{"id":"https://openalex.org/W2132977283","doi":"https://doi.org/10.1186/1471-2105-8-374","title":"Statistical power of phylo-HMM for evolutionarily conserved element detection","display_name":"Statistical power of phylo-HMM for evolutionarily conserved element detection","publication_year":2007,"publication_date":"2007-10-05","ids":{"openalex":"https://openalex.org/W2132977283","doi":"https://doi.org/10.1186/1471-2105-8-374","mag":"2132977283","pmid":"https://pubmed.ncbi.nlm.nih.gov/17919331"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-374","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-374","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-374","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060018541","display_name":"Xiaodan Fan","orcid":"https://orcid.org/0000-0002-2744-9030"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodan Fan","raw_affiliation_strings":["Department of Statistics, Harvard University, Boston, MA, USA. xfan@fas.harvard.edu","Department of Statistics, Harvard University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Harvard University, Boston, MA, USA. xfan@fas.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801851002","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Statistics, Harvard University, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058745924","display_name":"Jun Zhu","orcid":"https://orcid.org/0000-0003-0834-8178"},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhu","raw_affiliation_strings":["Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc., Seattle, WA, USA","Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210148890"]},{"raw_affiliation_string":"Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc, Seattle, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071946434","display_name":"Eric E. Schadt","orcid":"https://orcid.org/0000-0002-7892-8808"},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I4210148890","display_name":"Rosetta Stone (United States)","ror":"https://ror.org/05a1nta88","country_code":"US","type":"company","lineage":["https://openalex.org/I4210148890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric E Schadt","raw_affiliation_strings":["Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc., Seattle, WA, USA","Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc., Seattle, WA, USA","institution_ids":["https://openalex.org/I4210148890"]},{"raw_affiliation_string":"Genetics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc, Seattle, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012820890","display_name":"Jun S. Liu","orcid":"https://orcid.org/0000-0002-4450-7239"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun S Liu","raw_affiliation_strings":["Department of Statistics, Harvard University, Boston, MA, USA","Department of Statistics, Harvard University, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Statistics, Harvard University, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012820890"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.5029,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.64346263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"1","first_page":"374","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.499099999666214,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.499099999666214,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.24619999527931213,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"Comparative genomics","score":0.7526749968528748},{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.6961269974708557},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.682004988193512},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5964273810386658},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5663305521011353},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5540089011192322},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5480310320854187},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.547491729259491},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.44951605796813965},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.42230290174484253},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.37395018339157104},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.29761070013046265},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.28105247020721436},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21978184580802917},{"id":"https://openalex.org/keywords/base-sequence","display_name":"Base sequence","score":0.15854117274284363},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.08665221929550171}],"concepts":[{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.7526749968528748},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.6961269974708557},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.682004988193512},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5964273810386658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5663305521011353},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5540089011192322},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5480310320854187},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.547491729259491},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44951605796813965},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.42230290174484253},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37395018339157104},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29761070013046265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28105247020721436},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21978184580802917},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.15854117274284363},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08665221929550171},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2105-8-374","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-374","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-374","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17919331","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17919331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/4454170","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4454170","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ed0c18e72b8b4967b4b0305585f361d4","is_oa":true,"landing_page_url":"https://doaj.org/article/ed0c18e72b8b4967b4b0305585f361d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 374 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2194792","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-374","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-374","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-374","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.7099999785423279}],"awards":[{"id":"https://openalex.org/G1362299450","display_name":null,"funder_award_id":"R01-GM078990","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6995586792","display_name":null,"funder_award_id":"R01 GM078990","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132977283.pdf","grobid_xml":"https://content.openalex.org/works/W2132977283.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1519916936","https://openalex.org/W1525734744","https://openalex.org/W1579352620","https://openalex.org/W1593676244","https://openalex.org/W1821582542","https://openalex.org/W1957469265","https://openalex.org/W1964918240","https://openalex.org/W1984195830","https://openalex.org/W1989563297","https://openalex.org/W1995945562","https://openalex.org/W2009596137","https://openalex.org/W2016839209","https://openalex.org/W2026315272","https://openalex.org/W2030410522","https://openalex.org/W2038287860","https://openalex.org/W2039665204","https://openalex.org/W2043419192","https://openalex.org/W2046374070","https://openalex.org/W2049633694","https://openalex.org/W2054624670","https://openalex.org/W2057568687","https://openalex.org/W2057829817","https://openalex.org/W2069739265","https://openalex.org/W2085442947","https://openalex.org/W2085637422","https://openalex.org/W2087892194","https://openalex.org/W2089657469","https://openalex.org/W2095824228","https://openalex.org/W2095869463","https://openalex.org/W2102424972","https://openalex.org/W2107010419","https://openalex.org/W2112132489","https://openalex.org/W2116251070","https://openalex.org/W2119632499","https://openalex.org/W2123242139","https://openalex.org/W2124608480","https://openalex.org/W2125838338","https://openalex.org/W2128607924","https://openalex.org/W2141411672","https://openalex.org/W2144322830","https://openalex.org/W2145191876","https://openalex.org/W2149513033","https://openalex.org/W2155237411","https://openalex.org/W2156521045","https://openalex.org/W2157674573","https://openalex.org/W2163941254","https://openalex.org/W2169384293","https://openalex.org/W2169472710","https://openalex.org/W3106889297"],"related_works":["https://openalex.org/W1493660383","https://openalex.org/W2759519215","https://openalex.org/W4318240630","https://openalex.org/W2353729507","https://openalex.org/W2350466590","https://openalex.org/W1542620732","https://openalex.org/W3031625301","https://openalex.org/W4386771068","https://openalex.org/W1968252650","https://openalex.org/W2364340602"],"abstract_inverted_index":{"BACKGROUND:":[0],"An":[1],"important":[2,65],"goal":[3],"of":[4,10,48,55,69,78,100,107,119,144,159],"comparative":[5,92,151],"genomics":[6,93,152],"is":[7,82],"the":[8,30,46,53,56,63,67,97,104,108,117,120,123,142,157],"identification":[9],"functional":[11],"elements":[12,23,102,110],"through":[13],"conservation":[14,98],"analysis.":[15],"Phylo-HMM":[16],"was":[17],"recently":[18],"introduced":[19],"to":[20,44,140],"detect":[21],"conserved":[22,101,109],"based":[24],"on":[25,60,138],"multiple":[26],"genome":[27],"alignments,":[28],"but":[29],"method":[31],"has":[32],"not":[33],"been":[34],"rigorously":[35],"evaluated.":[36],"RESULTS:":[37],"We":[38,50],"report":[39],"here":[40],"a":[41],"simulation":[42],"study":[43],"investigate":[45],"power":[47,54,160],"phylo-HMM.":[49],"show":[51],"that":[52],"phylo-HMM":[57],"approach":[58],"depends":[59],"many":[61],"factors,":[62],"most":[64],"being":[66],"number":[68,143],"species-specific":[70],"genomes":[71,145],"used":[72],"and":[73,103,122,146],"evolutionary":[74,148],"distances":[75],"between":[76],"pairs":[77],"species.":[79],"This":[80],"finding":[81],"consistent":[83],"with":[84],"results":[85,133],"reported":[86],"by":[87],"other":[88],"groups":[89],"for":[90,135],"simpler":[91],"models.":[94],"In":[95,115],"addition,":[96],"ratio":[99],"expected":[105],"length":[106],"are":[111,127],"also":[112],"major":[113],"factors.":[114,130],"contrast,":[116],"influence":[118],"topology":[121],"nucleotide":[124],"substitution":[125],"model":[126],"relatively":[128],"minor":[129],"CONCLUSION:":[131],"Our":[132],"provide":[134],"general":[136],"guidelines":[137],"how":[139],"select":[141],"their":[147],"distance":[149],"in":[150],"studies,":[153],"as":[154,156],"well":[155],"level":[158],"we":[161],"can":[162],"expect":[163],"under":[164],"different":[165],"parameter":[166],"settings.":[167]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}