{"id":"https://openalex.org/W1974436271","doi":"https://doi.org/10.1186/1471-2105-9-110","title":"SPIKE \u2013 a database, visualization and analysis tool of cellular signaling pathways","display_name":"SPIKE \u2013 a database, visualization and analysis tool of cellular signaling pathways","publication_year":2008,"publication_date":"2008-02-20","ids":{"openalex":"https://openalex.org/W1974436271","doi":"https://doi.org/10.1186/1471-2105-9-110","mag":"1974436271","pmid":"https://pubmed.ncbi.nlm.nih.gov/18289391"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-9-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-110","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-110","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043516734","display_name":"Ran Elkon","orcid":"https://orcid.org/0000-0003-3440-1286"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ran Elkon","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. ranel@post.tau.ac.il","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. ranel@post.tau.ac.il","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063624596","display_name":"Rita Vesterman","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rita Vesterman","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019933547","display_name":"Nira Amit","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nira Amit","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088681851","display_name":"Igor Ulitsky","orcid":"https://orcid.org/0000-0003-0555-6561"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Igor Ulitsky","raw_affiliation_strings":["School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","School of Computer Science Tel Aviv University Tel Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"School of Computer Science Tel Aviv University Tel Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065009968","display_name":"Idan Zohar","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Idan Zohar","raw_affiliation_strings":["School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","School of Computer Science Tel Aviv University Tel Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"School of Computer Science Tel Aviv University Tel Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053221914","display_name":"Mali Weisz","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mali Weisz","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019907390","display_name":"Gilad Mass","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gilad Mass","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075833913","display_name":"Nir Orlev","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nir Orlev","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056860053","display_name":"Giora Sternberg","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Giora Sternberg","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012596437","display_name":"Ran Blekhman","orcid":"https://orcid.org/0000-0003-3218-613X"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Ran Blekhman","raw_affiliation_strings":["Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","Department of Human Genetics, University of Chicago, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005360401","display_name":"Jackie Assa","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jackie Assa","raw_affiliation_strings":["School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","School of Computer Science Tel Aviv University Tel Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"School of Computer Science Tel Aviv University Tel Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086398854","display_name":"Yosef Shiloh","orcid":"https://orcid.org/0000-0002-1538-6060"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yosef Shiloh","raw_affiliation_strings":["The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038806020","display_name":"Ron Shamir","orcid":"https://orcid.org/0000-0003-1889-9870"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ron Shamir","raw_affiliation_strings":["School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","School of Computer Science Tel Aviv University Tel Aviv Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Tel Aviv University, Tel Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"School of Computer Science Tel Aviv University Tel Aviv Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5038806020"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.5273,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.88992399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"110","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9233999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9233999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6475011110305786},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.6320353150367737},{"id":"https://openalex.org/keywords/upload","display_name":"Upload","score":0.5842908620834351},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.496235191822052},{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.4846135079860687},{"id":"https://openalex.org/keywords/data-visualization","display_name":"Data visualization","score":0.4652021825313568},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4286264479160309},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.42309021949768066},{"id":"https://openalex.org/keywords/pace","display_name":"Pace","score":0.4142327308654785},{"id":"https://openalex.org/keywords/human\u2013computer-interaction","display_name":"Human\u2013computer interaction","score":0.3350023627281189},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.29388970136642456},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.26757729053497314},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2376590371131897},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20664018392562866},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.1341225504875183}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6475011110305786},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.6320353150367737},{"id":"https://openalex.org/C71901391","wikidata":"https://www.wikidata.org/wiki/Q7126699","display_name":"Upload","level":2,"score":0.5842908620834351},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.496235191822052},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.4846135079860687},{"id":"https://openalex.org/C172367668","wikidata":"https://www.wikidata.org/wiki/Q6504956","display_name":"Data visualization","level":3,"score":0.4652021825313568},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4286264479160309},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.42309021949768066},{"id":"https://openalex.org/C2777526511","wikidata":"https://www.wikidata.org/wiki/Q691543","display_name":"Pace","level":2,"score":0.4142327308654785},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3350023627281189},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29388970136642456},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.26757729053497314},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2376590371131897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20664018392562866},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.1341225504875183},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D003628","descriptor_name":"Database Management Systems","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-9-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-110","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-110","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18289391","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18289391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f4e1c2a6c64b4c38811228c45adc4c4f","is_oa":true,"landing_page_url":"https://doaj.org/article/f4e1c2a6c64b4c38811228c45adc4c4f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 9, Iss 1, p 110 (2008)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2263022","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2263022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-9-110","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-9-110","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-9-110","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1974436271.pdf","grobid_xml":"https://content.openalex.org/works/W1974436271.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1876024155","https://openalex.org/W1989684700","https://openalex.org/W1994803330","https://openalex.org/W1999994899","https://openalex.org/W2000752368","https://openalex.org/W2001964005","https://openalex.org/W2005602200","https://openalex.org/W2021239799","https://openalex.org/W2028044172","https://openalex.org/W2045478141","https://openalex.org/W2049483248","https://openalex.org/W2097407024","https://openalex.org/W2097698606","https://openalex.org/W2101181377","https://openalex.org/W2107580398","https://openalex.org/W2110699703","https://openalex.org/W2113024448","https://openalex.org/W2121905803","https://openalex.org/W2123280311","https://openalex.org/W2128036243","https://openalex.org/W2137672139","https://openalex.org/W2140863273","https://openalex.org/W2142237411","https://openalex.org/W2147714160","https://openalex.org/W2153624566","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2162853466","https://openalex.org/W4213060373","https://openalex.org/W4255855797","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2386723501","https://openalex.org/W2387879414","https://openalex.org/W2390304029","https://openalex.org/W2354923724","https://openalex.org/W2146830340","https://openalex.org/W4288601434","https://openalex.org/W2377101853","https://openalex.org/W2362180844","https://openalex.org/W1484449898","https://openalex.org/W2889493020"],"abstract_inverted_index":{"BACKGROUND:":[0],"Biological":[1],"signaling":[2,73,87,223],"pathways":[3],"that":[4,111,139,164,177],"govern":[5],"cellular":[6],"physiology":[7],"form":[8],"an":[9,25],"intricate":[10],"web":[11],"of":[12,33,72,85,104,116,125,206,212,222,228],"tightly":[13],"regulated":[14],"interlocking":[15],"processes.":[16],"Data":[17],"on":[18,56,131,230],"these":[19,34],"regulatory":[20,117],"networks":[21,142,224,232],"are":[22,67],"accumulating":[23],"at":[24],"unprecedented":[26],"pace.":[27],"The":[28,209],"assimilation,":[29],"visualization":[30,109],"and":[31,44,95,123,128,152,158,186,225],"interpretation":[32],"data":[35,96,130,170,202],"have":[36],"become":[37],"a":[38,57,155,161,184,216],"major":[39],"challenge":[40],"in":[41,120,194,203],"biological":[42,86],"research,":[43],"once":[45],"met,":[46],"will":[47,180],"greatly":[48],"boost":[49],"our":[50],"ability":[51],"to":[52,168,171],"understand":[53],"cell":[54],"functioning":[55],"systems":[58],"level.":[59],"RESULTS:":[60],"To":[61],"cope":[62],"with":[63,233],"this":[64],"challenge,":[65],"we":[66],"developing":[68],"the":[69,93,105,121,132,141,178,195,220,226],"SPIKE":[70,75,172,213],"knowledge-base":[71],"pathways.":[74,88],"contains":[76],"three":[77],"main":[78],"software":[79],"components:":[80],"1)":[81],"A":[82,108],"database":[83],"(DB)":[84],"Carefully":[89],"curated":[90],"information":[91],"from":[92,97],"literature":[94],"large":[98],"public":[99],"sources":[100],"constitute":[101],"distinct":[102],"tiers":[103],"DB.":[106,173],"2)":[107],"package":[110],"allows":[112,165],"interactive":[113],"graphic":[114],"representations":[115],"interactions":[118],"stored":[119],"DB":[122,179],"superposition":[124],"functional":[126,145],"genomic":[127],"proteomic":[129],"maps.":[133],"3)":[134],"An":[135],"algorithmic":[136],"inference":[137],"engine":[138],"analyzes":[140],"for":[143,219],"novel":[144],"interplays":[146],"between":[147],"network":[148],"components.SPIKE":[149],"is":[150,176],"designed":[151],"implemented":[153],"as":[154],"community":[156],"tool":[157],"therefore":[159],"provides":[160],"user-friendly":[162],"interface":[163],"registered":[166],"users":[167],"upload":[169],"Our":[174],"vision":[175],"be":[181],"populated":[182],"by":[183,191],"distributed":[185],"highly":[187],"collaborative":[188],"effort":[189],"undertaken":[190],"multiple":[192],"groups":[193],"research":[196],"community,":[197],"where":[198],"each":[199],"group":[200],"contributes":[201],"its":[204],"field":[205],"expertise.":[207],"CONCLUSION:":[208],"integrated":[210],"capabilities":[211],"make":[214],"it":[215],"powerful":[217],"platform":[218],"analysis":[221],"integration":[227],"knowledge":[229],"such":[231],"omics":[234],"data.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}
