{"id":"https://openalex.org/W1988785484","doi":"https://doi.org/10.1186/1471-2105-9-204","title":"Major copy proportion analysis of tumor samples using SNP arrays","display_name":"Major copy proportion analysis of tumor samples using SNP arrays","publication_year":2008,"publication_date":"2008-04-21","ids":{"openalex":"https://openalex.org/W1988785484","doi":"https://doi.org/10.1186/1471-2105-9-204","mag":"1988785484","pmid":"https://pubmed.ncbi.nlm.nih.gov/18426588"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-204","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-204","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-204","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038883988","display_name":"Li Cheng","orcid":"https://orcid.org/0000-0001-5173-5056"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheng Li","raw_affiliation_strings":["Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, 3 Blackfan Circle, Boston, MA 02115, USA. cli@hsph.harvard.edu","Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, 3 Blackfan Circle, Boston, MA 02115, USA. cli@hsph.harvard.edu","institution_ids":["https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Departments of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041980697","display_name":"Rameen Beroukhim","orcid":"https://orcid.org/0000-0001-6303-3609"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rameen Beroukhim","raw_affiliation_strings":["Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","Broad Institute of Harvard and MIT, Cambridge, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053012736","display_name":"Barbara A. Weir","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara A Weir","raw_affiliation_strings":["Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","Broad Institute of Harvard and MIT, Cambridge, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078967801","display_name":"Wendy Winckler","orcid":"https://orcid.org/0009-0008-9893-9652"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Winckler","raw_affiliation_strings":["Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","Broad Institute of Harvard and MIT, Cambridge, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055048393","display_name":"Levi A. Garraway","orcid":"https://orcid.org/0000-0003-3739-0471"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levi A Garraway","raw_affiliation_strings":["Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","Broad Institute of Harvard and MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057346782","display_name":"William R. Sellers","orcid":"https://orcid.org/0000-0002-3539-9803"},"institutions":[{"id":"https://openalex.org/I1309400984","display_name":"Boston Biomedical Research Institute","ror":"https://ror.org/04rqpth59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1309400984"]},{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R Sellers","raw_affiliation_strings":["Novartis Institutes of BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA","Novartis Institutes of Biomedical Research, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes of BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I1309400984","https://openalex.org/I4210117619"]},{"raw_affiliation_string":"Novartis Institutes of Biomedical Research, Cambridge, USA","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056373767","display_name":"Matthew Meyerson","orcid":"https://orcid.org/0000-0002-9133-8108"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Meyerson","raw_affiliation_strings":["Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","Broad Institute of Harvard and MIT, Cambridge, USA","Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, MA, 02141, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney St., Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Deparment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5038883988"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210134579"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.6174,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94894163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"204","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9797000288963318,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9797000288963318,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6242727041244507},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6117634773254395},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5992785692214966},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5658037066459656},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5366501212120056},{"id":"https://openalex.org/keywords/snp-array","display_name":"SNP array","score":0.4764269292354584},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.34759336709976196},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.1546396017074585},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15312498807907104},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08907634019851685}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6242727041244507},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6117634773254395},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5992785692214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5658037066459656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5366501212120056},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.4764269292354584},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.34759336709976196},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1546396017074585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15312498807907104},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08907634019851685}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-9-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-204","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-204","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18426588","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18426588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/4889440","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4889440","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:857c1f5e0f3d409b931802b7e1cae9fa","is_oa":false,"landing_page_url":"https://doaj.org/article/857c1f5e0f3d409b931802b7e1cae9fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 204 (2008)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/58684","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/58684","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central Ltd","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2375907","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2375907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-204","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-204","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-204","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3861104527","display_name":null,"funder_award_id":"1P50 CA090578","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5120804435","display_name":null,"funder_award_id":"P50 CA090578","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7558449095","display_name":null,"funder_award_id":"K08 CA122833","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G766505551","display_name":null,"funder_award_id":"R01 HG002341","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8785456675","display_name":null,"funder_award_id":"CA090578","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8886392624","display_name":null,"funder_award_id":"5R01 HG002341","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988785484.pdf","grobid_xml":"https://content.openalex.org/works/W1988785484.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1501095088","https://openalex.org/W1512173429","https://openalex.org/W1708068686","https://openalex.org/W1963916765","https://openalex.org/W1970761420","https://openalex.org/W1992249022","https://openalex.org/W1999486841","https://openalex.org/W2001627828","https://openalex.org/W2001931464","https://openalex.org/W2009570821","https://openalex.org/W2033041275","https://openalex.org/W2036662022","https://openalex.org/W2038437697","https://openalex.org/W2054193808","https://openalex.org/W2066721762","https://openalex.org/W2072854915","https://openalex.org/W2096916467","https://openalex.org/W2101510083","https://openalex.org/W2104224322","https://openalex.org/W2104241530","https://openalex.org/W2110227850","https://openalex.org/W2113574907","https://openalex.org/W2113784410","https://openalex.org/W2114044152","https://openalex.org/W2116753165","https://openalex.org/W2118411662","https://openalex.org/W2122410503","https://openalex.org/W2124873881","https://openalex.org/W2125255775","https://openalex.org/W2143362349","https://openalex.org/W2147696849","https://openalex.org/W2149681218","https://openalex.org/W2150703778","https://openalex.org/W2151595196","https://openalex.org/W2155707112","https://openalex.org/W2161810908","https://openalex.org/W2796856748","https://openalex.org/W3102508024","https://openalex.org/W4238573378"],"related_works":["https://openalex.org/W2164855536","https://openalex.org/W1997352593","https://openalex.org/W2143489661","https://openalex.org/W2070581548","https://openalex.org/W4281711902","https://openalex.org/W3206555169","https://openalex.org/W3016573916","https://openalex.org/W2329144129","https://openalex.org/W2410422322","https://openalex.org/W2966739945"],"abstract_inverted_index":{"BACKGROUND:":[0],"Single":[1],"nucleotide":[2],"polymorphisms":[3],"(SNPs)":[4],"are":[5,16,207],"the":[6,12,192,211],"most":[7],"common":[8],"genetic":[9],"variations":[10],"in":[11,41,210],"human":[13,34],"genome":[14],"and":[15,36,43,64,70,73,80,107,116,128,132,145,151,175,188,204],"useful":[17],"as":[18],"genomic":[19],"markers.":[20],"Oligonucleotide":[21],"SNP":[22,57,89,119],"microarrays":[23],"have":[24,37,48],"been":[25,38],"developed":[26],"for":[27,60,141],"high-throughput":[28],"genotyping":[29],"of":[30,87,185,194,197],"up":[31],"to":[32,55,96,122,171,179],"900,000":[33],"SNPs":[35],"used":[39,50,111],"widely":[40],"linkage":[42],"cancer":[44],"genomics":[45],"studies.":[46],"We":[47,78,110],"previously":[49],"Hidden":[51],"Markov":[52],"Models":[53],"(HMM)":[54],"analyze":[56],"array":[58,90,120],"data":[59],"inferring":[61],"copy":[62,83,129,153,181],"numbers":[63],"loss-of-heterozygosity":[65],"(LOH)":[66],"from":[67,101,159],"paired":[68],"normal":[69,146,187],"tumor":[71,75,168,189,199],"samples":[72,190],"unpaired":[74],"samples.":[76,148,200],"RESULTS:":[77],"proposed":[79],"implemented":[81],"major":[82,150],"proportion":[84],"(MCP)":[85],"analysis":[86,125,140,170,174,184,196,203],"oligonucleotide":[88],"data.":[91],"A":[92],"HMM":[93],"was":[94],"constructed":[95],"infer":[97],"unobserved":[98],"MCP":[99,124,135,163,166,183,195],"states":[100],"observed":[102],"allele-specific":[103],"signals":[104],"through":[105],"emission":[106],"transition":[108],"distributions.":[109],"10":[112],"K,":[113],"100":[114],"K":[115,118],"250":[117],"datasets":[121],"compare":[123],"with":[126],"LOH":[127,139,169],"number":[130],"analysis,":[131],"showed":[133],"that":[134],"performs":[136],"better":[137],"than":[138],"allelic-imbalanced":[142,160],"chromosome":[143],"regions":[144,161],"contaminated":[147],"The":[149,201],"minor":[152],"alleles":[154],"can":[155],"also":[156],"be":[157],"inferred":[158],"by":[162],"analysis.":[164],"CONCLUSION:":[165],"extends":[167],"allelic":[172],"imbalance":[173],"supplies":[176],"complementary":[177],"information":[178],"total":[180],"numbers.":[182],"mixing":[186],"suggests":[191],"utility":[193],"normal-contaminated":[198],"described":[202],"visualization":[205],"methods":[206],"readily":[208],"available":[209],"user-friendly":[212],"dChip":[213],"software.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}