{"id":"https://openalex.org/W2127204815","doi":"https://doi.org/10.1186/1471-2164-15-s1-s8","title":"Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans","display_name":"Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2127204815","doi":"https://doi.org/10.1186/1471-2164-15-s1-s8","mag":"2127204815","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564680"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-15-s1-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s8","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S8","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043019551","display_name":"Ben\u2010Yang Liao","orcid":"https://orcid.org/0000-0003-1163-3113"},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ben-Yang Liao","raw_affiliation_strings":["Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, R.O.C","Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, R.O.C","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, R.O.C","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016381994","display_name":"Andrew Ying-Fei Chang","orcid":"https://orcid.org/0000-0001-5949-9836"},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Andrew Chang","raw_affiliation_strings":["Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, R.O.C","Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, 350, Taiwan, R.O.C","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Division of Biostatistics & Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, R.O.C","institution_ids":["https://openalex.org/I165441096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165441096"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.7115,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70792472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"Suppl 1","first_page":"S8","last_page":"S8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.47839999198913574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.47839999198913574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.29429998993873596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctcf","display_name":"CTCF","score":0.9401711225509644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.8462079763412476},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"Gene duplication","score":0.7619969248771667},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6565617322921753},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6509248614311218},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6447241306304932},{"id":"https://openalex.org/keywords/functional-divergence","display_name":"Functional divergence","score":0.6178468465805054},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4781150221824646},{"id":"https://openalex.org/keywords/tandem-exon-duplication","display_name":"Tandem exon duplication","score":0.46170857548713684},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.45958012342453003},{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.417064905166626},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39934056997299194},{"id":"https://openalex.org/keywords/gene-family","display_name":"Gene family","score":0.3377632796764374},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.33664724230766296}],"concepts":[{"id":"https://openalex.org/C2778760011","wikidata":"https://www.wikidata.org/wiki/Q21163346","display_name":"CTCF","level":5,"score":0.9401711225509644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8462079763412476},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7619969248771667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6565617322921753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6509248614311218},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6447241306304932},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.6178468465805054},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4781150221824646},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.46170857548713684},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.45958012342453003},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.417064905166626},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39934056997299194},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.3377632796764374},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33664724230766296}],"mesh":[{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076246","descriptor_name":"CCCTC-Binding Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2164-15-s1-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s8","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S8","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:24564680","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4046690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4046690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-15-s1-s8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s8","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S8","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1276013671","display_name":null,"funder_award_id":"NSC 101-","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127204815.pdf","grobid_xml":"https://content.openalex.org/works/W2127204815.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W806969531","https://openalex.org/W1966794959","https://openalex.org/W1970298574","https://openalex.org/W1971231926","https://openalex.org/W1973726475","https://openalex.org/W1983275320","https://openalex.org/W1986263614","https://openalex.org/W1989373989","https://openalex.org/W1991527658","https://openalex.org/W1997025224","https://openalex.org/W1998667996","https://openalex.org/W2004184848","https://openalex.org/W2008004759","https://openalex.org/W2019591778","https://openalex.org/W2019937806","https://openalex.org/W2021200545","https://openalex.org/W2033331470","https://openalex.org/W2048512322","https://openalex.org/W2053929909","https://openalex.org/W2056182546","https://openalex.org/W2063086867","https://openalex.org/W2077697996","https://openalex.org/W2078028724","https://openalex.org/W2098298179","https://openalex.org/W2102619694","https://openalex.org/W2102999073","https://openalex.org/W2110335151","https://openalex.org/W2114835309","https://openalex.org/W2122879816","https://openalex.org/W2124388496","https://openalex.org/W2125397535","https://openalex.org/W2125469896","https://openalex.org/W2127974994","https://openalex.org/W2132023322","https://openalex.org/W2135123683","https://openalex.org/W2145825942","https://openalex.org/W2156626022","https://openalex.org/W2157394198","https://openalex.org/W2158647405","https://openalex.org/W2160470947","https://openalex.org/W2259938310","https://openalex.org/W2519244818","https://openalex.org/W4229487902"],"related_works":["https://openalex.org/W3012693835","https://openalex.org/W2735826995","https://openalex.org/W3014694882","https://openalex.org/W4321786133","https://openalex.org/W2899714688","https://openalex.org/W2019937806","https://openalex.org/W2091857626","https://openalex.org/W1970221653","https://openalex.org/W2765671423","https://openalex.org/W4389547050"],"abstract_inverted_index":{"BACKGROUND:":[0],"During":[1],"eukaryotic":[2],"genome":[3],"evolution,":[4],"tandem":[5,98],"gene":[6,17],"duplication":[7,99],"is":[8,36,133],"the":[9,45,54,59,85,142,147],"most":[10],"frequent":[11],"event":[12],"giving":[13],"rise":[14],"to":[15,146],"clustered":[16],"families.":[18],"However,":[19],"how":[20],"expression":[21,76,79,125],"divergence":[22,73,126],"between":[23,81,105],"tandemly":[24,128],"duplicated":[25,129],"genes":[26,113],"has":[27,66],"emerged":[28],"and":[29,58,78,152],"maintained":[30],"remain":[31],"unclear.":[32],"In":[33],"particular,":[34],"it":[35],"unknown":[37],"if":[38],"epigenetic":[39,56],"regulators":[40],"have":[41],"been":[42],"involved":[43,114],"in":[44,64,71,74,84,115],"process.":[46],"RESULTS:":[47],"We":[48],"demonstrate":[49],"that":[50],"CCCTC-binding":[51],"factor":[52],"(CTCF),":[53],"master":[55],"regulator":[57],"only":[60],"known":[61],"insulator":[62],"protein":[63],"humans,":[65],"played":[67],"a":[68],"predominant":[69],"role":[70],"generating":[72],"both":[75],"profiles":[77],"levels":[80],"adjacent":[82,95],"paralogs":[83],"human":[86],"genome.":[87],"This":[88,107,131],"phenomenon":[89],"was":[90,109],"not":[91],"observed":[92],"for":[93,112],"non-paralogous":[94],"genes.":[96,130],"After":[97],"events,":[100],"CTCF-binding":[101,122],"sites":[102,123],"gradually":[103],"accumulate":[104],"paralogs.":[106],"trend":[108],"more":[110],"prominent":[111],"particular":[116],"functions.":[117],"CONCLUSIONS:":[118],"The":[119],"accumulation":[120],"of":[121,127,144,149],"drives":[124],"process":[132],"likely":[134],"targeted":[135],"by":[136],"natural":[137],"selection.":[138],"Our":[139],"study":[140],"reveals":[141],"importance":[143],"CTCF":[145],"evolution":[148],"animal":[150],"diversity":[151],"complexity.":[153]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}