{"id":"https://openalex.org/W2103209361","doi":"https://doi.org/10.1186/1471-2105-8-290","title":"Computation of significance scores of unweighted Gene Set Enrichment Analyses","display_name":"Computation of significance scores of unweighted Gene Set Enrichment Analyses","publication_year":2007,"publication_date":"2007-08-06","ids":{"openalex":"https://openalex.org/W2103209361","doi":"https://doi.org/10.1186/1471-2105-8-290","mag":"2103209361","pmid":"https://pubmed.ncbi.nlm.nih.gov/17683603"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-290","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-290","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-8-290.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-8-290.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020280119","display_name":"Andreas Keller","orcid":"https://orcid.org/0000-0002-5361-0895"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Keller","raw_affiliation_strings":["Center for Bioinformatics, Saarland University, Building E1 1, 66804 Saarbr\u00fccken, Germany. ack@bioinf.uni-sb.de","Center for Bioinformatics Saarland University Saarbr\u00fccken Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland University, Building E1 1, 66804 Saarbr\u00fccken, Germany. ack@bioinf.uni-sb.de","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Center for Bioinformatics Saarland University Saarbr\u00fccken Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015677497","display_name":"Christina Backes","orcid":"https://orcid.org/0000-0001-9330-9290"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Backes","raw_affiliation_strings":["Center for Bioinformatics, Saarland University, Building E1 1, 66804, Saarbr\u00fccken, Germany","Center for Bioinformatics Saarland University Saarbr\u00fccken Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland University, Building E1 1, 66804, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Center for Bioinformatics Saarland University Saarbr\u00fccken Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085594740","display_name":"Hans\u2010Peter Lenhof","orcid":"https://orcid.org/0000-0002-5820-9961"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Lenhof","raw_affiliation_strings":["Center for Bioinformatics, Saarland University, Building E1 1, 66804, Saarbr\u00fccken, Germany","Center for Bioinformatics Saarland University Saarbr\u00fccken Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland University, Building E1 1, 66804, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Center for Bioinformatics Saarland University Saarbr\u00fccken Germany","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020280119"],"corresponding_institution_ids":["https://openalex.org/I91712215"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.0189,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.86262779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"290","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7793999910354614,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.7793999910354614,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.7329025864601135},{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"Nonparametric statistics","score":0.677956223487854},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.6002155542373657},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5869825482368469},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5371255278587341},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.4808157682418823},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.46769192814826965},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4346989095211029},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4338025152683258},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4268089234828949},{"id":"https://openalex.org/keywords/significance-analysis-of-microarrays","display_name":"Significance analysis of microarrays","score":0.42526233196258545},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.4243320822715759},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3497970998287201},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3363804519176483},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2930746376514435},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2401348352432251},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23288756608963013},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2246364951133728},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19373351335525513}],"concepts":[{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.7329025864601135},{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.677956223487854},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.6002155542373657},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5869825482368469},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5371255278587341},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.4808157682418823},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.46769192814826965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4346989095211029},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4338025152683258},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4268089234828949},{"id":"https://openalex.org/C77360908","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Significance analysis of microarrays","level":5,"score":0.42526233196258545},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.4243320822715759},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3497970998287201},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3363804519176483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2930746376514435},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2401348352432251},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23288756608963013},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2246364951133728},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19373351335525513},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018307","descriptor_name":"Neoplasms, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2105-8-290","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-290","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-8-290.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17683603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17683603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f9bacbd8cf844536a401c179304c3323","is_oa":true,"landing_page_url":"https://doaj.org/article/f9bacbd8cf844536a401c179304c3323","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 290 (2007)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1994690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1994690","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-290","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-290","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2105-8-290.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103209361.pdf","grobid_xml":"https://content.openalex.org/works/W2103209361.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1981093360","https://openalex.org/W1982428412","https://openalex.org/W1997921822","https://openalex.org/W2014620140","https://openalex.org/W2075019355","https://openalex.org/W2086934780","https://openalex.org/W2099396594","https://openalex.org/W2102074241","https://openalex.org/W2103017472","https://openalex.org/W2105022693","https://openalex.org/W2110065044","https://openalex.org/W2115012618","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2130687290","https://openalex.org/W2134672568","https://openalex.org/W2134889157","https://openalex.org/W2135030836","https://openalex.org/W2136479434","https://openalex.org/W2154021172","https://openalex.org/W2154362705","https://openalex.org/W2155723007","https://openalex.org/W2165674132","https://openalex.org/W2166512255","https://openalex.org/W4247469419"],"related_works":["https://openalex.org/W2077508419","https://openalex.org/W2021333301","https://openalex.org/W2006114390","https://openalex.org/W2380800094","https://openalex.org/W2056203905","https://openalex.org/W4385400511","https://openalex.org/W2162206208","https://openalex.org/W2023660371","https://openalex.org/W4289761835","https://openalex.org/W2507906577"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gene":[1,110],"Set":[2,111],"Enrichment":[3,112],"Analysis":[4],"(GSEA)":[5],"is":[6,143],"a":[7,84,98],"computational":[8],"method":[9],"for":[10,25,103],"the":[11,43,54,57,70,93,131,138],"statistical":[12],"evaluation":[13],"of":[14,17,40,56,69,76,92,108,119,137,167],"sorted":[15,38],"lists":[16],"genes":[18,55],"or":[19,63,67],"proteins.":[20],"Originally":[21],"GSEA":[22,51,77],"was":[23],"developed":[24],"interpreting":[26],"microarray":[27],"gene":[28,44],"expression":[29,165],"data,":[30],"but":[31,162],"it":[32,155],"can":[33],"be":[34],"applied":[35,154],"to":[36,158],"any":[37],"list":[39,45],"genes.":[41],"Given":[42],"and":[46,146,173],"an":[47],"arbitrary":[48],"biological":[49],"category,":[50],"evaluates":[52],"whether":[53],"considered":[58],"category":[59],"are":[60,78],"randomly":[61],"distributed":[62],"accumulated":[64],"on":[65],"top":[66],"bottom":[68],"list.":[71],"Usually,":[72],"significance":[73,106],"scores":[74],"(p-values)":[75],"computed":[79],"by":[80,130],"nonparametric":[81,120],"permutation":[82,121],"tests,":[83,122],"time":[85],"consuming":[86],"procedure":[87],"that":[88],"yields":[89],"only":[90,157],"estimates":[91],"p-values.":[94],"RESULTS:":[95],"We":[96],"present":[97],"novel":[99],"dynamic":[100,140],"programming":[101,141],"algorithm":[102,115,142],"calculating":[104],"exact":[105],"values":[107],"unweighted":[109],"Analyses.":[113],"Our":[114],"avoids":[116],"typical":[117],"problems":[118],"as":[123],"varying":[124],"findings":[125],"in":[126],"different":[127],"runs":[128],"caused":[129],"random":[132],"sampling":[133],"procedure.":[134],"Another":[135],"advantage":[136],"presented":[139],"its":[144],"runtime":[145],"memory":[147],"efficiency.":[148],"To":[149],"test":[150],"our":[151],"algorithm,":[152],"we":[153],"not":[156],"simulated":[159],"data":[160],"sets,":[161],"additionally":[163],"evaluated":[164],"profiles":[166],"squamous":[168],"cell":[169],"lung":[170],"cancer":[171],"tissue":[172],"autologous":[174],"unaffected":[175],"tissue.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}