{"id":"https://openalex.org/W2032757954","doi":"https://doi.org/10.1186/1471-2105-8-73","title":"Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases","display_name":"Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases","publication_year":2007,"publication_date":"2007-03-05","ids":{"openalex":"https://openalex.org/W2032757954","doi":"https://doi.org/10.1186/1471-2105-8-73","mag":"2032757954"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-73","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-73","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-73","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113528023","display_name":"Karolina L. Tkaczuk","orcid":null},"institutions":[{"id":"https://openalex.org/I188884621","display_name":"Lodz University of Technology","ror":"https://ror.org/00s8fpf52","country_code":"PL","type":"education","lineage":["https://openalex.org/I188884621"]},{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]},{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Karolina L Tkaczuk","raw_affiliation_strings":["Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Technical University of Lodz, Stefanowskiego 4/10 St., PL- 90-924, Lodz, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Technical University of Lodz, Lodz, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Technical University of Lodz, Stefanowskiego 4/10 St., PL- 90-924, Lodz, Poland","institution_ids":["https://openalex.org/I34250744","https://openalex.org/I188884621"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Technical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I34250744","https://openalex.org/I188884621"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072592637","display_name":"Stanis\u0142aw Dunin-Horkawicz","orcid":"https://orcid.org/0000-0002-4581-1558"},"institutions":[{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Stanislaw Dunin-Horkawicz","raw_affiliation_strings":["Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland,"],"affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland,","institution_ids":["https://openalex.org/I4210120699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000130184","display_name":"El\u017cbieta Purta","orcid":"https://orcid.org/0000-0003-0960-548X"},"institutions":[{"id":"https://openalex.org/I4210128244","display_name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences","ror":"https://ror.org/034tvp782","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210128244","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Elzbieta Purta","raw_affiliation_strings":["Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a St., PL-02-106, Warsaw, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a St., PL-02-106, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210128244"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003280938","display_name":"Janusz M. Bujnicki","orcid":"https://orcid.org/0000-0002-6633-165X"},"institutions":[{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]},{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Janusz M Bujnicki","raw_affiliation_strings":["Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Umultowska 89, PL-61-614, Poznan, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Umultowska 89, PL-61-614, Poznan, Poland","institution_ids":["https://openalex.org/I59411706"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4 St., PL-02-109, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland","institution_ids":["https://openalex.org/I59411706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113528023"],"corresponding_institution_ids":["https://openalex.org/I188884621","https://openalex.org/I34250744","https://openalex.org/I4210120699"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.2439,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.96493914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.8398351669311523},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.7062833905220032},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.6584265232086182},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6469365358352661},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.6115380525588989},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.5841822028160095},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.5430727005004883},{"id":"https://openalex.org/keywords/threading","display_name":"Threading (protein sequence)","score":0.511532187461853},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4961114823818207},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.492546409368515},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.49193906784057617},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.4704282283782959},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.43286484479904175},{"id":"https://openalex.org/keywords/structural-alignment","display_name":"Structural alignment","score":0.43251746892929077},{"id":"https://openalex.org/keywords/protein-family","display_name":"Protein family","score":0.4261506497859955},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.4256446361541748},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"Homology modeling","score":0.42517516016960144},{"id":"https://openalex.org/keywords/superfamily","display_name":"SUPERFAMILY","score":0.4222835898399353},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.41362541913986206},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.31678569316864014},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.29265254735946655},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22334742546081543},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07301369309425354}],"concepts":[{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.8398351669311523},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.7062833905220032},{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.6584265232086182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6469365358352661},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.6115380525588989},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5841822028160095},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.5430727005004883},{"id":"https://openalex.org/C200307862","wikidata":"https://www.wikidata.org/wiki/Q7797175","display_name":"Threading (protein sequence)","level":3,"score":0.511532187461853},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4961114823818207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.492546409368515},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.49193906784057617},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4704282283782959},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.43286484479904175},{"id":"https://openalex.org/C4668613","wikidata":"https://www.wikidata.org/wiki/Q4116110","display_name":"Structural alignment","level":5,"score":0.43251746892929077},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.4261506497859955},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.4256446361541748},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.42517516016960144},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.4222835898399353},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.41362541913986206},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31678569316864014},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.29265254735946655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22334742546081543},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07301369309425354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2105-8-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-73","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-73","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e443b9928d994bf897545d57de68ce1f","is_oa":true,"landing_page_url":"https://doaj.org/article/e443b9928d994bf897545d57de68ce1f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 73 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1829167","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1829167","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-73","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-73","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-73","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G4467077504","display_name":null,"funder_award_id":"AI056034","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032757954.pdf","grobid_xml":"https://content.openalex.org/works/W2032757954.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W10876090","https://openalex.org/W50988404","https://openalex.org/W1011130015","https://openalex.org/W1480395323","https://openalex.org/W1519266993","https://openalex.org/W1569208976","https://openalex.org/W1583586808","https://openalex.org/W1601234927","https://openalex.org/W1627086342","https://openalex.org/W1652248213","https://openalex.org/W1711482514","https://openalex.org/W1783714080","https://openalex.org/W1965517743","https://openalex.org/W1971596502","https://openalex.org/W1972433022","https://openalex.org/W1977738109","https://openalex.org/W1978683810","https://openalex.org/W1981026353","https://openalex.org/W1981575795","https://openalex.org/W1984451904","https://openalex.org/W1985595125","https://openalex.org/W1991962290","https://openalex.org/W1996135412","https://openalex.org/W1996186501","https://openalex.org/W1997637252","https://openalex.org/W1998300401","https://openalex.org/W1999653273","https://openalex.org/W2002266033","https://openalex.org/W2003852785","https://openalex.org/W2004228538","https://openalex.org/W2005568256","https://openalex.org/W2006178602","https://openalex.org/W2007905902","https://openalex.org/W2013404472","https://openalex.org/W2013734705","https://openalex.org/W2014521800","https://openalex.org/W2015642465","https://openalex.org/W2018073387","https://openalex.org/W2018207366","https://openalex.org/W2022058405","https://openalex.org/W2026478054","https://openalex.org/W2030748296","https://openalex.org/W2036370308","https://openalex.org/W2037913221","https://openalex.org/W2046192291","https://openalex.org/W2047446171","https://openalex.org/W2047603136","https://openalex.org/W2050679015","https://openalex.org/W2052885644","https://openalex.org/W2053621743","https://openalex.org/W2054113027","https://openalex.org/W2059324241","https://openalex.org/W2059837038","https://openalex.org/W2060804379","https://openalex.org/W2061678041","https://openalex.org/W2062123114","https://openalex.org/W2062166748","https://openalex.org/W2069923579","https://openalex.org/W2071241692","https://openalex.org/W2071637074","https://openalex.org/W2072871227","https://openalex.org/W2072948654","https://openalex.org/W2082388363","https://openalex.org/W2084466582","https://openalex.org/W2086591998","https://openalex.org/W2086779374","https://openalex.org/W2089859866","https://openalex.org/W2093822336","https://openalex.org/W2096495474","https://openalex.org/W2100071542","https://openalex.org/W2102041979","https://openalex.org/W2104759327","https://openalex.org/W2106066024","https://openalex.org/W2106692939","https://openalex.org/W2109806386","https://openalex.org/W2110863368","https://openalex.org/W2115713787","https://openalex.org/W2116709001","https://openalex.org/W2116774744","https://openalex.org/W2125725297","https://openalex.org/W2126149511","https://openalex.org/W2130280638","https://openalex.org/W2132740573","https://openalex.org/W2132926880","https://openalex.org/W2133168873","https://openalex.org/W2136495792","https://openalex.org/W2136765832","https://openalex.org/W2138872556","https://openalex.org/W2139582206","https://openalex.org/W2140074311","https://openalex.org/W2141885858","https://openalex.org/W2142125112","https://openalex.org/W2143210482","https://openalex.org/W2144483796","https://openalex.org/W2144998676","https://openalex.org/W2145268834","https://openalex.org/W2146058063","https://openalex.org/W2146396346","https://openalex.org/W2153187042","https://openalex.org/W2155606054","https://openalex.org/W2157206486","https://openalex.org/W2158714788","https://openalex.org/W2158985494","https://openalex.org/W2159099958","https://openalex.org/W2162739292","https://openalex.org/W2164843630","https://openalex.org/W2166718648","https://openalex.org/W2166972165","https://openalex.org/W2172242080","https://openalex.org/W2188699182","https://openalex.org/W2479345183","https://openalex.org/W4210400672","https://openalex.org/W6603431814"],"related_works":["https://openalex.org/W1994518388","https://openalex.org/W1989090710","https://openalex.org/W24291664","https://openalex.org/W1741740882","https://openalex.org/W4246922469","https://openalex.org/W2040198144","https://openalex.org/W2044284701","https://openalex.org/W2075451741","https://openalex.org/W2980805969","https://openalex.org/W2070693796"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"SPOUT":[2,51,119,145,169,212,223,262,306,325,373],"methyltransferases":[3],"(MTases)":[4],"are":[5,268],"a":[6,19,173,231,366],"large":[7],"class":[8],"of":[9,34,58,78,105,107,116,132,168,189,198,210,221,241,260,265,299,317,328,352,362,372,377,383],"S-adenosyl-L-methionine-dependent":[10],"enzymes":[11],"that":[12,310,332],"exhibit":[13],"an":[14],"unusual":[15],"alpha/beta":[16],"fold":[17],"with":[18,230],"very":[20],"deep":[21],"topological":[22],"knot.":[23],"In":[24,343],"2001,":[25],"when":[26],"no":[27,74],"crystal":[28,56],"structures":[29,57,109],"were":[30],"available":[31],"for":[32,155,177,234,369],"any":[33],"these":[35,79,266],"proteins,":[36],"Anantharaman,":[37],"Koonin,":[38],"and":[39,45,48,64,91,94,110,121,137,147,152,171,201,237,243,248,273,275,301,339,355,375],"Aravind":[40],"identified":[41,118,253],"homology":[42],"between":[43,304],"SpoU":[44],"TrmD":[46],"MTases":[47,60,170,331,374],"defined":[49],"the":[50,71,144,156,165,178,186,190,207,211,217,222,261,297,311,350,353,381],"superfamily.":[52,191,213,263],"Since":[53],"then,":[54],"multiple":[55,174],"knotted":[59],"have":[61,162,193],"been":[62,82,282,293],"solved":[63],"numerous":[65],"new":[66,232,258],"homologous":[67],"sequences":[68,111],"appeared":[69],"in":[70,245,285,380],"databases.":[72],"However,":[73],"comprehensive":[75,367],"comparative":[76],"analysis":[77,364],"proteins":[80],"has":[81,281,292],"carried":[83,101],"out":[84,102,334],"to":[85,95,112,122,205],"classify":[86],"them":[87],"based":[88],"on":[89,128,296,349],"structural":[90],"evolutionary":[92,208],"criteria":[93],"guide":[96],"functional":[97,250,378],"predictions.":[98],"Results":[99],"We":[100,161,192,215,252],"extensive":[103],"searches":[104],"databases":[106],"protein":[108,255],"collect":[113],"all":[114,305,318],"members":[115,259],"previously":[117,124],"MTases,":[120],"identify":[123],"unknown":[125],"homologs.":[126],"Based":[127,295],"sequence":[129,175,242],"clustering,":[130],"characterization":[131,371],"domain":[133],"architecture,":[134],"structure":[135,244],"predictions":[136],"sequence/structure":[138],"comparisons,":[139],"we":[140,184,308,346],"re-defined":[141],"families":[142,256,267,307],"within":[143],"superfamily":[146,224],"predicted":[148],"putative":[149],"active":[150],"sites":[151],"biochemical":[153,290],"functions":[154],"so":[157],"far":[158],"uncharacterized":[159,270],"members.":[160],"also":[163,194,347],"delineated":[164],"common":[166],"core":[167],"inferred":[172],"alignment":[176],"conserved":[179],"knot":[180,354],"region,":[181],"from":[182],"which":[183],"calculated":[185],"phylogenetic":[187,196,219],"tree":[188,220],"studied":[195],"distribution":[197],"different":[199,246],"families,":[200,247],"used":[202],"this":[203,344],"information":[204],"infer":[206],"history":[209],"Conclusion":[214],"present":[216],"first":[218],"since":[225],"it":[226],"was":[227],"defined,":[228],"together":[229],"scheme":[233],"its":[235,289],"classification,":[236],"discussion":[238],"about":[239],"conservation":[240],"their":[249],"implications.":[251],"four":[254],"as":[257],"Three":[264],"functionally":[269],"(COG1772,":[271],"COG1901,":[272],"COG4080),":[274],"one":[276],"(COG1756":[277],"represented":[278],"by":[279],"Nep1p)":[280],"already":[283],"implicated":[284],"RNA":[286,330],"metabolism,":[287],"but":[288],"function":[291],"unknown.":[294],"inference":[298],"orthologous":[300],"paralogous":[302],"relationships":[303],"propose":[309,356],"Last":[312],"Universal":[313],"Common":[314],"Ancestor":[315],"(LUCA)":[316],"extant":[319],"organisms":[320],"contained":[321],"at":[322],"least":[323],"three":[324],"members,":[326],"ancestors":[327],"contemporary":[329],"carry":[333],"m":[335],"1":[336],"G,":[337],"m3U,":[338],"2'O-ribose":[340],"methylation,":[341],"respectively.":[342],"work":[345],"speculate":[348],"origin":[351],"possible":[357],"'unknotted'":[358],"ancestors.":[359],"The":[360],"results":[361],"our":[363],"provide":[365],"'roadmap'":[368],"experimental":[370],"interpretation":[376],"studies":[379],"light":[382],"sequence-structure":[384],"relationships.":[385]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
