{"id":"https://openalex.org/W2002758187","doi":"https://doi.org/10.1186/1471-2342-9-12","title":"Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults","display_name":"Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults","publication_year":2009,"publication_date":"2009-07-06","ids":{"openalex":"https://openalex.org/W2002758187","doi":"https://doi.org/10.1186/1471-2342-9-12","mag":"2002758187","pmid":"https://pubmed.ncbi.nlm.nih.gov/19580676"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2342-9-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-9-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/track/pdf/10.1186/1471-2342-9-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/track/pdf/10.1186/1471-2342-9-12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036615199","display_name":"Tiffany W. Chow","orcid":"https://orcid.org/0000-0003-1936-8000"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802437833","display_name":"Baycrest Hospital","ror":"https://ror.org/03gp5b411","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802437833"]},{"id":"https://openalex.org/I4405262013","display_name":"Baycrest Centre for Geriatric Care","ror":"https://ror.org/00vd0rf02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802437833","https://openalex.org/I4405262013"]},{"id":"https://openalex.org/I4405263474","display_name":"Rotman Research Institute","ror":"https://ror.org/01kvpec59","country_code":"CA","type":"education","lineage":["https://openalex.org/I4405258058","https://openalex.org/I4405263474"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tiffany W Chow","raw_affiliation_strings":["The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada. tchow@rotman-baycrest.on.ca","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada. tchow@rotman-baycrest.on.ca","institution_ids":["https://openalex.org/I2802437833","https://openalex.org/I4405262013","https://openalex.org/I4405263474"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087173411","display_name":"David C. Mamo","orcid":null},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David C Mamo","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021932877","display_name":"Hiroyuki Uchida","orcid":"https://orcid.org/0000-0002-0628-7036"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hiroyuki Uchida","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044840695","display_name":"Ariel Graff\u2010Guerrero","orcid":"https://orcid.org/0000-0001-9301-2171"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ariel Graff-Guerrero","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057013440","display_name":"Sylvain Houle","orcid":"https://orcid.org/0000-0002-4231-6316"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sylvain Houle","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007203242","display_name":"Gwenn S. Smith","orcid":"https://orcid.org/0000-0003-0706-5440"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802437833","display_name":"Baycrest Hospital","ror":"https://ror.org/03gp5b411","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802437833"]},{"id":"https://openalex.org/I4405262013","display_name":"Baycrest Centre for Geriatric Care","ror":"https://ror.org/00vd0rf02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802437833","https://openalex.org/I4405262013"]},{"id":"https://openalex.org/I4405263474","display_name":"Rotman Research Institute","ror":"https://ror.org/01kvpec59","country_code":"CA","type":"education","lineage":["https://openalex.org/I4405258058","https://openalex.org/I4405263474"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gwenn S Smith","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2802437833","https://openalex.org/I4405262013","https://openalex.org/I4405263474"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000921316","display_name":"Bruce G. Pollock","orcid":"https://orcid.org/0000-0003-0802-3998"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bruce G Pollock","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019562259","display_name":"Benoit H. Mulsant","orcid":"https://orcid.org/0000-0002-0303-6450"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit H Mulsant","raw_affiliation_strings":["Centre for Addiction and Mental Health, Toronto, ON, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, Canada","Centre for Addiction and Mental Health","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Centre for Addiction and Mental Health","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087173411"],"corresponding_institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I185261750"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.5835,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.59570023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5871999859809875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5871999859809875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraclass-correlation","display_name":"Intraclass correlation","score":0.6708637475967407},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.6196058988571167},{"id":"https://openalex.org/keywords/binding-potential","display_name":"Binding potential","score":0.5948038697242737},{"id":"https://openalex.org/keywords/5-ht-receptor","display_name":"5-HT receptor","score":0.4994192123413086},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4993934631347656},{"id":"https://openalex.org/keywords/serotonin","display_name":"Serotonin","score":0.4924103021621704},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4839073121547699},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.4366443157196045},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4001893103122711},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.33635979890823364},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2520948350429535},{"id":"https://openalex.org/keywords/clinical-psychology","display_name":"Clinical psychology","score":0.17060187458992004},{"id":"https://openalex.org/keywords/psychometrics","display_name":"Psychometrics","score":0.14451876282691956}],"concepts":[{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.6708637475967407},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6196058988571167},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.5948038697242737},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.4994192123413086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4993934631347656},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4924103021621704},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4839073121547699},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4366443157196045},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4001893103122711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33635979890823364},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2520948350429535},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.17060187458992004},{"id":"https://openalex.org/C171606756","wikidata":"https://www.wikidata.org/wiki/Q506132","display_name":"Psychometrics","level":2,"score":0.14451876282691956},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2342-9-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-9-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/track/pdf/10.1186/1471-2342-9-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:19580676","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19580676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/84176","is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/84176","pdf_url":"https://utoronto.scholaris.ca/bitstreams/9ac21855-4197-49ca-b9ca-eee76969faed/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2722606","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2722606","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"},{"id":"pmh:oai:www.um.edu.mt:123456789/23579","is_oa":true,"landing_page_url":"https://www.um.edu.mt/library/oar//handle/123456789/23579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400782","display_name":"OAR@UM (University of Malta)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I197854408","host_organization_name":"University of Malta","host_organization_lineage":["https://openalex.org/I197854408"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4c9496dee0d54c16a28826f4eb779b54","is_oa":false,"landing_page_url":"https://doaj.org/article/4c9496dee0d54c16a28826f4eb779b54","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 9, Iss 1, p 12 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2342-9-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-9-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/track/pdf/10.1186/1471-2342-9-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2848516984","display_name":null,"funder_award_id":"MH 01621","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8832794615","display_name":"Monoamiergic Function in Geriatric Psychiatry","funder_award_id":"7k02mh001621-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G942577508","display_name":null,"funder_award_id":"F32 AG022802","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310321","display_name":"Ontario Innovation Trust","ror":"https://ror.org/03vaedy56"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002758187.pdf","grobid_xml":"https://content.openalex.org/works/W2002758187.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W5652266","https://openalex.org/W1513749687","https://openalex.org/W1787663985","https://openalex.org/W1934926274","https://openalex.org/W1977638423","https://openalex.org/W1982946614","https://openalex.org/W1984754451","https://openalex.org/W1988668967","https://openalex.org/W1999617042","https://openalex.org/W2001310902","https://openalex.org/W2006412233","https://openalex.org/W2010166974","https://openalex.org/W2023488340","https://openalex.org/W2034770460","https://openalex.org/W2035249996","https://openalex.org/W2047359051","https://openalex.org/W2053126345","https://openalex.org/W2053343116","https://openalex.org/W2054765812","https://openalex.org/W2054831953","https://openalex.org/W2066698241","https://openalex.org/W2068475798","https://openalex.org/W2073061978","https://openalex.org/W2074210823","https://openalex.org/W2085459598","https://openalex.org/W2088474260","https://openalex.org/W2088494755","https://openalex.org/W2095489655","https://openalex.org/W2110198065","https://openalex.org/W2111464173","https://openalex.org/W2121887890","https://openalex.org/W2127005038","https://openalex.org/W2134560546","https://openalex.org/W2137741077","https://openalex.org/W2154747831","https://openalex.org/W2159733079","https://openalex.org/W2163432791","https://openalex.org/W2170904543","https://openalex.org/W2219800195","https://openalex.org/W2307936244","https://openalex.org/W3001275908","https://openalex.org/W4246108751","https://openalex.org/W4300628483"],"related_works":["https://openalex.org/W2058091174","https://openalex.org/W3099606857","https://openalex.org/W1828383458","https://openalex.org/W4206347286","https://openalex.org/W2156790153","https://openalex.org/W2419529664","https://openalex.org/W4290155861","https://openalex.org/W2037492675","https://openalex.org/W2016684134","https://openalex.org/W1976805986"],"abstract_inverted_index":{"BACKGROUND:":[0],"Position":[1],"emission":[2],"tomography":[3],"(PET)":[4],"imaging":[5],"using":[6],"[18F]-setoperone":[7,52,82,137,147],"to":[8,16,46,144],"quantify":[9],"cortical":[10,112],"5-HT2A":[11],"receptors":[12],"has":[13],"the":[14,48,97,104,108,120,133],"potential":[15,99],"inform":[17],"pharmacological":[18],"treatments":[19],"for":[20,60],"geriatric":[21],"depression":[22],"and":[23,110,117,148],"dementia.":[24],"Prior":[25],"reports":[26],"indicate":[27],"a":[28,55],"significant":[29],"normal":[30],"aging":[31],"effect":[32],"on":[33,85,103],"serotonin":[34],"5HT2A":[35],"receptor":[36],"(5HT2AR)":[37],"binding":[38,98],"potential.":[39],"The":[40,93],"purpose":[41],"of":[42,51,136,146],"this":[43],"study":[44],"was":[45],"assess":[47],"test-retest":[49,134],"variability":[50,135],"PET":[53,83,138],"with":[54,119],"high":[56],"resolution":[57],"scanner":[58],"(HRRT)":[59],"measuring":[61],"5HT2AR":[62,150],"availability":[63],"in":[64,96,107,125,139,152],"subjects":[65,74,141],"greater":[66],"than":[67],"60":[68],"years":[69],"old.":[70],"METHODS:":[71],"Six":[72],"healthy":[73],"(age":[75],"range":[76],"=":[77],"65-78":[78],"years)":[79],"completed":[80],"two":[81,86,105],"scans":[84],"separate":[87],"occasions":[88,106],"5-16":[89],"weeks":[90],"apart.":[91],"RESULTS:":[92],"average":[94],"difference":[95],"(BPND)":[100],"as":[101],"measured":[102],"frontal":[109],"temporal":[111],"regions":[113],"ranged":[114],"between":[115],"2":[116],"12%,":[118],"lowest":[121],"intraclass":[122],"correlation":[123],"coefficient":[124],"anterior":[126],"cingulate":[127],"regions.":[128],"CONCLUSION:":[129],"We":[130],"conclude":[131],"that":[132,145],"elderly":[140],"is":[142],"comparable":[143],"other":[149],"radiotracers":[151],"younger":[153],"subject":[154],"samples.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2025-10-10T00:00:00"}
