{"id":"https://openalex.org/W1968636531","doi":"https://doi.org/10.1186/1471-2105-9-486","title":"Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classification","display_name":"Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classification","publication_year":2008,"publication_date":"2008-11-17","ids":{"openalex":"https://openalex.org/W1968636531","doi":"https://doi.org/10.1186/1471-2105-9-486","mag":"1968636531","pmid":"https://pubmed.ncbi.nlm.nih.gov/19014681"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-486","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-486","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-486","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013077058","display_name":"Michael Gormley","orcid":"https://orcid.org/0000-0002-6438-4141"},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gormley","raw_affiliation_strings":["School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA. michael.patrick.gormley@drexel.edu","School of BioMedical Engineering, Drexel University, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA. michael.patrick.gormley@drexel.edu","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of BioMedical Engineering, Drexel University, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055266606","display_name":"Ayd\u0131n T\u00f6zeren","orcid":null},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aydin Tozeren","raw_affiliation_strings":["School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA","School of BioMedical Engineering, Drexel University, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]},{"raw_affiliation_string":"School of BioMedical Engineering, Drexel University, Philadelphia, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055266606"],"corresponding_institution_ids":["https://openalex.org/I72816309"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.702,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68999187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"486","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.4812999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.4812999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.29429998993873596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7376283407211304},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6790434122085571},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6453386545181274},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5912066102027893},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5850694179534912},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5732965469360352},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5369688272476196},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5260465145111084},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5212750434875488},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.48358744382858276},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4587578773498535}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7376283407211304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6790434122085571},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6453386545181274},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5912066102027893},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5850694179534912},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5732965469360352},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5369688272476196},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5260465145111084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5212750434875488},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48358744382858276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4587578773498535}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005812","descriptor_name":"Genes, Switch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-9-486","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-486","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-486","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19014681","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19014681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:dcc9bbe69afc42258c78a4b2241d79e0","is_oa":true,"landing_page_url":"https://doaj.org/article/dcc9bbe69afc42258c78a4b2241d79e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 486 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2620272","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2620272","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-486","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-486","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-486","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6898797682","display_name":null,"funder_award_id":"232240","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1968636531.pdf","grobid_xml":"https://content.openalex.org/works/W1968636531.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1576773659","https://openalex.org/W1586448719","https://openalex.org/W1759376742","https://openalex.org/W1965696995","https://openalex.org/W1966701961","https://openalex.org/W1967064280","https://openalex.org/W1968621198","https://openalex.org/W1977556410","https://openalex.org/W1978770080","https://openalex.org/W1980548655","https://openalex.org/W1987877477","https://openalex.org/W1989045342","https://openalex.org/W1989297334","https://openalex.org/W1990033381","https://openalex.org/W2014606320","https://openalex.org/W2017408113","https://openalex.org/W2020541351","https://openalex.org/W2036555234","https://openalex.org/W2049633694","https://openalex.org/W2051907993","https://openalex.org/W2056466917","https://openalex.org/W2056933088","https://openalex.org/W2061050682","https://openalex.org/W2071949631","https://openalex.org/W2075078512","https://openalex.org/W2082293045","https://openalex.org/W2087684630","https://openalex.org/W2091576663","https://openalex.org/W2092778532","https://openalex.org/W2092857742","https://openalex.org/W2098216772","https://openalex.org/W2103017472","https://openalex.org/W2109363337","https://openalex.org/W2120920194","https://openalex.org/W2122400112","https://openalex.org/W2128985829","https://openalex.org/W2130201056","https://openalex.org/W2130410032","https://openalex.org/W2130925862","https://openalex.org/W2133449490","https://openalex.org/W2134783591","https://openalex.org/W2135000328","https://openalex.org/W2136097953","https://openalex.org/W2137476312","https://openalex.org/W2139501009","https://openalex.org/W2140736261","https://openalex.org/W2143129697","https://openalex.org/W2146646206","https://openalex.org/W2147246240","https://openalex.org/W2148995578","https://openalex.org/W2150473224","https://openalex.org/W2150926065","https://openalex.org/W2152012752","https://openalex.org/W2154354945","https://openalex.org/W2154554404","https://openalex.org/W2155933886","https://openalex.org/W2157795344","https://openalex.org/W2159482845","https://openalex.org/W2160619422","https://openalex.org/W2163563958","https://openalex.org/W2163986503","https://openalex.org/W2164628006","https://openalex.org/W2168266830","https://openalex.org/W2168561598","https://openalex.org/W2170040895","https://openalex.org/W2170989872","https://openalex.org/W2327913548","https://openalex.org/W3129711340","https://openalex.org/W3152026761","https://openalex.org/W4240861547","https://openalex.org/W4245024447","https://openalex.org/W4247469419","https://openalex.org/W4253934678","https://openalex.org/W4294107304","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W1996185163","https://openalex.org/W170658859","https://openalex.org/W2081127504","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W2183420549","https://openalex.org/W2490137852","https://openalex.org/W2039699813","https://openalex.org/W2081507994","https://openalex.org/W1972696957"],"abstract_inverted_index":{"BACKGROUND:":[0],"Large-scale":[1],"compilation":[2],"of":[3,15,23,27,40,42,59,66,77,97,116,145,150,162,183,216,246,268],"gene":[4,99,201],"expression":[5,102,240],"microarray":[6,87,117,207],"datasets":[7,140],"across":[8],"diverse":[9],"biological":[10],"phenotypes":[11],"provided":[12,238],"a":[13,17,78,231],"means":[14],"gathering":[16],"priori":[18],"knowledge":[19],"in":[20,30,72,108,113,137,153,168,186,191,209,243,257],"the":[21,31,63,95,160,195,244,269],"form":[22],"identification":[24,161],"and":[25,33,46,54,132,147,156,172,211,222,259,266],"annotation":[26],"bimodal":[28,67,98,200,217,253],"genes":[29,38,50,68,127,152,167,185,218,254],"human":[32,44],"mouse":[34],"genomes.":[35],"These":[36],"switch-like":[37,126,151,166],"consist":[39],"15%":[41],"known":[43],"genes,":[45],"are":[47,189,225,255],"enriched":[48],"with":[49,121,227],"coding":[51,219],"for":[52,69,142,159,220,234],"extracellular":[53,221],"membrane":[55,223],"proteins.":[56],"It":[57],"is":[58,241],"interest":[60],"to":[61,125,177,194,272],"determine":[62],"prediction":[64],"potential":[65,232],"class":[70],"discovery":[71],"large-scale":[73],"datasets.":[74],"RESULTS:":[75],"Use":[76],"model-based":[79,114],"clustering":[80,115],"algorithm":[81],"accurately":[82],"classified":[83],"more":[84],"than":[85],"400":[86],"samples":[88],"into":[89],"19":[90],"different":[91],"tissue":[92,130,175,228],"types":[93],"on":[94],"basis":[96],"expression.":[100],"Bimodal":[101],"patterns":[103],"were":[104],"also":[105,128],"highly":[106],"effective":[107],"differentiating":[109],"between":[110],"infectious":[111,133,187,212],"diseases":[112,157],"data.":[118],"Supervised":[119],"classification":[120],"feature":[122],"selection":[123],"restricted":[124],"recognized":[129],"specific":[131,135],"disease":[134,188],"signatures":[136,205],"independent":[138],"test":[139],"reserved":[141],"validation.":[143],"Determination":[144],"\"on\"":[146],"\"off\"":[148],"states":[149],"various":[154],"tissues":[155],"allowed":[158],"activated/deactivated":[163],"pathways.":[164],"Activated":[165],"neural,":[169],"skeletal":[170],"muscle":[171,174],"cardiac":[173],"tend":[176],"have":[178],"tissue-specific":[179,264],"roles.":[180],"A":[181,214],"majority":[182],"activated":[184],"involved":[190,256],"processes":[192],"related":[193],"immune":[196,270],"response.":[197],"CONCLUSION:":[198],"Switch-like":[199],"sets":[202],"capture":[203],"genome-wide":[204],"from":[206],"data":[208],"health":[210],"disease.":[213,247],"subset":[215],"proteins":[224],"associated":[226],"specificity,":[229],"indicating":[230],"role":[233],"them":[235],"as":[236],"biomarkers":[237],"that":[239,252],"altered":[242],"onset":[245],"Furthermore,":[248],"we":[249],"provide":[250],"evidence":[251],"temporally":[258],"spatially":[260],"active":[261],"mechanisms":[262],"including":[263],"functions":[265],"response":[267],"system":[271],"invading":[273],"pathogens.":[274]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}