{"id":"https://openalex.org/W2116533175","doi":"https://doi.org/10.1186/1471-2164-15-s1-s7","title":"A nucleosomal approach to inferring causal relationships of histone modifications","display_name":"A nucleosomal approach to inferring causal relationships of histone modifications","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2116533175","doi":"https://doi.org/10.1186/1471-2164-15-s1-s7","mag":"2116533175","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564627"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-15-s1-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s7","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040528788","display_name":"Ngoc Tu Le","orcid":"https://orcid.org/0000-0002-3078-8172"},"institutions":[{"id":"https://openalex.org/I177738480","display_name":"Japan Advanced Institute of Science and Technology","ror":"https://ror.org/03frj4r98","country_code":"JP","type":"education","lineage":["https://openalex.org/I177738480"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ngoc Le","raw_affiliation_strings":["Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan","Japan Advanced Institute of Science and Technology, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan","institution_ids":["https://openalex.org/I177738480"]},{"raw_affiliation_string":"Japan Advanced Institute of Science and Technology, Ishikawa, Japan","institution_ids":["https://openalex.org/I177738480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101646487","display_name":"Tu Bao Ho","orcid":"https://orcid.org/0000-0001-5951-643X"},"institutions":[{"id":"https://openalex.org/I177738480","display_name":"Japan Advanced Institute of Science and Technology","ror":"https://ror.org/03frj4r98","country_code":"JP","type":"education","lineage":["https://openalex.org/I177738480"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tu Ho","raw_affiliation_strings":["Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan","Japan Advanced Institute of Science and Technology, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa, 923-1292, Japan","institution_ids":["https://openalex.org/I177738480"]},{"raw_affiliation_string":"Japan Advanced Institute of Science and Technology, Ishikawa, Japan","institution_ids":["https://openalex.org/I177738480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017730405","display_name":"Bich Hai Ho","orcid":"https://orcid.org/0000-0002-6344-0180"},"institutions":[{"id":"https://openalex.org/I70349855","display_name":"Vietnam Academy of Science and Technology","ror":"https://ror.org/02wsd5p50","country_code":"VN","type":"government","lineage":["https://openalex.org/I70349855"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Bich Ho","raw_affiliation_strings":["Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam","Vietnam Academy of Science and Technology, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam","institution_ids":["https://openalex.org/I70349855"]},{"raw_affiliation_string":"Vietnam Academy of Science and Technology, Hanoi, Vietnam","institution_ids":["https://openalex.org/I70349855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069075456","display_name":"Dang Hung Tran","orcid":"https://orcid.org/0000-0001-7691-6486"},"institutions":[{"id":"https://openalex.org/I135822937","display_name":"Hanoi National University of Education","ror":"https://ror.org/0360g3z42","country_code":"VN","type":"education","lineage":["https://openalex.org/I135822937"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Dang Tran","raw_affiliation_strings":["Hanoi National University of Education, 36 Xuan Thuy, Cau Giay, Hanoi, Vietnam","Hanoi National University of Education, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hanoi National University of Education, 36 Xuan Thuy, Cau Giay, Hanoi, Vietnam","institution_ids":["https://openalex.org/I135822937"]},{"raw_affiliation_string":"Hanoi National University of Education, Hanoi, Vietnam","institution_ids":["https://openalex.org/I135822937"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.698,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70141131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"15","issue":"Suppl 1","first_page":"S7","last_page":"S7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8777999877929688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8777999877929688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.6586231589317322},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6444753408432007},{"id":"https://openalex.org/keywords/nucleosome","display_name":"Nucleosome","score":0.5906648635864258},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.5890384912490845},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.540340781211853},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5308699607849121},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5227539539337158},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.46862250566482544},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4540879726409912},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.43104642629623413},{"id":"https://openalex.org/keywords/causal-structure","display_name":"Causal structure","score":0.4210147261619568},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.30209383368492126},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28719720244407654},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.222545325756073},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13439980149269104},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.1055963933467865},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10386580228805542}],"concepts":[{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.6586231589317322},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6444753408432007},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.5906648635864258},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5890384912490845},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.540340781211853},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5308699607849121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5227539539337158},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.46862250566482544},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4540879726409912},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.43104642629623413},{"id":"https://openalex.org/C163504300","wikidata":"https://www.wikidata.org/wiki/Q2364925","display_name":"Causal structure","level":2,"score":0.4210147261619568},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30209383368492126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28719720244407654},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.222545325756073},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13439980149269104},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1055963933467865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10386580228805542},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2164-15-s1-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s7","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:24564627","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:europepmc.org:3023403","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4046832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-15-s1-s7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s7","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S7","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309617","display_name":"National Foundation for Science and Technology Development","ror":"https://ror.org/04rw64z44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116533175.pdf","grobid_xml":"https://content.openalex.org/works/W2116533175.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W56162370","https://openalex.org/W1511986666","https://openalex.org/W1565545733","https://openalex.org/W1590398161","https://openalex.org/W1975844453","https://openalex.org/W1986411314","https://openalex.org/W1995404170","https://openalex.org/W2002698073","https://openalex.org/W2006918465","https://openalex.org/W2008906462","https://openalex.org/W2011026836","https://openalex.org/W2014996535","https://openalex.org/W2015398713","https://openalex.org/W2015416439","https://openalex.org/W2017840637","https://openalex.org/W2018966815","https://openalex.org/W2022237004","https://openalex.org/W2023348831","https://openalex.org/W2030637684","https://openalex.org/W2036781609","https://openalex.org/W2040878522","https://openalex.org/W2041090138","https://openalex.org/W2044826047","https://openalex.org/W2054672812","https://openalex.org/W2055327776","https://openalex.org/W2058613034","https://openalex.org/W2059016225","https://openalex.org/W2061372269","https://openalex.org/W2064117044","https://openalex.org/W2064219816","https://openalex.org/W2072152932","https://openalex.org/W2073307618","https://openalex.org/W2077165618","https://openalex.org/W2078149659","https://openalex.org/W2078370799","https://openalex.org/W2083245183","https://openalex.org/W2089689396","https://openalex.org/W2090184738","https://openalex.org/W2096083625","https://openalex.org/W2096718637","https://openalex.org/W2105522597","https://openalex.org/W2108871359","https://openalex.org/W2109947083","https://openalex.org/W2119000216","https://openalex.org/W2122708083","https://openalex.org/W2134087142","https://openalex.org/W2140277449","https://openalex.org/W2144792857","https://openalex.org/W2147524392","https://openalex.org/W2149310258","https://openalex.org/W2151681456","https://openalex.org/W2154053567","https://openalex.org/W2155725346","https://openalex.org/W2155990718","https://openalex.org/W2156821248","https://openalex.org/W2159203162","https://openalex.org/W2161409973","https://openalex.org/W2161868542","https://openalex.org/W2170112109","https://openalex.org/W2611370172","https://openalex.org/W2964184712","https://openalex.org/W3099289621"],"related_works":["https://openalex.org/W2795212387","https://openalex.org/W2030573967","https://openalex.org/W2988805143","https://openalex.org/W4285490847","https://openalex.org/W2113512405","https://openalex.org/W4318473910","https://openalex.org/W2113253885","https://openalex.org/W2020842184","https://openalex.org/W1979616193","https://openalex.org/W2082280880"],"abstract_inverted_index":{"MOTIVATION:":[0],"Histone":[1],"proteins":[2],"are":[3,68,134,143],"subject":[4],"to":[5,43,84,103],"various":[6],"posttranslational":[7],"modifications":[8,67],"(PTMs).":[9],"Elucidating":[10],"their":[11],"functional":[12],"relationships":[13,46,106,142,194],"is":[14,59],"crucial":[15],"toward":[16],"understanding":[17],"many":[18],"biological":[19],"processes.":[20],"Bayesian":[21],"network":[22,148],"(BN)-based":[23],"approaches":[24],"have":[25],"shown":[26],"the":[27,63,86,89,112,121,154,163,166,191,197],"advantage":[28,164],"of":[29,37,47,107,123,132,150,165,171,190,216],"revealing":[30],"causal":[31,45,105,204],"relationships,":[32],"rather":[33],"than":[34],"simple":[35],"cooccurrences,":[36],"PTMs.":[38],"Previous":[39],"works":[40],"employing":[41],"BNs":[42],"infer":[44,104],"PTMs":[48,133,152],"require":[49],"that":[50,65,114,196],"all":[51],"confounders":[52,131],"should":[53,210],"be":[54,82,211],"included.":[55],"This":[56],"assumption,":[57],"however,":[58],"unavoidably":[60],"violated":[61],"given":[62],"fact":[64],"several":[66],"often":[69],"regulated":[70],"by":[71,137],"a":[72,99,147],"common":[73],"but":[74,88],"unobserved":[75],"factor.":[76],"An":[77],"existing":[78],"non-parametric":[79],"method":[80,102,199],"can":[81,200],"applied":[83],"tackle":[85],"problem":[87],"complexity":[90],"and":[91,153,174],"inflexibility":[92],"make":[93],"it":[94,185],"impractical.":[95],"RESULTS:":[96],"We":[97],"propose":[98],"novel":[100],"BN-based":[101],"histone":[108,207,217],"modifications.":[109],"First,":[110],"from":[111,146,176],"evidence":[113],"nucleosome":[115],"organization":[116],"in":[117,169],"vivo":[118],"significantly":[119],"affects":[120],"activities":[122],"PTM":[124],"regulators":[125],"working":[126],"on":[127,158],"chromatin":[128],"substrate,":[129],"hidden":[130],"selectively":[135],"introduced":[136],"an":[138],"information-theoretic":[139],"criterion.":[140],"Causal":[141],"then":[144],"inferred":[145],"model":[149],"both":[151],"derived":[155],"confounders.":[156],"Application":[157],"human":[159],"epigenomic":[160],"data":[161,181],"shows":[162],"proposed":[167,198],"method,":[168],"terms":[170],"computational":[172],"performance":[173],"support":[175],"literature.":[177],"Requiring":[178],"less":[179],"strict":[180],"assumptions":[182],"also":[183],"makes":[184],"more":[186],"practical.":[187],"Interestingly,":[188],"analysis":[189],"most":[192],"significant":[193],"suggests":[195],"recover":[201],"biologically":[202],"relevant":[203],"effects":[205],"between":[206],"modifications,":[208],"which":[209],"important":[212],"for":[213],"future":[214],"investigation":[215],"crosstalk.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}