{"id":"https://openalex.org/W1972831383","doi":"https://doi.org/10.1186/1471-2105-9-140","title":"Normalization of oligonucleotide arrays based on the least-variant set of genes","display_name":"Normalization of oligonucleotide arrays based on the least-variant set of genes","publication_year":2008,"publication_date":"2008-03-05","ids":{"openalex":"https://openalex.org/W1972831383","doi":"https://doi.org/10.1186/1471-2105-9-140","mag":"1972831383","pmid":"https://pubmed.ncbi.nlm.nih.gov/18318917"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010513681","display_name":"Stefano Calza","orcid":"https://orcid.org/0000-0003-4996-7995"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT","SE"],"is_corresponding":false,"raw_author_name":"Stefano Calza","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. calza@med.unibs.it","Department of Biomedical Sciences and Biotechnology, University of Brescia, , Italy","Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. calza@med.unibs.it","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Biomedical Sciences and Biotechnology, University of Brescia, , Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025616611","display_name":"Davide Valentini","orcid":"https://orcid.org/0000-0002-6771-7175"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Davide Valentini","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012606625","display_name":"Yudi Pawitan","orcid":"https://orcid.org/0000-0003-0324-7052"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Yudi Pawitan","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012606625"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.3869,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.88148507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"140","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.8981899619102478},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5543644428253174},{"id":"https://openalex.org/keywords/housekeeping-gene","display_name":"Housekeeping gene","score":0.5236080288887024},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4569677412509918},{"id":"https://openalex.org/keywords/database-normalization","display_name":"Database normalization","score":0.4148303270339966},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38810494542121887},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38360005617141724},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.35952028632164},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3395461440086365},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3199479281902313},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.316244512796402},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28638651967048645},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2376704216003418},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.14393001794815063}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.8981899619102478},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5543644428253174},{"id":"https://openalex.org/C33922130","wikidata":"https://www.wikidata.org/wiki/Q419232","display_name":"Housekeeping gene","level":4,"score":0.5236080288887024},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4569677412509918},{"id":"https://openalex.org/C162984825","wikidata":"https://www.wikidata.org/wiki/Q339072","display_name":"Database normalization","level":3,"score":0.4148303270339966},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38810494542121887},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38360005617141724},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35952028632164},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3395461440086365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3199479281902313},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.316244512796402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28638651967048645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2376704216003418},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14393001794815063},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-9-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18318917","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18318917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:700b4edb4e86472593b8320aaedca59c","is_oa":true,"landing_page_url":"https://doaj.org/article/700b4edb4e86472593b8320aaedca59c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 140 (2008)","raw_type":"article"},{"id":"pmh:oai:iris.unibs.it:11379/24107","is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/24107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2324100","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2324100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-140","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-140","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-140","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1972831383.pdf","grobid_xml":"https://content.openalex.org/works/W1972831383.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1482401268","https://openalex.org/W1502713942","https://openalex.org/W1527271891","https://openalex.org/W1606576385","https://openalex.org/W1945743004","https://openalex.org/W1986080495","https://openalex.org/W2038437697","https://openalex.org/W2056541273","https://openalex.org/W2056818201","https://openalex.org/W2063862573","https://openalex.org/W2069225806","https://openalex.org/W2081098333","https://openalex.org/W2100668965","https://openalex.org/W2109453886","https://openalex.org/W2112017685","https://openalex.org/W2112982595","https://openalex.org/W2118160663","https://openalex.org/W2119274294","https://openalex.org/W2120865735","https://openalex.org/W2130301347","https://openalex.org/W2133111499","https://openalex.org/W2135401714","https://openalex.org/W2140774750","https://openalex.org/W2145879504","https://openalex.org/W2149697028","https://openalex.org/W2166059867","https://openalex.org/W2170989872","https://openalex.org/W2332516757","https://openalex.org/W2489822048","https://openalex.org/W4241653265","https://openalex.org/W4243634040","https://openalex.org/W4399637561"],"related_works":["https://openalex.org/W4241705247","https://openalex.org/W2145362441","https://openalex.org/W2101622345","https://openalex.org/W3134304369","https://openalex.org/W1982601504","https://openalex.org/W2582603276","https://openalex.org/W2175373041","https://openalex.org/W4386281023","https://openalex.org/W4312138714","https://openalex.org/W2096302356"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2,68,77,107,134,184],"well":[3],"known":[4],"that":[5,76,149],"the":[6,16,39,42,82,95,102,110,157,164,172],"normalization":[7,20,53,74,151,154],"step":[8],"of":[9,38,44,57,81,94,99,115],"microarray":[10],"data":[11],"makes":[12],"a":[13,47,73,88,125,129],"difference":[14],"in":[15,28,46,109,186],"downstream":[17],"analysis.":[18],"All":[19],"methods":[21,54,155],"rely":[22],"on":[23,92],"certain":[24],"assumptions,":[25],"so":[26],"differences":[27],"results":[29],"can":[30],"be":[31],"traced":[32],"to":[33,36,71,136,171],"different":[34],"sensitivities":[35],"violation":[37,80],"assumptions.":[40],"Illustrating":[41],"lack":[43],"robustness,":[45],"striking":[48],"spike-in":[49,166],"experiment":[50],"all":[51],"existing":[52,138],"fail":[55],"because":[56],"an":[58],"imbalance":[59],"between":[60],"up-":[61],"and":[62],"down-regulated":[63],"genes.":[64],"This":[65],"means":[66],"it":[67],"still":[69],"important":[70],"develop":[72,87],"method":[75,133],"robust":[78,111],"against":[79],"standard":[83,158],"assumptions":[84,159],"RESULTS:":[85],"We":[86,147],"new":[89],"algorithm":[90],"based":[91],"identification":[93],"least-variant":[96],"set":[97,127],"(LVS)":[98],"genes":[100,120],"across":[101],"arrays.":[103],"The":[104,119,132],"array-to-array":[105],"variation":[106],"evaluated":[108],"linear":[112],"model":[113],"fit":[114],"pre-normalized":[116],"probe-level":[117],"data.":[118],"are":[121,160],"then":[122],"used":[123],"as":[124,142],"reference":[126],"for":[128],"non-linear":[130],"normalization.":[131,178],"applicable":[135],"any":[137],"expression":[139],"summaries,":[140],"such":[141],"MAS5":[143],"or":[144],"RMA.":[145],"CONCLUSION:":[146],"show":[148],"LVS":[150,168],"outperforms":[152],"other":[153],"when":[156],"not":[161],"satisfied.":[162],"In":[163],"complex":[165],"study,":[167],"performs":[169],"similarly":[170],"ideal":[173],"(in":[174],"practice":[175],"unknown)":[176],"housekeeping-gene":[177],"An":[179],"R":[180],"package":[181],"called":[182],"lvs":[183],"available":[185],"http://www.meb.ki.se/~yudpaw.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}