{"id":"https://openalex.org/W1991057836","doi":"https://doi.org/10.1186/1471-2105-9-254","title":"New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background","display_name":"New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background","publication_year":2008,"publication_date":"2008-05-30","ids":{"openalex":"https://openalex.org/W1991057836","doi":"https://doi.org/10.1186/1471-2105-9-254","mag":"1991057836","pmid":"https://pubmed.ncbi.nlm.nih.gov/18513389"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-254","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-254","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-254","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067078296","display_name":"Silvana Penco","orcid":"https://orcid.org/0000-0003-1050-095X"},"institutions":[{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]},{"id":"https://openalex.org/I4210094195","display_name":"Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda","ror":"https://ror.org/00htrxv69","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094195"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvana Penco","raw_affiliation_strings":["Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca' Granda Hospital P.za Ospedale Maggiore 3, 20100 Milan, Italy. silvana.penco@ospedaleniguarda.it","Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca' Granda Hospital P.za Ospedale Maggiore 3, 20100 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca' Granda Hospital P.za Ospedale Maggiore 3, 20100 Milan, Italy. silvana.penco@ospedaleniguarda.it","institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210094195"]},{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca' Granda Hospital P.za Ospedale Maggiore 3, 20100 Milan, Italy","institution_ids":["https://openalex.org/I4210094195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021545379","display_name":"Massimo Buscema","orcid":"https://orcid.org/0000-0003-4356-0510"},"institutions":[{"id":"https://openalex.org/I4210104163","display_name":"Semeion Centro Ricerche di Scienze della Comunicazione","ror":"https://ror.org/01ac4hv54","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210104163"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Buscema","raw_affiliation_strings":["Semeion Research Center, Via Sersale 117, 00128, Rome, Italy","Semeion Research Center, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semeion Research Center, Via Sersale 117, 00128, Rome, Italy","institution_ids":["https://openalex.org/I4210104163"]},{"raw_affiliation_string":"Semeion Research Center, Rome, Italy","institution_ids":["https://openalex.org/I4210104163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029234307","display_name":"Maria Cristina Patrosso","orcid":null},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2803066834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Cristina Patrosso","raw_affiliation_strings":["Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca\u2019 Granda Hospital P.za Ospedale Maggiore 3, 20100, Milan, Italy","Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca\u2019 Granda Hospital P.za Ospedale Maggiore 3, 20100, Milan, Italy","institution_ids":["https://openalex.org/I2803066834","https://openalex.org/I4210087357"]},{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073113","display_name":"Alessandro Marocchi","orcid":null},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2803066834","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210087357","display_name":"Ospedale Maggiore","ror":"https://ror.org/0053ctp29","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087357"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Marocchi","raw_affiliation_strings":["Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca\u2019 Granda Hospital P.za Ospedale Maggiore 3, 20100, Milan, Italy","Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Niguarda Ca\u2019 Granda Hospital P.za Ospedale Maggiore 3, 20100, Milan, Italy","institution_ids":["https://openalex.org/I2803066834","https://openalex.org/I4210087357"]},{"raw_affiliation_string":"Medical Genetics, Clinical Chemistry and Clinical Pathology Laboratory, Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048150723","display_name":"Enzo Grossi","orcid":"https://orcid.org/0000-0003-0346-2684"},"institutions":[{"id":"https://openalex.org/I4210132761","display_name":"Bracco (Italy)","ror":"https://ror.org/03wjptj96","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210132761"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enzo Grossi","raw_affiliation_strings":["Bracco SpA Medical Department, Via E. Folli 50, 20134, Milan, Italy","Bracco SpA Medical Department, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bracco SpA Medical Department, Via E. Folli 50, 20134, Milan, Italy","institution_ids":["https://openalex.org/I4210132761"]},{"raw_affiliation_string":"Bracco SpA Medical Department, Milan, Italy","institution_ids":["https://openalex.org/I4210132761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067078296"],"corresponding_institution_ids":["https://openalex.org/I4210087357","https://openalex.org/I4210094195"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.7933,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84096985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"254","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7033184766769409},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"Amyotrophic lateral sclerosis","score":0.6813547611236572},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.4821602702140808},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4456602931022644},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43586140871047974},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3836992681026459},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3660184144973755},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3207830786705017},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.24595630168914795},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22255703806877136},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15033775568008423}],"concepts":[{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7033184766769409},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.6813547611236572},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.4821602702140808},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4456602931022644},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43586140871047974},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3836992681026459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3660184144973755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3207830786705017},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24595630168914795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22255703806877136},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15033775568008423}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-9-254","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-254","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-254","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18513389","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18513389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:dcb9853ca861482384367cf08bd1025a","is_oa":true,"landing_page_url":"https://doaj.org/article/dcb9853ca861482384367cf08bd1025a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 254 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2443147","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2443147","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-254","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-254","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-254","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.47999998927116394,"display_name":"Reduced inequalities"},{"id":"https://metadata.un.org/sdg/16","score":0.4099999964237213,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991057836.pdf","grobid_xml":"https://content.openalex.org/works/W1991057836.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W183625566","https://openalex.org/W1543480871","https://openalex.org/W1963577579","https://openalex.org/W1966170928","https://openalex.org/W1966360257","https://openalex.org/W1968177047","https://openalex.org/W1970923939","https://openalex.org/W1972482021","https://openalex.org/W1988583259","https://openalex.org/W1991426267","https://openalex.org/W2004508412","https://openalex.org/W2009969871","https://openalex.org/W2015288960","https://openalex.org/W2033356785","https://openalex.org/W2071510501","https://openalex.org/W2071921711","https://openalex.org/W2090302955","https://openalex.org/W2091548875","https://openalex.org/W2109353557","https://openalex.org/W2111605100","https://openalex.org/W2118259897","https://openalex.org/W2120807984","https://openalex.org/W2120966575","https://openalex.org/W2121632523","https://openalex.org/W2123779560","https://openalex.org/W2130271153","https://openalex.org/W2134099387","https://openalex.org/W2142830469","https://openalex.org/W2143662702","https://openalex.org/W2158743699","https://openalex.org/W2158787641","https://openalex.org/W2166226596","https://openalex.org/W2167277498","https://openalex.org/W2169493549","https://openalex.org/W2170108800","https://openalex.org/W2324160010","https://openalex.org/W2921140124","https://openalex.org/W3207342693","https://openalex.org/W4236884331","https://openalex.org/W4300402905"],"related_works":["https://openalex.org/W2070831599","https://openalex.org/W4206749202","https://openalex.org/W2154294661","https://openalex.org/W2393752460","https://openalex.org/W2048256717","https://openalex.org/W2059706093","https://openalex.org/W4292226083","https://openalex.org/W2970628625","https://openalex.org/W4387118726","https://openalex.org/W2775560057"],"abstract_inverted_index":{"BACKGROUND:":[0],"Few":[1],"genetic":[2,35,48,64,193,269,332,344],"factors":[3,37],"predisposing":[4,66],"to":[5,22,46,60,67,76,232,239,259,272,314],"the":[6,18,68,139,177,207,265,319,339],"sporadic":[7,106,196,335],"form":[8],"of":[9,42,88,94,119,141,157,179,190,206,255,267,321,334,341],"amyotrophic":[10],"lateral":[11],"sclerosis":[12],"(ALS)":[13],"have":[14,126,132,164,170],"been":[15,127,133,165,171],"identified,":[16],"but":[17],"pathology":[19],"itself":[20],"seems":[21],"be":[23],"a":[24,62,191,199,322,328,342],"true":[25],"multifactorial":[26],"disease":[27],"in":[28,104,195],"which":[29],"complex":[30,316],"interactions":[31],"between":[32],"environmental":[33],"and":[34,90,101,109,123,145,161,183,203,224,236,290,302,311],"susceptibility":[36],"take":[38],"place.":[39],"The":[40,129,167,216,244],"purpose":[41],"this":[43],"study":[44,307],"was":[45,74,214],"approach":[47,263,315],"data":[49,208],"with":[50,135,173,209,220,248],"an":[51,253,309],"innovative":[52],"statistical":[53,147,185],"method":[54,313,326],"such":[55],"as":[56],"artificial":[57,120,158,211,324],"neural":[58,121,143,159,181,212],"networks":[59,122,144,160,182,213],"identify":[61],"possible":[63],"background":[65,194],"disease.":[69],"A":[70],"DNA":[71,200],"multiarray":[72,201],"panel":[73,202],"applied":[75],"genotype":[77],"more":[78],"than":[79],"60":[80],"polymorphisms":[81],"within":[82],"35":[83],"genes":[84],"selected":[85],"from":[86,138,176,230,237,275],"pathways":[87],"lipid":[89],"homocysteine":[91],"metabolism,":[92],"regulation":[93],"blood":[95],"pressure,":[96],"coagulation,":[97],"inflammation,":[98],"cellular":[99],"adhesion":[100],"matrix":[102],"integrity,":[103],"54":[105],"ALS":[107,197,336],"patients":[108],"208":[110],"controls.":[111],"Advanced":[112,150,249],"intelligent":[113,151],"systems":[114,152],"based":[115,153],"on":[116,154],"novel":[117,155,323],"coupling":[118,156],"evolutionary":[124,162],"algorithms":[125,163],"applied.":[128,166],"results":[130,168],"obtained":[131,169,219,247],"compared":[134,172],"those":[136,174],"derived":[137,175],"use":[140,178],"standard":[142,180],"classical":[146,184],"analysis":[148],"RESULTS:":[149],"analysis.":[186],"An":[187],"unexpected":[188],"discovery":[189],"strong":[192,343],"using":[198],"analytical":[204],"processing":[205],"advanced":[210],"found.":[215],"predictive":[217],"accuracy":[218],"Linear":[221],"Discriminant":[222],"Analysis":[223],"Standard":[225],"Artificial":[226],"Neural":[227],"Networks":[228],"ranged":[229],"70%":[231],"79%":[233],"(average":[234,241],"75.31%)":[235],"69.1":[238],"86.2%":[240],"76.6%)":[242],"respectively.":[243],"corresponding":[245],"value":[246],"Intelligent":[250],"Systems":[251],"reached":[252],"average":[254],"96.0%":[256],"(range":[257],"94.4":[258],"97.6%).":[260],"This":[261,306],"latter":[262],"allowed":[264],"identification":[266],"seven":[268,296],"variants":[270],"essential":[271],"differentiate":[273],"cases":[274],"controls:":[276],"apolipoprotein":[277],"E":[278],"arg158cys;":[279],"hepatic":[280],"lipase":[281],"-480":[282],"C/T;":[283],"endothelial":[284],"nitric":[285],"oxide":[286],"synthase":[287],"690":[288],"C/T":[289],"glu298asp;":[291],"vitamin":[292],"K-dependent":[293],"coagulation":[294],"factor":[295],"arg353glu,":[297],"glycoprotein":[298],"Ia/IIa":[299],"873":[300],"G/A":[301],"E-selectin":[303],"ser128arg.":[304],"CONCLUSION:":[305],"provides":[308],"alternative":[310],"reliable":[312],"diseases.":[317],"Indeed,":[318],"application":[320],"intelligence-based":[325],"offers":[327],"new":[329],"insight":[330],"into":[331],"markers":[333],"pointing":[337],"out":[338],"existence":[340],"background.":[345]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
