{"id":"https://openalex.org/W1984048213","doi":"https://doi.org/10.1186/1471-2105-8-322","title":"Statistical validation of megavariate effects in ASCA","display_name":"Statistical validation of megavariate effects in ASCA","publication_year":2007,"publication_date":"2007-08-30","ids":{"openalex":"https://openalex.org/W1984048213","doi":"https://doi.org/10.1186/1471-2105-8-322","mag":"1984048213","pmid":"https://pubmed.ncbi.nlm.nih.gov/17760983"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-322","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-322","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-322","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091036585","display_name":"Dani\u00ebl J. Vis","orcid":"https://orcid.org/0009-0003-9522-5535"},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]},{"id":"https://openalex.org/I1295801184","display_name":"Netherlands Institute for Neuroscience","ror":"https://ror.org/05csn2x06","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1295801184","https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I4210148356","display_name":"GGD Amsterdam","ror":"https://ror.org/04gbbq803","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210088893","https://openalex.org/I4210148356"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Daniel J Vis","raw_affiliation_strings":["BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands. science@danielvis.nl","BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands. science@danielvis.nl","institution_ids":["https://openalex.org/I1295801184"]},{"raw_affiliation_string":"BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210148356","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017155895","display_name":"Johan A. Westerhuis","orcid":"https://orcid.org/0000-0002-6747-9779"},"institutions":[{"id":"https://openalex.org/I4210148356","display_name":"GGD Amsterdam","ror":"https://ror.org/04gbbq803","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210088893","https://openalex.org/I4210148356"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan A Westerhuis","raw_affiliation_strings":["BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210148356","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083251527","display_name":"Age K. Smilde","orcid":"https://orcid.org/0000-0002-3052-4644"},"institutions":[{"id":"https://openalex.org/I4210148356","display_name":"GGD Amsterdam","ror":"https://ror.org/04gbbq803","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210088893","https://openalex.org/I4210148356"]},{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Age K Smilde","raw_affiliation_strings":["BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands","TNO Quality of Life, Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems Data Analysis group, Swammerdam Institute for Life Science, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210148356","https://openalex.org/I887064364"]},{"raw_affiliation_string":"TNO Quality of Life, Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038766778","display_name":"J. van der Greef","orcid":null},"institutions":[{"id":"https://openalex.org/I4210164629","display_name":"Pension Fund for Care and Well-Being","ror":"https://ror.org/05a8epj20","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210164629"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan van der Greef","raw_affiliation_strings":["TNO Quality of Life, Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO Quality of Life, Zeist, The Netherlands","institution_ids":["https://openalex.org/I4210164629"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091036585"],"corresponding_institution_ids":["https://openalex.org/I1295801184","https://openalex.org/I4210148356","https://openalex.org/I887064364"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.6912,"has_fulltext":true,"cited_by_count":150,"citation_normalized_percentile":{"value":0.89891245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"322","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.7875895500183105},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.694192111492157},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5609489679336548},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.5449846982955933},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.5388784408569336},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5128346085548401},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.46664097905158997},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.45855826139450073},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"Statistical analysis","score":0.441841185092926},{"id":"https://openalex.org/keywords/experimental-data","display_name":"Experimental data","score":0.44110655784606934},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.4291459619998932},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36609959602355957},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35327762365341187},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3276800811290741},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.31392645835876465},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2566114664077759},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22310814261436462},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19609859585762024},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18629664182662964},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.17151865363121033},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10699304938316345}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7875895500183105},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.694192111492157},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5609489679336548},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.5449846982955933},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.5388784408569336},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5128346085548401},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.46664097905158997},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.45855826139450073},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.441841185092926},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.44110655784606934},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4291459619998932},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36609959602355957},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35327762365341187},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3276800811290741},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31392645835876465},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2566114664077759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22310814261436462},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19609859585762024},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18629664182662964},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.17151865363121033},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10699304938316345},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001969","descriptor_name":"Bromobenzenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001969","descriptor_name":"Bromobenzenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001969","descriptor_name":"Bromobenzenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1186/1471-2105-8-322","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-322","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-322","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17760983","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17760983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:dare.uva.nl:openaire/87a12e5a-e5bb-462a-8342-f1bbdd35a4f3","is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/statistical-validation-of-megavariate-effects-in-asca(87a12e5a-e5bb-462a-8342-f1bbdd35a4f3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vis, D J, Westerhuis, J A, Smilde, A K & van der Greef, J 2007, 'Statistical validation of megavariate effects in ASCA.', BMC Bioinformatics, vol. 8, pp. 322.","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2863643","is_oa":true,"landing_page_url":"https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-322","pdf_url":"https://hdl.handle.net/1887/59685","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.219.503","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.219.503","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1471-2105-8-322.pdf","raw_type":"text"},{"id":"pmh:oai:dare.uva.nl:publications/87a12e5a-e5bb-462a-8342-f1bbdd35a4f3","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:doaj.org/article:14db5eb497ff410f804a1b0325e93c47","is_oa":false,"landing_page_url":"https://doaj.org/article/14db5eb497ff410f804a1b0325e93c47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 322 (2007)","raw_type":"article"},{"id":"pmh:oai:oai-pmh.tno.nl:22520","is_oa":false,"landing_page_url":"https://resolver.tno.nl/uuid:22e23780-c52c-49d4-bac7-98d79594bcfa","pdf_url":null,"source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/59685","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/59685","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-322","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pubmedcentral.nih.gov:2211757","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2211757","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:22e23780-c52c-49d4-bac7-98d79594bcfa","is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:22e23780-c52c-49d4-bac7-98d79594bcfa","pdf_url":null,"source":{"id":"https://openalex.org/S4306402238","display_name":"Repository hosted by TU Delft Library (TU Delft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 8","raw_type":"article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/87a12e5a-e5bb-462a-8342-f1bbdd35a4f3","is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/statistical-validation-of-megavariate-effects-in-asca(87a12e5a-e5bb-462a-8342-f1bbdd35a4f3).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 8. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-322","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-322","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-322","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984048213.pdf","grobid_xml":"https://content.openalex.org/works/W1984048213.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1506214197","https://openalex.org/W1515242458","https://openalex.org/W1973778137","https://openalex.org/W1995945562","https://openalex.org/W2018135213","https://openalex.org/W2061111312","https://openalex.org/W2074875978","https://openalex.org/W2082676707","https://openalex.org/W2098562143","https://openalex.org/W2120909294","https://openalex.org/W2150985501","https://openalex.org/W2157795344","https://openalex.org/W2170656342","https://openalex.org/W2369825981","https://openalex.org/W2580359449","https://openalex.org/W3024574697","https://openalex.org/W3106889297","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2021333301","https://openalex.org/W4246719347","https://openalex.org/W2077508419","https://openalex.org/W2006114390","https://openalex.org/W2380800094","https://openalex.org/W2056203905","https://openalex.org/W2055801436","https://openalex.org/W4385400511","https://openalex.org/W2162206208","https://openalex.org/W2023660371"],"abstract_inverted_index":{"BACKGROUND:":[0],"Innovative":[1],"extensions":[2,47],"of":[3,12,39,48,73,80,142],"(M)":[4],"ANOVA":[5],"gain":[6],"common":[7],"ground":[8],"for":[9,158],"the":[10,49,70,74,85,94,129,143,172],"analysis":[11,21],"designed":[13],"metabolomics":[14,30,118,127,162],"experiments.":[15,34],"ASCA":[16],"is":[17,42,59,82,88,96,103,169],"such":[18],"a":[19,78],"multivariate":[20],"method;":[22],"it":[23],"has":[24],"successfully":[25],"estimated":[26],"effects":[27,41,64,137,160],"in":[28],"megavariate":[29,40,46,63],"data":[31,107,119,163],"from":[32,91],"biological":[33],"However,":[35],"rigorous":[36],"statistical":[37],"validation":[38,168],"still":[43],"problematic":[44],"because":[45],"classical":[50],"F-test":[51],"do":[52],"not":[53],"exist.":[54],"METHODS:":[55],"A":[56],"permutation":[57,101],"approach":[58,102],"used":[60,115],"to":[61],"validate":[62],"observed":[65,86],"with":[66,122,148],"ASCA.":[67],"By":[68],"permuting":[69],"class":[71],"labels":[72],"underlying":[75,161],"experimental":[76],"design,":[77],"distribution":[79,93],"no-effect":[81],"calculated.":[83],"If":[84],"effect":[87,95,133],"clearly":[89],"different":[90],"this":[92,126,149],"deemed":[97],"significant":[98],"RESULTS:":[99],"The":[100,152],"studied":[104],"using":[105,171],"simulated":[106],"which":[108],"gave":[109],"successful":[110],"results.":[111],"It":[112],"was":[113],"then":[114],"on":[116],"real-life":[117],"set":[120],"dealing":[121],"bromobenzene-dosed":[123],"rats.":[124],"In":[125],"experiment":[128],"dosage":[130],"and":[131],"time-interaction":[132],"were":[134],"validated,":[135],"both":[136],"are":[138],"significant.":[139],"Histological":[140],"screening":[141],"treated":[144],"rats'":[145],"liver":[146],"agrees":[147],"finding.":[150],"CONCLUSION:":[151],"suggested":[153],"procedure":[154],"gives":[155],"approximate":[156],"p-values":[157],"testing":[159],"sets.":[164],"Therefore,":[165],"performing":[166],"model":[167],"possible":[170],"proposed":[173],"procedure.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
