{"id":"https://openalex.org/W2124410988","doi":"https://doi.org/10.1186/1751-0473-2-8","title":"NFU-Enabled FASTA: moving bioinformatics applications onto wide area networks","display_name":"NFU-Enabled FASTA: moving bioinformatics applications onto wide area networks","publication_year":2007,"publication_date":"2007-11-26","ids":{"openalex":"https://openalex.org/W2124410988","doi":"https://doi.org/10.1186/1751-0473-2-8","mag":"2124410988","pmid":"https://pubmed.ncbi.nlm.nih.gov/18039379"},"language":"en","primary_location":{"id":"doi:10.1186/1751-0473-2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1751-0473-2-8","pdf_url":"https://scfbm.biomedcentral.com/counter/pdf/10.1186/1751-0473-2-8","source":{"id":"https://openalex.org/S45786803","display_name":"Source Code for Biology and Medicine","issn_l":"1751-0473","issn":["1751-0473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Source Code for Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://scfbm.biomedcentral.com/counter/pdf/10.1186/1751-0473-2-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052536656","display_name":"Erich J. Baker","orcid":"https://orcid.org/0000-0002-7798-5704"},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erich J Baker","raw_affiliation_strings":["Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","institution_ids":["https://openalex.org/I157394403"]},{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047609717","display_name":"Guan Ning Lin","orcid":"https://orcid.org/0000-0001-9496-0149"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]},{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guan N Lin","raw_affiliation_strings":["Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","Department of Computer Science, University of Missouri, Columbia, MO, USA","Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA","Department of Computer Science, University of Missouri, Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","institution_ids":["https://openalex.org/I157394403"]},{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, MO, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA","institution_ids":["https://openalex.org/I157394403"]},{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101414825","display_name":"Huadong Liu","orcid":"https://orcid.org/0000-0003-2503-1148"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huadong Liu","raw_affiliation_strings":["Department of Computer Science, University of Tennessee, Knoxville, TN, USA","DEPARTMENT OF COMPUTER SCIENCE, UNIVERSITY OF TENNESSEE, KNOXVILLE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Tennessee, Knoxville, TN, USA","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"DEPARTMENT OF COMPUTER SCIENCE, UNIVERSITY OF TENNESSEE, KNOXVILLE, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032143932","display_name":"Ravi Kosuri","orcid":null},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Kosuri","raw_affiliation_strings":["Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, TX, USA","institution_ids":["https://openalex.org/I157394403"]},{"raw_affiliation_string":"Department of Computer Science, School of Engineering and Computer Science, Baylor University, Waco, USA","institution_ids":["https://openalex.org/I157394403"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052536656"],"corresponding_institution_ids":["https://openalex.org/I157394403"],"apc_list":null,"apc_paid":null,"fwci":0.1345,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54513997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.5960000157356262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8151426911354065},{"id":"https://openalex.org/keywords/backplane","display_name":"Backplane","score":0.7590007781982422},{"id":"https://openalex.org/keywords/the-internet","display_name":"The Internet","score":0.6988956928253174},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.6524140238761902},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.5366275906562805},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.52863609790802},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4856494665145874},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.4852695167064667},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.3303825855255127},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.18870970606803894},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.09415781497955322}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8151426911354065},{"id":"https://openalex.org/C134256836","wikidata":"https://www.wikidata.org/wiki/Q545913","display_name":"Backplane","level":2,"score":0.7590007781982422},{"id":"https://openalex.org/C110875604","wikidata":"https://www.wikidata.org/wiki/Q75","display_name":"The Internet","level":2,"score":0.6988956928253174},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.6524140238761902},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.5366275906562805},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.52863609790802},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4856494665145874},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.4852695167064667},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.3303825855255127},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.18870970606803894},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.09415781497955322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1751-0473-2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1751-0473-2-8","pdf_url":"https://scfbm.biomedcentral.com/counter/pdf/10.1186/1751-0473-2-8","source":{"id":"https://openalex.org/S45786803","display_name":"Source Code for Biology and Medicine","issn_l":"1751-0473","issn":["1751-0473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Source Code for Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:18039379","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18039379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Source code for biology and medicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2211279","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2211279","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Source Code Biol Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1751-0473-2-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1751-0473-2-8","pdf_url":"https://scfbm.biomedcentral.com/counter/pdf/10.1186/1751-0473-2-8","source":{"id":"https://openalex.org/S45786803","display_name":"Source Code for Biology and Medicine","issn_l":"1751-0473","issn":["1751-0473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Source Code for Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309840","display_name":"Baylor University","ror":"https://ror.org/005781934"},{"id":"https://openalex.org/F4320315068","display_name":"University of Tennessee, Knoxville","ror":"https://ror.org/020f3ap87"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124410988.pdf","grobid_xml":"https://content.openalex.org/works/W2124410988.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1480272951","https://openalex.org/W1500025646","https://openalex.org/W1558365920","https://openalex.org/W1574829624","https://openalex.org/W1591224570","https://openalex.org/W2011632360","https://openalex.org/W2018793184","https://openalex.org/W2029419194","https://openalex.org/W2042035199","https://openalex.org/W2096773800","https://openalex.org/W2107751776","https://openalex.org/W2126319539","https://openalex.org/W2129216359","https://openalex.org/W2137219595","https://openalex.org/W2150934173","https://openalex.org/W2160065857","https://openalex.org/W2487161826","https://openalex.org/W2635987763","https://openalex.org/W4233053832","https://openalex.org/W4244818997"],"related_works":["https://openalex.org/W3099531851","https://openalex.org/W2142856902","https://openalex.org/W2317728138","https://openalex.org/W2142667731","https://openalex.org/W2387896425","https://openalex.org/W2000372772","https://openalex.org/W1587587577","https://openalex.org/W2048167795","https://openalex.org/W2214328014","https://openalex.org/W2380988690"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advances":[1],"in":[2,111],"Internet":[3,63,143],"technologies":[4,24],"have":[5],"allowed":[6],"life":[7,200],"science":[8],"researchers":[9],"to":[10,17,48,70,136,166,179,184],"reach":[11],"beyond":[12],"the":[13,22,62,85,93,130,157,192,211,216,222],"lab-centric":[14],"research":[15],"paradigm":[16],"create":[18],"distributed":[19,27,181],"collaborations.":[20],"Of":[21],"existing":[23],"that":[25,33,78,126,209],"support":[26,35],"collaborations,":[28],"there":[29],"are":[30,133],"currently":[31],"none":[32],"simultaneously":[34],"data":[36,90,132,153,172,196],"storage":[37,187],"and":[38,88,118,218],"computation":[39,150,163,207,214],"as":[40],"a":[41,67,96,108,177,185,206],"shared":[42,186],"network":[43],"resource,":[44],"enabling":[45],"computational":[46],"burden":[47,212],"be":[49],"wholly":[50],"removed":[51],"from":[52,215],"participating":[53],"clients.":[54],"Software":[55],"using":[56],"computation-enable":[57],"logistical":[58,105,120,137],"networking":[59,121],"components":[60],"of":[61,95,129,190,195,213],"Backplane":[64,144],"Protocol":[65,145],"provides":[66,176,205],"suitable":[68],"means":[69,178],"accomplish":[71],"these":[72],"tasks.":[73],"Here,":[74],"we":[75],"demonstrate":[76],"software":[77],"enables":[79],"this":[80,174],"approach":[81,175],"by":[82],"distributing":[83],"both":[84],"FASTA":[86,112,148],"algorithm":[87,113,149],"appropriate":[89],"sets":[91,154],"within":[92,156,221],"framework":[94,208],"wide":[97],"area":[98],"network.":[99,159,223],"RESULTS:":[100],"For":[101],"large":[102,152,171,193],"datasets,":[103],"computation-enabled":[104],"networks":[106],"provide":[107],"significant":[109],"reduction":[110],"running":[114],"time":[115],"over":[116,151,169],"local":[117],"non-distributed":[119],"frameworks.":[122],"We":[123],"also":[124],"find":[125],"genome-scale":[127],"sizes":[128],"stored":[131,155],"easily":[134],"adaptable":[135],"networks.":[138],"CONCLUSION:":[139],"Network":[140],"function":[141],"unit-enabled":[142],"effectively":[146],"distributes":[147],"scaleable":[158],"In":[160,202],"situations":[161],"where":[162],"is":[164],"subject":[165],"parallel":[167],"solution":[168],"very":[170],"sets,":[173],"allow":[180],"collaborators":[182],"access":[183],"resource":[188],"capable":[189],"storing":[191],"volumes":[194],"equated":[197],"with":[198],"modern":[199],"science.":[201],"addition,":[203],"it":[204,220],"removes":[210],"client":[217],"places":[219]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}