{"id":"https://openalex.org/W2100488300","doi":"https://doi.org/10.1186/1687-4153-2011-5","title":"Measuring and analyzing tissue specificity of human genes and protein complexes","display_name":"Measuring and analyzing tissue specificity of human genes and protein complexes","publication_year":2011,"publication_date":"2011-08-04","ids":{"openalex":"https://openalex.org/W2100488300","doi":"https://doi.org/10.1186/1687-4153-2011-5","mag":"2100488300","pmid":"https://pubmed.ncbi.nlm.nih.gov/21970702"},"language":"en","primary_location":{"id":"doi:10.1186/1687-4153-2011-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1687-4153-2011-5","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/1687-4153-2011-5","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/1687-4153-2011-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060331837","display_name":"Dorothea Emig","orcid":null},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dorothea Emig","raw_affiliation_strings":["Max Planck Institute for Informatics, Campus E1,4, 66123 Saarbr\u00fccken, Germany. dorothea.emig@mpi-inf.mpg.de","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Campus E1,4, 66123 Saarbr\u00fccken, Germany. dorothea.emig@mpi-inf.mpg.de","institution_ids":[]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072736528","display_name":"Tim Kacprowski","orcid":"https://orcid.org/0000-0002-5393-2413"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Kacprowski","raw_affiliation_strings":["Max Planck Institute for Informatics, Campus E1.4, 66123, Saarbr\u00fccken, Germany","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Campus E1.4, 66123, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108484144","display_name":"Mario Albrecht","orcid":null},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mario Albrecht","raw_affiliation_strings":["Max Planck Institute for Informatics, Campus E1.4, 66123, Saarbr\u00fccken, Germany","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Informatics, Campus E1.4, 66123, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060331837"],"corresponding_institution_ids":["https://openalex.org/I149899117"],"apc_list":null,"apc_paid":null,"fwci":0.8004,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71743681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2011","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.7117540240287781},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6781544089317322},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6033488512039185},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5832951664924622},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5565831661224365},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4787032902240753},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4263323247432709},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39545196294784546},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34427356719970703}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.7117540240287781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6781544089317322},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6033488512039185},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5832951664924622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5565831661224365},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4787032902240753},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4263323247432709},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39545196294784546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34427356719970703}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1186/1687-4153-2011-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1687-4153-2011-5","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/1687-4153-2011-5","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},{"id":"pmid:21970702","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21970702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP journal on bioinformatics & systems biology","raw_type":null},{"id":"pmh:oai:edoc.mpg.de:536625","is_oa":false,"landing_page_url":"http://edoc.mpg.de/536625","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nykter, Matti; Ruusuvuori, Pekka; Carlberg, Carsten; Yli-Harja, Olli: Seventh International Workshop on Computational Systems\\nBiology, WCSB 2010, Tampere International Center for Signal Processing, 27-30 (2010)","raw_type":"Conference-Paper"},{"id":"pmh:oai:edoc.mpg.de:618817","is_oa":true,"landing_page_url":"http://edoc.mpg.de/618817","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology, v.2011, 5,1-5,6 (2011)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2191540","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3186740","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_1323759","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-1592-C","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TICSP series","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:pure.mpg.de:item_1562536","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0010-1354-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1687-4153-2011-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1687-4153-2011-5","pdf_url":"https://bsb-eurasipjournals.springeropen.com/track/pdf/10.1186/1687-4153-2011-5","source":{"id":"https://openalex.org/S22696228","display_name":"EURASIP Journal on Bioinformatics and Systems Biology","issn_l":"1687-4145","issn":["1687-4145","1687-4153"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EURASIP Journal on Bioinformatics and Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8054614244","display_name":null,"funder_award_id":"KFO 129","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2100488300.pdf","grobid_xml":"https://content.openalex.org/works/W2100488300.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2001125421","https://openalex.org/W2034578963","https://openalex.org/W2098979213","https://openalex.org/W2117949279","https://openalex.org/W2130479394","https://openalex.org/W2148043260","https://openalex.org/W2148911704","https://openalex.org/W2153091158","https://openalex.org/W2155804510","https://openalex.org/W2158948118","https://openalex.org/W2164683872","https://openalex.org/W4210430020","https://openalex.org/W4233437719"],"related_works":["https://openalex.org/W2041540252","https://openalex.org/W2796636403","https://openalex.org/W170658859","https://openalex.org/W2041374557","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W2490137852","https://openalex.org/W2388669904","https://openalex.org/W1995366224"],"abstract_inverted_index":{"Proteins":[0],"and":[1,28,35,52,67],"their":[2,15],"interactions":[3,51],"are":[4,80,96],"essential":[5],"for":[6,20,83],"the":[7,46,62,72],"survival":[8],"of":[9,14,48,64],"each":[10],"human":[11],"cell.":[12],"Knowledge":[13],"tissue":[16],"occurrence":[17],"is":[18],"important":[19],"understanding":[21],"biological":[22,108],"processes.":[23],"Therefore,":[24],"we":[25],"analyzed":[26],"microarray":[27,94],"high-throughput":[29,88,119],"RNA-sequencing":[30],"data":[31,41,95],"to":[32,44,115],"identify":[33],"tissue-specific":[34,65],"universally":[36],"expressed":[37,85,101],"genes.":[38,102],"Gene":[39],"expression":[40],"were":[42],"used":[43],"investigate":[45],"presence":[47],"proteins,":[49],"protein":[50,53],"complexes":[54],"in":[55],"different":[56],"tissues.":[57],"Our":[58],"comparison":[59],"shows":[60],"that":[61,78,106],"detection":[63],"genes":[66,86],"proteins":[68],"strongly":[69],"depends":[70],"on":[71,93,111],"applied":[73],"measurement":[74],"technique.":[75],"We":[76],"found":[77],"microarrays":[79,112],"less":[81],"sensitive":[82],"low":[84],"than":[87],"sequencing.":[89],"Functional":[90],"analyses":[91],"based":[92,110],"thus":[97],"biased":[98],"towards":[99],"high":[100],"This":[103],"also":[104],"means":[105],"previous":[107],"findings":[109],"might":[113],"have":[114],"be":[116],"re-examined":[117],"using":[118],"sequencing":[120],"results.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
