{"id":"https://openalex.org/W2036932064","doi":"https://doi.org/10.1186/1471-2342-11-12","title":"Patient Discomfort Associated with the Use of Intra-arterial Iodinated Contrast Media: A Meta-Analysis of Comparative Randomized Controlled Trials","display_name":"Patient Discomfort Associated with the Use of Intra-arterial Iodinated Contrast Media: A Meta-Analysis of Comparative Randomized Controlled Trials","publication_year":2011,"publication_date":"2011-05-24","ids":{"openalex":"https://openalex.org/W2036932064","doi":"https://doi.org/10.1186/1471-2342-11-12","mag":"2036932064","pmid":"https://pubmed.ncbi.nlm.nih.gov/21609484"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2342-11-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-11-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/1471-2342-11-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/1471-2342-11-12","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008382551","display_name":"Peter A. McCullough","orcid":"https://orcid.org/0000-0002-0997-6355"},"institutions":[{"id":"https://openalex.org/I1320343167","display_name":"Ascension","ror":"https://ror.org/00s1szh94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320343167"]},{"id":"https://openalex.org/I4210119340","display_name":"Providence Park Hospital","ror":"https://ror.org/01sdn5x73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320343167","https://openalex.org/I4210119340"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A McCullough","raw_affiliation_strings":["St, John Providence Health System, Department of Medicine, Cardiology Section, Providence Park Heart Institute, Novi, MI, USA. peteramccullough@gmail.com","St. John Providence Health System, Department of Medicine, Cardiology Section, Providence Park Heart Institute, Novi, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St, John Providence Health System, Department of Medicine, Cardiology Section, Providence Park Heart Institute, Novi, MI, USA. peteramccullough@gmail.com","institution_ids":["https://openalex.org/I4210119340"]},{"raw_affiliation_string":"St. John Providence Health System, Department of Medicine, Cardiology Section, Providence Park Heart Institute, Novi, USA","institution_ids":["https://openalex.org/I1320343167"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026828012","display_name":"Patrizio Capasso","orcid":null},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrizio Capasso","raw_affiliation_strings":["Department of Radiology, Division of Vascular & Interventional Radiology University of Kentucky, Lexington, KY, USA","Department of Radiology, Division of Vascular & Interventional Radiology University of Kentucky, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Division of Vascular & Interventional Radiology University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Radiology, Division of Vascular & Interventional Radiology University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008382551"],"corresponding_institution_ids":["https://openalex.org/I1320343167","https://openalex.org/I4210119340"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.4109,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.54347826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7942000031471252,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7942000031471252,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.9085641503334045},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.6946925520896912},{"id":"https://openalex.org/keywords/iodixanol","display_name":"Iodixanol","score":0.6587436199188232},{"id":"https://openalex.org/keywords/confidence-interval","display_name":"Confidence interval","score":0.5917407274246216},{"id":"https://openalex.org/keywords/jadad-scale","display_name":"Jadad scale","score":0.5642422437667847},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.535440981388092},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.5328426957130432},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.4699837267398834},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4460954964160919},{"id":"https://openalex.org/keywords/cochrane-library","display_name":"Cochrane Library","score":0.09608665108680725},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.09174451231956482}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9085641503334045},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6946925520896912},{"id":"https://openalex.org/C2780929046","wikidata":"https://www.wikidata.org/wiki/Q2419291","display_name":"Iodixanol","level":3,"score":0.6587436199188232},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5917407274246216},{"id":"https://openalex.org/C136524200","wikidata":"https://www.wikidata.org/wiki/Q3136977","display_name":"Jadad scale","level":4,"score":0.5642422437667847},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.535440981388092},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5328426957130432},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4699837267398834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4460954964160919},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.09608665108680725},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09174451231956482},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2779786684","wikidata":"https://www.wikidata.org/wiki/Q906156","display_name":"Contrast medium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007455","descriptor_name":"Iodine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014283","descriptor_name":"Triiodobenzoic Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017678","descriptor_name":"Sex Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2342-11-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-11-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/1471-2342-11-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:21609484","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21609484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3125247","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3125247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"},{"id":"pmh:oai:uknowledge.uky.edu:radiology_facpub-1000","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/radiology_facpub/1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Radiology Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a677f179939c4db8b225191de2a6bdb6","is_oa":true,"landing_page_url":"https://doaj.org/article/a677f179939c4db8b225191de2a6bdb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 11, Iss 1, p 12 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2342-11-12","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2342-11-12","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/1471-2342-11-12","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2036932064.pdf","grobid_xml":"https://content.openalex.org/works/W2036932064.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W16041468","https://openalex.org/W188543915","https://openalex.org/W1709724220","https://openalex.org/W1964435302","https://openalex.org/W1965436499","https://openalex.org/W1973461665","https://openalex.org/W1976422116","https://openalex.org/W1979173416","https://openalex.org/W1981430237","https://openalex.org/W1986215651","https://openalex.org/W1995774294","https://openalex.org/W2007934136","https://openalex.org/W2029084431","https://openalex.org/W2034776067","https://openalex.org/W2052813073","https://openalex.org/W2056296058","https://openalex.org/W2056803053","https://openalex.org/W2059561235","https://openalex.org/W2068898056","https://openalex.org/W2069846414","https://openalex.org/W2071742939","https://openalex.org/W2073129446","https://openalex.org/W2073272769","https://openalex.org/W2079344598","https://openalex.org/W2087549573","https://openalex.org/W2099077139","https://openalex.org/W2107328434","https://openalex.org/W2131404826","https://openalex.org/W2133706053","https://openalex.org/W2138308794","https://openalex.org/W2147615829","https://openalex.org/W2154597714","https://openalex.org/W2156313803","https://openalex.org/W2157823046","https://openalex.org/W2172082065","https://openalex.org/W2314670561","https://openalex.org/W2400755664","https://openalex.org/W2467786129","https://openalex.org/W2500509522","https://openalex.org/W2802044024","https://openalex.org/W2887768525","https://openalex.org/W2890681387","https://openalex.org/W3209376675","https://openalex.org/W4239459065","https://openalex.org/W4248635938","https://openalex.org/W4323053618"],"related_works":["https://openalex.org/W2025725179","https://openalex.org/W2005853657","https://openalex.org/W2019846923","https://openalex.org/W2076126922","https://openalex.org/W2029084431","https://openalex.org/W4239459065","https://openalex.org/W2409626964","https://openalex.org/W1995774294","https://openalex.org/W4248635938","https://openalex.org/W2063571950"],"abstract_inverted_index":{"BACKGROUND:":[0],"Discomfort":[1],"characterized":[2],"by":[3],"pain":[4,216],"and":[5,38,70,95,140,165,226,265,267,291],"warmth":[6,233,282],"are":[7],"common":[8],"adverse":[9],"effects":[10],"associated":[11,44,105,287],"with":[12,45,55,106,122,188,219,223,242,271,281,288],"the":[13,41,65,107,110,213,230,261],"use":[14,108],"of":[15,23,64,103,109,135,145,156,193,204,207,215,232,236,245,274,308],"intra-arterial":[16,133,296],"iodinated":[17],"contrast":[18,47,58],"media":[19,48,59],"(CM).":[20],"The":[21,276],"objective":[22],"this":[24],"review":[25,63],"was":[26,98,158,182,217,258,286],"to":[27,39,52,100],"pool":[28],"patient-reported":[29],"outcomes":[30],"available":[31,72],"from":[32],"head-to-head":[33,118],"randomized":[34],"controlled":[35],"trials":[36,121],"(RCTs)":[37],"compare":[40,101],"discomfort":[42,104,130,154,262,294],"rates":[43,102],"iso-osmolar":[46],"(IOCM;":[49],"i.e.,":[50],"iodixanol)":[51],"those":[53],"reported":[54,128],"various":[56,114,166],"low-osmolar":[57],"(LOCM).":[60],"METHODS:":[61],"A":[62,143,209,254],"literature":[66],"published":[67],"between":[68,161,260],"1990":[69],"2009":[71],"through":[73],"Medline,":[74],"Medline":[75],"Preprints,":[76],"Embase,":[77],"Biological":[78],"Abstracts,":[79,82,85],"BioBase,":[80],"Cab":[81],"International":[83],"Pharmaceutical":[84],"Life":[86],"Sciences":[87],"Collection,":[88],"Inside":[89],"Conferences,":[90],"Energy":[91],"Database,":[92],"Engineering":[93],"Index":[94],"Technology":[96],"Collection":[97],"performed":[99],"IOCM":[111,164,181,220,239,285],"(iodixanol)":[112],"vs.":[113],"LOCM":[115],"agents":[116],"in":[117,212,302],"RCTs.":[119],"All":[120],"a":[123,189,268,305],"Jadad":[124],"score":[125],"\u22652":[126],"that":[127],"patient":[129,293],"data":[131,299],"following":[132],"administration":[134],"CM":[136,309],"were":[137,151,279],"reviewed,":[138],"coded,":[139],"extracted.":[141],"RESULTS:":[142],"total":[144],"22":[146],"RCTs":[147],"(n":[148],"=":[149,179,252],"8087)":[150],"included.":[152],"Overall":[153],"(regardless":[155],"severity)":[157],"significantly":[159],"different":[160],"patients":[162],"receiving":[163],"LOCMs":[167,186,241],"(risk":[168],"difference":[169],"[RD]":[170],"-0.049;":[171],"95%":[172],"confidence":[173],"interval":[174],"[CI]:":[175],"-0.076,":[176],"-0.021;":[177],"p":[178,199,251],"0.001).":[180],"favored":[183,238],"over":[184,240],"all":[185],"combined":[187],"summary":[190],"RD":[191,244],"value":[192],"-0.188":[194],"(95%":[195,247],"CI:":[196,248],"-0.265,":[197],"-0.112;":[198],"<":[200],"0.001)":[201],"for":[202],"incidence":[203],"pain,":[205],"regardless":[206,235],"severity.":[208],"greater":[210],"reduction":[211],"magnitude":[214],"observed":[218,259,280],"(iodixanol),":[221],"particularly":[222],"selective":[224],"limb":[225],"carotid/intracerebral":[227],"procedures.":[228],"Similarly,":[229],"meta-analysis":[231],"sensation,":[234],"severity,":[237],"an":[243],"-0.043":[246],"-0.074,":[249],"-0.011;":[250],"0.008).":[253],"positive":[255],"linear":[256],"relationship":[257,270],"effect":[263],"size":[264],"age":[266],"negative":[269],"increasing":[272],"proportion":[273],"women.":[275],"opposite":[277],"trends":[278],"sensation.":[283],"CONCLUSIONS:":[284],"less":[289],"frequent":[290],"severe":[292],"during":[295],"administration.":[297],"These":[298],"support":[300],"differences":[301],"osmolality":[303],"as":[304],"possible":[306],"determinant":[307],"discomfort.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}