{"id":"https://openalex.org/W2045843285","doi":"https://doi.org/10.1186/1471-2105-9-276","title":"Discovering functional interaction patterns in protein-protein interaction networks","display_name":"Discovering functional interaction patterns in protein-protein interaction networks","publication_year":2008,"publication_date":"2008-06-11","ids":{"openalex":"https://openalex.org/W2045843285","doi":"https://doi.org/10.1186/1471-2105-9-276","mag":"2045843285","pmid":"https://pubmed.ncbi.nlm.nih.gov/18547430"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-276","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-276","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-276.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-276.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030955666","display_name":"Mehmet Emin Turanalp","orcid":null},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet E Turanalp","raw_affiliation_strings":["Department of Computer Engineering, Selcuk University, Alaaddin Keykubat Kampusu, 42075 Selcuklu, Konya, Turkey. eturanalp@selcuk.edu.tr","Department of Computer Engineering, Selcuk University, Alaaddin Keykubat Kampusu, Selcuklu, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Selcuk University, Alaaddin Keykubat Kampusu, 42075 Selcuklu, Konya, Turkey. eturanalp@selcuk.edu.tr","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"Department of Computer Engineering, Selcuk University, Alaaddin Keykubat Kampusu, Selcuklu, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045764563","display_name":"Tolga Can","orcid":"https://orcid.org/0000-0002-5532-0154"},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Tolga Can","raw_affiliation_strings":["Department of Computer Engineering, Middle East Technical University, Inonu Bulvari, 06531, Cankaya, Ankara, Turkey","Department of Computer Engineering, Middle East Technical University, Cankaya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Middle East Technical University, Inonu Bulvari, 06531, Cankaya, Ankara, Turkey","institution_ids":["https://openalex.org/I201799495"]},{"raw_affiliation_string":"Department of Computer Engineering, Middle East Technical University, Cankaya, Turkey","institution_ids":["https://openalex.org/I201799495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045764563"],"corresponding_institution_ids":["https://openalex.org/I201799495"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.7798,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70329105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"276","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-interaction-networks","display_name":"Protein Interaction Networks","score":0.7365530729293823},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6896659731864929},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6750401258468628},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.668926477432251},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.6505271196365356},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5965090990066528},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5883415937423706},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5250463485717773},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.5048604607582092},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4346684515476227},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.41204094886779785},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21570387482643127},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21199440956115723}],"concepts":[{"id":"https://openalex.org/C2909613950","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Protein Interaction Networks","level":3,"score":0.7365530729293823},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6896659731864929},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6750401258468628},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.668926477432251},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.6505271196365356},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5965090990066528},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5883415937423706},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5250463485717773},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.5048604607582092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4346684515476227},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.41204094886779785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21570387482643127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21199440956115723},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-9-276","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-276","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-276.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18547430","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18547430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:25fb01c01ec04ba3b6a08cafc6a3173c","is_oa":false,"landing_page_url":"https://doaj.org/article/25fb01c01ec04ba3b6a08cafc6a3173c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 276 (2008)","raw_type":"article"},{"id":"pmh:oai:open.metu.edu.tr:11511/47646","is_oa":true,"landing_page_url":"https://hdl.handle.net/11511/47646","pdf_url":null,"source":{"id":"https://openalex.org/S4306402495","display_name":"OpenMETU (Middle East Technical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201799495","host_organization_name":"Middle East Technical University","host_organization_lineage":["https://openalex.org/I201799495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2442100","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2442100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-276","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-276","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-9-276.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4723556032","display_name":"\u0130statistiksel metotlar ile genom-\u00f6l\u00e7ekli protein a\u011flar\u0131n\u0131n olu\u015fturulmas\u0131 ve analizi","funder_award_id":"106E128","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045843285.pdf","grobid_xml":"https://content.openalex.org/works/W2045843285.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1560734048","https://openalex.org/W1783384641","https://openalex.org/W1850739480","https://openalex.org/W1918391659","https://openalex.org/W1978920477","https://openalex.org/W2003652380","https://openalex.org/W2004734764","https://openalex.org/W2013502943","https://openalex.org/W2019827052","https://openalex.org/W2037036397","https://openalex.org/W2046618236","https://openalex.org/W2060460012","https://openalex.org/W2065304353","https://openalex.org/W2079007492","https://openalex.org/W2084619201","https://openalex.org/W2098045561","https://openalex.org/W2103017472","https://openalex.org/W2103165401","https://openalex.org/W2105597691","https://openalex.org/W2106336008","https://openalex.org/W2108150886","https://openalex.org/W2108544104","https://openalex.org/W2113654464","https://openalex.org/W2116447934","https://openalex.org/W2118446779","https://openalex.org/W2118781674","https://openalex.org/W2122345971","https://openalex.org/W2124354935","https://openalex.org/W2126359798","https://openalex.org/W2126969584","https://openalex.org/W2128674962","https://openalex.org/W2130687290","https://openalex.org/W2131456688","https://openalex.org/W2134046693","https://openalex.org/W2135526239","https://openalex.org/W2135805255","https://openalex.org/W2136316164","https://openalex.org/W2136760026","https://openalex.org/W2136850043","https://openalex.org/W2140412523","https://openalex.org/W2147405597","https://openalex.org/W2149310258","https://openalex.org/W2151176490","https://openalex.org/W2152495216","https://openalex.org/W2159482845","https://openalex.org/W2160556205","https://openalex.org/W2161644024","https://openalex.org/W2163736554","https://openalex.org/W2167869241","https://openalex.org/W2170726034","https://openalex.org/W2533430062","https://openalex.org/W4213245422","https://openalex.org/W4247469419","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W1987705964","https://openalex.org/W1841073402","https://openalex.org/W2045843285","https://openalex.org/W4377086792","https://openalex.org/W2414873431","https://openalex.org/W2949751838","https://openalex.org/W2145100112","https://openalex.org/W2137238644"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,108],"recent":[2],"years,":[3],"a":[4,41,119,136,149,207,237],"considerable":[5],"amount":[6],"of":[7,16,22,25,29,33,51,53,68,72,77,84,86,89,95,100,103,116,172,180,202,209,219,244,250],"research":[8,57],"effort":[9],"has":[10,61],"been":[11],"directed":[12],"to":[13,124],"the":[14,20,65,101,131,217,241],"analysis":[15,235],"biological":[17,43],"networks":[18,24,60,74,91,147,201],"with":[19],"availability":[21],"genome-scale":[23],"genes":[26],"and/or":[27],"proteins":[28,52,117],"an":[30,54,226,234],"increasing":[31],"number":[32,208],"organisms.":[34],"A":[35],"protein-protein":[36],"interaction":[37,128,190,213,223,253],"(PPI)":[38],"network":[39,44,121,229],"is":[40,177,255],"particular":[42],"which":[45],"represents":[46],"physical":[47],"interactions":[48],"between":[49],"pairs":[50],"organism.":[55],"Major":[56],"on":[58,63,199,240],"PPI":[59,69,73,90,120,146,200,228,245],"focused":[62],"understanding":[64],"topological":[66],"organization":[67,243],"networks,":[70],"evolution":[71],"and":[75,98,205],"identification":[76,140,153],"conserved":[78],"subnetworks":[79],"across":[80],"different":[81],"species,":[82],"discovery":[83,158],"modules":[85],"interaction,":[87],"use":[88],"for":[92,145,162,187],"functional":[93,114,132,189,212,222,252],"annotation":[94],"uncharacterized":[96],"proteins,":[97],"improvement":[99],"accuracy":[102],"currently":[104],"available":[105,256],"networks.":[106,246],"RESULTS:":[107],"this":[109],"article,":[110],"we":[111,185],"map":[112],"known":[113],"annotations":[115],"onto":[118],"in":[122,130,192,225],"order":[123],"identify":[125],"frequently":[126,210],"occurring":[127,211],"patterns":[129,191,224,254],"space.":[133],"We":[134,195],"propose":[135],"new":[137,238],"frequent":[138,151],"pattern":[139],"technique,":[141],"PPISpan,":[142,220],"adapted":[143],"specifically":[144],"from":[148],"well-known":[150],"subgraph":[152],"method,":[154],"gSpan.":[155],"Existing":[156],"module":[157],"techniques":[159],"either":[160],"look":[161,186],"specific":[163],"clique-like":[164],"highly":[165],"interacting":[166],"protein":[167],"clusters":[168,182],"or":[169,183],"linear":[170],"paths":[171],"interaction.":[173],"However,":[174],"our":[175],"goal":[176],"different;":[178],"instead":[179],"single":[181],"pathways,":[184],"recurring":[188,221],"arbitrary":[193],"topologies.":[194],"have":[196],"applied":[197],"PPISpan":[198],"Saccharomyces":[203],"cerevisiae":[204],"identified":[206,251],"patterns.":[214],"CONCLUSION:":[215],"With":[216],"help":[218],"organism's":[227],"can":[230],"be":[231],"identified.":[232],"Such":[233],"offers":[236],"perspective":[239],"modular":[242],"The":[247],"complete":[248],"list":[249],"at":[257],"http://bioserver.ceng.metu.edu.tr/PPISpan/.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}