{"id":"https://openalex.org/W2037373619","doi":"https://doi.org/10.1186/1471-2105-9-246","title":"Using the longest significance run to estimate region-specific p-values in genetic association mapping studies","display_name":"Using the longest significance run to estimate region-specific p-values in genetic association mapping studies","publication_year":2008,"publication_date":"2008-05-27","ids":{"openalex":"https://openalex.org/W2037373619","doi":"https://doi.org/10.1186/1471-2105-9-246","mag":"2037373619","pmid":"https://pubmed.ncbi.nlm.nih.gov/18503718"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-246","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-246","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-246","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-246","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065685048","display_name":"Ie\u2010Bin Lian","orcid":"https://orcid.org/0000-0003-3992-6049"},"institutions":[{"id":"https://openalex.org/I70522481","display_name":"National Changhua University of Education","ror":"https://ror.org/005gkfa10","country_code":"TW","type":"education","lineage":["https://openalex.org/I70522481"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ie-Bin Lian","raw_affiliation_strings":["1Department of Mathematics, National Changhua University of Education, Changhua 500, Taiwan. maiblian@cc.ncue.edu.tw","Department of Mathematics, National Changhua University of Education, Changhua, Taiwan"],"affiliations":[{"raw_affiliation_string":"1Department of Mathematics, National Changhua University of Education, Changhua 500, Taiwan. maiblian@cc.ncue.edu.tw","institution_ids":["https://openalex.org/I70522481"]},{"raw_affiliation_string":"Department of Mathematics, National Changhua University of Education, Changhua, Taiwan","institution_ids":["https://openalex.org/I70522481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103466949","display_name":"Yi-Hsien Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Hsien Lin","raw_affiliation_strings":["Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108619170","display_name":"Ying-Chao Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Chao Lin","raw_affiliation_strings":["Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Bioinformatics Program, Taiwan International Graduate Program, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Bioinformatics Program, Taiwan International Graduate Program, Taipei, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084398188","display_name":"Hsin\u2010Chou Yang","orcid":"https://orcid.org/0000-0001-6853-7881"},"institutions":[{"id":"https://openalex.org/I4210141710","display_name":"Institute of Statistical Science, Academia Sinica","ror":"https://ror.org/044gv5910","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210141710","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Chou Yang","raw_affiliation_strings":["Institute of Statistical Science, Academia Sinica, Taipei, 115, Taiwan","Institute of Statistical Science, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Statistical Science, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210141710"]},{"raw_affiliation_string":"Institute of Statistical Science, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210141710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078704171","display_name":"Chee\u2010Jen Chang","orcid":"https://orcid.org/0000-0002-7725-7555"},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chee-Jang Chang","raw_affiliation_strings":["Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Taoyuan, 333, Taiwan","\u2021 Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Taoyuan, 333, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"\u2021 Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028466052","display_name":"Cathy S.J. Fann","orcid":"https://orcid.org/0000-0001-9025-2276"},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cathy SJ Fann","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065685048"],"corresponding_institution_ids":["https://openalex.org/I70522481"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1905,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62481067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"1","first_page":"246","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.8718856573104858},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.8035808205604553},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.8024048805236816},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.5420388579368591},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.5184780955314636},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.5155794024467468},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"False positive rate","score":0.5040820837020874},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.48584625124931335},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4812200367450714},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4529586434364319},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4520941376686096},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4443434178829193},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.4107186794281006},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.402662992477417},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35144495964050293},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35119372606277466},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.310335248708725},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.28111159801483154},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23567447066307068},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.10803362727165222}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.8718856573104858},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.8035808205604553},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.8024048805236816},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.5420388579368591},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5184780955314636},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5155794024467468},{"id":"https://openalex.org/C95922358","wikidata":"https://www.wikidata.org/wiki/Q5432725","display_name":"False positive rate","level":2,"score":0.5040820837020874},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48584625124931335},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4812200367450714},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4529586434364319},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4520941376686096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4443434178829193},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.4107186794281006},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.402662992477417},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35144495964050293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35119372606277466},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.310335248708725},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.28111159801483154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23567447066307068},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.10803362727165222}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-9-246","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-246","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-246","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18503718","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18503718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:033a2381d6554e6093199e963c3e6bde","is_oa":true,"landing_page_url":"https://doaj.org/article/033a2381d6554e6093199e963c3e6bde","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 246 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2430975","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2430975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-246","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-246","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-246","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037373619.pdf","grobid_xml":"https://content.openalex.org/works/W2037373619.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1504510381","https://openalex.org/W1522239197","https://openalex.org/W1543868019","https://openalex.org/W1596515083","https://openalex.org/W1944558458","https://openalex.org/W1967668456","https://openalex.org/W1975709333","https://openalex.org/W1987680287","https://openalex.org/W1996509864","https://openalex.org/W2006142312","https://openalex.org/W2016258379","https://openalex.org/W2018823764","https://openalex.org/W2018983027","https://openalex.org/W2019854250","https://openalex.org/W2025143098","https://openalex.org/W2027748690","https://openalex.org/W2035836238","https://openalex.org/W2035848143","https://openalex.org/W2036306946","https://openalex.org/W2052182252","https://openalex.org/W2056859449","https://openalex.org/W2066874799","https://openalex.org/W2073116379","https://openalex.org/W2082122713","https://openalex.org/W2086242051","https://openalex.org/W2091734073","https://openalex.org/W2098611654","https://openalex.org/W2102945991","https://openalex.org/W2110065044","https://openalex.org/W2111050441","https://openalex.org/W2148911704","https://openalex.org/W2149512324","https://openalex.org/W2152664025","https://openalex.org/W2157862001","https://openalex.org/W2166349250","https://openalex.org/W2206749611","https://openalex.org/W4230225009"],"related_works":["https://openalex.org/W2093104131","https://openalex.org/W2333750400","https://openalex.org/W2467227750","https://openalex.org/W4293336298","https://openalex.org/W2178204436","https://openalex.org/W4300887971","https://openalex.org/W2104806243","https://openalex.org/W2106547200","https://openalex.org/W4212966421","https://openalex.org/W2093463665"],"abstract_inverted_index":{"The":[0],"proposed":[1],"LSR":[2,23],"method":[3,24],"provides":[4],"an":[5],"efficient":[6],"exploratory":[7],"tool":[8],"for":[9],"the":[10,22,35],"analysis":[11],"of":[12,14],"sequences":[13],"dense":[15],"genetic":[16],"markers.":[17],"Our":[18],"results":[19],"show":[20],"that":[21],"has":[25],"better":[26],"power":[27],"and":[28],"lower":[29],"false":[30],"discovery":[31],"rate":[32],"comparing":[33],"with":[34],"locus-specific":[36],"multiple":[37],"tests.":[38]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}