{"id":"https://openalex.org/W1588012429","doi":"https://doi.org/10.1186/1471-2105-8-376","title":"Single TNF\u03b1 trimers mediating NF-\u03ba B activation: stochastic robustness of NF-\u03ba B signaling","display_name":"Single TNF\u03b1 trimers mediating NF-\u03ba B activation: stochastic robustness of NF-\u03ba B signaling","publication_year":2007,"publication_date":"2007-10-09","ids":{"openalex":"https://openalex.org/W1588012429","doi":"https://doi.org/10.1186/1471-2105-8-376","mag":"1588012429","pmid":"https://pubmed.ncbi.nlm.nih.gov/17925009"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-376","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-376","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/1471-2105-8-376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024103451","display_name":"Tomasz Lipniacki","orcid":"https://orcid.org/0000-0002-3488-2561"},"institutions":[{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Tomasz Lipniacki","raw_affiliation_strings":["Institute of Fundamental Technological Research, Swietokrzyska 21, 00-049 Warsaw, Poland. tlipnia@ippt.gov.pl","Institute of Fundamental Technological Research, Swietokrzyska 21, 00-049, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental Technological Research, Swietokrzyska 21, 00-049 Warsaw, Poland. tlipnia@ippt.gov.pl","institution_ids":["https://openalex.org/I4210119410"]},{"raw_affiliation_string":"Institute of Fundamental Technological Research, Swietokrzyska 21, 00-049, Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007617587","display_name":"Krzysztof Puszy\u0144ski","orcid":"https://orcid.org/0000-0002-5546-4916"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof Puszynski","raw_affiliation_strings":["Institute of Automation, Silesian Technical University, 44-100, Gliwice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Automation, Silesian Technical University, 44-100, Gliwice, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090742668","display_name":"Pawel Paszek","orcid":"https://orcid.org/0000-0002-0363-0716"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Pawel Paszek","raw_affiliation_strings":["Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown St., University of Liverpool, Liverpool, L69 7ZB, UK","Department of Statistics, Rice University, 6100 Main St. MS-138, Houston, TX, 77005, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Cell Imaging, School of Biological Sciences, Bioscience Research Building, Crown St., University of Liverpool, Liverpool, L69 7ZB, UK","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Department of Statistics, Rice University, 6100 Main St. MS-138, Houston, TX, 77005, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056656832","display_name":"Allan R. Brasier","orcid":"https://orcid.org/0000-0002-5012-4090"},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan R Brasier","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555-1060, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555-1060, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071222148","display_name":"Marek Kimmel","orcid":"https://orcid.org/0000-0001-8161-890X"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marek Kimmel","raw_affiliation_strings":["Department of Statistics, Rice University, 6100 Main St. MS-138, Houston, TX, 77005, USA","Institute of Automation, Silesian Technical University, 44-100, Gliwice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rice University, 6100 Main St. MS-138, Houston, TX, 77005, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Institute of Automation, Silesian Technical University, 44-100, Gliwice, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024103451"],"corresponding_institution_ids":["https://openalex.org/I4210119410"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.9898,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.87885329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"376","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6186044812202454},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6063202023506165},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6012129187583923},{"id":"https://openalex.org/keywords/nf-\u03bab","display_name":"NF-\u03baB","score":0.5678125619888306},{"id":"https://openalex.org/keywords/tumor-necrosis-factor-alpha","display_name":"Tumor necrosis factor alpha","score":0.49875330924987793},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.498185396194458},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.4736391603946686},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.46882981061935425},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4639856815338135},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.4623165726661682},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4386017918586731},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4307515025138855},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42331042885780334},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.27886050939559937},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22909939289093018}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6186044812202454},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6063202023506165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6012129187583923},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5678125619888306},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.49875330924987793},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.498185396194458},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4736391603946686},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46882981061935425},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4639856815338135},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4623165726661682},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4386017918586731},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4307515025138855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42331042885780334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27886050939559937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22909939289093018}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-8-376","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-376","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17925009","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17925009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2222661","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2222661","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:daddf2b72bb24d3490f7da0978cdd37e","is_oa":true,"landing_page_url":"https://doaj.org/article/daddf2b72bb24d3490f7da0978cdd37e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 376 (2007)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/eebc0f9a-1b20-49fe-a19a-41a4f9dce962","is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/eebc0f9a-1b20-49fe-a19a-41a4f9dce962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipniacki, T, Puszynski, K, Paszek, P, Brasier, A R & Kimmel, M 2007, 'Single TNF\u03b1 trimers mediating NF-\u03baB activation: Stochastic robustness of NF-\u03baB signaling', BMC Bioinformatics, vol. 8, 376. https://doi.org/10.1186/1471-2105-8-376","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/eebc0f9a-1b20-49fe-a19a-41a4f9dce962","is_oa":false,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/single-tnf-trimers-mediating-nfb-activation-stochastic-robustness-of-nfb-signaling(eebc0f9a-1b20-49fe-a19a-41a4f9dce962).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lipniacki, T, Puszynski, K, Paszek, P, Brasier, A R & Kimmel, M 2007, 'Single TNF\u03b1 trimers mediating NF-\u03baB activation: Stochastic robustness of NF-\u03baB signaling', BMC Bioinformatics, vol. 8, 376. https://doi.org/10.1186/1471-2105-8-376","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-376","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-376","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.5299999713897705,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W74890516","https://openalex.org/W1480466711","https://openalex.org/W1521031916","https://openalex.org/W1544401280","https://openalex.org/W1591712454","https://openalex.org/W1596801838","https://openalex.org/W1603490726","https://openalex.org/W1606805257","https://openalex.org/W1617394022","https://openalex.org/W1641228030","https://openalex.org/W1661180389","https://openalex.org/W1694093395","https://openalex.org/W1965748221","https://openalex.org/W1968117332","https://openalex.org/W1968488417","https://openalex.org/W1978319180","https://openalex.org/W1980415233","https://openalex.org/W1982528660","https://openalex.org/W1987536174","https://openalex.org/W1992282800","https://openalex.org/W1993927835","https://openalex.org/W1993936200","https://openalex.org/W1994375291","https://openalex.org/W1995747121","https://openalex.org/W2007415331","https://openalex.org/W2007875429","https://openalex.org/W2018435536","https://openalex.org/W2019307738","https://openalex.org/W2021673674","https://openalex.org/W2045316789","https://openalex.org/W2051831012","https://openalex.org/W2059053384","https://openalex.org/W2061911508","https://openalex.org/W2063116057","https://openalex.org/W2063116863","https://openalex.org/W2067052005","https://openalex.org/W2067160012","https://openalex.org/W2071902635","https://openalex.org/W2074097004","https://openalex.org/W2074401358","https://openalex.org/W2077046573","https://openalex.org/W2081880634","https://openalex.org/W2090610011","https://openalex.org/W2091161875","https://openalex.org/W2091198609","https://openalex.org/W2097545235","https://openalex.org/W2103029515","https://openalex.org/W2111167674","https://openalex.org/W2116094765","https://openalex.org/W2121905328","https://openalex.org/W2125937596","https://openalex.org/W2130091936","https://openalex.org/W2134558816","https://openalex.org/W2135940271","https://openalex.org/W2136771298","https://openalex.org/W2138843474","https://openalex.org/W2139852477","https://openalex.org/W2141688036","https://openalex.org/W2144217311","https://openalex.org/W2158548087","https://openalex.org/W2158896327","https://openalex.org/W2165526493","https://openalex.org/W2170720109","https://openalex.org/W2171327609","https://openalex.org/W2312571711","https://openalex.org/W2600160877","https://openalex.org/W3206419998","https://openalex.org/W4210393422"],"related_works":["https://openalex.org/W1977028102","https://openalex.org/W1523254788","https://openalex.org/W1993987848","https://openalex.org/W2914530652","https://openalex.org/W1921622578","https://openalex.org/W2349610456","https://openalex.org/W1589838961","https://openalex.org/W2412757382","https://openalex.org/W2133584350","https://openalex.org/W2374261164"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,211,228],"NF-kappaB":[2,64,118,129,244,249],"regulatory":[3,22],"network":[4,28],"controls":[5],"innate":[6],"immune":[7,186],"response":[8],"by":[9,29,54,63,201],"transducing":[10],"variety":[11],"of":[12,31,48,75,82,84,101,117,135,144,235,248],"pathogen-derived":[13],"and":[14,57,59,208,246],"cytokine":[15],"stimuli":[16],"into":[17,80],"well":[18],"defined":[19],"single-cell":[20,214],"gene":[21,136,142],"events.":[23],"RESULTS:":[24],"We":[25],"analyze":[26],"the":[27,32,110,115,126,133,165,184,194,231],"means":[30],"model":[33,229],"combining":[34],"a":[35,94,99,123,152],"deterministic":[36],"description":[37],"for":[38],"molecular":[39,78],"species":[40],"with":[41,45,71],"large":[42],"cellular":[43],"concentrations":[44],"two":[46,149],"classes":[47],"stochastic":[49,67,154],"switches:":[50],"cell-surface":[51],"receptor":[52],"activation":[53,62,247],"TNFalpha":[55,96,237],"ligand,":[56],"IkappaBalpha":[58],"A20":[60],"genes":[61],"molecules.":[65],"Both":[66,176],"switches":[68],"are":[69,103,178],"associated":[70],"amplification":[72,111],"pathways":[73],"capable":[74],"translating":[76],"single":[77,236],"events":[79],"tens":[81],"thousands":[83],"synthesized":[85],"or":[86,226],"degraded":[87],"proteins.":[88],"Here,":[89],"we":[90],"show":[91],"that":[92,114,193,233],"at":[93],"low":[95],"dose":[97],"only":[98,131],"fraction":[100],"cells":[102,109,160,217],"activated,":[104],"but":[105,138,168],"in":[106,156,183,189,206],"these":[107],"activated":[108],"mechanisms":[112],"assure":[113],"amplitude":[116],"nuclear":[119,128],"translocation":[120,245],"remains":[121],"above":[122],"threshold.":[124],"Similarly,":[125],"lower":[127],"concentration":[130],"reduces":[132],"probability":[134],"activation,":[137],"does":[139],"not":[140],"reduce":[141],"expression":[143],"those":[145],"responding.":[146],"CONCLUSION:":[147],"These":[148],"effects":[150,177],"provide":[151],"particular":[153],"robustness":[155],"cell":[157,190],"regulation,":[158],"allowing":[159],"to":[161,164,173,180,199,218,241],"respond":[162],"differently":[163],"same":[166],"stimuli,":[167],"causing":[169],"their":[170,220],"individual":[171,221],"responses":[172,191,215],"be":[174,181],"unequivocal.":[175],"likely":[179],"crucial":[182],"early":[185],"response:":[187],"Diversity":[188],"causes":[192],"tissue":[195],"defense":[196],"is":[197,239],"harder":[198],"overcome":[200],"relatively":[202],"simple":[203],"programs":[204],"coded":[205],"viruses":[207],"other":[209],"pathogens.":[210],"more":[212],"focused":[213],"help":[216],"choose":[219],"fates":[222],"such":[223],"as":[224],"apoptosis":[225],"proliferation.":[227],"supports":[230],"hypothesis":[232],"binding":[234],"ligands":[238],"sufficient":[240],"induce":[242],"massive":[243],"dependent":[250],"genes.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}