{"id":"https://openalex.org/W1982578831","doi":"https://doi.org/10.1186/1472-6947-12-117","title":"Evaluating genomic tests from bench to bedside: a practical framework","display_name":"Evaluating genomic tests from bench to bedside: a practical framework","publication_year":2012,"publication_date":"2012-10-19","ids":{"openalex":"https://openalex.org/W1982578831","doi":"https://doi.org/10.1186/1472-6947-12-117","mag":"1982578831","pmid":"https://pubmed.ncbi.nlm.nih.gov/23078403"},"language":"en","primary_location":{"id":"doi:10.1186/1472-6947-12-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6947-12-117","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/1472-6947-12-117","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/1472-6947-12-117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004444208","display_name":"Jennifer S Lin","orcid":"https://orcid.org/0000-0001-9169-7410"},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer S Lin","raw_affiliation_strings":["Center for Health Research, Kaiser Permanente Northwest, 3800 N, Interstate Ave, Portland , OR 97227, USA. Jennifer.S.Lin@kpchr.org","Center for Health Research - Kaiser Permanente Northwest, Portland, USA"],"affiliations":[{"raw_affiliation_string":"Center for Health Research, Kaiser Permanente Northwest, 3800 N, Interstate Ave, Portland , OR 97227, USA. Jennifer.S.Lin@kpchr.org","institution_ids":["https://openalex.org/I4210114677"]},{"raw_affiliation_string":"Center for Health Research - Kaiser Permanente Northwest, Portland, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107841407","display_name":"Matthew Thompson","orcid":null},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Matthew Thompson","raw_affiliation_strings":["Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","Department of Primary Care Health Sciences, University of Oxford, Oxford, OX1 2ET, UK","Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","Center for Health Research, Kaiser Permanente Northwest, Portland, USA"],"affiliations":[{"raw_affiliation_string":"Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","institution_ids":["https://openalex.org/I4210114677"]},{"raw_affiliation_string":"Department of Primary Care Health Sciences, University of Oxford, Oxford, OX1 2ET, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Center for Health Research, Kaiser Permanente Northwest, Portland, USA","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069385226","display_name":"Katrina A.B. Goddard","orcid":"https://orcid.org/0000-0001-9535-8993"},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]},{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina AB Goddard","raw_affiliation_strings":["Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","Center for Health Research - Kaiser Permanente Northwest, Portland, USA"],"affiliations":[{"raw_affiliation_string":"Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","institution_ids":["https://openalex.org/I4210114677"]},{"raw_affiliation_string":"Center for Health Research - Kaiser Permanente Northwest, Portland, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011008405","display_name":"Margaret Piper","orcid":"https://orcid.org/0000-0002-6231-9653"},"institutions":[{"id":"https://openalex.org/I2801415451","display_name":"Blue Cross Blue Shield Association","ror":"https://ror.org/02jcrd051","country_code":"US","type":"other","lineage":["https://openalex.org/I2801415451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A Piper","raw_affiliation_strings":["Blue Cross and Blue Shield Association Technology Evaluation Center, Chicago, IL, 60601, USA","Blue Cross and Blue Shield Association Technology Evaluation Center, Chicago, USA"],"affiliations":[{"raw_affiliation_string":"Blue Cross and Blue Shield Association Technology Evaluation Center, Chicago, IL, 60601, USA","institution_ids":["https://openalex.org/I2801415451"]},{"raw_affiliation_string":"Blue Cross and Blue Shield Association Technology Evaluation Center, Chicago, USA","institution_ids":["https://openalex.org/I2801415451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027878704","display_name":"Carl Heneghan","orcid":"https://orcid.org/0000-0002-1009-1992"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carl Heneghan","raw_affiliation_strings":["Department of Primary Care Health Sciences, University of Oxford, Oxford, OX1 2ET, UK","Department of Primary Care Health Sciences University of Oxford  Oxford UK"],"affiliations":[{"raw_affiliation_string":"Department of Primary Care Health Sciences, University of Oxford, Oxford, OX1 2ET, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Primary Care Health Sciences University of Oxford  Oxford UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082093687","display_name":"Evelyn P Whitlock","orcid":"https://orcid.org/0000-0003-3581-0743"},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn P Whitlock","raw_affiliation_strings":["Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","Center for Health Research - Kaiser Permanente Northwest, Portland, USA"],"affiliations":[{"raw_affiliation_string":"Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, 97227, OR, USA","institution_ids":["https://openalex.org/I4210114677"]},{"raw_affiliation_string":"Center for Health Research - Kaiser Permanente Northwest, Portland, USA","institution_ids":["https://openalex.org/I1343052199"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5004444208"],"corresponding_institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.6212,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.72109242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"117","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.5660389065742493},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.5356571078300476},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5354132056236267},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5228031873703003},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5138790607452393},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.4965072274208069},{"id":"https://openalex.org/keywords/hierarchy","display_name":"Hierarchy","score":0.48298871517181396},{"id":"https://openalex.org/keywords/stakeholder","display_name":"Stakeholder","score":0.45442014932632446},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41830772161483765},{"id":"https://openalex.org/keywords/test-strategy","display_name":"Test strategy","score":0.4100014567375183},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.3332361578941345},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.32702532410621643},{"id":"https://openalex.org/keywords/knowledge-management","display_name":"Knowledge management","score":0.3236207365989685},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2839210033416748},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13850566744804382},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09471970796585083}],"concepts":[{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.5660389065742493},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.5356571078300476},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5354132056236267},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5228031873703003},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5138790607452393},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.4965072274208069},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.48298871517181396},{"id":"https://openalex.org/C201305675","wikidata":"https://www.wikidata.org/wiki/Q852998","display_name":"Stakeholder","level":2,"score":0.45442014932632446},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41830772161483765},{"id":"https://openalex.org/C188598960","wikidata":"https://www.wikidata.org/wiki/Q7705805","display_name":"Test strategy","level":3,"score":0.4100014567375183},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3332361578941345},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.32702532410621643},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.3236207365989685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2839210033416748},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13850566744804382},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09471970796585083},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C39549134","wikidata":"https://www.wikidata.org/wiki/Q133080","display_name":"Public relations","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1472-6947-12-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6947-12-117","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/1472-6947-12-117","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:23078403","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23078403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:130ec4a68ce745b8b69647d258e7629f","is_oa":true,"landing_page_url":"https://doaj.org/article/130ec4a68ce745b8b69647d258e7629f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 12, Iss 1, p 117 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2544049","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3538070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:725733ee-152f-4ace-b1b8-b69fa2ab9227","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:725733ee-152f-4ace-b1b8-b69fa2ab9227","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1186/1472-6947-12-117","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6947-12-117","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/1472-6947-12-117","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982578831.pdf","grobid_xml":"https://content.openalex.org/works/W1982578831.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1825912167","https://openalex.org/W1971348077","https://openalex.org/W1972537482","https://openalex.org/W1979629145","https://openalex.org/W1984477277","https://openalex.org/W1996271555","https://openalex.org/W2012946235","https://openalex.org/W2019689469","https://openalex.org/W2025846586","https://openalex.org/W2032466066","https://openalex.org/W2042825711","https://openalex.org/W2046980386","https://openalex.org/W2050117484","https://openalex.org/W2050552569","https://openalex.org/W2052716780","https://openalex.org/W2062137132","https://openalex.org/W2062787238","https://openalex.org/W2072964603","https://openalex.org/W2083726396","https://openalex.org/W2099356722","https://openalex.org/W2100374926","https://openalex.org/W2103848163","https://openalex.org/W2106708634","https://openalex.org/W2140485884","https://openalex.org/W2140657380","https://openalex.org/W2140879413","https://openalex.org/W2142073070","https://openalex.org/W2151726995","https://openalex.org/W2152615936","https://openalex.org/W2165592168","https://openalex.org/W2188312187","https://openalex.org/W2394539365","https://openalex.org/W2624083618","https://openalex.org/W2746339049","https://openalex.org/W2915602243","https://openalex.org/W3209934666","https://openalex.org/W4292496387"],"related_works":["https://openalex.org/W4206785888","https://openalex.org/W1843462531","https://openalex.org/W2901037869","https://openalex.org/W91919785","https://openalex.org/W2595132782","https://openalex.org/W2945471511","https://openalex.org/W256841256","https://openalex.org/W4248817909","https://openalex.org/W4367048510","https://openalex.org/W2171601412"],"abstract_inverted_index":{"The":[0],"development":[1,154],"of":[2,7,66,97,109,155,183,193,198,214],"genomic":[3,67,114,143,156],"tests":[4,21,157],"is":[5,91,147],"one":[6],"the":[8,27,35,105,153,169,180,190,194],"most":[9],"significant":[10],"technological":[11],"advances":[12],"in":[13,16,41,104,129,142,152,178],"medical":[14,130],"testing":[15,131],"recent":[17],"decades.":[18],"As":[19],"these":[20],"become":[22],"increasingly":[23],"available,":[24],"so":[25],"does":[26],"need":[28,174],"for":[29,63,80,113],"a":[30,53,58,94,110,184,212],"pragmatic":[31],"framework":[32,54,74,90,117,146,187],"to":[33,43,75,126,175,221],"evaluate":[34],"evidence":[36,39],"base":[37],"and":[38,61,86,100,107,122,134,162,167,207],"gaps":[40,172],"order":[42],"facilitate":[44],"informed":[45],"decision-making.":[46],"In":[47],"this":[48,73],"article":[49],"we":[50],"describe":[51],"such":[52],"that":[55,173,217],"can":[56,71,101],"provide":[57],"common":[59],"language":[60],"benchmarks":[62],"different":[64],"stakeholders":[65],"testing.":[68,115,144],"Each":[69],"stakeholder":[70],"use":[72],"specify":[76],"their":[77,84],"respective":[78],"thresholds":[79],"decision-making,":[81],"depending":[82],"on":[83,189],"perspective":[85],"particular":[87],"needs.":[88],"This":[89,145],"applicable":[92],"across":[93],"broad":[95],"range":[96],"test":[98,199],"applications":[99],"be":[102,176,219],"helpful":[103],"application":[106],"communication":[108],"regulatory":[111],"science":[112],"Our":[116,186],"builds":[118],"upon":[119],"existing":[120],"work":[121],"incorporates":[123],"principles":[124],"familiar":[125],"researchers":[127],"involved":[128,141],"(both":[132],"diagnostic":[133],"prognostic)":[135],"generally,":[136],"as":[137,139],"well":[138],"those":[140],"organized":[148],"around":[149],"six":[150],"phases":[151],"beginning":[158],"with":[159,164],"marker":[160],"identification":[161],"ending":[163],"population":[165],"impact,":[166],"highlights":[168],"important":[170],"knowledge":[171],"filled":[177],"establishing":[179],"clinical":[181,191],"relevance":[182],"test.":[185],"focuses":[188],"appropriateness":[192],"four":[195],"main":[196],"dimensions":[197],"research":[200],"questions":[201],"(population/setting,":[202],"intervention/index":[203],"test,":[204,206],"comparators/reference":[205],"outcomes)":[208],"rather":[209],"than":[210],"prescribing":[211],"hierarchy":[213],"study":[215],"designs":[216],"should":[218],"used":[220],"address":[222],"each":[223],"phase.":[224]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}