{"id":"https://openalex.org/W2134488721","doi":"https://doi.org/10.1186/1471-2105-9-s2-s6","title":"A three-state prediction of single point mutations on protein stability changes","display_name":"A three-state prediction of single point mutations on protein stability changes","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2134488721","doi":"https://doi.org/10.1186/1471-2105-9-s2-s6","mag":"2134488721","pmid":"https://pubmed.ncbi.nlm.nih.gov/18387208"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-S2-S6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029911656","display_name":"Emidio Capriotti","orcid":"https://orcid.org/0000-0002-2323-0963"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Emidio Capriotti","raw_affiliation_strings":["Structural Genomics Unit, Bioinformatics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain. ecapriotti@cipf.es","Structural Genomics Unit, Bioinformatics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Structural Genomics Unit, Bioinformatics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain. ecapriotti@cipf.es","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Structural Genomics Unit, Bioinformatics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060232841","display_name":"Piero Fariselli","orcid":"https://orcid.org/0000-0003-1811-4762"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Fariselli","raw_affiliation_strings":["Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy"],"affiliations":[{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079319034","display_name":"Ivan Rossi","orcid":"https://orcid.org/0000-0002-2077-7496"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]},{"id":"https://openalex.org/I4210119786","display_name":"Cineca","ror":"https://ror.org/02f013h18","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210119786"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ivan Rossi","raw_affiliation_strings":["BioDec Srl, via Calzavecchio 20/2, Casalecchio di Reno Bologna, Italy","Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy"],"affiliations":[{"raw_affiliation_string":"BioDec Srl, via Calzavecchio 20/2, Casalecchio di Reno Bologna, Italy","institution_ids":["https://openalex.org/I4210119786"]},{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053410790","display_name":"Rita Casadio","orcid":"https://orcid.org/0000-0002-7462-7039"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Casadio","raw_affiliation_strings":["Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy"],"affiliations":[{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, via Irnerio 42, 40126, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029911656"],"corresponding_institution_ids":["https://openalex.org/I4210165109"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.0328,"has_fulltext":true,"cited_by_count":336,"citation_normalized_percentile":{"value":0.91730495,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"S2","first_page":"S6","last_page":"S6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutral-mutation","display_name":"Neutral mutation","score":0.7050259709358215},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6825383901596069},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5104771852493286},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5075300931930542},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.462650865316391},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.454372376203537},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37583622336387634},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2663196325302124},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.212485671043396},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10208666324615479}],"concepts":[{"id":"https://openalex.org/C149129301","wikidata":"https://www.wikidata.org/wiki/Q3883802","display_name":"Neutral mutation","level":3,"score":0.7050259709358215},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6825383901596069},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5104771852493286},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5075300931930542},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.462650865316391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.454372376203537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37583622336387634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2663196325302124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.212485671043396},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10208666324615479}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-9-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18387208","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18387208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/46475","is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/46475","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e02a53eaf13749ca9fc923bd822171d9","is_oa":true,"landing_page_url":"https://doaj.org/article/e02a53eaf13749ca9fc923bd822171d9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss Suppl 2, p S6 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2323669","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2323669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.research.unipd.it:11577/3184051","is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/3184051","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-s2-s6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-s2-s6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-S2-S6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"},{"score":0.4399999976158142,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134488721.pdf","grobid_xml":"https://content.openalex.org/works/W2134488721.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2008708467","https://openalex.org/W2019574765","https://openalex.org/W2075481658","https://openalex.org/W2092387745","https://openalex.org/W2099672241","https://openalex.org/W2113710405","https://openalex.org/W2116502736","https://openalex.org/W2119549626","https://openalex.org/W2121519777","https://openalex.org/W2125677968","https://openalex.org/W2129651861","https://openalex.org/W2132540199","https://openalex.org/W2136447744","https://openalex.org/W2136513422","https://openalex.org/W2145644903","https://openalex.org/W2152279845","https://openalex.org/W2158714788","https://openalex.org/W2161504103"],"related_works":["https://openalex.org/W2550943714","https://openalex.org/W3212350425","https://openalex.org/W2388007221","https://openalex.org/W2511508046","https://openalex.org/W1974452506","https://openalex.org/W4318691823","https://openalex.org/W2363458739","https://openalex.org/W4386878600","https://openalex.org/W2385244308","https://openalex.org/W2028961943"],"abstract_inverted_index":{"Our":[0],"method":[1],"improves":[2],"the":[3,6,9,27,36,40,44,47,60],"quality":[4],"of":[5,8,23,26,39,46,51,59,73],"prediction":[7],"free":[10,52],"energy":[11,53],"change":[12],"due":[13],"to":[14],"single":[15],"point":[16],"protein":[17],"mutations":[18,75],"by":[19],"adopting":[20],"a":[21,71],"hypothesis":[22],"thermodynamic":[24,37],"reversibility":[25],"existing":[28],"experimental":[29,49],"data.":[30],"By":[31],"this":[32],"we":[33],"both":[34],"recast":[35],"symmetry":[38],"problem":[41],"and":[42],"balance":[43],"distribution":[45],"available":[48],"measurements":[50],"changes.":[54],"This":[55],"eliminates":[56],"possible":[57],"overestimations":[58],"previously":[61],"described":[62],"methods":[63],"trained":[64],"on":[65],"an":[66],"unbalanced":[67],"data":[68],"set":[69],"comprising":[70],"number":[72],"destabilizing":[74],"higher":[76],"than":[77],"stabilizing":[78],"ones.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":31},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":19}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}