{"id":"https://openalex.org/W1763179423","doi":"https://doi.org/10.1186/1471-2164-16-s2-s14","title":"Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosispyrazinamidase enzyme and pyrazinamide susceptibility","display_name":"Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosispyrazinamidase enzyme and pyrazinamide susceptibility","publication_year":2015,"publication_date":"2015-01-21","ids":{"openalex":"https://openalex.org/W1763179423","doi":"https://doi.org/10.1186/1471-2164-16-s2-s14","mag":"1763179423","pmid":"https://pubmed.ncbi.nlm.nih.gov/25708048"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-16-s2-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-16-s2-s14","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-16-S2-S14","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-16-S2-S14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048138862","display_name":"Chakshu Vats","orcid":null},"institutions":[{"id":"https://openalex.org/I863896202","display_name":"Delhi Technological University","ror":"https://ror.org/01ztcvt22","country_code":"IN","type":"education","lineage":["https://openalex.org/I863896202"]},{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chakshu Vats","raw_affiliation_strings":["Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","Department of Biotechnology; Delhi Technological University; New Delhi India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","institution_ids":["https://openalex.org/I863896202","https://openalex.org/I3141573830"]},{"raw_affiliation_string":"Department of Biotechnology; Delhi Technological University; New Delhi India","institution_ids":["https://openalex.org/I863896202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051429490","display_name":"Jaspreet Kaur Dhanjal","orcid":"https://orcid.org/0000-0003-4226-3063"},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jaspreet Kaur Dhanjal","raw_affiliation_strings":["School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, 110067","School of Biotechnology, Jawaharlal Nehru University, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, 110067","institution_ids":["https://openalex.org/I152429107"]},{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101901828","display_name":"Sukriti Goyal","orcid":"https://orcid.org/0000-0001-7583-2256"},"institutions":[{"id":"https://openalex.org/I102117144","display_name":"Banasthali University","ror":"https://ror.org/05ycegt40","country_code":"IN","type":"education","lineage":["https://openalex.org/I102117144"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sukriti Goyal","raw_affiliation_strings":["School of Bioscience and Biotechnology, Banasthali University, Tonk, Rajasthan, India, 304022","School of Bioscience and Biotechnology, Banasthali University, Tonk, Rajasthan, India"],"affiliations":[{"raw_affiliation_string":"School of Bioscience and Biotechnology, Banasthali University, Tonk, Rajasthan, India, 304022","institution_ids":["https://openalex.org/I102117144"]},{"raw_affiliation_string":"School of Bioscience and Biotechnology, Banasthali University, Tonk, Rajasthan, India","institution_ids":["https://openalex.org/I102117144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009450999","display_name":"Ankita Gupta","orcid":"https://orcid.org/0000-0002-1117-6007"},"institutions":[{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I863896202","display_name":"Delhi Technological University","ror":"https://ror.org/01ztcvt22","country_code":"IN","type":"education","lineage":["https://openalex.org/I863896202"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankita Gupta","raw_affiliation_strings":["Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","Department of Biotechnology; Delhi Technological University; New Delhi India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","institution_ids":["https://openalex.org/I863896202","https://openalex.org/I3141573830"]},{"raw_affiliation_string":"Department of Biotechnology; Delhi Technological University; New Delhi India","institution_ids":["https://openalex.org/I863896202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077482251","display_name":"Navneeta Bharadvaja","orcid":"https://orcid.org/0000-0001-6727-9622"},"institutions":[{"id":"https://openalex.org/I863896202","display_name":"Delhi Technological University","ror":"https://ror.org/01ztcvt22","country_code":"IN","type":"education","lineage":["https://openalex.org/I863896202"]},{"id":"https://openalex.org/I3141573830","display_name":"Department of Biotechnology","ror":"https://ror.org/03tjsyq23","country_code":"IN","type":"funder","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navneeta Bharadvaja","raw_affiliation_strings":["Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","Department of Biotechnology; Delhi Technological University; New Delhi India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Delhi Technological University, New Delhi, India, 110042","institution_ids":["https://openalex.org/I863896202","https://openalex.org/I3141573830"]},{"raw_affiliation_string":"Department of Biotechnology; Delhi Technological University; New Delhi India","institution_ids":["https://openalex.org/I863896202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017589215","display_name":"Abhinav Grover","orcid":"https://orcid.org/0000-0002-3296-7860"},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhinav Grover","raw_affiliation_strings":["School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, 110067","School of Biotechnology, Jawaharlal Nehru University, New Delhi, India"],"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, 110067","institution_ids":["https://openalex.org/I152429107"]},{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048138862"],"corresponding_institution_ids":["https://openalex.org/I3141573830","https://openalex.org/I863896202"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":3.3024,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92202943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"S2","first_page":"S14","last_page":"S14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.984000027179718,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"Pyrazinamide","score":0.8744722604751587},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.7495818138122559},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6482610702514648},{"id":"https://openalex.org/keywords/prodrug","display_name":"Prodrug","score":0.6110016703605652},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.5915163159370422},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5676796436309814},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5497980713844299},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.45297473669052124},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.43273982405662537},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.42821332812309265},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.3761114478111267},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20471179485321045},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16900837421417236},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.16359388828277588},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.0855235755443573}],"concepts":[{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.8744722604751587},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7495818138122559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6482610702514648},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.6110016703605652},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5915163159370422},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5676796436309814},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5497980713844299},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45297473669052124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43273982405662537},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.42821332812309265},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.3761114478111267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20471179485321045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16900837421417236},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.16359388828277588},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0855235755443573},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011718","descriptor_name":"Pyrazinamide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2164-16-s2-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-16-s2-s14","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-16-S2-S14","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:25708048","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25708048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4331714","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4331714","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-16-s2-s14","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-16-s2-s14","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-16-S2-S14","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8799999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320317740","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1763179423.pdf","grobid_xml":"https://content.openalex.org/works/W1763179423.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W122562142","https://openalex.org/W1890317675","https://openalex.org/W1896254721","https://openalex.org/W1971389950","https://openalex.org/W1976666288","https://openalex.org/W1985588649","https://openalex.org/W1986538901","https://openalex.org/W1988971060","https://openalex.org/W1990194768","https://openalex.org/W1991357372","https://openalex.org/W2009313526","https://openalex.org/W2014321835","https://openalex.org/W2019463286","https://openalex.org/W2021832765","https://openalex.org/W2024788317","https://openalex.org/W2031168104","https://openalex.org/W2031772330","https://openalex.org/W2036882334","https://openalex.org/W2037723053","https://openalex.org/W2047544230","https://openalex.org/W2066204878","https://openalex.org/W2077776336","https://openalex.org/W2081912151","https://openalex.org/W2082893192","https://openalex.org/W2083786789","https://openalex.org/W2091472887","https://openalex.org/W2098335911","https://openalex.org/W2099109129","https://openalex.org/W2101078720","https://openalex.org/W2102188715","https://openalex.org/W2102321517","https://openalex.org/W2119603196","https://openalex.org/W2119960901","https://openalex.org/W2126917152","https://openalex.org/W2129716166","https://openalex.org/W2130479394","https://openalex.org/W2135378152","https://openalex.org/W2139562897","https://openalex.org/W2140387095","https://openalex.org/W2142635609","https://openalex.org/W2150700849","https://openalex.org/W2151460035","https://openalex.org/W2153755133","https://openalex.org/W2171541901","https://openalex.org/W2239829266","https://openalex.org/W2274640761","https://openalex.org/W2477408078","https://openalex.org/W4229917921"],"related_works":["https://openalex.org/W2150579925","https://openalex.org/W2791697302","https://openalex.org/W2493613850","https://openalex.org/W2896632005","https://openalex.org/W2183266068","https://openalex.org/W2380167321","https://openalex.org/W2007070373","https://openalex.org/W2388615761","https://openalex.org/W2351380870","https://openalex.org/W4387653263"],"abstract_inverted_index":{"Pyrazinamide":[0],"(PZA)":[1],"is":[2,56,65],"one":[3],"of":[4,30,32,48,68],"the":[5,28,33,46,66,69,73,83,95],"most":[6],"effective":[7],"first":[8],"line":[9],"treatments":[10],"against":[11,54],"tuberculosis":[12],"disease.":[13],"The":[14],"drug":[15,49],"generally":[16],"has":[17,40],"bacteriostatic":[18],"action.":[19],"It":[20],"also":[21],"acts":[22],"on":[23],"bacterial":[24,51],"spores":[25],"which":[26,64,86],"eliminates":[27],"chances":[29],"resurfacing":[31],"infection.":[34],"However,":[35],"in":[36,45,60,94],"recent":[37],"years":[38],"there":[39],"been":[41],"a":[42],"major":[43],"increase":[44],"occurrence":[47],"resistant":[50],"strains.":[52],"Resistance":[53],"PZA":[55],"caused":[57],"by":[58,85],"mutations":[59],"pyrazinamidase":[61],"(PncA)":[62],"protein":[63],"activator":[67],"prodrug":[70],"PZA.":[71],"In":[72],"present":[74],"study,":[75],"we":[76],"have":[77],"tried":[78],"to":[79,90],"gain":[80],"insights":[81],"into":[82],"mechanism":[84],"resistance":[87],"develops":[88],"due":[89],"K96R":[91],"mutation":[92],"occurring":[93],"PncA":[96],"catalytic":[97],"region":[98]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}