{"id":"https://openalex.org/W2063691120","doi":"https://doi.org/10.1186/1471-2164-15-s1-s11","title":"Genome sequencing of high-penicillin producing industrial strain of Penicillium chrysogenum","display_name":"Genome sequencing of high-penicillin producing industrial strain of Penicillium chrysogenum","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2063691120","doi":"https://doi.org/10.1186/1471-2164-15-s1-s11","mag":"2063691120","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564352"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-15-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s11","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S11","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100723485","display_name":"Fuqiang Wang","orcid":"https://orcid.org/0000-0002-7777-3541"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fu-Qiang Wang","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058056521","display_name":"Jun Zhong","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhong","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China","University of Chinese Academy of Sciences, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072878810","display_name":"Ying Zhao","orcid":"https://orcid.org/0000-0002-5511-6284"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zhao","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009289581","display_name":"Jingfa Xiao","orcid":"https://orcid.org/0000-0002-2835-4340"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingfa Xiao","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780844","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0002-5281-9769"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080006546","display_name":"Meng Dai","orcid":"https://orcid.org/0000-0001-5919-7512"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Dai","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014210735","display_name":"Guizhen Zheng","orcid":"https://orcid.org/0000-0002-6269-826X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guizhen Zheng","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425671","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-9386-8938"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728445","display_name":"Jun Yu","orcid":"https://orcid.org/0000-0002-2702-055X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Yu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125441","display_name":"Jiayan Wu","orcid":"https://orcid.org/0000-0001-6048-405X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiayan Wu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074983649","display_name":"Bao-Ling Duan","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Baoling Duan","raw_affiliation_strings":["New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Engineering Research Center of Microbial Medicine, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Shijiazhuang, Hebei, 050015, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074983649","https://openalex.org/A5109125441"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":17.3632,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.99587814,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"15","issue":"S1","first_page":"S11","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8747000098228455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.8747000098228455,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillium-chrysogenum","display_name":"Penicillium chrysogenum","score":0.9002997279167175},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7646422982215881},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6871687173843384},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6474887728691101},{"id":"https://openalex.org/keywords/whole-genome-sequencing","display_name":"Whole genome sequencing","score":0.6161546111106873},{"id":"https://openalex.org/keywords/secondary-metabolism","display_name":"Secondary metabolism","score":0.5615226626396179},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5485438108444214},{"id":"https://openalex.org/keywords/penicillin","display_name":"Penicillin","score":0.49036359786987305},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.4157830476760864},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.16455212235450745},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.10038489103317261}],"concepts":[{"id":"https://openalex.org/C2777270571","wikidata":"https://www.wikidata.org/wiki/Q137155","display_name":"Penicillium chrysogenum","level":2,"score":0.9002997279167175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7646422982215881},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6871687173843384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6474887728691101},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.6161546111106873},{"id":"https://openalex.org/C2777157883","wikidata":"https://www.wikidata.org/wiki/Q3360529","display_name":"Secondary metabolism","level":4,"score":0.5615226626396179},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5485438108444214},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.49036359786987305},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4157830476760864},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16455212235450745},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.10038489103317261},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007218","descriptor_name":"Industrial Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010408","descriptor_name":"Penicillium chrysogenum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010408","descriptor_name":"Penicillium chrysogenum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010408","descriptor_name":"Penicillium chrysogenum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010408","descriptor_name":"Penicillium chrysogenum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010408","descriptor_name":"Penicillium chrysogenum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2164-15-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s11","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S11","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:24564352","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4046689","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4046689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-15-s1-s11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-15-s1-s11","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-15-S1-S11","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.4099999964237213}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063691120.pdf","grobid_xml":"https://content.openalex.org/works/W2063691120.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W173990885","https://openalex.org/W190540197","https://openalex.org/W1519781644","https://openalex.org/W1543281315","https://openalex.org/W1969550578","https://openalex.org/W1971403296","https://openalex.org/W1974839399","https://openalex.org/W1985471440","https://openalex.org/W1990073542","https://openalex.org/W1990709411","https://openalex.org/W1995089537","https://openalex.org/W1995102273","https://openalex.org/W1996720933","https://openalex.org/W2006665034","https://openalex.org/W2010091762","https://openalex.org/W2013392419","https://openalex.org/W2022366078","https://openalex.org/W2024828771","https://openalex.org/W2025243821","https://openalex.org/W2035593347","https://openalex.org/W2053421240","https://openalex.org/W2053822489","https://openalex.org/W2054624670","https://openalex.org/W2055043387","https://openalex.org/W2061680337","https://openalex.org/W2067659886","https://openalex.org/W2071501400","https://openalex.org/W2080416549","https://openalex.org/W2091448229","https://openalex.org/W2101595316","https://openalex.org/W2103017472","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2109478474","https://openalex.org/W2112814753","https://openalex.org/W2119923823","https://openalex.org/W2121016876","https://openalex.org/W2124960286","https://openalex.org/W2125349979","https://openalex.org/W2126057141","https://openalex.org/W2128114769","https://openalex.org/W2128242967","https://openalex.org/W2130347047","https://openalex.org/W2130769450","https://openalex.org/W2133579817","https://openalex.org/W2136145671","https://openalex.org/W2137296022","https://openalex.org/W2138068428","https://openalex.org/W2138270253","https://openalex.org/W2138345179","https://openalex.org/W2139760555","https://openalex.org/W2141708465","https://openalex.org/W2143325524","https://openalex.org/W2148853951","https://openalex.org/W2152087907","https://openalex.org/W2152178770","https://openalex.org/W2154397429","https://openalex.org/W2160303737","https://openalex.org/W2165463056","https://openalex.org/W2165759219","https://openalex.org/W2169105416","https://openalex.org/W2177846120","https://openalex.org/W4232052881","https://openalex.org/W4236541940","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W1978587146","https://openalex.org/W4242806758","https://openalex.org/W1978321665","https://openalex.org/W2743477607","https://openalex.org/W2033217310","https://openalex.org/W2127374770","https://openalex.org/W2125928717","https://openalex.org/W2788274730","https://openalex.org/W2015344427","https://openalex.org/W2153695721"],"abstract_inverted_index":{"BACKGROUND:":[0],"Due":[1],"to":[2],"the":[3,11,67,110,151,184,200,242,248,256],"importance":[4],"of":[5,13,28,34,52,71,93,113,117,143,154,194,205,209],"Penicillium":[6],"chrysogenum":[7,81,211],"holding":[8],"in":[9,109,121,139,148,165,183,187,255],"medicine,":[10],"genome":[12,42,50,68,85,111,203,217],"low-penicillin":[14],"producing":[15,55,73],"laboratorial":[16],"strain":[17,57,79,208],"Wisconsin54-1255":[18,114],"had":[19],"been":[20],"sequenced":[21,76],"and":[22,32,96,98,115,126,150,173,212,236,252],"fully":[23],"annotated.":[24],"Through":[25],"classical":[26],"mutagenesis":[27],"Wisconsin54-1255,":[29],"product":[30],"titers":[31],"productivities":[33],"penicillin":[35,145,195],"have":[36],"dramatically":[37],"increased,":[38],"but":[39],"what":[40],"underlying":[41],"structural":[43,69,99],"variations":[44,70,226],"is":[45,58,157],"still":[46],"little":[47],"known.":[48],"Therefore,":[49],"sequencing":[51],"a":[53,90,133,140,215,220],"high-penicillin":[54,72,207,249],"industrial":[56,78,206],"very":[59],"meaningful.":[60],"RESULTS:":[61],"To":[62],"reveal":[63],"more":[64],"insights":[65,246],"into":[66,247],"strain,":[74],"we":[75,88,131,160,178,227],"an":[77],"P.":[80,210],"NCPC10086.":[82],"By":[83],"whole":[84],"comparative":[86,216],"analysis,":[87],"observed":[89],"large":[91],"number":[92],"mutations,":[94],"insertions":[95],"deletions,":[97],"variations.":[100],"There":[101],"are":[102,119,229],"69":[103],"new":[104],"genes":[105,168,185],"that":[106],"not":[107],"exist":[108],"sequence":[112,204],"some":[116,180],"them":[118],"involved":[120,169],"energy":[122,232],"metabolism,":[123,233],"nitrogen":[124,171,234],"metabolism":[125,172,235],"glutathione":[127],"metabolism.":[128],"Most":[129],"importantly,":[130],"discovered":[132,228],"53.7":[134],"Kb":[135],"\"new":[136],"shift":[137],"fragment\"":[138],"seven":[141],"copies":[142],"determinative":[144],"biosynthesis":[146],"cluster":[147],"NCPC10086":[149],"arrangement":[152],"type":[153],"amplified":[155],"region":[156],"unique.":[158],"Moreover,":[159],"presented":[161],"two":[162],"large-scale":[163],"translocations":[164],"NCPC10086,":[166],"containing":[167],"energy,":[170],"peroxysome":[174],"pathway.":[175],"At":[176],"last,":[177],"found":[179],"non-synonymous":[181],"mutations":[182],"participating":[186],"homogentisate":[188],"pathway":[189],"or":[190],"working":[191],"as":[192],"regulators":[193],"biosynthesis.":[196],"CONCLUSIONS:":[197],"We":[198],"provided":[199],"first":[201],"high-quality":[202],"carried":[213],"out":[214],"analysis":[218],"with":[219,231],"low-producing":[221],"experimental":[222],"strain.":[223],"The":[224],"genomic":[225],"related":[230],"so":[237],"on.":[238],"These":[239],"findings":[240],"demonstrate":[241],"potential":[243],"information":[244],"for":[245],"yielding":[250],"mechanism":[251],"metabolic":[253],"engineering":[254],"future.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
