{"id":"https://openalex.org/W2164627561","doi":"https://doi.org/10.1186/1471-2105-8-121","title":"A network perspective on the topological importance of enzymes and their phylogenetic conservation","display_name":"A network perspective on the topological importance of enzymes and their phylogenetic conservation","publication_year":2007,"publication_date":"2007-04-11","ids":{"openalex":"https://openalex.org/W2164627561","doi":"https://doi.org/10.1186/1471-2105-8-121","mag":"2164627561","pmid":"https://pubmed.ncbi.nlm.nih.gov/17425808"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035832600","display_name":"Wei\u2010Chung Liu","orcid":"https://orcid.org/0000-0001-8041-8789"},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wei-chung Liu","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. wliu56@gate.sinica.edu.tw","Institute of Biomedical Sciences, Academia Sinica, Taipei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. wliu56@gate.sinica.edu.tw","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei","institution_ids":["https://openalex.org/I4210096666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102644282","display_name":"Wen-hsien Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-hsien Lin","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Academia Sinica, Taipei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei","institution_ids":["https://openalex.org/I4210096666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081811745","display_name":"Andrew Davis","orcid":"https://orcid.org/0000-0001-9030-4355"},"institutions":[{"id":"https://openalex.org/I4210117675","display_name":"Max Planck Institute for Chemical Ecology","ror":"https://ror.org/02ks53214","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210117675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrew J Davis","raw_affiliation_strings":["Biochemistry Section, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany","Biochemistry Section, Max Planck Institute for Chemical Ecology, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Section, Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210117675"]},{"raw_affiliation_string":"Biochemistry Section, Max Planck Institute for Chemical Ecology, Jena, Germany","institution_ids":["https://openalex.org/I4210117675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044566654","display_name":"Ferenc Jord\u00e1n","orcid":"https://orcid.org/0000-0002-0224-6472"},"institutions":[{"id":"https://openalex.org/I2799841867","display_name":"Hungarian Natural History Museum","ror":"https://ror.org/04y1zat75","country_code":"HU","type":"archive","lineage":["https://openalex.org/I2799841867"]},{"id":"https://openalex.org/I4210161853","display_name":"Budapest Institute","ror":"https://ror.org/050hvq478","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210161853"]},{"id":"https://openalex.org/I4210099710","display_name":"Collegium Budapest","ror":"https://ror.org/00j39nx61","country_code":"HU","type":"other","lineage":["https://openalex.org/I4210099710"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Ferenc Jord\u00e1n","raw_affiliation_strings":["Animal Ecology Research Group, HAS, Hungarian Natural History Museum, Ludovika t. 2., H-1083, Budapest, Hungary","Collegium Budapest, Institute for Advanced Study, Szenth\u00e1roms\u00e1g utca 2, H-1014, Budapest, Hungary","Animal Ecology Research Group, HAS, Hungarian Natural History Museum, Budapest, Hungary","Collegium Budapest, Institute for Advanced Study, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Ecology Research Group, HAS, Hungarian Natural History Museum, Ludovika t. 2., H-1083, Budapest, Hungary","institution_ids":["https://openalex.org/I2799841867"]},{"raw_affiliation_string":"Collegium Budapest, Institute for Advanced Study, Szenth\u00e1roms\u00e1g utca 2, H-1014, Budapest, Hungary","institution_ids":["https://openalex.org/I4210099710"]},{"raw_affiliation_string":"Animal Ecology Research Group, HAS, Hungarian Natural History Museum, Budapest, Hungary","institution_ids":["https://openalex.org/I2799841867"]},{"raw_affiliation_string":"Collegium Budapest, Institute for Advanced Study, Budapest, Hungary","institution_ids":["https://openalex.org/I4210099710","https://openalex.org/I4210161853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053912961","display_name":"Hsih\u2010Te Yang","orcid":"https://orcid.org/0000-0002-4851-1374"},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsih-te Yang","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Academia Sinica, Taipei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei","institution_ids":["https://openalex.org/I4210096666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039723620","display_name":"Ming\u2010Jing Hwang","orcid":"https://orcid.org/0000-0002-9657-5663"},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-jing Hwang","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","Institute of Biomedical Sciences, Academia Sinica, Taipei"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210096666"]},{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei","institution_ids":["https://openalex.org/I4210096666"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035832600"],"corresponding_institution_ids":["https://openalex.org/I4210096666"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.6912,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.904612,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"121","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.41659998893737793,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.9229412078857422},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.7141215205192566},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.705482542514801},{"id":"https://openalex.org/keywords/phylogenetic-network","display_name":"Phylogenetic network","score":0.6033579707145691},{"id":"https://openalex.org/keywords/closeness","display_name":"Closeness","score":0.5849319100379944},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5156716108322144},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5050538182258606},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.49681833386421204},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4309334456920624},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.4139626920223236},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3772258460521698},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26227831840515137},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2248205840587616},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1981835663318634},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.16251549124717712},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11457875370979309}],"concepts":[{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.9229412078857422},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.7141215205192566},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.705482542514801},{"id":"https://openalex.org/C26619641","wikidata":"https://www.wikidata.org/wiki/Q3142246","display_name":"Phylogenetic network","level":4,"score":0.6033579707145691},{"id":"https://openalex.org/C2779545769","wikidata":"https://www.wikidata.org/wiki/Q5135364","display_name":"Closeness","level":2,"score":0.5849319100379944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5156716108322144},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5050538182258606},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.49681833386421204},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4309334456920624},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.4139626920223236},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3772258460521698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26227831840515137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2248205840587616},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1981835663318634},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.16251549124717712},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11457875370979309},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-8-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17425808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17425808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:5013db35ffc4434d828a3c115c6d8ff8","is_oa":false,"landing_page_url":"https://doaj.org/article/5013db35ffc4434d828a3c115c6d8ff8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 121 (2007)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:349832","is_oa":false,"landing_page_url":"http://edoc.mpg.de/349832","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BioMed Central, v.8 (2007)","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1955749","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1955749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_439165","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0012-A6C6-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-121","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-121","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-121","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.75,"display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2164627561.pdf","grobid_xml":"https://content.openalex.org/works/W2164627561.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W950821216","https://openalex.org/W1577525534","https://openalex.org/W1757313384","https://openalex.org/W1879806063","https://openalex.org/W1971788485","https://openalex.org/W1983202741","https://openalex.org/W1989921625","https://openalex.org/W1992306474","https://openalex.org/W1996529795","https://openalex.org/W2008620264","https://openalex.org/W2025663053","https://openalex.org/W2028561804","https://openalex.org/W2029918421","https://openalex.org/W2045403483","https://openalex.org/W2057885377","https://openalex.org/W2061901927","https://openalex.org/W2082616165","https://openalex.org/W2094399313","https://openalex.org/W2098709515","https://openalex.org/W2099551325","https://openalex.org/W2103731920","https://openalex.org/W2112090702","https://openalex.org/W2114484738","https://openalex.org/W2122407999","https://openalex.org/W2126001334","https://openalex.org/W2130790725","https://openalex.org/W2140000393","https://openalex.org/W2144885342","https://openalex.org/W2155331065","https://openalex.org/W2159460045","https://openalex.org/W2162422091","https://openalex.org/W2163480486","https://openalex.org/W2167232457","https://openalex.org/W3103786587","https://openalex.org/W3129191898","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W1973509935","https://openalex.org/W4389076551","https://openalex.org/W2097992793","https://openalex.org/W2107855069","https://openalex.org/W2611574733","https://openalex.org/W2241641394","https://openalex.org/W2140653560","https://openalex.org/W2348831795","https://openalex.org/W2514739320","https://openalex.org/W4312461432"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"metabolic":[2,66,298],"network":[3,89,103,117,201,241,276,287,323],"is":[4,71,75,127,180,237,296],"the":[5,14,17,44,51,65,91,108,111,218,230,311,314,346],"sum":[6],"of":[7,47,53,77,95,105,113,115,175,187,235,239,302,313,321],"all":[8,140],"chemical":[9],"transformations":[10],"or":[11,50,110],"reactions":[12],"in":[13,27,34,64,191,198,265,284,310,317,334,345],"cell,":[15],"with":[16,153,160,164,251,259],"metabolites":[18],"being":[19],"interconnected":[20],"by":[21,205,210],"enzyme-catalyzed":[22],"reactions.":[23],"Many":[24],"enzymes":[25,236,344],"exist":[26],"numerous":[28],"species":[29,56,268],"while":[30],"others":[31],"occur":[32,264,333],"only":[33],"a":[35,116,125,136,322],"few.":[36],"We":[37,100,194,213,278],"ask":[38],"if":[39],"there":[40],"are":[41,172,308],"relationships":[42],"between":[43,143,220],"phylogenetic":[45,73,149,189,221,233,247,292],"profile":[46,74,150,190,222,234,248,293],"an":[48,87,199],"enzyme,":[49],"number":[52,112],"different":[54],"bacterial":[55,192,267,336],"that":[57,72,182,196,232,246,263,273,280],"contain":[58],"it,":[59],"and":[60,97,130,156,169,178,223,253,306,330],"its":[61],"topological":[62,78,106,176,224],"importance":[63,177],"network.":[67,315,348],"Our":[68,227,243],"null":[69,83],"hypothesis":[70,84,231],"independent":[76,238],"importance.":[79,225,242,277],"To":[80],"test":[81],"our":[82],"we":[85],"constructed":[86],"enzyme":[88,200,240],"from":[90,342],"KEGG":[92],"(Kyoto":[93],"Encyclopedia":[94],"Genes":[96],"Genomes)":[98],"database.":[99],"calculated":[101],"three":[102],"indices":[104],"importance:":[107],"degree":[109,252],"connections":[114],"node;":[118],"closeness":[119,165,170,211,260],"centrality,":[120,255],"which":[121],"measures":[122,174],"how":[123,134],"close":[124],"node":[126,137],"to":[128,270],"others;":[129],"betweenness":[131,154,168,206,254],"centrality":[132,155,207,290],"measuring":[133],"frequently":[135],"appears":[138],"on":[139],"shortest":[141],"paths":[142],"two":[144],"other":[145,343],"nodes.":[146],"RESULTS:":[147],"Enzyme":[148],"correlates":[151,249],"best":[152],"also":[157,214],"quite":[158],"closely":[159],"degree,":[161],"but":[162,208,256],"poorly":[163],"centrality.":[166,212,261],"Both":[167],"centralities":[171],"non-local":[173],"it":[179],"intriguing":[181],"they":[183],"have":[184,274],"contrasting":[185],"power":[186],"predicting":[188],"species.":[193,337],"speculate":[195,279],"redundancy":[197],"may":[202],"be":[203,271,325],"reflected":[204],"not":[209,309],"discuss":[215],"factors":[216],"influencing":[217],"correlation":[219],"CONCLUSION:":[226],"analysis":[228],"falsifies":[229],"results":[244],"show":[245],"better":[250],"less":[257],"so":[258],"Enzymes":[262,316],"many":[266,335],"tend":[269],"those":[272],"high":[275],"this":[281],"phenomenon":[282],"originates":[283],"mechanisms":[285],"driving":[286],"evolution.":[288],"Closeness":[289],"reflects":[291],"poorly.":[294],"This":[295],"because":[297],"networks":[299],"often":[300],"consist":[301],"distinct":[303],"functional":[304],"modules":[305],"some":[307],"centre":[312],"these":[318],"peripheral":[319],"parts":[320],"might":[324],"important":[326],"for":[327],"cell":[328],"survival":[329],"should":[331],"therefore":[332],"They":[338],"are,":[339],"however,":[340],"distant":[341],"same":[347]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}