{"id":"https://openalex.org/W2142372384","doi":"https://doi.org/10.1186/1471-2105-8-101","title":"LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise","display_name":"LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise","publication_year":2007,"publication_date":"2007-03-26","ids":{"openalex":"https://openalex.org/W2142372384","doi":"https://doi.org/10.1186/1471-2105-8-101","mag":"2142372384","pmid":"https://pubmed.ncbi.nlm.nih.gov/17386085"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2105-8-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-101","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-101","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039429080","display_name":"Dante Mantini","orcid":"https://orcid.org/0000-0001-6485-5559"},"institutions":[{"id":"https://openalex.org/I4210136872","display_name":"Tecnologie Avanzate (Italy)","ror":"https://ror.org/04kevy945","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210136872"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dante Mantini","raw_affiliation_strings":["Istituto Tecnologie Avanzate Biomediche, Fondazione G. D'Annunzio, Chieti, Italy. d.mantini@unich.it <d.mantini@unich.it>","Istituto Tecnologie Avanzate Biomediche (ITAB), Fondazione \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Tecnologie Avanzate Biomediche, Fondazione G. D'Annunzio, Chieti, Italy. d.mantini@unich.it <d.mantini@unich.it>","institution_ids":["https://openalex.org/I4210136872"]},{"raw_affiliation_string":"Istituto Tecnologie Avanzate Biomediche (ITAB), Fondazione \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I4210136872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072776539","display_name":"Francesca Petrucci","orcid":null},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Petrucci","raw_affiliation_strings":["Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000615064","display_name":"Damiana Pieragostino","orcid":"https://orcid.org/0000-0003-1015-3484"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Damiana Pieragostino","raw_affiliation_strings":["Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","institution_ids":[]},{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037946109","display_name":"Piero Del Boccio","orcid":"https://orcid.org/0000-0003-1653-2194"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Del Boccio","raw_affiliation_strings":["Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","institution_ids":[]},{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053476405","display_name":"Marta Di Nicola","orcid":"https://orcid.org/0000-0003-1748-1931"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Di Nicola","raw_affiliation_strings":["Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103422612","display_name":"Carmine Di Ilio","orcid":null},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmine Di Ilio","raw_affiliation_strings":["Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075406326","display_name":"Giorgio Federici","orcid":null},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210123352","display_name":"Bambino Ges\u00f9 Children's Hospital","ror":"https://ror.org/02sy42d13","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Federici","raw_affiliation_strings":["Dipartimento di Medicina Interna, Universit\u00e0 di Roma \"Tor Vergata\", Roma, Italy","Ospedale Pediatrico Bambino Ges\u00f9, IRCCS, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna, Universit\u00e0 di Roma \"Tor Vergata\", Roma, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Ospedale Pediatrico Bambino Ges\u00f9, IRCCS, Roma, Italy","institution_ids":["https://openalex.org/I4210123352","https://openalex.org/I4210153126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054208280","display_name":"Paolo Sacchetta","orcid":"https://orcid.org/0000-0002-1410-3946"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Sacchetta","raw_affiliation_strings":["Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026145039","display_name":"Silvia Comani","orcid":"https://orcid.org/0000-0001-8100-457X"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]},{"id":"https://openalex.org/I4210136872","display_name":"Tecnologie Avanzate (Italy)","ror":"https://ror.org/04kevy945","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210136872"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Comani","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Bioimmagini, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","Istituto Tecnologie Avanzate Biomediche (ITAB), Fondazione \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Bioimmagini, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]},{"raw_affiliation_string":"Istituto Tecnologie Avanzate Biomediche (ITAB), Fondazione \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I4210136872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076115568","display_name":"Andrea Urbani","orcid":"https://orcid.org/0000-0001-9168-3174"},"institutions":[{"id":"https://openalex.org/I39387349","display_name":"University of Chieti-Pescara","ror":"https://ror.org/00qjgza05","country_code":"IT","type":"education","lineage":["https://openalex.org/I39387349"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Andrea Urbani","raw_affiliation_strings":["Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Europeo Ricerca sul Cervello (CERC), IRCCS-Fondazione S. Lucia, Roma, Italy","institution_ids":[]},{"raw_affiliation_string":"Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione \"G.D'Annunzio\", Chieti, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Scienze Biomediche, Universit\u00e0 \"G. D'Annunzio\", Chieti, Italy","institution_ids":["https://openalex.org/I39387349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5076115568"],"corresponding_institution_ids":["https://openalex.org/I39387349"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.6995,"has_fulltext":true,"cited_by_count":146,"citation_normalized_percentile":{"value":0.95515639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7355999946594238,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7355999946594238,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.22759999334812164,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.6739262342453003},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.5861201286315918},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5016565322875977},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.498593807220459},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44645440578460693},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.4432174861431122},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.427661657333374},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.4269734025001526},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38710030913352966},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.37804463505744934},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.36719805002212524},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2554551959037781},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07851099967956543}],"concepts":[{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.6739262342453003},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5861201286315918},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5016565322875977},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.498593807220459},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44645440578460693},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.4432174861431122},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.427661657333374},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.4269734025001526},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38710030913352966},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.37804463505744934},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36719805002212524},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2554551959037781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07851099967956543},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2105-8-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-101","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-101","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17386085","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17386085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/245755","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/245755","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol. 8 (1), Art.No. ARTN 101","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:330d198bc74940eab5fb676503e76bc3","is_oa":false,"landing_page_url":"https://doaj.org/article/330d198bc74940eab5fb676503e76bc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 8, Iss 1, p 101 (2007)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1818279","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1847688","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:9b644dd9-e0dd-4b00-92b8-a28ef6d5a044","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:9b644dd9-e0dd-4b00-92b8-a28ef6d5a044","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1186/1471-2105-8-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2105-8-101","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-8-101","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326081","display_name":"Regione Piemonte","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2142372384.pdf","grobid_xml":"https://content.openalex.org/works/W2142372384.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1487970588","https://openalex.org/W1977184198","https://openalex.org/W1998067552","https://openalex.org/W2003868797","https://openalex.org/W2029400956","https://openalex.org/W2031643671","https://openalex.org/W2062470093","https://openalex.org/W2075851722","https://openalex.org/W2083870231","https://openalex.org/W2090907035","https://openalex.org/W2094229819","https://openalex.org/W2095485643","https://openalex.org/W2109606373","https://openalex.org/W2110739536","https://openalex.org/W2111987315","https://openalex.org/W2112909603","https://openalex.org/W2120968240","https://openalex.org/W2123989476","https://openalex.org/W2137565982","https://openalex.org/W2137838906","https://openalex.org/W2139564441","https://openalex.org/W2146197170","https://openalex.org/W2168130065"],"related_works":["https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W3089769884","https://openalex.org/W2031369865","https://openalex.org/W1969295409","https://openalex.org/W2010715465","https://openalex.org/W2558197048","https://openalex.org/W3150792906","https://openalex.org/W2039928317","https://openalex.org/W1999883774"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mass":[1],"spectrometry":[2],"protein":[3,26,43,107,177,203,228],"profiling":[4],"is":[5,30,49,52,66,89,172],"a":[6,19,36,72,98,126],"promising":[7],"tool":[8],"for":[9,22,39,57,125,223],"biomarker":[10,244],"discovery":[11],"in":[12,76,175,193,240],"clinical":[13],"proteomics.":[14],"However,":[15],"the":[16,23,40,69,77,83,95,106,130,134,138,150,154,157,214,224,241],"development":[17],"of":[18,25,42,71,82,97,129,146,156,195,226,232,243],"reliable":[20,127],"approach":[21],"separation":[24],"signals":[27,108],"from":[28,45,86,109,137,163],"noise":[29,59,74,132],"required.":[31],"In":[32],"this":[33],"paper,":[34],"LIMPIC,":[35],"computational":[37],"method":[38],"detection":[41,65,99],"peaks":[44,84],"linear-mode":[46],"MALDI-TOF":[47,139],"data":[48],"proposed.":[50],"LIMPIC":[51,113,170,219,236],"based":[53],"on":[54,94,200,213],"novel":[55],"techniques":[56],"background":[58,131],"reduction":[60],"and":[61,102,133,185,197,205],"baseline":[62,135],"removal.":[63],"Peak":[64],"performed":[67],"considering":[68],"presence":[70],"non-homogeneous":[73],"level":[75],"mass":[78,140],"spectrum.":[79],"A":[80],"comparison":[81,182],"collected":[85],"multiple":[87],"spectra":[88],"used":[90,222],"to":[91,104,116],"classify":[92],"them":[93],"basis":[96],"rate":[100],"parameter,":[101],"hence":[103],"separate":[105],"other":[110,120],"disturbances.":[111],"RESULTS:":[112],"preprocessing":[114,122],"proves":[115],"be":[117,161,221,238],"superior":[118,191],"than":[119],"classical":[121],"techniques,":[123],"allowing":[124],"decomposition":[128],"drift":[136],"spectra.":[141,165],"It":[142],"provides":[143],"lower":[144],"coefficient":[145],"variation":[147],"associated":[148],"with":[149,183,218],"peak":[151,215],"intensity,":[152],"improving":[153],"reliability":[155],"information":[158,212],"that":[159,169],"can":[160],"extracted":[162,217],"single":[164],"Our":[166],"results":[167],"show":[168],"peak-picking":[171,187],"effective":[173],"even":[174],"low":[176],"concentration":[178],"regimes.":[179],"The":[180,210],"analytical":[181],"commercial":[184],"freeware":[186],"algorithms":[188],"demonstrates":[189],"its":[190],"performances":[192],"terms":[194],"sensitivity":[196],"specificity,":[198],"both":[199],"in-vitro":[201],"purified":[202],"samples":[204],"human":[206],"plasma":[207],"samples.":[208],"CONCLUSION:":[209],"quantitative":[211],"intensity":[216],"could":[220],"recognition":[225],"significant":[227],"profiles":[229],"by":[230],"means":[231],"advanced":[233],"statistic":[234],"tools:":[235],"might":[237],"valuable":[239],"perspective":[242],"discovery.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}