{"id":"https://openalex.org/W1984343213","doi":"https://doi.org/10.1186/1752-0509-1-21","title":"A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells","display_name":"A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells","publication_year":2007,"publication_date":"2007-05-11","ids":{"openalex":"https://openalex.org/W1984343213","doi":"https://doi.org/10.1186/1752-0509-1-21","mag":"1984343213","pmid":"https://pubmed.ncbi.nlm.nih.gov/17498300"},"language":"en","primary_location":{"id":"doi:10.1186/1752-0509-1-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-21","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-21","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100691044","display_name":"Zheng Li","orcid":"https://orcid.org/0000-0002-4987-0205"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Li","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA. lizheng1@gmail.com","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA. lizheng1@gmail.com","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018885786","display_name":"Shireesh Srivastava","orcid":"https://orcid.org/0000-0001-6139-1904"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shireesh Srivastava","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045682980","display_name":"Xuerui Yang","orcid":"https://orcid.org/0000-0002-7731-2147"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuerui Yang","raw_affiliation_strings":["Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007379322","display_name":"Sheenu Mittal","orcid":"https://orcid.org/0000-0002-5246-9666"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheenu Mittal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, USA","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA,","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084780687","display_name":"P.R. Norton","orcid":"https://orcid.org/0000-0001-5039-3920"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Norton","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI 49503, USA and","Van Andel Institute, Grand Rapids, MI, 49503, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI 49503, USA and","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, 49503, USA","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078641175","display_name":"James H. Resau","orcid":null},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Resau","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI 49503, USA and","Van Andel Institute, Grand Rapids, MI, 49503, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI 49503, USA and","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, 49503, USA","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046744833","display_name":"Brian B. Haab","orcid":"https://orcid.org/0000-0002-3471-1535"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Haab","raw_affiliation_strings":["Van Andel Institute, Grand Rapids, MI 49503, USA and","Van Andel Institute, Grand Rapids, MI, 49503, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI 49503, USA and","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"Van Andel Institute, Grand Rapids, MI, 49503, USA","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102757744","display_name":"Christina Chan","orcid":"https://orcid.org/0009-0003-7693-8206"},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christina Chan","raw_affiliation_strings":["Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5102757744"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":2.4215,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88446368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1","issue":"1","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.29440000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.29440000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6967619061470032},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5684574842453003},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5261901021003723},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5164194703102112},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4725377559661865},{"id":"https://openalex.org/keywords/fatty-acid","display_name":"Fatty acid","score":0.4695468544960022},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.45694005489349365},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"Fatty acid metabolism","score":0.4487893283367157},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.41727566719055176},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.413848876953125},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4100439250469208},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3610910177230835},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33339810371398926},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2269664704799652}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6967619061470032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5684574842453003},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5261901021003723},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5164194703102112},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4725377559661865},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4695468544960022},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.45694005489349365},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.4487893283367157},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.41727566719055176},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.413848876953125},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4100439250469208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3610910177230835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33339810371398926},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2269664704799652}],"mesh":[{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080924","descriptor_name":"Aldehyde Dehydrogenase 1 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009245","descriptor_name":"NADH Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018197","descriptor_name":"Hepatoblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050697","descriptor_name":"Retinal Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1752-0509-1-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-21","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-21","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:17498300","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17498300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:1885270","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1885270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1752-0509-1-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1752-0509-1-21","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/1752-0509-1-21","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G3065287108","display_name":"QSB:  Quantitative Systems Approach to Hepatic Metabolism:  To Elucidate the Effect of Tumor Necrosis Factor-alpha","funder_award_id":"0331297","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4516757180","display_name":"QSB: Unraveling Palmitate-induced Apoptosis and Oleate-conferred Cytoprotection by Systems Analysis and RNA Interference","funder_award_id":"0425821","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7514763369","display_name":"QSB:  Quantitative Systems Approach for Understanding Hepatic Metabolism","funder_award_id":"0222747","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320316470","display_name":"Michigan State University Foundation","ror":"https://ror.org/04njz3m02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984343213.pdf","grobid_xml":"https://content.openalex.org/works/W1984343213.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W119892048","https://openalex.org/W192881907","https://openalex.org/W1582044367","https://openalex.org/W1588860282","https://openalex.org/W1967619202","https://openalex.org/W1971305983","https://openalex.org/W1971839518","https://openalex.org/W1976829005","https://openalex.org/W1979721410","https://openalex.org/W1982584622","https://openalex.org/W1996728257","https://openalex.org/W2008614724","https://openalex.org/W2014269154","https://openalex.org/W2015436473","https://openalex.org/W2023316050","https://openalex.org/W2030901818","https://openalex.org/W2033536687","https://openalex.org/W2039495520","https://openalex.org/W2042901969","https://openalex.org/W2051915753","https://openalex.org/W2053292890","https://openalex.org/W2056732254","https://openalex.org/W2061813962","https://openalex.org/W2067057146","https://openalex.org/W2072756792","https://openalex.org/W2078111650","https://openalex.org/W2080387521","https://openalex.org/W2086276885","https://openalex.org/W2086946222","https://openalex.org/W2090982434","https://openalex.org/W2101596844","https://openalex.org/W2109302907","https://openalex.org/W2109324504","https://openalex.org/W2114472618","https://openalex.org/W2118338384","https://openalex.org/W2118912353","https://openalex.org/W2121647436","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2139363724","https://openalex.org/W2139803734","https://openalex.org/W2152311269","https://openalex.org/W2155772701","https://openalex.org/W2156688711","https://openalex.org/W2162051951","https://openalex.org/W2162244331","https://openalex.org/W2172136994","https://openalex.org/W2184757737","https://openalex.org/W2314673390","https://openalex.org/W4246376195","https://openalex.org/W4251102758"],"related_works":["https://openalex.org/W4288069755","https://openalex.org/W1854805732","https://openalex.org/W3180007124","https://openalex.org/W2332273970","https://openalex.org/W4229007988","https://openalex.org/W2183420549","https://openalex.org/W3168346427","https://openalex.org/W2012175027","https://openalex.org/W2081507994","https://openalex.org/W2077582941"],"abstract_inverted_index":{"BACKGROUND:":[0],"Free":[1],"fatty":[2,37,99,127],"acids":[3],"(FFA)":[4],"and":[5,34,44,64,68,94,116,130,162,167,190,215,232],"tumor":[6],"necrosis":[7],"factor":[8],"alpha":[9],"(TNF-alpha)":[10],"have":[11],"been":[12],"implicated":[13],"in":[14,97,138,176,211],"the":[15,55,59,66,76,91,114,120,135,140,152,158,165,172,183,186,191,213,241,256],"pathogenesis":[16],"of":[17,32,61,107,185,240],"many":[18],"obesity-related":[19],"metabolic":[20,67,173,192],"disorders.":[21],"When":[22],"human":[23],"hepatoblastoma":[24],"cells":[25],"(HepG2)":[26],"were":[27,72,134,179,253,258],"exposed":[28],"to":[29,41,53,74,84,89,112,151,156],"different":[30],"types":[31],"FFA":[33,63],"TNF-alpha,":[35,65],"saturated":[36,62,98],"acid":[38,100,128],"was":[39,47,82,110,149],"found":[40],"be":[42],"cytotoxic":[43,141,214],"its":[45],"toxicity":[46,60],"exacerbated":[48],"by":[49,181,255],"TNF-alpha.":[50],"In":[51],"order":[52],"identify":[54,113,157],"processes":[56,115],"associated":[57],"with":[58,194],"gene":[69,144,168,188],"expression":[70,184],"profiles":[71,193],"measured":[73],"characterize":[75],"cellular":[77],"states.":[78],"A":[79,103],"computational":[80],"model":[81],"developed":[83,111],"integrate":[85],"these":[86],"disparate":[87],"data":[88,155],"reveal":[90],"underlying":[92],"pathways":[93,161],"mechanisms":[95,209],"involved":[96,210],"toxicity.":[101,121],"RESULTS:":[102],"hierarchical":[104,205],"framework":[105],"consisting":[106],"three":[108],"stages":[109],"genes":[117,166],"that":[118,126,170,252],"regulate":[119,171],"First,":[122],"discriminant":[123],"analysis":[124,147,257],"identified":[125,175,180,221],"oxidation":[129],"intracellular":[131],"triglyceride":[132],"accumulation":[133],"most":[136],"relevant":[137],"differentiating":[139],"phenotype.":[142],"Second,":[143],"set":[145],"enrichment":[146],"(GSEA)":[148],"applied":[150],"cDNA":[153],"microarray":[154],"transcriptionally":[159],"altered":[160],"processes.":[163],"Finally,":[164],"sets":[169,189],"responses":[174],"step":[177],"1":[178],"integrating":[182],"enriched":[187],"a":[195],"multi-block":[196],"partial":[197],"least":[198],"squares":[199],"(MBPLS)":[200],"regression":[201],"model.":[202],"CONCLUSION:":[203],"The":[204],"approach":[206],"suggested":[207,254],"potential":[208],"mediating":[212],"cytoprotective":[216],"pathways,":[217],"as":[218,220,225,238,246],"well":[219,247],"novel":[222],"targets,":[223],"such":[224],"NADH":[226],"dehydrogenases,":[227],"aldehyde":[228],"dehydrogenases":[229],"1A1":[230],"(ALDH1A1)":[231],"endothelial":[233],"membrane":[234],"protein":[235],"3":[236],"(EMP3)":[237],"modulator":[239],"toxic":[242],"phenotypes.":[243],"These":[244],"predictions,":[245],"as,":[248],"some":[249],"specific":[250],"targets":[251],"experimentally":[259],"validated.":[260]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}