{"id":"https://openalex.org/W1786194602","doi":"https://doi.org/10.1186/1471-2105-8-41","title":"FUNC: a package for detecting significant associations between gene sets and ontological annotations","display_name":"FUNC: a package for detecting significant associations between gene sets and ontological annotations","publication_year":2007,"publication_date":"2007-02-06","ids":{"openalex":"https://openalex.org/W1786194602","doi":"https://doi.org/10.1186/1471-2105-8-41","mag":"1786194602","pmid":"https://pubmed.ncbi.nlm.nih.gov/17284313"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-41","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009866023","display_name":"Kay Pr\u00fcfer","orcid":"https://orcid.org/0000-0001-6242-3058"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kay Pr\u00fcfer","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany. pruefer@eva.mpg.de","Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany. pruefer@eva.mpg.de","institution_ids":["https://openalex.org/I4210118560"]},{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031322683","display_name":"Bjoern Muetzel","orcid":"https://orcid.org/0000-0003-2991-8096"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bjoern Muetzel","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100884221","display_name":"Hong-Hai Do","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hong-Hai Do","raw_affiliation_strings":["Interdisciplinary Center for Bioinformatics, University of Leipzig, H\u00e4rtelstr. 16-18, D-04107, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Center for Bioinformatics, University of Leipzig, H\u00e4rtelstr. 16-18, D-04107, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003462114","display_name":"G\u00fcnter Wei\u00df","orcid":"https://orcid.org/0000-0003-0709-2158"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunter Weiss","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044447616","display_name":"Philipp Khaitovich","orcid":"https://orcid.org/0000-0002-4305-0054"},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Philipp Khaitovich","raw_affiliation_strings":["Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China","Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210106477"]},{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075756237","display_name":"Erhard Rahm","orcid":"https://orcid.org/0000-0002-2665-1114"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erhard Rahm","raw_affiliation_strings":["Interdisciplinary Center for Bioinformatics, University of Leipzig, H\u00e4rtelstr. 16-18, D-04107, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Center for Bioinformatics, University of Leipzig, H\u00e4rtelstr. 16-18, D-04107, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012216367","display_name":"Svante P\u00e4\u00e4bo","orcid":"https://orcid.org/0000-0002-4670-6311"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Svante P\u00e4\u00e4bo","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019027915","display_name":"Michael Lachmann","orcid":"https://orcid.org/0000-0002-1086-9717"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Lachmann","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010791096","display_name":"Wolfgang Enard","orcid":"https://orcid.org/0000-0002-4056-0550"},"institutions":[{"id":"https://openalex.org/I4210118560","display_name":"Max Planck Institute for Evolutionary Anthropology","ror":"https://ror.org/02a33b393","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210118560"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Enard","raw_affiliation_strings":["Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210118560"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009866023"],"corresponding_institution_ids":["https://openalex.org/I4210118560"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1110,"currency":"EUR","value_usd":1197},"fwci":4.3969,"has_fulltext":true,"cited_by_count":188,"citation_normalized_percentile":{"value":0.95181819,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8400999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8400999903678894,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6202375888824463},{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.5694832801818848},{"id":"https://openalex.org/keywords/gene-annotation","display_name":"Gene Annotation","score":0.519635796546936},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5190873146057129},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.48908597230911255},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.48614975810050964},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.46943023800849915},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.46355903148651123},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.42166274785995483},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.3645687699317932},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.362932413816452},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.323733925819397},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22178080677986145},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18079745769500732},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10693231225013733},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.10508263111114502},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08547741174697876}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6202375888824463},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.5694832801818848},{"id":"https://openalex.org/C2908923196","wikidata":"https://www.wikidata.org/wiki/Q5205742","display_name":"Gene Annotation","level":4,"score":0.519635796546936},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5190873146057129},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.48908597230911255},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.48614975810050964},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.46943023800849915},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.46355903148651123},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.42166274785995483},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3645687699317932},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.362932413816452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.323733925819397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22178080677986145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18079745769500732},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10693231225013733},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.10508263111114502},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08547741174697876},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2105-8-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17284313","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17284313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pure.mpg.de:item_1554941","is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-000F-FFAE-F","pdf_url":"http://hdl.handle.net/11858/00-001M-0000-000F-FFAE-F","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1fbed935d68b49cd9e17ab44018c6f81","is_oa":false,"landing_page_url":"https://doaj.org/article/1fbed935d68b49cd9e17ab44018c6f81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 41 (2007)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:334157","is_oa":false,"landing_page_url":"http://edoc.mpg.de/334157","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, v.8 (2007)","raw_type":"Article"},{"id":"pmh:oai:lips.informatik.uni-leipzig.de:1870","is_oa":false,"landing_page_url":"http://lips.informatik.uni-leipzig.de/?q=node/1870","pdf_url":null,"source":{"id":"https://openalex.org/S4377196964","display_name":"Publikation Server (Leipzig University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I926574661","host_organization_name":"Leipzig University","host_organization_lineage":["https://openalex.org/I926574661"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 2007, 8:41","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:1800870","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-41","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-41","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-41","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1786194602.pdf","grobid_xml":"https://content.openalex.org/works/W1786194602.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1535641839","https://openalex.org/W1596515083","https://openalex.org/W1689369637","https://openalex.org/W1847694155","https://openalex.org/W1963916765","https://openalex.org/W1970129369","https://openalex.org/W1982603712","https://openalex.org/W2010888033","https://openalex.org/W2030923426","https://openalex.org/W2046875666","https://openalex.org/W2056179629","https://openalex.org/W2058846847","https://openalex.org/W2065702910","https://openalex.org/W2075844835","https://openalex.org/W2098647860","https://openalex.org/W2099889778","https://openalex.org/W2102992354","https://openalex.org/W2103017472","https://openalex.org/W2107268689","https://openalex.org/W2108819945","https://openalex.org/W2110065044","https://openalex.org/W2113381189","https://openalex.org/W2115759361","https://openalex.org/W2116525802","https://openalex.org/W2120024428","https://openalex.org/W2123106337","https://openalex.org/W2124388496","https://openalex.org/W2127833142","https://openalex.org/W2130410032","https://openalex.org/W2134121810","https://openalex.org/W2138247507","https://openalex.org/W2139036189","https://openalex.org/W2139703939","https://openalex.org/W2151763757","https://openalex.org/W2152545090","https://openalex.org/W2167119716","https://openalex.org/W2796856748","https://openalex.org/W4213387068"],"related_works":["https://openalex.org/W2189374991","https://openalex.org/W2171537806","https://openalex.org/W2164883151","https://openalex.org/W2967275775","https://openalex.org/W2112871141","https://openalex.org/W2136890152","https://openalex.org/W2107952955","https://openalex.org/W2122634659","https://openalex.org/W2900623522","https://openalex.org/W2095370181"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genome-wide":[1],"expression,":[2],"sequence":[3,118],"and":[4,20,30,48,55,91,104,140,155,172],"association":[5],"studies":[6],"typically":[7],"yield":[8],"large":[9],"sets":[10,43,103],"of":[11,60,72,121,133,137,147,161],"gene":[12,42,102],"candidates,":[13],"which":[14],"must":[15],"then":[16],"be":[17,52],"further":[18],"analysed":[19],"interpreted.":[21],"Information":[22],"about":[23],"these":[24],"genes":[25],"is":[26,64,152,165],"increasingly":[27],"being":[28],"captured":[29],"organized":[31],"in":[32,57,111],"ontologies,":[33],"such":[34,73],"as":[35],"the":[36,41,58,69,85,122,126,134,138,145,148,159,169],"Gene":[37],"Ontology.":[38],"Relationships":[39],"between":[40,101],"identified":[44],"by":[45],"experimental":[46],"methods":[47,96],"biological":[49],"knowledge":[50],"can":[51],"made":[53],"explicit":[54],"used":[56],"interpretation":[59],"results.":[61,149],"However,":[62],"it":[63],"often":[65],"difficult":[66],"to":[67,97,143],"assess":[68],"statistical":[70],"significance":[71,136],"analyses":[74],"since":[75],"many":[76],"inter-dependent":[77],"categories":[78],"are":[79,108],"tested":[80],"simultaneously.":[81],"RESULTS:":[82],"We":[83],"developed":[84],"program":[86],"package":[87],"FUNC":[88,151],"that":[89],"includes":[90],"expands":[92],"on":[93],"currently":[94],"available":[95,167],"identify":[98],"significant":[99],"associations":[100],"ontological":[105],"annotations.":[106],"Implemented":[107],"several":[109],"tests":[110],"particular":[112],"well":[113],"suited":[114],"for":[115,158],"genome":[116],"wide":[117],"comparisons,":[119],"estimates":[120],"family-wise":[123],"error":[124],"rate,":[125,129],"false":[127],"discovery":[128],"a":[130,153,176],"sensitive":[131],"estimator":[132],"global":[135],"results":[139],"an":[141],"algorithm":[142],"reduce":[144],"complexity":[146],"CONCLUSION:":[150],"versatile":[154],"useful":[156],"tool":[157],"analysis":[160],"genome-wide":[162],"data.":[163],"It":[164],"freely":[166],"under":[168],"GPL":[170],"license":[171],"also":[173],"accessible":[174],"via":[175],"web":[177],"service.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":15}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}