416809},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.47405239939689636},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.4358285963535309},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.4274144470691681},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.35901886224746704},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3204415440559387},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2241758406162262},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16706892848014832},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07836395502090454},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.07241272926330566},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0694737434387207}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8669870495796204},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6917896270751953},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.614305853843689},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5207265019416809},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.47405239939689636},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4358285963535309},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4274144470691681},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35901886224746704},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3204415440559387},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2241758406162262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16706892848014832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07836395502090454},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07241272926330566},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0694737434387207}],"mesh":[{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1752-0509-1-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-26","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-26","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17555602","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17555602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:ark:/13030/qt94s8m5r4","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:4105420a087846aaa9b03d5459c60760","is_oa":false,"landing_page_url":"https://doaj.org/article/4105420a087846aaa9b03d5459c60760","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 1, Iss 1, p 26 (2007)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt94s8m5r4","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/94s8m5r4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology, vol 1, iss 1","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1191675","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1925256","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-26","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-26","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-26","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2059546521.pdf","grobid_xml":"https://content.openalex.org/works/W2059546521.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W29254702","https://openalex.org/W1511778745","https://openalex.org/W1543388089","https://openalex.org/W1568975972","https://openalex.org/W1605353467","https://openalex.org/W1804428368","https://openalex.org/W1838348255","https://openalex.org/W1964491374","https://openalex.org/W1965607919","https://openalex.org/W1967679421","https://openalex.org/W1968286256","https://openalex.org/W1968653468","https://openalex.org/W1985090800","https://openalex.org/W1990969593","https://openalex.org/W1996529795","https://openalex.org/W2009940763","https://openalex.org/W2009990638","https://openalex.org/W2010148230","https://openalex.org/W2022012525","https://openalex.org/W2028123491","https://openalex.org/W2038518692","https://openalex.org/W2061657437","https://openalex.org/W2071902637","https://openalex.org/W2089476104","https://openalex.org/W2090710180","https://openalex.org/W2091368301","https://openalex.org/W2096245011","https://openalex.org/W2102961219","https://openalex.org/W2107600018","https://openalex.org/W2112062799","https://openalex.org/W2116738290","https://openalex.org/W2119201072","https://openalex.org/W2128482141","https://openalex.org/W2130652856","https://openalex.org/W2131731929","https://openalex.org/W2133659075","https://openalex.org/W2140354550","https://openalex.org/W2141632349","https://openalex.org/W2146622826","https://openalex.org/W2155075775","https://openalex.org/W2157635835","https://openalex.org/W2158023121","https://openalex.org/W2159482845","https://openalex.org/W2335266012","https://openalex.org/W2969855747","https://openalex.org/W4249292531","https://openalex.org/W4256259619"],"related_works":["https://openalex.org/W4308058527","https://openalex.org/W2972094210","https://openalex.org/W2110949356","https://openalex.org/W2801208719","https://openalex.org/W1538374398","https://openalex.org/W2050407936","https://openalex.org/W2042252940","https://openalex.org/W2411061500","https://openalex.org/W3160640465","https://openalex.org/W2394233015"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mycobacterium":[1,108],"tuberculosis":[2,37,55,109,292],"continues":[3],"to":[4,41,84,87,132,184,189,202,211],"be":[5,62,85],"a":[6,18,99],"major":[7],"pathogen":[8],"in":[9,26,113,144,152,166,186,214,257,260,263,266,284],"the":[10,21,29,39,49,76,104,128,150,153,164,172,233,254,281,285],"third":[11],"world,":[12],"killing":[13],"almost":[14],"2":[15],"million":[16],"people":[17],"year":[19],"by":[20,170,279],"most":[22],"recent":[23],"estimates.":[24],"Even":[25],"industrialized":[27],"countries,":[28],"emergence":[30],"of":[31,36,48,54,103,107,127,155,179,218,248,253,287],"multi-drug":[32],"resistant":[33],"(MDR)":[34],"strains":[35],"hails":[38],"need":[40,83],"develop":[42],"additional":[43],"medications":[44],"for":[45,52,64,232,291],"treatment.":[46],"Many":[47],"drugs":[50],"used":[51,63],"treatment":[53,293],"target":[56],"metabolic":[57,105],"enzymes.":[58],"Genome-scale":[59],"models":[60,82],"can":[61,124],"analysis,":[65],"discovery,":[66],"and":[67,93,120,123,138,160,192,246,259,265],"as":[68,135],"hypothesis":[69],"generating":[70],"tools,":[71],"which":[72],"will":[73],"hopefully":[74],"assist":[75],"rational":[77],"drug":[78,289,300],"development":[79],"process.":[80],"These":[81],"able":[86],"assimilate":[88],"data":[89,158,223],"from":[90,208],"large":[91],"datasets":[92],"analyze":[94],"them.":[95],"RESULTS:":[96],"We":[97,140],"completed":[98],"bottom":[100],"up":[101],"reconstruction":[102],"network":[106,165],"H37Rv.":[110],"This":[111],"functional":[112],"silico":[114,145,261,267],"bacterium,":[115],"iNJ661,":[116],"contains":[117],"661":[118],"genes":[119],"939":[121],"reactions":[122,180],"produce":[125],"many":[126],"complex":[129],"compounds":[130],"characteristic":[131],"tuberculosis,":[133],"such":[134],"mycolic":[136],"acids":[137],"mycocerosates.":[139],"grew":[141],"this":[142],"bacterium":[143],"on":[146],"various":[147],"media,":[148,216],"analyzed":[149,163],"model":[151],"context":[154,286],"multiple":[156],"high-throughput":[157],"sets,":[159,177],"finally":[161],"we":[162,197,294],"an":[167],"'unbiased'":[168],"manner":[169],"calculating":[171],"Hard":[173],"Coupled":[174],"Reaction":[175],"(HCR)":[176],"groups":[178],"that":[181,272],"are":[182,273],"forced":[183],"operate":[185],"unison":[187],"due":[188],"mass":[190],"conservation":[191],"connectivity":[193],"constraints.":[194],"CONCLUSION:":[195],"Although":[196],"observed":[198],"growth":[199],"rates":[200],"comparable":[201],"experimental":[203,222,276],"observations":[204],"(doubling":[205],"times":[206],"ranging":[207],"about":[209,228],"12":[210],"24":[212],"hours)":[213],"different":[215,244],"comparisons":[217],"gene":[219,240],"essentiality":[220],"with":[221],"were":[224,237],"less":[225],"encouraging":[226],"(generally":[227],"55%).":[229],"The":[230],"reasons":[231],"often":[234],"conflicting":[235],"results":[236,268],"multi-fold,":[238],"including":[239],"expression":[241],"variability":[242],"under":[243],"conditions":[245],"lack":[247],"complete":[249],"biological":[250],"knowledge.":[251],"Some":[252],"inconsistencies":[255],"between":[256],"vitro":[258],"or":[262],"vivo":[264],"highlight":[269],"specific":[270],"loci":[271],"worth":[274],"further":[275],"investigations.":[277],"Finally,":[278],"considering":[280],"HCR":[282],"sets":[283],"known":[288],"targets":[290],"proposed":[295],"new":[296],"alternative,":[297],"but":[298],"equivalent":[299],"targets.":[301]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":25}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
