{"id":"https://openalex.org/W1993817351","doi":"https://doi.org/10.1186/1471-2105-9-238","title":"Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction","display_name":"Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction","publication_year":2008,"publication_date":"2008-05-16","ids":{"openalex":"https://openalex.org/W1993817351","doi":"https://doi.org/10.1186/1471-2105-9-238","mag":"1993817351","pmid":"https://pubmed.ncbi.nlm.nih.gov/18485205"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-238","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-238","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-238","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-238","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066140517","display_name":"William S. Bush","orcid":"https://orcid.org/0000-0002-9729-6519"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William S Bush","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. wbush@chgr.mc.vanderbilt.edu","Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. wbush@chgr.mc.vanderbilt.edu","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I200719446"]},{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I4210105714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004289607","display_name":"Todd L. Edwards","orcid":"https://orcid.org/0000-0003-4318-6119"},"institutions":[{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd L Edwards","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I4210105714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052578174","display_name":"Scott Dudek","orcid":"https://orcid.org/0000-0003-2904-3824"},"institutions":[{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M Dudek","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I4210105714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049579672","display_name":"Brett A. McKinney","orcid":"https://orcid.org/0000-0002-9494-8833"},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett A McKinney","raw_affiliation_strings":["Department of Genetics, University of Alabama School of Medicine, Birmingham, Alabama, USA","Department of Genetics, University of Alabama School of Medicine,Birmingham,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Alabama School of Medicine, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Genetics, University of Alabama School of Medicine,Birmingham,USA","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081769614","display_name":"Marylyn D. Ritchie","orcid":"https://orcid.org/0000-0002-1208-1720"},"institutions":[{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marylyn D Ritchie","raw_affiliation_strings":["Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA and","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585","https://openalex.org/I4210105714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066140517"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210105714","https://openalex.org/I901861585"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.0898,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.93998858,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"238","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9714999794960022,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9714999794960022,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.7620531320571899},{"id":"https://openalex.org/keywords/contingency-table","display_name":"Contingency table","score":0.6891027688980103},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.5925173759460449},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.5853289365768433},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.547286868095398},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4902677834033966},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.4771556258201599},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.46568694710731506},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4562160074710846},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4493671655654907},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38482028245925903},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.31320762634277344},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1774359941482544},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17568305134773254},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1690765619277954},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1530369520187378}],"concepts":[{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.7620531320571899},{"id":"https://openalex.org/C91998498","wikidata":"https://www.wikidata.org/wiki/Q1541178","display_name":"Contingency table","level":2,"score":0.6891027688980103},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.5925173759460449},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.5853289365768433},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.547286868095398},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4902677834033966},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.4771556258201599},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.46568694710731506},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4562160074710846},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4493671655654907},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38482028245925903},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.31320762634277344},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1774359941482544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17568305134773254},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1690765619277954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1530369520187378},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014894","descriptor_name":"Weights and Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014894","descriptor_name":"Weights and Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014894","descriptor_name":"Weights and Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-9-238","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-238","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-238","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18485205","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18485205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:aa24b243569548cfb7d252d6bb78b3c1","is_oa":true,"landing_page_url":"https://doaj.org/article/aa24b243569548cfb7d252d6bb78b3c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 238 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2412877","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2412877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-238","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-238","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-238","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1097375383","display_name":null,"funder_award_id":"AG20135","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1993817351.pdf","grobid_xml":"https://content.openalex.org/works/W1993817351.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W392423658","https://openalex.org/W1524761913","https://openalex.org/W1554403518","https://openalex.org/W1588282782","https://openalex.org/W1887790309","https://openalex.org/W1966315117","https://openalex.org/W1966360257","https://openalex.org/W1976634586","https://openalex.org/W1987389174","https://openalex.org/W1988550919","https://openalex.org/W1990748933","https://openalex.org/W1993537263","https://openalex.org/W1994050986","https://openalex.org/W2020066516","https://openalex.org/W2031648200","https://openalex.org/W2033393393","https://openalex.org/W2040709122","https://openalex.org/W2043192290","https://openalex.org/W2050301854","https://openalex.org/W2059208857","https://openalex.org/W2064539914","https://openalex.org/W2075454710","https://openalex.org/W2079951177","https://openalex.org/W2083944388","https://openalex.org/W2084150578","https://openalex.org/W2085739707","https://openalex.org/W2085989833","https://openalex.org/W2089112228","https://openalex.org/W2102109283","https://openalex.org/W2102898385","https://openalex.org/W2104605543","https://openalex.org/W2115268776","https://openalex.org/W2124023336","https://openalex.org/W2131878646","https://openalex.org/W2152575748","https://openalex.org/W2154572047","https://openalex.org/W2164145253","https://openalex.org/W2166336042","https://openalex.org/W2170913656","https://openalex.org/W2171800571","https://openalex.org/W2303043072","https://openalex.org/W2338857253","https://openalex.org/W2898106971","https://openalex.org/W2912485311","https://openalex.org/W4230581167","https://openalex.org/W4297572109"],"related_works":["https://openalex.org/W4386773228","https://openalex.org/W3003558595","https://openalex.org/W2752163332","https://openalex.org/W3195675344","https://openalex.org/W2044363112","https://openalex.org/W2130566053","https://openalex.org/W2018863440","https://openalex.org/W2137338763","https://openalex.org/W3113118296","https://openalex.org/W2096599016"],"abstract_inverted_index":{"BACKGROUND:":[0],"Multifactor":[1],"Dimensionality":[2],"Reduction":[3],"(MDR)":[4],"has":[5,241],"been":[6,243],"introduced":[7],"previously":[8],"as":[9,62,80,245],"a":[10,20,81,102,122,235,246],"non-parametric":[11],"statistical":[12],"method":[13],"for":[14,126,249],"detecting":[15,250],"gene-gene":[16,95,251],"interactions.":[17],"MDR":[18,92,120,217],"performs":[19],"dimensional":[21],"reduction":[22],"by":[23,43,97],"assigning":[24],"multi-locus":[25,236],"genotypes":[26],"to":[27,87,93,105],"either":[28],"high-":[29],"or":[30,65,155],"low-risk":[31],"groups":[32],"and":[33,39,71,75,117,157,176,188,202,214],"measuring":[34],"the":[35,47,56,63,89,115,137,143,151,158,162,195,199,212,229,257],"percentage":[36],"of":[37,52,91,119,124,139,150,161,216,231,259],"cases":[38,74],"controls":[40,76],"incorrectly":[41,72],"labelled":[42,73],"this":[44,111],"classification":[45,48,58,99,184,223],"-":[46,146,165],"error.":[49,224],"The":[50,69],"combination":[51],"variables":[53,233],"that":[54,209],"produces":[55],"lowest":[57],"error":[59,100,185],"is":[60],"selected":[61],"best":[64],"most":[66],"fit":[67],"model.":[68,237],"correctly":[70],"can":[77,253],"be":[78,254],"expressed":[79],"two-way":[82,127],"contingency":[83,128],"table.":[84],"We":[85,131],"sought":[86],"improve":[88,211],"ability":[90],"detect":[94],"interactions":[96],"replacing":[98],"with":[101,256],"different":[103],"measure":[104],"score":[106],"model":[107,144,163],"quality.":[108],"RESULTS:":[109],"In":[110],"study,":[112],"we":[113],"compare":[114],"detection":[116,168,178,182,190,213],"power":[118,215],"using":[121,169,183,222],"variety":[123],"measures":[125,197,208,226],"table":[129],"analysis.":[130],"simulated":[132,219],"40":[133],"genetic":[134],"models,":[135,175],"varying":[136],"number":[138],"disease":[140,152],"loci":[141,153],"in":[142,218,234],"(2":[145],"5),":[147],"allele":[148],"frequencies":[149],"(.2/.8":[154],".4/.6)":[156],"broad-sense":[159],"heritability":[160],"(.05":[164],".3).":[166],"Overall,":[167],"NMI":[170],"was":[171,179,191],"65.36%":[172],"across":[173],"all":[174],"specific":[177,189],"59.4%":[180],"versus":[181],"at":[186],"62%":[187],"52.2%.":[192],"CONCLUSION:":[193],"Of":[194],"10":[196],"evaluated,":[198],"likelihood":[200],"ratio":[201],"normalized":[203],"mutual":[204],"information":[205],"(NMI)":[206],"are":[207],"consistently":[210],"data":[220],"over":[221],"These":[225],"also":[227],"reduce":[228],"inclusion":[230],"spurious":[232],"Thus,":[238],"MDR,":[239],"which":[240],"already":[242],"demonstrated":[244],"powerful":[247],"tool":[248],"interactions,":[252],"improved":[255],"use":[258],"alternative":[260],"fitness":[261],"functions.":[262]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
