{"id":"https://openalex.org/W2087240661","doi":"https://doi.org/10.1186/1471-2105-8-408","title":"Growing functional modules from a seed protein via integration of protein interaction and gene expression data","display_name":"Growing functional modules from a seed protein via integration of protein interaction and gene expression data","publication_year":2007,"publication_date":"2007-10-23","ids":{"openalex":"https://openalex.org/W2087240661","doi":"https://doi.org/10.1186/1471-2105-8-408","mag":"2087240661","pmid":"https://pubmed.ncbi.nlm.nih.gov/17956603"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-408","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-408","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-408","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052903619","display_name":"Ioannis A. Maraziotis","orcid":null},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis A Maraziotis","raw_affiliation_strings":["Department of Medical Physics, School of Medicine, University of Patras, GR26500 Patras, Greece. imarazi@heart.med.upatras.gr","Department of Medical Physics School of Medicine, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, School of Medicine, University of Patras, GR26500 Patras, Greece. imarazi@heart.med.upatras.gr","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Department of Medical Physics School of Medicine, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089495557","display_name":"Konstantina Dimitrakopoulou","orcid":"https://orcid.org/0000-0001-7159-0093"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantina Dimitrakopoulou","raw_affiliation_strings":["Department of Medical Physics, School of Medicine, University of Patras, GR26500, Patras, Greece","Department of Medical Physics School of Medicine, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, School of Medicine, University of Patras, GR26500, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Department of Medical Physics School of Medicine, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080347335","display_name":"Anastasios Bezerianos","orcid":"https://orcid.org/0000-0002-8199-6000"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Anastasios Bezerianos","raw_affiliation_strings":["Department of Medical Physics, School of Medicine, University of Patras, GR26500, Patras, Greece","Department of Medical Physics School of Medicine, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, School of Medicine, University of Patras, GR26500, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]},{"raw_affiliation_string":"Department of Medical Physics School of Medicine, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080347335"],"corresponding_institution_ids":["https://openalex.org/I174878644"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":2.6402,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.90196457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"408","last_page":"408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5688443779945374},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5643001198768616},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.5443288087844849},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5108048915863037},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.49423936009407043},{"id":"https://openalex.org/keywords/mathematical-proof","display_name":"Mathematical proof","score":0.4811788499355316},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.46642810106277466},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.46012139320373535},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4598582088947296},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.41824251413345337},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4151104688644409},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3921215534210205},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2372722327709198},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21026942133903503}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5688443779945374},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5643001198768616},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.5443288087844849},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5108048915863037},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.49423936009407043},{"id":"https://openalex.org/C108710211","wikidata":"https://www.wikidata.org/wiki/Q11538","display_name":"Mathematical proof","level":2,"score":0.4811788499355316},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.46642810106277466},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.46012139320373535},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4598582088947296},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.41824251413345337},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4151104688644409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3921215534210205},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2372722327709198},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21026942133903503},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-8-408","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-408","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-408","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17956603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17956603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/177988","is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/177988","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20201031","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:00352a0a10cf484ca916dc020c9fd8ba","is_oa":false,"landing_page_url":"https://doaj.org/article/00352a0a10cf484ca916dc020c9fd8ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 408 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1832693","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2233647","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-408","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-408","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-408","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2087240661.pdf"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1644749979","https://openalex.org/W1918391659","https://openalex.org/W1932560099","https://openalex.org/W1967638691","https://openalex.org/W1970156673","https://openalex.org/W1971227936","https://openalex.org/W1984220047","https://openalex.org/W1999154602","https://openalex.org/W2031098293","https://openalex.org/W2031119996","https://openalex.org/W2033141310","https://openalex.org/W2035469525","https://openalex.org/W2035895822","https://openalex.org/W2037036397","https://openalex.org/W2038920443","https://openalex.org/W2053677366","https://openalex.org/W2060705109","https://openalex.org/W2061439657","https://openalex.org/W2063847889","https://openalex.org/W2065304353","https://openalex.org/W2081931663","https://openalex.org/W2084619201","https://openalex.org/W2088139821","https://openalex.org/W2096501714","https://openalex.org/W2100585269","https://openalex.org/W2100628741","https://openalex.org/W2100874612","https://openalex.org/W2103453943","https://openalex.org/W2108735638","https://openalex.org/W2109145995","https://openalex.org/W2113654464","https://openalex.org/W2115159360","https://openalex.org/W2119043225","https://openalex.org/W2121507105","https://openalex.org/W2123733630","https://openalex.org/W2123781000","https://openalex.org/W2124166542","https://openalex.org/W2127886165","https://openalex.org/W2136850043","https://openalex.org/W2137917513","https://openalex.org/W2138003801","https://openalex.org/W2138582694","https://openalex.org/W2150566147","https://openalex.org/W2150926065","https://openalex.org/W2152495216","https://openalex.org/W2159518929","https://openalex.org/W2162142896","https://openalex.org/W2164954378","https://openalex.org/W2165364443","https://openalex.org/W2167869241","https://openalex.org/W2172049947","https://openalex.org/W3036819080"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4386628104","https://openalex.org/W4206945140","https://openalex.org/W2509687359","https://openalex.org/W4212865750","https://openalex.org/W2362023034","https://openalex.org/W2063941210"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nowadays":[1],"modern":[2],"biology":[3],"aims":[4],"at":[5,46],"unravelling":[6],"the":[7,15,24,30,50,57,88,100,109,118,126,135,139,168,172,196],"strands":[8],"of":[9,26,32,59,67,90,111,120,159,171,198,223],"complex":[10],"biological":[11],"structures":[12],"such":[13],"as":[14,132,189,226,228],"protein-protein":[16],"interaction":[17,113],"(PPI)":[18],"networks.":[19],"A":[20],"key":[21],"concept":[22,197],"in":[23,37,77,156,220],"organization":[25],"PPI":[27,136,141],"networks":[28,48],"is":[29,130],"existence":[31],"dense":[33],"subnetworks":[34,52],"(functional":[35],"modules)":[36],"them.":[38],"In":[39,99],"recent":[40],"approaches":[41],"clustering":[42],"algorithms":[43,69],"were":[44,53],"applied":[45],"these":[47,68],"and":[49,94,114,138,195],"resulting":[51],"evaluated":[54],"by":[55,175],"estimating":[56],"coverage":[58],"well-established":[60],"protein":[61,112,179,187],"complexes":[62],"they":[63],"contained.":[64],"However,":[65],"most":[66],"elaborate":[70],"on":[71,209],"an":[72,164],"unweighted":[73],"graph":[74,142,174],"structure":[75],"which":[76,181],"turn":[78],"fails":[79],"to":[80,87,145,216],"elevate":[81],"those":[82],"interactions":[83],"that":[84,107,166,212],"would":[85],"contribute":[86],"construction":[89],"biologically":[91,121],"more":[92],"valid":[93,122],"coherent":[95],"functional":[96,123,154,169,203,229],"modules.":[97,124,204],"RESULTS:":[98],"current":[101],"study,":[102],"we":[103,162],"present":[104,163],"a":[105,177,184],"method":[106,214],"corroborates":[108],"integration":[110],"microarray":[115],"data":[116,194,211],"via":[117],"discovery":[119],"Initially":[125],"gene":[127],"expression":[128],"information":[129],"overlaid":[131],"weights":[133],"onto":[134],"network":[137],"enriched":[140],"allows":[143],"us":[144],"exploit":[146],"its":[147],"topological":[148],"aspects,":[149],"while":[150],"simultaneously":[151],"highlights":[152],"enhanced":[153],"association":[155],"specific":[157],"pairs":[158],"proteins.":[160],"Then":[161],"algorithm":[165],"unveils":[167],"modules":[170],"weighted":[173],"expanding":[176],"kernel":[178],"set,":[180],"originates":[182],"from":[183],"given":[185],"'seed'":[186],"used":[188],"starting-point.":[190],"CONCLUSION:":[191],"The":[192],"integrated":[193],"our":[199,213],"approach":[200],"provide":[201],"reliable":[202],"We":[205],"give":[206,217],"proofs":[207],"based":[208],"yeast":[210],"manages":[215],"accurate":[218],"results":[219],"terms":[221],"both":[222],"structural":[224],"coherency,":[225],"well":[227],"consistency.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":11}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}